| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Yu, X Mao, W X L. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochemical and biophysical research communications. vol 331. issue 2. 2005-07-21. PMID:15850772. |
additionally, either constitutive activation of akt or blockage of the jnk pathway significantly diminished apoptosis induced by the combination. |
2005-07-21 |
2023-08-12 |
human |
| C Yu, X Mao, W X L. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochemical and biophysical research communications. vol 331. issue 2. 2005-07-21. PMID:15850772. |
collectively, these findings demonstrate that inactivation of mapk, akt, and activation of the jnk pathway contributes to the induction of apoptosis induced by fludarabine/ly. |
2005-07-21 |
2023-08-12 |
human |
| Hirofumi Fujita, Toshihiko Utsumi, Shikibu Muranaka, Tetsuya Ogino, Hiromi Yano, Jitsuo Akiyama, Tatsuji Yasuda, Kozo Utsum. Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. Biochemical pharmacology. vol 69. issue 12. 2005-07-19. PMID:15869745. |
involvement of ras/extracellular signal-regulated kinase, but not akt pathway in risedronate-induced apoptosis of u937 cells and its suppression by cytochalasin b. |
2005-07-19 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Toshihiko Utsumi, Shikibu Muranaka, Tetsuya Ogino, Hiromi Yano, Jitsuo Akiyama, Tatsuji Yasuda, Kozo Utsum. Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. Biochemical pharmacology. vol 69. issue 12. 2005-07-19. PMID:15869745. |
in this study, we investigated the molecular mechanism of risedronate-induced apoptosis of u937 cells, with a focus on extracellular signal-regulated kinase 1/2 (erk 1/2) and protein kinase b (akt) pathways, mitochondria-mediated apoptosis, and the effect of disruption of the actin cytoskeleton. |
2005-07-19 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Toshihiko Utsumi, Shikibu Muranaka, Tetsuya Ogino, Hiromi Yano, Jitsuo Akiyama, Tatsuji Yasuda, Kozo Utsum. Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. Biochemical pharmacology. vol 69. issue 12. 2005-07-19. PMID:15869745. |
the risedronate-induced apoptosis was independent of akt, another camp-dependent survival signaling kinase. |
2005-07-19 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Toshihiko Utsumi, Shikibu Muranaka, Tetsuya Ogino, Hiromi Yano, Jitsuo Akiyama, Tatsuji Yasuda, Kozo Utsum. Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B. Biochemical pharmacology. vol 69. issue 12. 2005-07-19. PMID:15869745. |
these results indicate that risedronate-induced apoptosis in u937 cells involves ras/erk, but not akt signaling pathway, and is dependent on mpt, and that disruption of the actin cytoskeleton inhibits the risedronate-induced apoptosis at its early step. |
2005-07-19 |
2023-08-12 |
Not clear |
| Radha Ananthakrishnan, Gordon W Moe, Michael J Goldenthal, José Marín-Garcí. Akt signaling pathway in pacing-induced heart failure. Molecular and cellular biochemistry. vol 268. issue 1-2. 2005-07-15. PMID:15724443. |
myocardial akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (tnf-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes iii and v and apoptosis initiation. |
2005-07-15 |
2023-08-12 |
Not clear |
| Radha Ananthakrishnan, Gordon W Moe, Michael J Goldenthal, José Marín-Garcí. Akt signaling pathway in pacing-induced heart failure. Molecular and cellular biochemistry. vol 268. issue 1-2. 2005-07-15. PMID:15724443. |
at severe heart failure (3-4 weeks of pacing), there was significant further increase in myocardial apoptosis, with pronounced decline in myocardial akt kinase activity. |
2005-07-15 |
2023-08-12 |
Not clear |
| Naoki Koizumi, Etsuro Hatano, Takashi Nitta, Masaharu Tada, Nobuko Harada, Kojiro Taura, Iwao Ikai, Yasuyuki Shimahar. Blocking of PI3K/Akt pathway enhances apoptosis induced by SN-38, an active form of CPT-11, in human hepatoma cells. International journal of oncology. vol 26. issue 5. 2005-07-12. PMID:15809721. |
on the other hand, sn-38 phosphorylated akt and pretreatment with pi3k inhibitors increased sn-38-induced apoptosis, indicating that resistance to sn-38 in hep3b occurs partly through the pi3k/akt not the nf-kappab pathway. |
2005-07-12 |
2023-08-12 |
human |
| M Raffaella Zocchi, Paola Contini, Massimo Alfano, Alessandro Pogg. Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit Tat-induced TGF-beta production by NK cells and TGF-beta-mediated NK cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 10. 2005-07-05. PMID:15879099. |
tgf-beta enhances starvation-induced nk cell apoptosis, significantly reduces transcription of the antiapoptotic protein bcl-2, and inhibits akt phosphorylation induced by oligomerization of the triggering nk cell receptor nkg2d. |
