| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wolfgang Link, Aranzazu Rosado, Jesus Fominaya, James E Thomas, Amancio Carner. Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt. Journal of cellular biochemistry. vol 95. issue 5. 2005-10-18. PMID:15838873. |
membrane localization of all class i pi 3-kinase isoforms suppresses c-myc-induced apoptosis in rat1 fibroblasts via akt. |
2005-10-18 |
2023-08-12 |
Not clear |
| Bo Zhou, Fuqiang Li, Hehua Chen, Jianguo Son. The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. The international journal of biochemistry & cell biology. vol 37. issue 7. 2005-10-11. PMID:15833279. |
the modulation of apoptosis by cyclic amp involves akt and epidermal growth factor receptor. |
2005-10-11 |
2023-08-12 |
Not clear |
| Bo Zhou, Fuqiang Li, Hehua Chen, Jianguo Son. The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. The international journal of biochemistry & cell biology. vol 37. issue 7. 2005-10-11. PMID:15833279. |
furthermore, forskolin decreased the akt phosphorylation, and the inhibition of phosphatidylinositol-3 kinase by ly294002 sensitized mv1lu cells to transforming growth factor-beta1-induced apoptosis. |
2005-10-11 |
2023-08-12 |
Not clear |
| Kulsoom Ghias, Chunguang Ma, Varsha Gandhi, Leonidas C Platanias, Nancy L Krett, Steven T Rose. 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma. Molecular cancer therapeutics. vol 4. issue 4. 2005-10-06. PMID:15827330. |
8-amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and akt kinase: role in induction of apoptosis in multiple myeloma. |
2005-10-06 |
2023-08-12 |
Not clear |
| I Deambrosis, E Scalabrino, M C Deregibus, G Camussi, B Bussolat. CD40-dependent activation of phosphatidylinositol 3-kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL. International journal of immunopathology and pharmacology. vol 18. issue 2. 2005-09-30. PMID:15888255. |
the aim of the present study was to investigate on cultured human mesangial cells (hmc) whether oxldl induces apoptosis by a mechanism dependent on the inhibition of akt survival pathway, and whether the engagement of mesangial cd40 by its ligand cd154 inhibits the apoptotic effect of oxldl. |
2005-09-30 |
2023-08-12 |
human |
| I Deambrosis, E Scalabrino, M C Deregibus, G Camussi, B Bussolat. CD40-dependent activation of phosphatidylinositol 3-kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL. International journal of immunopathology and pharmacology. vol 18. issue 2. 2005-09-30. PMID:15888255. |
tunel assays demonstrated that incubation of hmc for 24 h with oxldl, but not with unmodified ldl, induced a dose-dependent increase in apoptosis of hmc associated with a decrease in akt phosphorylation. |
2005-09-30 |
2023-08-12 |
human |
| K Hokeness, L H Qiu, M Vezeridis, B F Yan, S Mehta, Y S Wa. IFN-gamma enhances paclitaxel-induced apoptosis that is modulated by activation of caspases 8 and 3 with a concomitant down regulation of the AKT survival pathway in cultured human keratinocytes. Oncology reports. vol 13. issue 5. 2005-09-29. PMID:15809765. |
ifn-gamma enhances paclitaxel-induced apoptosis that is modulated by activation of caspases 8 and 3 with a concomitant down regulation of the akt survival pathway in cultured human keratinocytes. |
2005-09-29 |
2023-08-12 |
human |
| K Hokeness, L H Qiu, M Vezeridis, B F Yan, S Mehta, Y S Wa. IFN-gamma enhances paclitaxel-induced apoptosis that is modulated by activation of caspases 8 and 3 with a concomitant down regulation of the AKT survival pathway in cultured human keratinocytes. Oncology reports. vol 13. issue 5. 2005-09-29. PMID:15809765. |
the down-regulation of akt signal was preceded by the subsequent activation of caspases 8 and 3 leading to apoptosis. |
2005-09-29 |
2023-08-12 |
human |
| R T Allen, K D Krueger, A Dhume, D K Agrawa. Sustained Akt/PKB activation and transient attenuation of c-jun N-terminal kinase in the inhibition of apoptosis by IGF-1 in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 3. 2005-09-27. PMID:15909115. |
further, whereas transient expression of phosphorylated akt protected vsmcs from apoptosis by nearly 50%, expression of dominant interfering alleles of akt or pdk1 strongly inhibited igf-1-mediated vsmc survival. |
2005-09-27 |
2023-08-12 |
human |
| Masaaki Nomura, Daisuke Ichimatsu, Shuzo Moritani, Ichiko Koyama, Zigang Dong, Koichi Yokogawa, Ken-Ichi Miyamot. Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine. Molecular carcinogenesis. vol 44. issue 1. 2005-09-23. PMID:16044420. |
