| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Brooks Robey, Nissim Ha. Mitochondrial hexokinases: guardians of the mitochondria. Cell cycle (Georgetown, Tex.). vol 4. issue 5. 2006-03-03. PMID:15846094. |
recent demonstrations that growth factors and akt require glucose (glc) to prevent apoptosis and promote cell survival are compatible with this contention, as is a positive correlation between akt-regulated mitochondrial hexokinase (mthk) association and apoptotic resistance. |
2006-03-03 |
2023-08-12 |
Not clear |
| Manuel Rieber, Mary Strasberg Riebe. Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status. International journal of cancer. vol 118. issue 5. 2006-03-02. PMID:16152620. |
our data show for the first time that (a) cdk4 protein is an early target of betulinic acid-induced apoptosis and (b) unrestricted erk signaling favours betulinic acid-induced apoptosis, but this is counteracted by u0126, partly through counteracting chromatin condensation and restoring akt activation decreased by betulinic acid treatment. |
2006-03-02 |
2023-08-12 |
Not clear |
| Patrick C H Hsieh, Michael E Davis, Joseph Gannon, Catherine MacGillivray, Richard T Le. Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. The Journal of clinical investigation. vol 116. issue 1. 2006-03-02. PMID:16357943. |
pdgf-bb induced cardiomyocyte akt phosphorylation in a time- and dose-dependent manner and prevented apoptosis via pi3k/akt signaling. |
2006-03-02 |
2023-08-12 |
rat |
| Atsushi Saito, Takeshi Hayashi, Shuzo Okuno, Tatsuro Nishi, Pak H Cha. Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke. vol 37. issue 2. 2006-03-01. PMID:16397181. |
a proline-rich akt substrate (pras) contributes to the regulation of apoptosis after a variety of cell death stimuli, as well as in an in vivo transient focal cerebral ischemia (tfci) model. |
2006-03-01 |
2023-08-12 |
mouse |
| Masahiro Sugano, Keiko Tsuchida, Tomoji Hata, Naoki Makin. RNA interference targeting SHP-1 attenuates myocardial infarction in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 14. 2006-02-27. PMID:16223786. |
the src homology domain 2 (sh2)-containing tyrosine phosphatase-1 (shp-1) plays a key role in apoptosis and decreases phosphorylation of akt. |
2006-02-27 |
2023-08-12 |
rat |
| Masahiro Sugano, Keiko Tsuchida, Tomoji Hata, Naoki Makin. RNA interference targeting SHP-1 attenuates myocardial infarction in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 14. 2006-02-27. PMID:16223786. |
apoptosis of cardiomyocytes is thought to contribute to the increased area of acute myocardial infarction (ami), and akt activation exerts a powerful cardioprotective effect after ischemia. |
2006-02-27 |
2023-08-12 |
rat |
| Anita B Hjelmeland, Mark D Hjelmeland, Qing Shi, Janet L Hart, Darell D Bigner, Xiao-Fan Wang, Christopher D Kontos, Jeremy N Ric. Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. Cancer research. vol 65. issue 24. 2006-02-23. PMID:16357132. |
these effects are distinct from akt and forkhead family members that also interact with smad3 to regulate apoptosis or proliferation, respectively. |
2006-02-23 |
2023-08-12 |
human |
| Maralice Conacci-Sorrell, Anna Kaplan, Shani Raveh, Nancy Gavert, Takeshi Sakurai, Avri Ben-Ze'e. The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. Cancer research. vol 65. issue 24. 2006-02-23. PMID:16357171. |
we investigated the mechanisms by which nr-cam can confer properties related to tumor cell behavior and found that nr-cam expression in nih3t3 cells protects cells from apoptosis in the absence of serum by constitutively activating the extracellular signal-regulated kinase and akt signaling pathways. |
2006-02-23 |
2023-08-12 |
mouse |
| Y Itoh, T Yano, T Sendo, M Sueyasu, K Hirano, H Kanaide, R Oish. Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. Kidney international. vol 69. issue 2. 2006-02-23. PMID:16408118. |
like ioversol, c2 ceramide and the akt inhibitor src homology-6 induced apoptosis by reducing pakt and pcreb-like immunoreactivities, lowering bcl-2 expression and enhancing caspase-3 activity. |
2006-02-23 |
2023-08-12 |
mouse |
| Ulla Nuutinen, Ville Postila, Mikko Mättö, Jonna Eeva, Antti Ropponen, Mine Eray, Pekka Riikonen, Jukka Pelkone. Inhibition of PI3-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line. Experimental cell research. vol 312. issue 3. 2006-02-21. PMID:16309671. |
in contrast, inhibition of pi3-kinase or akt markedly enhanced dex-induced apoptosis. |
2006-02-21 |
2023-08-12 |
human |
| Ian Dang, Julie K Nelson, George H DeVrie. c-Kit receptor expression in normal human Schwann cells and Schwann cell lines derived from neurofibromatosis type 1 tumors. Journal of neuroscience research. vol 82. issue 4. 2006-02-16. PMID:16235251. |
