| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiwen Li, Genzou Takemura, Hideshi Okada, Shusaku Miyata, Masayasu Esaki, Rumi Maruyama, Hiromitsu Kanamori, Longhu Li, Atsushi Ogino, Yu Misao, Ngin C Khai, Atsushi Mikami, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwar. Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure. Laboratory investigation; a journal of technical methods and pathology. vol 86. issue 1. 2006-03-28. PMID:16304579. |
although activation of akt was noted in g-csf-treated hearts, vessel density was unchanged, and apoptosis was too rare to exert a meaningful effect. |
2006-03-28 |
2023-08-12 |
mouse |
| Alan Trounson, Alice Peba. A role for neurotrophins in embryonic stem cell growth. Developmental cell. vol 10. issue 2. 2006-03-27. PMID:16459295. |
neurotrophins act on embryonic cells through trk receptors to inhibit apoptosis by phosphorylation of akt. |
2006-03-27 |
2023-08-12 |
Not clear |
| Akiyasu Kanamori, Makoto Nakamura, Yoriko Nakanishi, Azusa Nagai, Hirokazu Mukuno, Yuko Yamada, Akira Neg. Akt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353229. |
the purpose of this study is to test whether episcleral vein cauterization (evc) to chronically elevate intraocular pressures (iops) in rats increase apoptosis of rgcs and affect activation of akt and its upstream insulin-like growth factor (igf)-1 receptor/insulin receptor. |
2006-03-23 |
2023-08-12 |
human |
| Yasushi Mukai, Yoshiyuki Rikitake, Ichiro Shiojima, Sebastian Wolfrum, Minoru Satoh, Kyosuke Takeshita, Yukio Hiroi, Salvatore Salomone, Hyung-Hwan Kim, Laura E Benjamin, Kenneth Walsh, James K Lia. Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453020. |
indeed, endothelial activation of akt resulted in less ec apoptosis in ligated arteries. |
2006-03-23 |
2023-08-12 |
mouse |
| Mallappa Anitha, Chetan Gondha, Roy Sutliff, Alexander Parsadanian, Simon Mwangi, Shanthi V Sitaraman, Shanthi Srinivasa. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453021. |
in streptozotocin-induced diabetic mice, there was evidence of myenteric neuronal apoptosis and reduced akt phosphorylation. |
2006-03-23 |
2023-08-12 |
mouse |
| Mallappa Anitha, Chetan Gondha, Roy Sutliff, Alexander Parsadanian, Simon Mwangi, Shanthi V Sitaraman, Shanthi Srinivasa. GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. The Journal of clinical investigation. vol 116. issue 2. 2006-03-23. PMID:16453021. |
the pathophysiological effects of hyperglycemia (apoptosis, reduced akt phosphorylation, loss of inhibitory neurons, motility changes) were reversed in diabetic glial fibrillary acidic protein-gdnf (gfap-gdnf) tg mice. |
2006-03-23 |
2023-08-12 |
mouse |
| Kamal Krishna Biswas, Salunya Tancharoen, Salunya Tancharon, Krishna Pada Sarker, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyam. Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. FEBS letters. vol 580. issue 2. 2006-03-21. PMID:16412424. |
cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (huh-7) through the activation of jnk1/2 and the downregulation of akt. |
2006-03-21 |
2023-08-12 |
human |
| M Nyåkern, P L Tazzari, C Finelli, C Bosi, M Y Follo, T Grafone, P P Piccaluga, G Martinelli, L Cocco, A M Martell. Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients. Leukemia. vol 20. issue 2. 2006-03-16. PMID:16341040. |
taken together, our results suggest that akt activation might be one of the factors contributing to the decreased apoptosis rate observed in patients with high-risk mds. |
2006-03-16 |
2023-08-12 |
human |
| Heng Zhao, Takayoshi Shimohata, Jade Q Wang, Guohua Sun, David W Schaal, Robert M Sapolsky, Gary K Steinber. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 42. 2006-03-15. PMID:16237183. |
akt kinase blocks apoptosis by phosphorylating the substrates forkhead transcription factor (fkhr) and glycogen synthase kinase 3beta (gsk3beta). |
2006-03-15 |
2023-08-12 |
rat |
| C Festuccia, P Muzi, D Millimaggi, L Biordi, G L Gravina, S Speca, A Angelucci, V Dolo, C Vicentini, M Bologn. Molecular aspects of gefitinib antiproliferative and pro-apoptotic effects in PTEN-positive and PTEN-negative prostate cancer cell lines. Endocrine-related cancer. vol 12. issue 4. 2006-03-10. PMID:16322337. |
