| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Motohiro Nomura, Naoko Nomura, Elizabeth W Newcomb, Yevgeniy Lukyanov, Cristina Tamasdan, David Zagza. Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells. Journal of cellular physiology. vol 201. issue 3. 2004-12-14. PMID:15389545. |
in addition, apoptosis was associated with the downregulation of the survival protein, phosphorylated akt (pakt), an important signaling protein in the pi3k pathway, that is overexpressed in many cancers including gliomas. |
2004-12-14 |
2023-08-12 |
human |
| Flavia Troglio, Cinara Echart, Alberto Gobbi, Tony Pawson, Pier Giuseppe Pelicci, Maria Grazia De Simoni, Giuliana Pelicc. The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 43. 2004-12-09. PMID:15494442. |
we demonstrate that (i) primary cultures of cortical neurons from rai-/- mice are more sensitive to apoptosis induced by hypoxia or oxidative stress; (ii) in rai-/- mice, ischemia/reperfusion injury induces severe neurological deficits, increased apoptosis and size of the infarct area, and significantly higher mortality; and (iii) rai functions as a stress-response gene that increases phosphatidylinositol 3-kinase activation and akt phosphorylation after hypoxic or oxidation insults. |
2004-12-09 |
2023-08-12 |
mouse |
| Toni Portis, Richard Longnecke. Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene. vol 23. issue 53. 2004-12-08. PMID:15361852. |
b cells from lmp2a transgenic mice were sensitive to apoptosis induction in the presence of specific inhibitors of ras, phosphatidylinositol 3-kinase (pi3k), and akt, indicating that lmp2a activates the ras/pi3k/akt pathway to mediate b-cell survival. |
2004-12-08 |
2023-08-12 |
mouse |
| Masahiro Oka, Akiko Kageyama, Mizuho Fukunaga, Toshinori Bito, Hiroshi Nagai, Chikako Nishigor. Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes. The Journal of investigative dermatology. vol 123. issue 5. 2004-12-07. PMID:15482482. |
furthermore, apoptosis of melanocytes induced by deprivation of itbi was prevented almost completely by infection with an adenovirus vector encoding a constitutively active mutant of either pi 3-kinase or akt. |
2004-12-07 |
2023-08-12 |
human |
| Yumi Tohyama, Tomoko Takano, Hirohei Yamamur. B cell responses to oxidative stress. Current pharmaceutical design. vol 10. issue 8. 2004-12-06. PMID:15032688. |
syk might inhibit the activation of caspase-9 through akt thereby protecting cells from oxidative stress-induced apoptosis. |
2004-12-06 |
2023-08-12 |
Not clear |
| Che-Lin Hu, Robert G Cowan, Rebecca M Harman, Susan M Quir. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor I-mediated suppression of apoptosis in granulosa cells. Molecular endocrinology (Baltimore, Md.). vol 18. issue 2. 2004-12-02. PMID:14593075. |
cell cycle progression and activation of akt kinase are required for insulin-like growth factor i-mediated suppression of apoptosis in granulosa cells. |
2004-12-02 |
2023-08-12 |
Not clear |
| Che-Lin Hu, Robert G Cowan, Rebecca M Harman, Susan M Quir. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor I-mediated suppression of apoptosis in granulosa cells. Molecular endocrinology (Baltimore, Md.). vol 18. issue 2. 2004-12-02. PMID:14593075. |
recombinant adenoviruses were used to test whether the downstream target of pi3k activation, akt kinase, was required for protection against apoptosis. |
2004-12-02 |
2023-08-12 |
Not clear |
| Che-Lin Hu, Robert G Cowan, Rebecca M Harman, Susan M Quir. Cell cycle progression and activation of Akt kinase are required for insulin-like growth factor I-mediated suppression of apoptosis in granulosa cells. Molecular endocrinology (Baltimore, Md.). vol 18. issue 2. 2004-12-02. PMID:14593075. |
therefore, activation of akt is not sufficient to protect granulosa cells from apoptosis in the absence of cell cycle progression. |
2004-12-02 |
2023-08-12 |
Not clear |
| K M Wahidur Rahman, Yiwei Li, Fazlul H Sarka. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutrition and cancer. vol 48. issue 1. 2004-12-02. PMID:15203382. |
inactivation of akt and nf-kappab play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. |
2004-12-02 |
2023-08-12 |
Not clear |
| K M Wahidur Rahman, Yiwei Li, Fazlul H Sarka. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutrition and cancer. vol 48. issue 1. 2004-12-02. PMID:15203382. |
