| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saravanan Ramamoorthy, Vinzenz Stepan, Andrea Todisc. Intracellular mechanisms mediating the anti-apoptotic action of gastrin. Biochemical and biophysical research communications. vol 323. issue 1. 2004-11-23. PMID:15351698. |
we previously reported that gastrin (g17) inhibits apoptosis of ar4-2j pancreatic adenocarcinoma cells, through the activation of akt. |
2004-11-23 |
2023-08-12 |
Not clear |
| Tong Wu, Jing Leng, Chang Han, Anthony Jake Demetri. The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. Molecular cancer therapeutics. vol 3. issue 3. 2004-11-09. PMID:15026550. |
the cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of akt and induces apoptosis in human cholangiocarcinoma cells. |
2004-11-09 |
2023-08-12 |
human |
| Tong Wu, Jing Leng, Chang Han, Anthony Jake Demetri. The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. Molecular cancer therapeutics. vol 3. issue 3. 2004-11-09. PMID:15026550. |
these findings suggest that celecoxib inhibits cholangiocarcinoma growth partly through induction of apoptosis and inhibition of akt phosphorylation. |
2004-11-09 |
2023-08-12 |
human |
| James E Thompson, Craig B Thompso. Putting the rap on Akt. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 22. issue 20. 2004-11-04. PMID:15483033. |
the protein kinase akt is activated in a wide variety of cancers, and this activation results in enhanced resistance to apoptosis through multiple mechanisms. |
2004-11-04 |
2023-08-12 |
Not clear |
| Sang Ho Choi, Su Yun Lyu, Won Bong Par. Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Archives of pharmacal research. vol 27. issue 1. 2004-11-02. PMID:14969342. |
mistletoe lectin induces apoptosis and telomerase inhibition in human a253 cancer cells through dephosphorylation of akt. |
2004-11-02 |
2023-08-12 |
human |
| Sang Ho Choi, Su Yun Lyu, Won Bong Par. Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Archives of pharmacal research. vol 27. issue 1. 2004-11-02. PMID:14969342. |
we also observed the inhibition of telomerase activity and induction of apoptosis resulted from dephosphorylation of akt in the survival signaling pathways. |
2004-11-02 |
2023-08-12 |
human |
| Ho-Young Lee, Hojin Moon, Kyung-Hee Chun, Yoon-Soo Chang, Khaled Hassan, Lin Ji, Reuben Lotan, Fadlo R Khuri, Waun Ki Hon. Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells. Journal of the National Cancer Institute. vol 96. issue 20. 2004-11-02. PMID:15494604. |
effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor sch66336 on akt expression and apoptosis in non-small-cell lung cancer cells. |
2004-11-02 |
2023-08-12 |
Not clear |
| Marie-Eve St-Germain, Veronique Gagnon, Isabelle Mathieu, Sophie Parent, Eric Asseli. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. International journal of oncology. vol 24. issue 5. 2004-11-01. PMID:15067356. |
inhibition of akt phosphorylation with specific pi 3-k inhibitors and down-regulation of cox-2 increased apoptosis in human endometrial cancer cells. |
2004-11-01 |
2023-08-12 |
human |
| Marie-Eve St-Germain, Veronique Gagnon, Isabelle Mathieu, Sophie Parent, Eric Asseli. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. International journal of oncology. vol 24. issue 5. 2004-11-01. PMID:15067356. |
likewise, transfection of mutated-pten cells with a dominant negative akt vector, resulted in cox-2 down-regulation and activation of apoptosis, as demonstrated by hoechst nuclear staining. |
2004-11-01 |
2023-08-12 |
human |
| Hironori Fujiwara, Tohru Yamakuni, Mitsuhiro Ueno, Masaaki Ishizuka, Takashi Shinkawa, Toshiaki Isobe, Yasushi Ohizum. IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells. The Journal of pharmacology and experimental therapeutics. vol 310. issue 3. 2004-11-01. PMID:15161934. |
ic101 induces apoptosis by akt dephosphorylation via an inhibition of heat shock protein 90-atp binding activity accompanied by preventing the interaction with akt in l1210 cells. |
