| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
in contrast, in response to mechanical forces generated during collagen contraction, akt is dephosphorylated and fibroblasts undergo apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
here, we show that ilk activity decreased in response to collagen matrix contraction, which correlated with akt dephosphorylation and induction of fibroblast apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
in contrast, enforced activation of beta1 integrin by activating antibody preserved ilk and akt activity during collagen matrix contraction, and this is associated with protection from collagen contraction-induced apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
knock-down of ilk by small, interfering rna (sirna) attenuated akt phosphorylation in response to ligation of beta1 integrin by collagen or activating antibody and enhanced fibroblast apoptosis in response to collagen contraction. |
2005-09-12 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
kinase dead ilk attenuated akt phosphorylation and enhanced fibroblast apoptosis, whereas hyperactive and wild type ilk augmented akt phosphorylation and protected fibroblasts from apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
constitutively active akt preserved akt activity and rescued ilk sirna-treated fibroblasts from collagen contraction-induced apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Patricia S Ritch, Steven L Carroll, Harald Sontheime. Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. vol 51. issue 3. 2005-09-08. PMID:15812817. |
moreover, nrg-1beta activates an inhibitor of apoptosis, akt, implying a possible role for this kinase in mediating nrg-1beta effects in gliomas. |
2005-09-08 |
2023-08-12 |
human |
| Yoon-Jin Lee, Dae-Hoon Lee, Chul-Koo Cho, Sangwoo Bae, Gil-Ja Jhon, Su-Jae Lee, Jae-Won Soh, Yun-Sil Le. HSP25 inhibits protein kinase C delta-mediated cell death through direct interaction. The Journal of biological chemistry. vol 280. issue 18. 2005-09-02. PMID:15731106. |
heat shock protein 25 (hsp25) interferes negatively with apoptosis through several pathways that involve its direct interaction with cytochrome c or akt. |
2005-09-02 |
2023-08-12 |
Not clear |
| R Le Panse, S Berrih-Akni. Thymic myoid cells protect thymocytes from apoptosis and modulate their differentiation: implication of the ERK and Akt signaling pathways. Cell death and differentiation. vol 12. issue 5. 2005-09-01. PMID:15775997. |
thymic myoid cells protect thymocytes from apoptosis and modulate their differentiation: implication of the erk and akt signaling pathways. |
2005-09-01 |
2023-08-12 |
Not clear |
| Shozo Nishida, Hiroshi Matsuoka, Masanobu Tsubaki, Yoshihiro Tanimori, Masasi Yanae, Yoshiki Fujii, Masahiro Iwak. Mevastatin induces apoptosis in HL60 cells dependently on decrease in phosphorylated ERK. Molecular and cellular biochemistry. vol 269. issue 1-2. 2005-09-01. PMID:15786722. |
these results suggested that mevastatin induced apoptosis when it inhibited ggpp biosynthesis and consequently decreased the level of phosphorylated erk, which was a survival signal; moreover, at that time, there was no influence on nf-kappab, akt, p38, and bcl-2. |
2005-09-01 |
2023-08-12 |
Not clear |
| S Hara, M Oya, R Mizuno, A Horiguchi, K Marumo, M Mura. Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Annals of oncology : official journal of the European Society for Medical Oncology. vol 16. issue 6. 2005-09-01. PMID:15851405. |
akt activation in renal cell carcinoma: contribution of a decreased pten expression and the induction of apoptosis by an akt inhibitor. |
2005-09-01 |
2023-08-12 |
human |
| Mihail S Iordanov, Aaron J Sundholm, Eric L Simpson, Jon M Hanifin, Olga P Ryabinina, Remy J Choi, Veselina B Korcheva, Pascal Schneider, Bruce E Magu. Cell death-induced activation of epidermal growth factor receptor in keratinocytes: implications for restricting epidermal damage in dermatitis. The Journal of investigative dermatology. vol 125. issue 1. 2005-09-01. PMID:15982313. |
