| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie-Claude Dery, Valerie Leblanc, Carl Shooner, Eric Asseli. Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12816542. |
these results suggest that increased akt expression and activity in response to estradiol may be an important mechanism to protect endometrial cells from apoptotic triggering and to induce endometrial cell proliferation, whereas inhibition of akt activity leads to caspase-3 activation and apoptosis in endometrial cells. |
2004-09-08 |
2023-08-12 |
rat |
| Laura M DeBusk, Dennis E Hallahan, Pengnian Charles Li. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway. Experimental cell research. vol 298. issue 1. 2004-09-08. PMID:15242771. |
blocking akt function abolishes angiopoietin 1 (ang1), a ligand for tie2, mediated ec survival, and activating akt rescues a tie2 blockade-induced ec apoptosis. |
2004-09-08 |
2023-08-12 |
Not clear |
| Laura M DeBusk, Dennis E Hallahan, Pengnian Charles Li. Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway. Experimental cell research. vol 298. issue 1. 2004-09-08. PMID:15242771. |
in contrast, activating akt rescues ec apoptosis induced by a vegf blockade, but interestingly, blocking akt function has no effects on vegf-induced ec survival, demonstrating that akt is sufficient but not required for vegf-mediated ec survival. |
2004-09-08 |
2023-08-12 |
Not clear |
| Hiroshi Ueda, Rika Morishita, Shuh Narumiya, Kanefusa Kato, Tomiko Asan. Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells. Experimental cell research. vol 298. issue 1. 2004-09-08. PMID:15242775. |
galphaq/11 signaling induces apoptosis through two pathways involving reduction of akt phosphorylation and activation of rhoa in hela cells. |
2004-09-08 |
2023-08-12 |
Not clear |
| Hiroshi Ueda, Rika Morishita, Shuh Narumiya, Kanefusa Kato, Tomiko Asan. Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells. Experimental cell research. vol 298. issue 1. 2004-09-08. PMID:15242775. |
these results demonstrate that gq/11 signaling induces apoptosis by reducing insulin-stimulated akt phosphorylation through tyrosine dephosphorylation and activating rhoa in hela cells. |
2004-09-08 |
2023-08-12 |
Not clear |
| Huamin Wang, Hua Wang, Wei Zhang, Helen J Huang, Warren S L Liao, Gregory N Fulle. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 8. 2004-09-02. PMID:15184909. |
as downstream targets of the pten and egfr signaling pathways, akt, nfkappab, and signal transducer and activator of transcription-3 (stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis. |
2004-09-02 |
2023-08-12 |
human |
| Laura Asnaghi, Angela Calastretti, Annamaria Bevilacqua, Igea D'Agnano, Giuliana Gatti, Gianfranco Canti, Domenico Delia, Sergio Capaccioli, Angelo Nicoli. Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208671. |
bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mtor and are regulated by akt. |
2004-09-02 |
2023-08-12 |
Not clear |
| Laura Asnaghi, Angela Calastretti, Annamaria Bevilacqua, Igea D'Agnano, Giuliana Gatti, Gianfranco Canti, Domenico Delia, Sergio Capaccioli, Angelo Nicoli. Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208671. |
in hek293 cells expressing akt mutants, the level of bcl-2 phosphorylation and the threshold of apoptosis induced by taxol or by nocodazole are significantly modified. |
2004-09-02 |
2023-08-12 |
Not clear |
| Deborah A Altomare, Hui Qin Wang, Kristine L Skele, Assunta De Rienzo, Andres J Klein-Szanto, Andrew K Godwin, Joseph R Test. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208673. |
akt mediates survival signals that protect cells from apoptosis and, thus, is a potentially important therapeutic target. |
2004-09-02 |
2023-08-12 |
human |
| Deborah A Altomare, Hui Qin Wang, Kristine L Skele, Assunta De Rienzo, Andres J Klein-Szanto, Andrew K Godwin, Joseph R Test. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208673. |
pretreatment of skov3 cells, which exhibit constitutive akt activity under low serum conditions, with the pi3k inhibitor ly294002 augmented cisplatin-induced apoptosis. |
2004-09-02 |
2023-08-12 |
human |
| Deborah A Altomare, Hui Qin Wang, Kristine L Skele, Assunta De Rienzo, Andres J Klein-Szanto, Andrew K Godwin, Joseph R Test. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208673. |
in contrast, ovarian cancer cell lines ovcar4 and ovcar5, which have low basal levels of akt activity, did not show increased cisplatin-induced apoptosis when pretreated with ly294002. |
2004-09-02 |
2023-08-12 |
human |
