| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina Jamnicki-Abegg, Dorothee Weihrauch, Paul S Pagel, Judy R Kersten, Zeljko J Bosnjak, David C Warltier, Martin W Bienengraebe. Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology. vol 103. issue 5. 2006-01-25. PMID:16249675. |
isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating akt and enhancing bcl-2 expression. |
2006-01-25 |
2023-08-12 |
Not clear |
| Marina Jamnicki-Abegg, Dorothee Weihrauch, Paul S Pagel, Judy R Kersten, Zeljko J Bosnjak, David C Warltier, Martin W Bienengraebe. Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology. vol 103. issue 5. 2006-01-25. PMID:16249675. |
the authors tested whether isoflurane reduces apoptosis in cardiomyocytes subjected to oxidative or inflammatory stress by enhancing akt and b-cell lymphoma-2 (bcl-2). |
2006-01-25 |
2023-08-12 |
Not clear |
| Larisa L Belyanskaya, Sally Hopkins-Donaldson, Stefanie Kurtz, Ana Paula Simões-Wüst, Shida Yousefi, Hans-Uwe Simon, Rolf Stahel, Uwe Zangemeister-Wittk. Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. International journal of cancer. vol 117. issue 5. 2006-01-23. PMID:15981204. |
cisplatin activates akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. |
2006-01-23 |
2023-08-12 |
Not clear |
| Larisa L Belyanskaya, Sally Hopkins-Donaldson, Stefanie Kurtz, Ana Paula Simões-Wüst, Shida Yousefi, Hans-Uwe Simon, Rolf Stahel, Uwe Zangemeister-Wittk. Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. International journal of cancer. vol 117. issue 5. 2006-01-23. PMID:15981204. |
we identified survivin as an anti-apoptotic protein in sclc cells that is regulated by akt, and demonstrate that treatment with the dna damaging agent cddp activates the pi3k/akt/survivin pathway that in part protects cells from drug-induced apoptosis. |
2006-01-23 |
2023-08-12 |
Not clear |
| Ning Gao, Mohamed Rahmani, Xianglin Shi, Paul Dent, Steven Gran. Synergistic antileukemic interactions between 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors involve Akt down-regulation and oxidative stress. Blood. vol 107. issue 1. 2006-01-23. PMID:16141349. |
together, these findings support a model in which antileukemic synergism between 2-me and hdacis stems primarily from induction of oxidative damage, leading in turn to akt inactivation and jnk activation, culminating in mitochondrial injury and apoptosis. |
2006-01-23 |
2023-08-12 |
human |
| Yan Shi, Sunanda J Chatterjee, Frank H Brands, Shan-Rong Shi, Llana Pootrakul, Clive R Taylor, Ram Datar, Richard J Cot. Role of coordinated molecular alterations in the development of androgen-independent prostate cancer: an in vitro model that corroborates clinical observations. BJU international. vol 97. issue 1. 2006-01-23. PMID:16336351. |
to investigate the role of potential downstream targets of her-2/neu, including the cell-cycle regulator p27, proliferation-associated protein ki-67, apoptosis inhibitor bcl-2, and signal-transduction molecule akt (which is associated with cell survival), as the development of androgen-independent prostate cancer (aipc) in patients who are initially responsive to androgen-ablation therapy (aat) is a significant clinical problem. |
2006-01-23 |
2023-08-12 |
Not clear |
| John G Pastorino, Jan B Hoek, Nataly Shulg. Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288047. |
akt activation inhibits apoptosis partly by promoting the binding of hxk ii to the mitochondria, but the mechanism through which akt accomplishes this has not been characterized. |
2006-01-18 |
2023-08-12 |
Not clear |
| Thomas L Andresen, Simon S Jensen, Robert Madsen, Kent Jørgense. Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue. Journal of medicinal chemistry. vol 48. issue 23. 2006-01-17. PMID:16279790. |
ael 1-4 were furthermore evaluated for their ability to prevent phosphorylation of the apoptosis regulating kinase akt, and a correlation was found between their cytotoxic activity and their ability to inhibit akt phosphorylation. |
2006-01-17 |
2023-08-12 |
Not clear |
| Feng Dong, Xiaochun Zhang, Loren E Wold, Qun Ren, Zhaojie Zhang, Jun Re. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. British journal of pharmacology. vol 145. issue 3. 2006-01-13. PMID:15765100. |
western blot analysis indicated that et-1 alleviated homocysteine (hcy)-induced apoptosis, likely acting by antagonizing the hcy-induced decreases in akt, pakt, pakt-to-akt, bcl-2-to-bax ratios and increases in bax and caveolin-1 expression. |
2006-01-13 |
2023-08-12 |
human |
| Feng Dong, Xiaochun Zhang, Loren E Wold, Qun Ren, Zhaojie Zhang, Jun Re. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. British journal of pharmacology. vol 145. issue 3. 2006-01-13. PMID:15765100. |