using a variety of inhibitors and blocking antibodies, we demonstrated that: (i) apoptosis is required for the generation of the signal(s) leading to the activation of egfr, erk, and akt; (ii) the activation of egfr, erk, and akt by fasl is indeed mediated by its bona fide receptor fas; (iii) the activation of egfr is essential for the subsequent activation of erk and akt; and (iv) apoptotic keratinocytes secrete soluble egfr ligands (including amphiregulin) that are processed from membrane-bound proligand forms by metalloproteinase(s). |
2005-09-01 |
2023-08-12 |
Not clear |
| Agata Klejman, Michał Wegrzynowicz, Erzsebet M Szatmari, Barbara Mioduszewska, Michał Hetman, Jan Albrech. Mechanisms of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione. Neurochemistry international. vol 47. issue 1-2. 2005-09-01. PMID:15985217. |
the mechanism underlying apoptosis may include inhibition of a survival kinase, akt, whose activatory phosphorylation at ser473 is reduced in neurons treated with 10 mm, but not 1 mm ammonia. |
2005-09-01 |
2023-08-12 |
rat |
| Shigetoshi Yano, Motohiro Morioka, Jun-Ichi Kuratsu, Kohji Fukunag. Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal death. Journal of pharmacological sciences. vol 97. issue 3. 2005-08-29. PMID:15764842. |
we here observed that cam-kk could directly activate akt, thereby preventing apoptosis in cultured cells. |
2005-08-29 |
2023-08-12 |
Not clear |
| Yuko Osajima-Hakomori, Izumi Miyake, Miki Ohira, Akira Nakagawara, Atsuko Nakagawa, Ryuichi Saka. Biological role of anaplastic lymphoma kinase in neuroblastoma. The American journal of pathology. vol 167. issue 1. 2005-08-25. PMID:15972965. |
the suppression of activated alk in neuroblastoma cells by rna interference significantly reduced the phosphorylation of shcc, mitogen-activated protein kinases, and akt, inducing rapid apoptosis in the cells. |
2005-08-25 |
2023-08-12 |
human |
| Xiaoying Yin, Hong Zhang, Francis Burrows, Lin Zhang, Carol G Shore. Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 10. 2005-08-23. PMID:15897590. |
ec5 induced g(1) growth arrest of tumor cells and apoptosis, with the degradation of client proteins including epidermal growth factor receptor, c-raf-1, akt, and cdk4 and inhibition of akt phosphorylation. |
2005-08-23 |
2023-08-12 |
mouse |
| Chyan-Jang Lee, Ching-Len Liao, Yi-Ling Li. Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection. Journal of virology. vol 79. issue 13. 2005-08-19. PMID:15956583. |
the lipid kinase, phosphatidylinositol 3-kinase (pi3k) and its downstream target akt have been implicated in the regulation of diverse cellular functions such as proliferation, and apoptosis. |
2005-08-19 |
2023-08-12 |
Not clear |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. Brain research. Brain research reviews. vol 49. issue 1. 2005-08-17. PMID:15960984. |
recent work has identified novel pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and the formation of neurofibrillary tangles through their downstream substrates that include glycogen synthase kinase-3beta, bad, and bcl-xl. |
2005-08-17 |
2023-08-12 |
Not clear |
| Lorenzo Magrassi, Luciano Conti, Andrea Lanterna, Chiara Zuccato, Marco Marchionni, Pamela Cassini, Cesare Arienta, Elena Cattane. Shc3 affects human high-grade astrocytomas survival. Oncogene. vol 24. issue 33. 2005-08-16. PMID:15870690. |
finally, we found that the expression of truncated variants of shc3 with dominant-negative effects in human high-grade glioma cells that maintain shc3 expression in vitro leads to a decreased akt posphorylation and increased apoptosis, thus resulting in impaired survival of the transfected cells. |
2005-08-16 |
2023-08-12 |
human |
| Sung-Shin Park, Yong-Nyun Kim, Yoon Kyung Jeon, Young A Kim, Ji Eun Kim, Heejung Kim, Chul Woo Ki. Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. Cancer chemotherapy and pharmacology. vol 56. issue 3. 2005-08-16. PMID:15883821. |
genistein-induced apoptosis via akt signaling pathway in anaplastic large-cell lymphoma. |
2005-08-16 |
2023-08-12 |
Not clear |