we reported that the egfr-selective tyrosine kinase inhibitor gefitinib (zd1839; iressa) is able to induce growth inhibition, g(1) arrest and apoptosis in pca cells and that its effectiveness is associated primarily with phosphatase and tensin homologue deleted from chromosome 10 (pten) expression (and thus akt activity). |
2006-03-10 |
2023-08-12 |
Not clear |
| Hikaru Machida, Syuichi Nakajima, Naoto Shikano, Junko Nishio, Shinobu Okada, Munehiko Asayama, Makoto Shirai, Nobuo Kubot. Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer science. vol 96. issue 12. 2006-03-10. PMID:16367912. |
however, in all three cell lines, 17aag increased radiation-induced apoptosis by reducing the expression of egfr and erbb-2 and inhibiting the phosphorylation of akt. |
2006-03-10 |
2023-08-12 |
human |
| Hikaru Machida, Syuichi Nakajima, Naoto Shikano, Junko Nishio, Shinobu Okada, Munehiko Asayama, Makoto Shirai, Nobuo Kubot. Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer science. vol 96. issue 12. 2006-03-10. PMID:16367912. |
furthermore, 17aag (1 microm) sensitized sq20b spheroids to radiation, and inhibition of akt activation by 17aag increased radiation-induced apoptosis in spheroids. |
2006-03-10 |
2023-08-12 |
human |
| Mathieu Derouet, Luke Thomas, Dale A Moulding, Cahit Akgul, Andrew Cross, Robert J Moots, Steven W Edward. Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 2. 2006-03-09. PMID:16393981. |
for example, sodium salicylate blocked gm-csf-stimulated erk and akt activation, but resulted in rapid and sustained activation of p38-mapk, an event mimicked by okadaic acid that also accelerates mcl-1 turnover and neutrophil apoptosis. |
2006-03-09 |
2023-08-12 |
Not clear |
| Eun Hyun Ahn, Joseph J Schroede. Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. Anticancer research. vol 26. issue 1A. 2006-03-09. PMID:16475687. |
the objective of this study was to investigate the effect of sphinganine, at a concentration that induces apoptosis, on the mitogen activated protein kinases (mapks) including erk1/erk2, jnk2/jnk1, and p38 mapk and akt (protein kinase b), which regulate cell proliferation and apoptosis. |
2006-03-09 |
2023-08-12 |
human |
| Eun Hyun Ahn, Joseph J Schroede. Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon cancer cells. Anticancer research. vol 26. issue 1A. 2006-03-09. PMID:16475687. |
the findings are consistent with a mechanism by which sphinganine induces apoptosis in ht-29 cells via early and strong activation of jnk and p38 mapk and weak inhibition of akt activation. |
2006-03-09 |
2023-08-12 |
human |
| Christopher Siatskas, John Underwood, Ali Ramezani, Robert G Hawley, Jeffrey A Medi. Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 12. 2006-03-07. PMID:16076962. |
functional assays showed that hsp70 and hsp105 protected transduced tf1 cells from apoptosis and premature senescence, in part through regulation of akt. |
2006-03-07 |
2023-08-12 |
human |
| Huai-Jing Tang, Xiaohong Jin, Shaomeng Wang, Dajun Yang, Yeyu Cao, Jianyong Chen, Dana R Gossett, Jiayuh Li. A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. Gynecologic oncology. vol 100. issue 2. 2006-03-07. PMID:16209885. |
activated akt kinases provide a cell survival signal that may confer resistance to apoptosis induced by conventional therapies in cancer cells. |
2006-03-07 |
2023-08-12 |
Not clear |
| M Kaimul Ahsan, Hajime Nakamura, Masaki Tanito, Kenichi Yamada, Hideo Utsumi, Junji Yodo. Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt. Free radical biology & medicine. vol 39. issue 12. 2006-03-07. PMID:16298680. |
thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (dep) by scavenging reactive oxygen species and by inhibiting dep-induced downregulation of akt. |
2006-03-07 |
2023-08-12 |
mouse |
| M Kaimul Ahsan, Hajime Nakamura, Masaki Tanito, Kenichi Yamada, Hideo Utsumi, Junji Yodo. Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt. Free radical biology & medicine. vol 39. issue 12. 2006-03-07. PMID:16298680. |
the downregulation of akt phosphorylation by dep resulted in apoptosis, which was prevented by trx-1. |
2006-03-07 |
2023-08-12 |
mouse |
| Kyung Song, Hui Wang, Tracy L Krebs, David Danielpou. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. The EMBO journal. vol 25. issue 1. 2006-03-07. PMID:16362038. |
here we provide the first report that the kinase activity of akt is necessary for its ability to suppress many tgf-beta responses, including s3 activation and induction of apoptosis. |
2006-03-07 |
2023-08-12 |
Not clear |