3 in summary, our results suggest that et-1 affects oxidative stress, proliferation and apoptosis possibly through et(b), nadph oxidase, akt, bax and caveolin-1-mediated mechanisms. |
2006-01-13 |
2023-08-12 |
human |
| Shigeki Miyamoto, Amy L Howes, John W Adams, Gerald W Dorn, Joan Heller Brow. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. The Journal of biological chemistry. vol 280. issue 46. 2006-01-10. PMID:16061478. |
ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of na+/ca2+ exchanger and akt. |
2006-01-10 |
2023-08-12 |
Not clear |
| Shigeki Miyamoto, Amy L Howes, John W Adams, Gerald W Dorn, Joan Heller Brow. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. The Journal of biological chemistry. vol 280. issue 46. 2006-01-10. PMID:16061478. |
interestingly, constitutively activated akt, which rescues cells from q209l-induced apoptosis, prevented the decrease in ncx expression, normalized cytosolic ca(2+) levels and spontaneous ca(2+) oscillations, shortened caffeine-induced ca(2+) transients, and prevented loss of the mitochondrial membrane potential. |
2006-01-10 |
2023-08-12 |
Not clear |
| Chang-Shi Chen, Shu-Chuan Weng, Ping-Hui Tseng, Ho-Pi Lin, Ching-Shih Che. Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. The Journal of biological chemistry. vol 280. issue 46. 2006-01-10. PMID:16186112. |
from a clinical perspective, identification of this pp1-facilitated dephosphorylation mechanism underscores the potential use of hdac inhibitors in lowering the apoptosis threshold for other therapeutic agents through akt down-regulation. |
2006-01-10 |
2023-08-12 |
Not clear |
| David Pim, Paola Massimi, Stephen M Dilworth, Lawrence Bank. Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A. Oncogene. vol 24. issue 53. 2005-12-29. PMID:16044149. |
protein kinase b (pkb) or akt is one of several second messenger kinases that are activated by cell attachment and growth factor signaling, and that transmit signals to the cell nucleus to inhibit apoptosis and thereby increase cell survival during proliferation. |
2005-12-29 |
2023-08-12 |
human |
| Juhua Chen, Payaningal R Somanath, Olga Razorenova, William S Chen, Nissim Hay, Paul Bornstein, Tatiana V Byzov. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nature medicine. vol 11. issue 11. 2005-12-28. PMID:16227992. |
akt kinases control essential cellular functions, including proliferation, apoptosis, metabolism and transcription, and have been proposed as promising targets for treatment of angiogenesis-dependent pathologies, such as cancer and ischemic injury. |
2005-12-28 |
2023-08-12 |
mouse |
| Leif E Johnson, Theo van Veen, Per A R Ekströ. Differential Akt activation in the photoreceptors of normal and rd1 mice. Cell and tissue research. vol 320. issue 2. 2005-12-23. PMID:15789220. |
the rd1 retina behaves identically in all but one respect, namely that the activation of akt in rod photoreceptors persists until these cells undergo apoptosis. |
2005-12-23 |
2023-08-12 |
mouse |
| Sun-Ryung Lee, Jae-Han Park, Eui Kyun Park, Chin Ha Chung, Shin-Sung Kang, Ok-Sun Ban. Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells. Journal of cellular physiology. vol 205. issue 2. 2005-12-22. PMID:15887249. |
expression of a myristoylated constitutively active form of akt (myr-akt) in pc12 cells could override cell-growth arrest at g2/m phase and apoptosis that were induced by etoposide treatment. |
2005-12-22 |
2023-08-12 |
Not clear |
| J Størling, J Binzer, A K Andersson, R A Züllig, M Tonnesen, R Lehmann, G A Spinas, S Sandler, N Billestrup, T Mandrup-Poulse. Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia. vol 48. issue 10. 2005-12-20. PMID:16132952. |
nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of jnk activity and inhibition of akt. |
2005-12-20 |
2023-08-12 |
Not clear |
| Yuanxin Hu, Joyce Yao, Zhixue Liu, Xia Liu, Haian Fu, Keqiang Y. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. The EMBO journal. vol 24. issue 20. 2005-12-20. PMID:16177823. |
thus, akt inhibits chromatin condensation during apoptosis by phosphorylating acinus in the nucleus, revealing a specific mechanism by which nuclear akt promotes cell survival. |
2005-12-20 |
2023-08-12 |
Not clear |
| Jaehwi Song, Timothy Clair, Ji Heon Noh, Jung Woo Eun, So Yeon Ryu, Shi Nae Lee, Young Min Ahn, Su Young Kim, Sug Hyung Lee, Won Sang Park, Nam Jin Yoo, Jung Young Lee, Suk Woo Na. Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate. Biochemical and biophysical research communications. vol 337. issue 3. 2005-12-15. PMID:16219296. |
furthermore, the effect of atx in preventing apoptosis appears to be mediated through the g-protein-coupled receptor pathway followed by the activation of phosphoinositide 3-kinase and akt pathway leading to enhanced cell survival. |
2005-12-15 |
2023-08-12 |
mouse |