| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanjeev Banerjee, Yuxiang Zhang, Shadan Ali, Mohammad Bhuiyan, Zhiwei Wang, Paul J Chiao, Philip A Philip, James Abbruzzese, Fazlul H Sarka. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer research. vol 65. issue 19. 2005-12-14. PMID:16204081. |
several genes that are known to inhibit apoptosis and contribute to chemoresistance such as nuclear factor-kappab (nf-kappab) and akt were assessed to investigate the basis for the observed chemosensitizing effects of genistein. |
2005-12-14 |
2023-08-12 |
human |
| Jiang-Yan Yang, Joël Walicki, David Michod, Gilles Dubuis, Christian Widman. Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15901831. |
impaired akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of rasgap at position 157. |
2005-12-12 |
2023-08-12 |
Not clear |
| Ravi Amaravadi, Craig B Thompso. The survival kinases Akt and Pim as potential pharmacological targets. The Journal of clinical investigation. vol 115. issue 10. 2005-12-12. PMID:16200194. |
the akt and pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. |
2005-12-12 |
2023-08-12 |
human |
| Chun-Sheng Kang, Pei-Yu Pu, Jie Li, Guang-Xiu Wan. [Inhibitory effect of antisense and dominant-negative AKT2 constructs on proliferation of glioma cell line TJ905]. Ai zheng = Aizheng = Chinese journal of cancer. vol 23. issue 11. 2005-12-09. PMID:15522171. |
serine/threonine kinase (akt) mediates a downstream signal transduction pathway of epidermal growth factor receptor (egfr), and plays an important role in survival and apoptosis of tumor cells. |
2005-12-09 |
2023-08-12 |
Not clear |
| Ke-Jie Yin, Jin-Moo Lee, Hong Chen, Jan Xu, Chung Y Hs. Abeta25-35 alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 25. issue 11. 2005-12-09. PMID:15973355. |
in the present study, we report that abeta25-35-induced cec apoptosis involves the inactivation of akt, a signaling kinase important in maintaining cell viability. |
2005-12-09 |
2023-08-12 |
Not clear |
| Jin Q Cheng, Craig W Lindsley, George Z Cheng, Hua Yang, Santo V Nicosi. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene. vol 24. issue 50. 2005-12-07. PMID:16288295. |
blockage of akt signaling results in apoptosis and growth inhibition of tumor cells with elevated akt. |
2005-12-07 |
2023-08-12 |
mouse |
| Keqiang Y. PIKE/nuclear PI 3-kinase signaling in preventing programmed cell death. Journal of cellular biochemistry. vol 96. issue 3. 2005-12-06. PMID:16088938. |
moreover, pretreatment of the control nucleus with pi(3,4,5)p3 alone mimics the anti-apoptotic activity of ngf by selectively preventing apoptosis, for which nuclear akt is required but not sufficient. |
2005-12-06 |
2023-08-12 |
Not clear |
| Mrinal K Ghosh, Pankaj Sharma, Phyllis C Harbor, Shaik O Rahaman, S Jaharul Haqu. PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. vol 24. issue 49. 2005-12-01. PMID:16007122. |
blockade of egfr activation inhibited the activation of both akt and stat3 in u87 and d54 gbm cells and induced spontaneous apoptosis, which were associated with reduction in the steady-state level of mcl-1. |
2005-12-01 |
2023-08-12 |
Not clear |
| Kristin A Waite, Michelle R Sinden, Charis En. Phytoestrogen exposure elevates PTEN levels. Human molecular genetics. vol 14. issue 11. 2005-11-28. PMID:15829497. |
active pten results in decreased phosphorylation of akt and mapk, the up-regulation of p27 and down-regulation of cyclin d1 protein levels resulting in decreased proliferation and an increase in apoptosis. |
2005-11-28 |
2023-08-12 |
human |
| Jiang-Yan Yang, Joël Walicki, Amar Abderrahmani, Marion Cornu, Gérard Waeber, Bernard Thorens, Christian Widman. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. The Journal of biological chemistry. vol 280. issue 38. 2005-11-28. PMID:16046410. |
fragment n also induced akt activity and protection against cytokine-induced apoptosis in primary pancreatic islet cells. |
2005-11-28 |
2023-08-12 |
Not clear |
| Anindya Goswami, Ravshan Burikhanov, Aurelie de Thonel, Naoya Fujita, Mamta Goswami, Yanming Zhao, John E Eriksson, Takashi Tsuruo, Vivek M Rangneka. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Molecular cell. vol 20. issue 1. 2005-11-28. PMID:16209943. |