2005-07-05 |
2023-08-12 |
Not clear |
| Hui Qin Wang, Deborah A Altomare, Kristine L Skele, Poulikos I Poulikakos, Francis P Kuhajda, Antonio Di Cristofano, Joseph R Test. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene. vol 24. issue 22. 2005-06-30. PMID:15806173. |
treatment with ly294002 abolished akt activity and potentiated apoptosis induced by fas inhibitors cerulenin or c75 only in cells with constitutively active akt, suggesting that constitutive activation of akt protects against fas inhibitor-induced cell death. |
2005-06-30 |
2023-08-12 |
mouse |
| Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto, Tatsuji Hanej. PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells. Journal of cellular biochemistry. vol 94. issue 1. 2005-06-28. PMID:15517593. |
the present results suggest that the level of pten expression and the phosphorylation status of akt were associated with apoptosis induced by calyculin a. |
2005-06-28 |
2023-08-12 |
human |
| Lian-Yu Lin, Chien-Yu Lin, Fong-Ming Ho, Chiau S Lia. Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells. Journal of cellular biochemistry. vol 94. issue 1. 2005-06-28. PMID:15526284. |
from our results we propose that, in huvecs, during early phase of high glucose exposure, apoptosis can be prevented by enhancement of enos activity through augmentation of the protein interaction between enos and hsp90 and recruitment of the activated akt. |
2005-06-28 |
2023-08-12 |
human |
| Michael Hahn, Weiqun Li, Chunrong Yu, Mohamed Rahmani, Paul Dent, Steven Gran. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Molecular cancer therapeutics. vol 4. issue 3. 2005-06-28. PMID:15767555. |
rapamycin and ucn-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the raf-1/mek/erk, akt, and jnk signal transduction pathways. |
2005-06-28 |
2023-08-12 |
human |
| Liyan Zhuang, Jayoung Kim, Rosalyn M Adam, Keith R Solomon, Michael R Freema. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. The Journal of clinical investigation. vol 115. issue 4. 2005-06-28. PMID:15776112. |
cholesterol elevation also promoted tumor growth, increased phosphorylation of akt, and reduced apoptosis in the xenografts. |
2005-06-28 |
2023-08-12 |
mouse |
| Rong Zhang, Dianhong Luo, Robert Miao, Lanfang Bai, Qingyuan Ge, William C Sessa, Wang Mi. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. vol 24. issue 24. 2005-06-28. PMID:15782121. |
hsp90 client protein akt has been shown to inhibit cell apoptosis in part by inhibiting proapoptotic kinase ask1 (apoptosis signal-regulating kinase 1) activity. |
2005-06-28 |
2023-08-12 |
Not clear |
| Stanley F Barnett, Deborah Defeo-Jones, Sheng Fu, Paula J Hancock, Kathleen M Haskell, Raymond E Jones, Jason A Kahana, Astrid M Kral, Karen Leander, Ling L Lee, John Malinowski, Elizabeth M McAvoy, Debbie D Nahas, Ronald G Robinson, Hans E Hube. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. The Biochemical journal. vol 385. issue Pt 2. 2005-06-27. PMID:15456405. |
these inhibitors were found to be cell-active and to block phosphorylation of akt at thr308 and ser473, reduce the levels of active akt in cells, block the phosphorylation of known akt substrates and promote trail (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in lncap prostate cancer cells. |
2005-06-27 |
2023-08-12 |
Not clear |
| Woo K Kim, Myung H Bang, Eul S Kim, Nam E Kang, Kyeong C Jung, Han J Cho, Jung H Y Par. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. The Journal of nutritional biochemistry. vol 16. issue 3. 2005-06-24. PMID:15741050. |
in this study, we assessed quercetin regulation of ht-29 and sw480 cell apoptosis and the influence of quercetin on the protein expression of erbb2, erbb3, akt, bax and bcl-2. |
2005-06-24 |
2023-08-12 |
human |
| Woo K Kim, Myung H Bang, Eul S Kim, Nam E Kang, Kyeong C Jung, Han J Cho, Jung H Y Par. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. The Journal of nutritional biochemistry. vol 16. issue 3. 2005-06-24. PMID:15741050. |
in conclusion, we have shown that quercetin inhibits cell growth and induces apoptosis in colon cancer cells, and that this may be mediated by its ability to down-regulate erbb2/erbb3 signaling and the akt pathway. |
2005-06-24 |
2023-08-12 |
human |
| Jangja Hong, Kenji Ishihara, Okpyo Zee, Kazuo Ohuch. Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60. Planta medica. vol 71. issue 4. 2005-06-21. PMID:15856405. |
phosphorylation of p44/42 mapk, p38 mapk and akt was not induced by apicularen a at 100 nm, suggesting that the apicularen a-induced apoptosis in hl-60 cells is not regulated by the activation of p44/42 mapk, p38 mapk or akt. |
2005-06-21 |
2023-08-12 |
human |