| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hans-Guido Wendel, Scott W Low. Reversing drug resistance in vivo. Cell cycle (Georgetown, Tex.). vol 3. issue 7. 2006-04-14. PMID:15190216. |
interestingly, lymphomas expressing akt, but not those expressing bcl-2 are sensitized to chemotherapy-induced apoptosis by the mtor inhibitor rapamycin, an effect that is countered by eif4e. |
2006-04-14 |
2023-08-12 |
human |
| Tzu-Hsuan Huang, Sherie L Morriso. A trimeric anti-HER2/neu ScFv and tumor necrosis factor-alpha fusion protein induces HER2/neu signaling and facilitates repair of injured epithelia. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16291729. |
activation of mapk and akt by anti-her2/neu scfv-tnf-alpha inhibited the apoptosis of skbr3 cells induced by actinomycin d. remarkably, anti-her2/neu scfv-tnf-alpha facilitated the repair of injured epithelia. |
2006-04-13 |
2023-08-12 |
human |
| Stephanie Y H Lee, Bibiana Munerol, Susan Pollard, Kuresh A Youdim, Ananth S Pannala, Gunter G C Kuhnle, Edward S Debnam, Catherine Rice-Evans, Jeremy P E Spence. The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth. Free radical biology & medicine. vol 40. issue 2. 2006-04-13. PMID:16413414. |
the latter was accompanied by caspase-3 activation and reductions in akt phosphorylation, suggesting activation of apoptosis via inhibition of prosurvival signaling. |
2006-04-13 |
2023-08-12 |
Not clear |
| Huajun Yan, Patrick Frost, Yijiang Shi, Bao Hoang, Sanjai Sharma, Myrna Fisher, Joseph Gera, Alan Lichtenstei. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer research. vol 66. issue 4. 2006-04-13. PMID:16489035. |
sensitization was achieved in multiple myeloma cells irrespective of their pten or p53 status, enhanced by activation of akt, and associated with stimulation of both intrinsic and extrinsic pathways of apoptosis. |
2006-04-13 |
2023-08-12 |
Not clear |
| Jiahua Tan, Ling Geng, Eugenia M Yazlovitskaya, Dennis E Hallaha. Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium. Cancer research. vol 66. issue 4. 2006-04-13. PMID:16489037. |
overexpression of the dominant negative mutant akt attenuated gsk-3beta phosphorylation at ser9 and enhanced radiation-induced apoptosis. |
2006-04-13 |
2023-08-12 |
mouse |
| Jiahua Tan, Ling Geng, Eugenia M Yazlovitskaya, Dennis E Hallaha. Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium. Cancer research. vol 66. issue 4. 2006-04-13. PMID:16489037. |
studies using gsk-3beta antagonists showed that gsk-3beta activity was required for apoptosis in endothelial cells treated simultaneously with akt antagonists and radiation. |
2006-04-13 |
2023-08-12 |
mouse |
| Luowei Li, Keeran Sampat, Nancy Hu, Julia Zakari, Stuart H Yusp. Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16338928. |
protein kinase c negatively regulates akt activity and modifies uvc-induced apoptosis in mouse keratinocytes. |
2006-04-11 |
2023-08-12 |
mouse |
| Luowei Li, Keeran Sampat, Nancy Hu, Julia Zakari, Stuart H Yusp. Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16338928. |
furthermore, the pkc-specific inhibitor, gf109203x, increased igf-1-induced phospho-ser-473-akt and akt kinase activity and enhanced igf-1 protection from uvc-induced apoptosis. |
2006-04-11 |
2023-08-12 |
mouse |
| Luowei Li, Keeran Sampat, Nancy Hu, Julia Zakari, Stuart H Yusp. Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. The Journal of biological chemistry. vol 281. issue 6. 2006-04-11. PMID:16338928. |
tpa also attenuated igf-1 and epidermal growth factor-induced phospho-ser-473-akt, reduced akt kinase activity, and blocked igf-1 protection from uvc-induced apoptosis. |
2006-04-11 |
2023-08-12 |
mouse |
| Paola Perego, Emilio Ciusani, Laura Gatti, Nives Carenini, Elisabetta Corna, Franco Zunin. Sensitization to gimatecan-induced apoptosis by tumor necrosis factor-related apoptosis inducing ligand in prostate carcinoma cells. Biochemical pharmacology. vol 71. issue 6. 2006-04-06. PMID:16438941. |