because akt plays a key role in signal transduction pathways leading to cell proliferation and apoptosis, our results provide novel insight into possible mechanisms of the chemotherapeutic effect of caffeine. |
2005-09-23 |
2023-08-12 |
mouse |
| Yosuke Osawa, Hiroshi Uchinami, Jacek Bielawski, Robert F Schwabe, Yusuf A Hannun, David A Brenne. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. The Journal of biological chemistry. vol 280. issue 30. 2005-09-22. PMID:15946935. |
ncdase prevented apoptosis both by reducing c16-ceramide and by activation of akt through s1p formation. |
2005-09-22 |
2023-08-12 |
mouse |
| Yosuke Osawa, Hiroshi Uchinami, Jacek Bielawski, Robert F Schwabe, Yusuf A Hannun, David A Brenne. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. The Journal of biological chemistry. vol 280. issue 30. 2005-09-22. PMID:15946935. |
therefore, the cross-talk between sphingolipids and akt pathway may determine hepatocyte apoptosis by tnf-alpha. |
2005-09-22 |
2023-08-12 |
mouse |
| Yang Yang, Takayuki Ikezoe, Tamotsu Takeuchi, Yoshihiro Adachi, Yuji Ohtsuki, Seisho Takeuchi, H Phillip Koeffler, Hirokuni Taguch. HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling. Cancer science. vol 96. issue 7. 2005-09-21. PMID:16053514. |
hiv-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer lncap cells in vitro and in vivo in conjunction with blockade of androgen receptor stat3 and akt signaling. |
2005-09-21 |
2023-08-12 |
mouse |
| Mallikarjuna Gu, Sivanandhan Dhanalakshmi, Sarumathi Mohan, Rana P Singh, Rajesh Agarwa. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15831527. |
these findings suggest that silibinin inhibits uvb-induced mapk and akt signaling and increases p53 in mouse skin, and that these effects of silibinin possibly lead to a decrease in uvb-caused proliferation and apoptosis, which might, in part, be responsible for its overall efficacy against photocarcinogenesis. |
2005-09-20 |
2023-08-12 |
mouse |
| b' Hongbo Hu, Cheng Jiang, Guangxun Li, Junxuan L\\xc3\\xb. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15845651.' |
since inactivation of the akt/protein kinase b negative regulator gene pten (phosphatase and tensin homologue deleted on chromosome 10) is common in prostate cancer (pca), we compared pten wild-type du145 pca cells (low basal akt activity) with pten-mutant lncap pca cells (high basal akt activity) for their apoptosis responses to the methylselenol precursor methylseleninic acid (msea) and sodium selenite, an inorganic salt. |
2005-09-20 |
2023-08-12 |
Not clear |
| b' Hongbo Hu, Cheng Jiang, Guangxun Li, Junxuan L\\xc3\\xb. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15845651.' |
transfection of du145 cells with a constitutively active akt increased their resistance to msea-induced apoptosis. |
2005-09-20 |
2023-08-12 |
Not clear |
| b' Hongbo Hu, Cheng Jiang, Guangxun Li, Junxuan L\\xc3\\xb. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis. vol 26. issue 8. 2005-09-20. PMID:15845651.' |
in summary, akt played an important role in regulating apoptosis sensitivity of lncap and du145 cells to msea. |
2005-09-20 |
2023-08-12 |
Not clear |
| Mohammed Akbar, Frances Calderon, Zhiming Wen, Hee-Yong Ki. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 31. 2005-09-20. PMID:16040805. |
docosapentaenoic acid, which replaces dha during n-3 fatty acid deficiency, was less effective in accumulating ps and translocating akt and thus less effective in preventing apoptosis. |
2005-09-20 |
2023-08-12 |
Not clear |
| Fuminori Teraishi, Shunsuke Kagawa, Takanori Watanabe, Yasuhisa Tango, Takeshi Kawashima, Tatsuo Umeoka, Masahiko Nisizaki, Noriaki Tanaka, Toshiyoshi Fujiwar. ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma. FEBS letters. vol 579. issue 19. 2005-09-16. PMID:16023108. |
zd1839 inhibited the phosphorylation of akt, and enhanced trail-induced apoptosis via activation of caspase-3 and caspase-9, and inactivation of bcl-xl. |
2005-09-16 |
2023-08-12 |
human |
| Linda S Steelman, Fred E Bertrand, James A McCubre. The complexity of PTEN: mutation, marker and potential target for therapeutic intervention. Expert opinion on therapeutic targets. vol 8. issue 6. 2005-09-15. PMID:15584861. |
ptdins(3,4,5)p(3) recruits kinases such as phosphoinositide-dependent kinase 1, which in turn phosphorylate akt, which phosphorylates other downstream proteins involved in regulation of apoptosis and cell-cycle progression. |
2005-09-15 |
2023-08-12 |
human |