| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Gran. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood. vol 105. issue 4. 2005-03-03. PMID:15494423. |
enforced expression of myristoylated akt but not constitutively active mek significantly attenuated ucn-01/l744832-induced apoptosis. |
2005-03-03 |
2023-08-12 |
human |
| Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Gran. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood. vol 105. issue 4. 2005-03-03. PMID:15494423. |
together, these findings suggest that farnesyltransferase inhibitors interrupt the cytoprotective akt and mapk pathways while reciprocally activating sapk/jnk in leukemia cells exposed to ucn-01 and, in so doing, dramatically increase mitochondria-dependent apoptosis. |
2005-03-03 |
2023-08-12 |
human |
| Tetsuya Mizutani, Shuetsu Fukushi, Masaaki Murakami, Toshio Hirano, Masayuki Saijo, Ichiro Kurane, Shigeru Morikaw. Tyrosine dephosphorylation of STAT3 in SARS coronavirus-infected Vero E6 cells. FEBS letters. vol 577. issue 1-2. 2005-03-02. PMID:15527783. |
in addition, weak activation of akt cannot prevent sars-cov infection-induced apoptosis in vero e6 cells. |
2005-03-02 |
2023-08-12 |
Not clear |
| Km Wahidur Rahman, Fazlul H Sarka. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Cancer research. vol 65. issue 1. 2005-03-02. PMID:15665315. |
our laboratory and others have shown that i3c induces apoptosis in breast cancer cells mediated by inactivation of akt and nuclear factor-kappab (nf-kappab) pathway. |
2005-03-02 |
2023-08-12 |
Not clear |
| Km Wahidur Rahman, Fazlul H Sarka. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Cancer research. vol 65. issue 1. 2005-03-02. PMID:15665315. |
hence, we investigated whether dim-induced apoptosis of breast cancer cells could also be mediated by inactivation of akt and nf-kappab. |
2005-03-02 |
2023-08-12 |
Not clear |
| Km Wahidur Rahman, Fazlul H Sarka. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells. Cancer research. vol 65. issue 1. 2005-03-02. PMID:15665315. |
taken together, these results showed for the first time that the inactivation of akt and nf-kappab activity also plays important roles in dim-induced apoptosis in breast cancer cells, which seems to be more relevant to in vivo situations. |
2005-03-02 |
2023-08-12 |
Not clear |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
gas6 inhibits apoptosis in vascular smooth muscle: role of axl kinase and akt. |
2005-03-01 |
2023-08-12 |
human |
| Eun-Ju Chang, Hong-Hee Kim, Jung-Eun Huh, In-Ae Kim, Jea Seung Ko, Chong-Pyoung Chung, Hyun-Man Ki. Low proliferation and high apoptosis of osteoblastic cells on hydrophobic surface are associated with defective Ras signaling. Experimental cell research. vol 303. issue 1. 2005-02-18. PMID:15572039. |
the overexpression of constitutively active form of ras and akt rescued those cells from apoptosis and recovered cell cycle progression. |
2005-02-18 |
2023-08-12 |
human |
| Young-Lai Cho, Kwang-Soon Lee, Seon-Jin Lee, Seung Namkoong, Young-Mi Kim, Hansoo Lee, Kwon-Soo Ha, Jeong-A Han, Young-Guen Kwon, Young-Myeong Ki. Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. Biochemical and biophysical research communications. vol 326. issue 4. 2005-02-18. PMID:15607733. |
amiloride potentiates trail-induced tumor cell apoptosis by intracellular acidification-dependent akt inactivation. |
2005-02-18 |
2023-08-12 |
Not clear |
| Young-Lai Cho, Kwang-Soon Lee, Seon-Jin Lee, Seung Namkoong, Young-Mi Kim, Hansoo Lee, Kwon-Soo Ha, Jeong-A Han, Young-Guen Kwon, Young-Myeong Ki. Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. Biochemical and biophysical research communications. vol 326. issue 4. 2005-02-18. PMID:15607733. |
these data suggest that amiloride sensitizes both tumor cells to trail-induced apoptosis by promoting akt dephosphorylation and caspase-8 activation via the intracellular acidification and that na(+)/h(+) exchanger inhibitors may play an important role in the anti-cancer activity of trail, especially, in trail-resistant tumors with highly active and expressed akt. |
2005-02-18 |
2023-08-12 |
Not clear |