2004-11-01 |
2023-08-12 |
Not clear |
| Reid Aikin, Dusica Maysinger, Lawrence Rosenber. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology. vol 145. issue 10. 2004-10-26. PMID:15242986. |
indeed, the increase in akt activation after isolation correlated with suppression of apoptosis signal-regulating kinase 1 (ask1), a kinase acting upstream of jnk, by phosphorylation at ser83. |
2004-10-26 |
2023-08-12 |
human |
| Yasunari Takada, Xianjun Fang, Md Saha Jamaluddin, Douglas D Boyd, Bharat B Aggarwa. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. The Journal of biological chemistry. vol 279. issue 38. 2004-10-25. PMID:15252041. |
genetic deletion of glycogen synthase kinase-3beta abrogates activation of ikappabalpha kinase, jnk, akt, and p44/p42 mapk but potentiates apoptosis induced by tumor necrosis factor. |
2004-10-25 |
2023-08-12 |
mouse |
| Tetsuya Mizutani, Shuetsu Fukushi, Masayuki Saijo, Ichiro Kurane, Shigeru Morikaw. Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells. Virology. vol 327. issue 2. 2004-10-14. PMID:15351204. |
importance of akt signaling pathway for apoptosis in sars-cov-infected vero e6 cells. |
2004-10-14 |
2023-08-12 |
Not clear |
| Tetsuya Mizutani, Shuetsu Fukushi, Masayuki Saijo, Ichiro Kurane, Shigeru Morikaw. Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells. Virology. vol 327. issue 2. 2004-10-14. PMID:15351204. |
the results of the present study indicated that before cell death, akt, which is an inhibitor of apoptosis, was also activated in response to viral replication. |
2004-10-14 |
2023-08-12 |
Not clear |
| Tetsuya Mizutani, Shuetsu Fukushi, Masayuki Saijo, Ichiro Kurane, Shigeru Morikaw. Importance of Akt signaling pathway for apoptosis in SARS-CoV-infected Vero E6 cells. Virology. vol 327. issue 2. 2004-10-14. PMID:15351204. |
these results suggested that weak activation of akt cannot prevent apoptosis induced by sars-cov infection in vero e6 cells. |
2004-10-14 |
2023-08-12 |
Not clear |
| Jin-Ping Liu, Ryan Schlosser, Wei-Ya Ma, Zigang Dong, Hao Feng, Long Liu, Xiao-Qing Huang, Yan Liu, David Wan-Cheng L. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Experimental eye research. vol 79. issue 3. 2004-10-12. PMID:15336502. |
human alphaa- and alphab-crystallins prevent uva-induced apoptosis through regulation of pkcalpha, raf/mek/erk and akt signaling pathways. |
2004-10-12 |
2023-08-12 |
human |
| Jin-Ping Liu, Ryan Schlosser, Wei-Ya Ma, Zigang Dong, Hao Feng, Long Liu, Xiao-Qing Huang, Yan Liu, David Wan-Cheng L. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Experimental eye research. vol 79. issue 3. 2004-10-12. PMID:15336502. |
instead, it activated akt kinase pathway to promote survival and thus counteracted the uva-induced apoptosis. |
2004-10-12 |
2023-08-12 |
human |
| Julian Downwar. PI 3-kinase, Akt and cell survival. Seminars in cell & developmental biology. vol 15. issue 2. 2004-10-07. PMID:15209377. |
akt has direct effects on the apoptosis machinery, for example targeting the pro-apoptotic bcl-2 related protein, bad. |
2004-10-07 |
2023-08-12 |
Not clear |
| Yasuyuki Sugishita, David W Leifer, Faton Agani, Michiko Watanabe, Steven A Fishe. Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tract. Developmental biology. vol 273. issue 2. 2004-10-06. PMID:15328013. |
furthermore, recombinant adenoviral-mediated expression of dominant negative akt, an inhibitor of tyrosine kinase receptor signaling, augmented cardiomyocyte apoptosis in the oft and constitutively active akt suppressed it. |
2004-10-06 |
2023-08-12 |
Not clear |
| Yong Liao, Mien-Chie Hun. A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342371. |
the adenoviral type 5 e1a protein has been shown to induce sensitization to different categories of anticancer drug-induced apoptosis, partly by down-regulation of the activity of a critical oncogenic kinase akt in both normal fibroblasts and epithelial breast cancer cells. |
2004-10-05 |
2023-08-12 |
human |