| Decheng Cai, Richard M McCarron, Erik Z Yu, Yingyue Li, John Hallenbec. Akt phosphorylation and kinase activity are down-regulated during hibernation in the 13-lined ground squirrel. Brain research. vol 1014. issue 1-2. 2004-08-30. PMID:15212987. |
akt is a key molecule in the insulin/insulin-like growth factor signal transduction pathway, which plays a critical role in the balance between survival and apoptosis. |
2004-08-30 |
2023-08-12 |
caenorhabditis_elegans |
| Lin Yang, Han C Dan, Mei Sun, Qiyuan Liu, Xia-meng Sun, Richard I Feldman, Andrew D Hamilton, Mark Polokoff, Santo V Nicosia, Meenhard Herlyn, Said M Sebti, Jin Q Chen. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer research. vol 64. issue 13. 2004-08-26. PMID:15231645. |
the inhibition of akt kinase resulted in suppression of cell growth and induction of apoptosis in human cancer cells that harbor constitutively activated akt due to overexpression of akt or other genetic alterations such as pten mutation. |
2004-08-26 |
2023-08-12 |
mouse |
| Mickol Reuveny, Hanna Heller, Eyal Benga. RhoA controls myoblast survival by inducing the phosphatidylinositol 3-kinase-Akt signaling pathway. FEBS letters. vol 569. issue 1-3. 2004-08-25. PMID:15225621. |
constitutive expression of an active form of akt prevents apoptosis in myoblasts treated with the rho inhibitor c3-transferase. |
2004-08-25 |
2023-08-12 |
Not clear |
| Marina S Vivarelli, Douglas McDonald, Mendy Miller, Nicole Cusson, Michelle Kelliher, Raif S Geh. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. The Journal of experimental medicine. vol 200. issue 3. 2004-08-24. PMID:15280422. |
rip(-/-) splenocytes exhibited increased apoptosis and impaired akt phosphorylation after lps stimulation. |
2004-08-24 |
2023-08-12 |
mouse |
| Isao Shiraishi, Jaime Melendez, Youngkeun Ahn, Maryanne Skavdahl, Elizabeth Murphy, Sara Welch, Erik Schaefer, Kenneth Walsh, Anthony Rosenzweig, Daniele Torella, Daria Nurzynska, Jan Kajstura, Annarosa Leri, Piero Anversa, Mark A Sussma. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circulation research. vol 94. issue 7. 2004-08-23. PMID:14988230. |
nuclear-targeted akt significantly elevated levels of phospho-akt and kinase activity and inhibited apoptosis as effectively as myristolated-akt in hypoxia-induced cell death. |
2004-08-23 |
2023-08-12 |
Not clear |
| Isao Shiraishi, Jaime Melendez, Youngkeun Ahn, Maryanne Skavdahl, Elizabeth Murphy, Sara Welch, Erik Schaefer, Kenneth Walsh, Anthony Rosenzweig, Daniele Torella, Daria Nurzynska, Jan Kajstura, Annarosa Leri, Piero Anversa, Mark A Sussma. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circulation research. vol 94. issue 7. 2004-08-23. PMID:14988230. |
collectively, these experiments show that targeting of akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling, opening new possibilities for therapeutic applications of nuclear-targeted akt to inhibit cell death associated with heart disease. |
2004-08-23 |
2023-08-12 |
Not clear |
| Ryungsa Kim, Kazuaki Tanabe, Manabu Emi, Yoko Uchida, Tetsuya Tog. Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (review). International journal of oncology. vol 24. issue 1. 2004-08-17. PMID:14654935. |
the molecular mechanism by which anticancer drugs induce apoptosis has been identified as mitochondrial dysfunction mediated by the release of cytochrome c. modulation of multiple antiapoptotic signaling pathways involving bcl-2 and akt, which are related to growth factor-stimulated signal transduction in cell survival, is essential for enhancement of the cytotoxic effect of anticancer drugs. |
2004-08-17 |
2023-08-12 |
Not clear |
| Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Paul Dent, Steven Gran. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood. vol 104. issue 2. 2004-08-17. PMID:15039284. |
in imatinib mesylate-resistant k562 cells displaying increased bcr/abl expression, bortezomib/flavopiridol treatment markedly increased apoptosis in association with down-regulation of bcr/abl and bclxl, and diminished phosphorylation of lyn, hck, crkl, and akt. |
2004-08-17 |
2023-08-12 |
human |
| Dawn M Flaherty, Sara L Hinde, Martha M Monick, Linda S Powers, Mary A Bradford, Timur Yarovinsky, Gary W Hunninghak. Adenovirus vectors activate survival pathways in lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 2. 2004-08-17. PMID:15107295. |
akt has been found to play a role in cell survival and apoptosis through its downstream effects on apoptosis-related proteins. |
2004-08-17 |
2023-08-12 |
Not clear |