| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Incheol Shin, Jeniffer Edl, Swati Biswas, P Charles Lin, Raymond Mernaugh, Carlos L Arteag. Proapoptotic activity of cell-permeable anti-Akt single-chain antibodies. Cancer research. vol 65. issue 7. 2005-05-26. PMID:15805282. |
furthermore, gst-anti-akt1-mts induced apoptosis in three cancer cell lines that express constitutively active akt. |
2005-05-26 |
2023-08-12 |
mouse |
| Dorottya Kövesdi, Katalin Pászty, Agnes Enyedi, Endre Kiss, János Matkó, Katalin Ludányi, Eva Rajnavölgyi, Gabriella Sárma. Antigen receptor-mediated signaling pathways in transitional immature B cells. Cellular signalling. vol 16. issue 8. 2005-05-19. PMID:15157667. |
we have detected a short-lived bcr-driven activation of mitogen-activated protein kinases (erk1/2 and p38 mapk) and akt/pkb in transitional immature b cells that correlated with the lack of c-fos expression, reduced phosphorylation of akt substrates and a susceptibility for apoptosis. |
2005-05-19 |
2023-08-12 |
mouse |
| Therese H Hemström, Bertrand Joseph, Gunnar Schulte, Rolf Lewensohn, Boris Zhivotovsk. PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage. Experimental cell research. vol 305. issue 1. 2005-05-17. PMID:15777800. |
however, ro 31-8220 increased the basal level of erk and akt phosphorylation in both cell lines, whereas akt phosphorylation was suppressed in the u1810 cells, which might influence apoptosis. |
2005-05-17 |
2023-08-12 |
Not clear |
| Kentaro Machida, Hiromasa Inoue, Koichiro Matsumoto, Miyuki Tsuda, Satoru Fukuyama, Hiroshi Koto, Hisamichi Aizawa, Yasuko Kureishi, Nobuyuki Hara, Yoichi Nakanish. Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. American journal of physiology. Lung cellular and molecular physiology. vol 288. issue 5. 2005-05-16. PMID:15618457. |
survival signals can be elicited by the activation of phosphatidylinositol 3-kinase (pi3k) and akt, both of which are known to be potent regulators of apoptosis, and akt in turn inactivates forkhead transcription factors, including fkhr (forkhead in rhabdomyosarcoma). |
2005-05-16 |
2023-08-12 |
mouse |
| Kentaro Machida, Hiromasa Inoue, Koichiro Matsumoto, Miyuki Tsuda, Satoru Fukuyama, Hiroshi Koto, Hisamichi Aizawa, Yasuko Kureishi, Nobuyuki Hara, Yoichi Nakanish. Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. American journal of physiology. Lung cellular and molecular physiology. vol 288. issue 5. 2005-05-16. PMID:15618457. |
we have investigated the effect of beta-agonists on apoptosis of local eosinophils isolated from the airways and the involvement of pi3k, akt, and fkhr in its survival signal. |
2005-05-16 |
2023-08-12 |
mouse |
| Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, Paul G Tiffen, Anton I Altaparmakov, Thomas G Burdon, Tomoichiro Asano, Bart Vanhaesebroeck, Christine J Watso. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature cell biology. vol 7. issue 4. 2005-05-16. PMID:15793565. |
in the absence of stat3 in vivo, upregulation of p55alpha and p50alpha is abrogated, levels of activated akt are sustained and apoptosis is prevented. |
2005-05-16 |
2023-08-12 |
Not clear |
| Naotaka Sekiguchi, Toyoshi Inoguchi, Kunihisa Kobayashi, Hajime Nawat. Effect of erythropoietin on endothelial cell apoptosis induced by high glucose. Diabetes research and clinical practice. vol 66 Suppl 1. 2005-05-12. PMID:15563957. |
to investigate a possible mechanism of epo's action on apoptosis, phosphorylation of akt was examined by applying epo. |
2005-05-12 |
2023-08-12 |
human |
| Naotaka Sekiguchi, Toyoshi Inoguchi, Kunihisa Kobayashi, Hajime Nawat. Effect of erythropoietin on endothelial cell apoptosis induced by high glucose. Diabetes research and clinical practice. vol 66 Suppl 1. 2005-05-12. PMID:15563957. |
epo was shown to phosphorylate akt, leading to the inhibition of caspase-3 activation and apoptosis induced by high glucose. |
2005-05-12 |
2023-08-12 |
human |
| Tianyan Gao, Frank Furnari, Alexandra C Newto. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular cell. vol 18. issue 1. 2005-05-12. PMID:15808505. |
phlpp: a phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth. |
2005-05-12 |
2023-08-12 |
Not clear |
| Tianyan Gao, Frank Furnari, Alexandra C Newto. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular cell. vol 18. issue 1. 2005-05-12. PMID:15808505. |