for the present study, we focused our investigation on important cell signaling molecules such as akt and nf-kappab during i3c-induced apoptosis in breast cancer cells. |
2004-12-02 |
2023-08-12 |
Not clear |
| K M Wahidur Rahman, Yiwei Li, Fazlul H Sarka. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutrition and cancer. vol 48. issue 1. 2004-12-02. PMID:15203382. |
from these results, we conclude that there is a direct cross-talk between akt and nf-kappab pathways and that the inactivation of akt and nf-kappab activity plays important roles in mediating i3c-induced apoptosis in breast cancer cells. |
2004-12-02 |
2023-08-12 |
Not clear |
| Salma Khan, Takashi Kumagai, Jaimini Vora, Namrata Bose, Indu Sehgal, Phillip H Koeffler, Shikha Bos. PTEN promoter is methylated in a proportion of invasive breast cancers. International journal of cancer. vol 112. issue 3. 2004-12-02. PMID:15382065. |
the pten protein is a negative regulator of the akt pathway, leading to suppression of apoptosis and increased cell survival. |
2004-12-02 |
2023-08-12 |
human |
| Erika Suzuki, Kazuko Handa, Marcos S Toledo, Senitiroh Hakomor. Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 41. 2004-12-02. PMID:15466700. |
in addition, sph induces apoptosis through a separate process: the blocking of "survival signal" through the akt kinase pathway induced by alpha3beta1-mediated cell adhesion to laminin 10/11 in extracellular matrix. |
2004-12-02 |
2023-08-12 |
Not clear |
| Koichiro Takeda, Takuro Kanekura, Tamotsu Kanzak. Negative feedback regulation of phosphatidylinositol 3-kinase/Akt pathway by over-expressed cyclooxygenase-2 in human epidermal cancer cells. The Journal of dermatology. vol 31. issue 7. 2004-11-30. PMID:15492414. |
the expression of bcl-2, which is regulated by akt, was reduced, and apoptosis was induced in hsc-5 cells compared to hacat cells. |
2004-11-30 |
2023-08-12 |
human |
| Orhan G Yigitbasi, Maher N Younes, Dao Doan, Samar A Jasser, Bradley A Schiff, Corazon D Bucana, Benjamin N Bekele, Isaiah J Fidler, Jeffrey N Myer. Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade. Cancer research. vol 64. issue 21. 2004-11-30. PMID:15520205. |
aee788 inhibited cell growth, induced apoptosis, and reduced the phosphorylation of egfr, vegfr-2, akt, and mitogen-activated protein kinase in both cell lines. |
2004-11-30 |
2023-08-12 |
mouse |
| Daiana Vasilcanu, Ada Girnita, Leonard Girnita, Radu Vasilcanu, Magnus Axelson, Olle Larsso. The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene. vol 23. issue 47. 2004-11-29. PMID:15334055. |
ppp preferentially reduced phosphorylated akt, as compared to phosphorylated erk1/2, and caused apoptosis. |
2004-11-29 |
2023-08-12 |
Not clear |
| James A McCubrey, John G Shelton, Linda S Steelman, Richard A Franklin, Thazepadath Sreevalsan, Martin McMaho. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene. vol 23. issue 47. 2004-11-29. PMID:15361836. |
the egf-r inhibitor ag1478 effectively inhibited mek, erk and akt activation, and induced apoptosis when the cells were grown in response to v-erbb:er. |
2004-11-29 |
2023-08-12 |
human |
| James A McCubrey, John G Shelton, Linda S Steelman, Richard A Franklin, Thazepadath Sreevalsan, Martin McMaho. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene. vol 23. issue 47. 2004-11-29. PMID:15361836. |
mek or pi3k inhibitors suppressed erk or akt activation, respectively, and induced apoptosis in the v-erbb:er-responsive cells. |
2004-11-29 |
2023-08-12 |
human |
| Guillermo Velasco, Ismael Galve-Roperh, Cristina Sánchez, Cristina Blázquez, Manuel Guzmá. Hypothesis: cannabinoid therapy for the treatment of gliomas? Neuropharmacology. vol 47. issue 3. 2004-11-24. PMID:15275820. |
cannabinoids induce apoptosis of glioma cells in culture via sustained ceramide accumulation, extracellular signal-regulated kinase activation and akt inhibition. |
2004-11-24 |
2023-08-12 |
Not clear |
| Juliet M Taylor, Peter J Crack, Jodee A Gould, Uğur Ali, Paul J Hertzog, Rocco C Iannell. Akt phosphorylation and NFkappaB activation are counterregulated under conditions of oxidative stress. Experimental cell research. vol 300. issue 2. 2004-11-24. PMID:15475010. |
therefore, our results suggest that the increased susceptibility of gpx1-/- cells to h2o2-induced apoptosis can be attributed in part to diminished activation of akt despite an up-regulation in the activation of the prosurvival nfkappab. |
2004-11-24 |
2023-08-12 |
Not clear |