although the c-kit ligand stem cell factor (scf) induces the phosphorylation of protein kinase b (or akt) and prevents apoptosis in schwann cells, scf has no effect on the proliferation or differentiation of schwann cells. |
2006-02-16 |
2023-08-12 |
human |
| Tin Oo Khor, Young-Sam Keum, Wen Lin, Jung-Hwan Kim, Rong Hu, Guoxiang Shen, Changjiang Xu, Avanthika Gopalakrishnan, Bandaru Reddy, Xi Zheng, Allan H Conney, Ah-Ng Tony Kon. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16423986. |
immunohistochemistry staining and western blot analysis revealed that the inhibition of akt and nuclear factor-kappab signaling pathways could contribute to the inhibition of cell proliferation and induction of apoptosis. |
2006-02-14 |
2023-08-12 |
mouse |
| Moammir H Aziz, Deric L Wheeler, Bhushan Bhamb, Ajit K Verm. Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424000. |
both tpa and uvr treatment of wild-type mice (a) increased the expression of proliferating cell nuclear antigen (pcna) and apoptosis; (b) stimulated the expression of cytokines tumor necrosis factor-alpha (tnf-alpha), granulocyte macrophage colony-stimulating factor (gm-csf), and granulocyte csf (g-csf); and (c) increased cyclooxygenase-2 (cox-2) expression and expression of phosphorylated akt (p-akt), p38, extracellular signal-regulated kinase-1 (erk1), and erk2. |
2006-02-14 |
2023-08-12 |
mouse |
| Patrick Y Chun, Felix Y Feng, Ashley M Scheurer, Mary A Davis, Theodore S Lawrence, Mukesh K Nyat. Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424033. |
this schedule caused decreased p(s473)akt, increased poly(adp-ribose) polymerase cleavage, and increased apoptosis compared with gemcitabine alone. |
2006-02-14 |
2023-08-12 |
mouse |
| Patrick Y Chun, Felix Y Feng, Ashley M Scheurer, Mary A Davis, Theodore S Lawrence, Mukesh K Nyat. Synergistic effects of gemcitabine and gefitinib in the treatment of head and neck carcinoma. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424033. |
this schedule in which gefitinib was used first was associated with stable levels of p(s473)akt and minimal poly(adp-ribose) polymerase cleavage and apoptosis. |
2006-02-14 |
2023-08-12 |
mouse |
| Herbert B Newto. Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 5: apoptosis and cell cycle. Expert review of anticancer therapy. vol 5. issue 2. 2006-02-07. PMID:15877531. |
the apoptosis pathway has numerous targets for molecular therapeutic development, including p53, bax, bcl-2, cflip, effector caspases, growth factor receptors, phosphatidylinositol-3-kinase, akt and apoptosis inhibitors. |
2006-02-07 |
2023-08-12 |
Not clear |
| Tahira Khan, Julie A Hixon, Jimmy K Stauffer, Erin Lincoln, Timothy C Back, Jason Brenner, Stephen Lockett, Kunio Nagashima, Douglas Powell, Jon M Wigginto. Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma. Journal of the National Cancer Institute. vol 98. issue 3. 2006-02-07. PMID:16449679. |
the antiapoptotic protein akt has been implicated as a possible mediator of the resistance of human neuroblastoma cells to apoptosis; the proapoptotic protein bid, is inhibited by activated akt. |
2006-02-07 |
2023-08-12 |
human |
| Azeddine Atfi, Lucile Abécassis, Marie-Francoise Bourgead. Bcr-Abl activates the AKT/Fox O3 signalling pathway to restrict transforming growth factor-beta-mediated cytostatic signals. EMBO reports. vol 6. issue 10. 2006-01-31. PMID:16113647. |
in contrast, we found that bcr-abl can target the protein kinase akt and the transcription factor fox o3 to interfere with growth inhibition and apoptosis in response to tgf-beta. |
2006-01-31 |
2023-08-12 |
human |
| Yan Shi, Xuesong Liu, Edward K Han, Ran Guan, Alexander R Shoemaker, Anatol Oleksijew, Keith W Woods, John P Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, Qun Li, Saul H Rosenberg, Vincent L Giranda, Yan Lu. Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo. Neoplasia (New York, N.Y.). vol 7. issue 11. 2006-01-26. PMID:16331885. |
synergy in apoptosis induction was observed when akt inhibitors were combined with doxorubicin or camptothecin. |
2006-01-26 |
2023-08-12 |
human |
| Yan Shi, Xuesong Liu, Edward K Han, Ran Guan, Alexander R Shoemaker, Anatol Oleksijew, Keith W Woods, John P Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, Qun Li, Saul H Rosenberg, Vincent L Giranda, Yan Lu. Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo. Neoplasia (New York, N.Y.). vol 7. issue 11. 2006-01-26. PMID:16331885. |
synergy with paclitaxel in apoptosis induction was evident in cells pretreated with paclitaxel, and enhancement of tumor delay by paclitaxel was demonstrated through cotreatment with akt inhibitor compound a (a-443654). |
2006-01-26 |
2023-08-12 |
human |