here, we identify a protein phosphatase, ph domain leucine-rich repeat protein phosphatase (phlpp), that specifically dephosphorylates the hydrophobic motif of akt (ser473 in akt1), triggering apoptosis and suppressing tumor growth. |
2005-05-12 |
2023-08-12 |
Not clear |
| Tianyan Gao, Frank Furnari, Alexandra C Newto. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular cell. vol 18. issue 1. 2005-05-12. PMID:15808505. |
the effects of phlpp on apoptosis are prevented in cells expressing an s473d construct of akt, revealing that the hydrophobic motif is the primary cellular target of phlpp. |
2005-05-12 |
2023-08-12 |
Not clear |
| Kwon-Seok Chae, Miguel Martin-Caraballo, Marc Anderson, Stuart E Drye. Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. Journal of neurophysiology. vol 93. issue 3. 2005-05-02. PMID:15509648. |
the protein kinase akt is a crucial regulator of neuronal survival and apoptosis. |
2005-05-02 |
2023-08-12 |
Not clear |
| Karin Söderlund, Gizeh Pérez-Tenorio, Olle Stå. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. International journal of oncology. vol 26. issue 1. 2005-05-02. PMID:15586221. |
furthermore, transfection of mcf-7 cells with constitutively active akt made the cells more resistant against apoptosis. |
2005-05-02 |
2023-08-12 |
human |
| Stéphanie François, Jamel El Benna, Pham M C Dang, Eric Pedruzzi, Marie-Anne Gougerot-Pocidalo, Carole Elbi. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 6. 2005-04-28. PMID:15749901. |
furthermore, analysis of intact cells by flow cytometry showed that tlr agonists delaying pmn apoptosis increased phosphorylation of akt, a major target of pi3k. |
2005-04-28 |
2023-08-12 |
human |
| Richard D Patten, Isaac Pourati, Mark J Aronovitz, Jason Baur, Flore Celestin, Xin Chen, Ashour Michael, Syed Haq, Simone Nuedling, Christian Grohe, Thomas Force, Michael E Mendelsohn, Richard H Kara. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circulation research. vol 95. issue 7. 2005-04-25. PMID:15345655. |
after mi, e2 replacement significantly increased activation of the prosurvival kinase, akt, and decreased cardiomyocyte apoptosis assessed by terminal deoxynucleotidyltransferase dutp nick-end labeling (tunel) staining and caspase 3 activation. |
2005-04-25 |
2023-08-12 |
mouse |
| Richard D Patten, Isaac Pourati, Mark J Aronovitz, Jason Baur, Flore Celestin, Xin Chen, Ashour Michael, Syed Haq, Simone Nuedling, Christian Grohe, Thomas Force, Michael E Mendelsohn, Richard H Kara. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circulation research. vol 95. issue 7. 2005-04-25. PMID:15345655. |
in vitro, e2 at 1 or 10 nmol/l caused a rapid 2.7-fold increase in akt phosphorylation and a decrease in apoptosis as measured by tunel staining, caspase 3 activation, and dna laddering in cultured neonatal rat cardiomyocytes. |
2005-04-25 |
2023-08-12 |
mouse |
| Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Shawn G Payne, Paul Dent, Sarah Spiegel, Steven Gran. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer research. vol 65. issue 6. 2005-04-25. PMID:15781658. |
coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through akt and erk1/2 inactivation and the generation of ceramide and reactive oxygen species. |
2005-04-25 |
2023-08-12 |
human |
| Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Shawn G Payne, Paul Dent, Sarah Spiegel, Steven Gran. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer research. vol 65. issue 6. 2005-04-25. PMID:15781658. |
together, these findings indicate that coadministration of hdacis with perifosine in human leukemia cells leads to akt and mek/erk disruption, a marked increase in ceramide and ros production, and a striking increase in mitochondrial injury and apoptosis. |
2005-04-25 |
2023-08-12 |
human |
| H Maeda, K Gopalrao Rajesh, H Maeda, R Suzuki, S Sasagur. Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activation of PI3-kinase/AKT signaling pathway under oxidative stress. Transplantation proceedings. vol 36. issue 4. 2005-04-22. PMID:15194403. |
recent reports have shown that activated akt, the downstream protein after phosphatidylinositol (pi) 3-kinase, is involved in cell survival by phosphorylating several proteins that mediate apoptosis. |
2005-04-22 |
2023-08-12 |
Not clear |
| Leigh A Knodler, B Brett Finlay, Olivia Steele-Mortime. The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15642738. |
the salmonella effector protein sopb protects epithelial cells from apoptosis by sustained activation of akt. |
2005-04-19 |
2023-08-12 |
Not clear |