the relative resistance of pc-3 cells to drug-induced apoptosis was associated with constitutive akt activation, higher levels of cflip-l and bcl-2, and lower levels of bax. |
2006-04-06 |
2023-08-12 |
Not clear |
| Dong Xiao, Shivendra V Sing. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16169930. |
diallyl trisulfide, a constituent of processed garlic, inactivates akt to trigger mitochondrial translocation of bad and caspase-mediated apoptosis in human prostate cancer cells. |
2006-04-04 |
2023-08-12 |
human |
| Dong Xiao, Shivendra V Sing. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16169930. |
here, we demonstrate that dats inactivates akt to trigger apoptosis in prostate cancer cells. |
2006-04-04 |
2023-08-12 |
human |
| Dong Xiao, Shivendra V Sing. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16169930. |
treatment of pc-3/du145 cells with apoptosis inducing concentration of dats (40 microm) resulted in a rapid decrease in ser(473) and thr(308) phosphorylation of akt leading to inhibition of its kinase activity. |
2006-04-04 |
2023-08-12 |
human |
| Dong Xiao, Shivendra V Sing. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16169930. |
ectopic expression of constitutively active akt conferred statistically significant protection against dats-induced apoptosis. |
2006-04-04 |
2023-08-12 |
human |
| Dong Xiao, Shivendra V Sing. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16169930. |
in conclusion, the present study demonstrates that dats-induced apoptosis in human prostate cancer cells is mediated, at least in part, by inactivation of akt signaling axis. |
2006-04-04 |
2023-08-12 |
human |
| Hiroya Takeuchi, Joseph Kim, Akihide Fujimoto, Naoyuki Umetani, Takuji Mori, Anton Bilchik, Rod Turner, Andy Tran, Christine Kuo, Dave S B Hoo. X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 21. 2006-04-04. PMID:16278380. |
x-linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/c-met pathway via akt signaling. |
2006-04-04 |
2023-08-12 |
Not clear |
| Jeong-Whun Kim, Robert L Ferris, Theresa L Whitesid. Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 21. 2006-04-04. PMID:16278415. |
ligand binding to ccr7 resulted in phosphorylation of akt and increased bcl-2 expression in cd8(+)ccr7(+) t cells, suggesting that ccr7 protects effector t cells from apoptosis through the phosphatidylinositol 3-kinase/akt pathway. |
2006-04-04 |
2023-08-12 |
Not clear |
| Kengo Nishimura, Wei Li, Yuji Hoshino, Takayuki Kadohama, Hidenori Asada, Shigetsugu Ohgi, Bauer E Sumpi. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. American journal of physiology. Cell physiology. vol 290. issue 3. 2006-04-04. PMID:16469863. |
ecs transfected with kinase-dead akt (ka179) as well as plasmids containing a point mutation in the pleckstrin homology domain of akt (rc25) not only prevented akt, gsk-3beta, and bad phosphorylation but also inhibited the cs-induced increase in cell number as well as the cs-induced protection against apoptosis (both p < 0.05). |
2006-04-04 |
2023-08-12 |
cattle |
| Dali Cai, Ying Wang, Oliver G Ottmann, Peter J Barth, Andreas Neubauer, Andreas Burcher. FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment. Blood. vol 107. issue 5. 2006-04-03. PMID:16304046. |
hdi-stimulated apoptosis in ph+ cells was caspase dependent, but independent from akt pathway inhibition. |
2006-04-03 |
2023-08-12 |
Not clear |
| Dali Cai, Ying Wang, Oliver G Ottmann, Peter J Barth, Andreas Neubauer, Andreas Burcher. FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment. Blood. vol 107. issue 5. 2006-04-03. PMID:16304046. |
in conclusion, constitutive akt activation causes apoptosis resistance to vpa/atra in aml, but not in ph+ leukemia. |
2006-04-03 |
2023-08-12 |
Not clear |