we report that akt physically binds to the pro-apoptotic protein par-4 via the par-4 leucine zipper domain and phosphorylates par-4 to inhibit apoptosis. |
2005-11-28 |
2023-08-12 |
Not clear |
| Anindya Goswami, Ravshan Burikhanov, Aurelie de Thonel, Naoya Fujita, Mamta Goswami, Yanming Zhao, John E Eriksson, Takashi Tsuruo, Vivek M Rangneka. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Molecular cell. vol 20. issue 1. 2005-11-28. PMID:16209943. |
suppression of akt activation by the pi3k-inhibitor pten or ly294002, akt expression by rna-interference, or akt function by dominant-negative akt caused apoptosis in cancer cells. |
2005-11-28 |
2023-08-12 |
Not clear |
| Anindya Goswami, Ravshan Burikhanov, Aurelie de Thonel, Naoya Fujita, Mamta Goswami, Yanming Zhao, John E Eriksson, Takashi Tsuruo, Vivek M Rangneka. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Molecular cell. vol 20. issue 1. 2005-11-28. PMID:16209943. |
apoptosis induced by inhibiting akt was blocked by inhibition of par-4 expression, but not by inhibition of other apoptosis agonists that are akt substrates, suggesting that inhibition of the pi3k-akt pathway leads to par-4-dependent apoptosis. |
2005-11-28 |
2023-08-12 |
Not clear |
| Anindya Goswami, Ravshan Burikhanov, Aurelie de Thonel, Naoya Fujita, Mamta Goswami, Yanming Zhao, John E Eriksson, Takashi Tsuruo, Vivek M Rangneka. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Molecular cell. vol 20. issue 1. 2005-11-28. PMID:16209943. |
thus, par-4 is essential for pten-inducible apoptosis, and inactivation of par-4 by akt promotes cancer cell survival. |
2005-11-28 |
2023-08-12 |
Not clear |
| T Kubota, T Yano, K Fujisaki, Y Itoh, R Oish. Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt. Apoptosis : an international journal on programmed cell death. vol 10. issue 2. 2005-11-21. PMID:15843896. |
these findings suggest that fenofibrate causes caspase-dependent apoptosis in human hepatocytes by inhibiting phosphorylation of akt, in which pparalpha is not involved. |
2005-11-21 |
2023-08-12 |
human |
| Xiaoning Bi, Jihua Liu, Yueqin Yao, Michel Baudry, Gary Lync. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain. The American journal of pathology. vol 167. issue 4. 2005-11-21. PMID:16192643. |
here we investigated possible contributions of a phosphatidylinositol-3 kinase cascade [pi3k, akt, glycogen synthase kinase-3beta (gsk-3beta)] that is linked to apoptosis and various degenerative conditions. |
2005-11-21 |
2023-08-12 |
mouse |
| Benedetta Bussolati, Maria Chiara Deregibus, Valentina Fonsato, Sophie Doublier, Tiziana Spatola, Simone Procida, Francesco Di Carlo, Giovanni Camuss. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. Journal of the American Society of Nephrology : JASN. vol 16. issue 7. 2005-11-15. PMID:15843472. |
in this study, oxidized ldl (oxldl) but not native ldl induced apoptosis in human cultured podocytes and reduced akt activity and p-akt/akt ratio. |
2005-11-15 |
2023-08-12 |
human |
| Benedetta Bussolati, Maria Chiara Deregibus, Valentina Fonsato, Sophie Doublier, Tiziana Spatola, Simone Procida, Francesco Di Carlo, Giovanni Camuss. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. Journal of the American Society of Nephrology : JASN. vol 16. issue 7. 2005-11-15. PMID:15843472. |
moreover, three different statins, mevastatin, pravastatin, and simvastatin, inhibited in a dose-dependent manner apoptosis and loss of nephrin induced by oxldl by stimulating akt activity. |
2005-11-15 |
2023-08-12 |
human |
| Soo-Jin Jeong, Cynthia A Pise-Masison, Michael F Radonovich, Hyeon Ung Park, John N Brad. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene. vol 24. issue 44. 2005-11-15. PMID:16007163. |
akt activation enhances resistance to apoptosis and induces cell survival signaling through multiple downstream pathways. |
2005-11-15 |
2023-08-12 |
Not clear |
| Natsuo Oka, Susumu Nakahara, Yukinori Takenaka, Tomoharu Fukumori, Victor Hogan, Hiro-Omi Kanayama, Takashi Yanagawa, Avraham Ra. Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells. Cancer research. vol 65. issue 17. 2005-11-15. PMID:16140916. |
galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating akt in human bladder carcinoma cells. |
2005-11-15 |
2023-08-12 |
human |