| Nicholas J Cartel, Martin Pos. Abrogation of apoptosis through PDGF-BB-induced sulfated glycosaminoglycan synthesis and secretion. American journal of physiology. Lung cellular and molecular physiology. vol 288. issue 2. 2005-02-11. PMID:15466249. |
transfection of constitutively active akt into fetal lung fibroblasts also safeguarded the cells from apoptosis induced by serum starvation. |
2005-02-11 |
2023-08-12 |
Not clear |
| Shenying Bao, Yijie Wang, Patricia Sweeney, Alpana Chaudhuri, Andrea I Doseff, Clay B Marsh, Daren L Knoel. Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 288. issue 1. 2005-02-10. PMID:15347568. |
keratinocyte growth factor induces akt kinase activity and inhibits fas-mediated apoptosis in a549 lung epithelial cells. |
2005-02-10 |
2023-08-12 |
Not clear |
| Haiming Ding, Chunhua Han, Jiuxiang Zhu, Ching-Shih Chen, Steven M D'Ambrosi. Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9. International journal of cancer. vol 113. issue 5. 2005-02-10. PMID:15499625. |
apoptosis and cell cycle arrest appeared to be independent of derivative induced inhibition of pdk1 and phosphorylation of akt and erk1/2. |
2005-02-10 |
2023-08-12 |
human |
| Rongbiao Pi, Wenming Li, Nelson T K Lee, Hugh H N Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J Sucher, Donald C Chang, Mingtao Li, Yifan Ha. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. Journal of neurochemistry. vol 91. issue 5. 2005-02-10. PMID:15569265. |
minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and akt pathways. |
2005-02-10 |
2023-08-12 |
Not clear |
| Rongbiao Pi, Wenming Li, Nelson T K Lee, Hugh H N Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J Sucher, Donald C Chang, Mingtao Li, Yifan Ha. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. Journal of neurochemistry. vol 91. issue 5. 2005-02-10. PMID:15569265. |
we reported here the robust neuroprotection by minocycline against glutamate-induced apoptosis through regulations of p38 and akt pathways. |
2005-02-10 |
2023-08-12 |
Not clear |
| Takehiro Matsuda, Alex Almasan, Mariko Tomita, Jun-nosuke Uchihara, Masato Masuda, Kazuiku Ohshiro, Nobuyuki Takasu, Hideo Yagita, Takao Ohta, Naoki Mor. Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines. Journal of virology. vol 79. issue 3. 2005-02-10. PMID:15650163. |
the sensitivity to apo2l was not correlated with expression levels of apo2l receptors, intracellular regulators of apoptosis (flice-inhibitory protein and active akt). |
2005-02-10 |
2023-08-12 |
human |
| Teresa G Tessner, Filipe Muhale, Terrence E Riehl, Shrikant Anant, William F Stenso. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. The Journal of clinical investigation. vol 114. issue 11. 2005-02-08. PMID:15578100. |
prostaglandin e2 reduces radiation-induced epithelial apoptosis through a mechanism involving akt activation and bax translocation. |
2005-02-08 |
2023-08-12 |
mouse |
| Teresa G Tessner, Filipe Muhale, Terrence E Riehl, Shrikant Anant, William F Stenso. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. The Journal of clinical investigation. vol 114. issue 11. 2005-02-08. PMID:15578100. |
inhibition of akt phosphorylation prevented the reduction of apoptosis by dmpge2 following radiation. |
2005-02-08 |
2023-08-12 |
mouse |
| Teresa G Tessner, Filipe Muhale, Terrence E Riehl, Shrikant Anant, William F Stenso. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. The Journal of clinical investigation. vol 114. issue 11. 2005-02-08. PMID:15578100. |
transfection of hct-116 cells with a constitutively active akt reduced apoptosis in irradiated cells to the same extent as in nontransfected cells treated with dmpge2. |
2005-02-08 |
2023-08-12 |
mouse |
| Teresa G Tessner, Filipe Muhale, Terrence E Riehl, Shrikant Anant, William F Stenso. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. The Journal of clinical investigation. vol 114. issue 11. 2005-02-08. PMID:15578100. |
the in vitro studies indicate that dmpge2, most likely by signaling through the e prostaglandin receptor ep2, reduces radiation-induced apoptosis through transactivation of the egfr and enhanced activation of akt and that this results in reduced bax translocation to the mitochondria. |
2005-02-08 |
2023-08-12 |
mouse |