| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deling Yin, Michael Woodruff, Ying Zhang, Sarah Whaley, Junying Miao, Kenneth Ferslew, Jing Zhao, Charles Stuar. Morphine promotes Jurkat cell apoptosis through pro-apoptotic FADD/P53 and anti-apoptotic PI3K/Akt/NF-kappaB pathways. Journal of neuroimmunology. vol 174. issue 1-2. 2006-07-06. PMID:16529824. |
moreover, inhibition of akt or nuclear factor-kappab (nf-kappab) expression by rna interference technology also dramatically increased morphine-induced apoptosis. |
2006-07-06 |
2023-08-12 |
human |
| Sara Cabodi, Agata Tinnirello, Paola Di Stefano, Brigitte Bisarò, Elena Ambrosino, Isabella Castellano, Anna Sapino, Riccardo Arisio, Federica Cavallo, Guido Forni, Marina Glukhova, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Guido Tarone, Paola Defilipp. p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer research. vol 66. issue 9. 2006-07-05. PMID:16651418. |
these phenotypes are associated with activation of src kinase, extracellular signal-regulated kinase 1/2, mitogen-activated protein kinase, and akt pathways, leading to an increased rate of proliferation and a decreased apoptosis. |
2006-07-05 |
2023-08-12 |
mouse |
| Dalya Rosner, Victoria Stoneman, Trevor Littlewood, Nicola McCarthy, Nichola Figg, Yinong Wang, George Tellides, Martin Bennet. Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism. The American journal of pathology. vol 168. issue 6. 2006-07-05. PMID:16723718. |
ifn-gamma increased fas-induced apoptosis in vitro by 46 +/- 8% (mean +/- sem, p = 0.04), an event that could be abrogated by inhibition of pi3k, akt, or jak-2. |
2006-07-05 |
2023-08-12 |
mouse |
| Dalya Rosner, Victoria Stoneman, Trevor Littlewood, Nicola McCarthy, Nichola Figg, Yinong Wang, George Tellides, Martin Bennet. Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism. The American journal of pathology. vol 168. issue 6. 2006-07-05. PMID:16723718. |
we conclude that ifn-gamma primes vsmcs to fas-induced apoptosis, in part by relocation of fas to the cell surface, a process that involves pi3k, akt, and jak-2/stat1. |
2006-07-05 |
2023-08-12 |
mouse |
| Laura Alaniz, Mariana G García, Carola Gallo-Rodriguez, Rosalía Agusti, Norma Sterín-Speziale, Silvia E Hajos, Elida Alvare. Hyaluronan oligosaccharides induce cell death through PI3-K/Akt pathway independently of NF-kappaB transcription factor. Glycobiology. vol 16. issue 5. 2006-06-29. PMID:16461453. |
cell behavior differed using native hyaluronan (ha), which induced pip(3) production, akt phosphorylation, and nf-kappab activation, although not related with cell survival since treatment with native ha showed no effect on apoptosis. |
2006-06-29 |
2023-08-12 |
Not clear |
| Iraide Alloza, Andy Baxter, Qian Chen, Rune Matthiesen, Koen Vandenbroec. Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum. Molecular pharmacology. vol 69. issue 5. 2006-06-26. PMID:16467190. |
ce has been shown to induce apoptosis in various cancer cells lines through a cox2-independent mechanism that seems to involve inactivation of protein kinase akt and inhibition of endoplasmic reticulum (er) ca2+ atpase. |
2006-06-26 |
2023-08-12 |
Not clear |
| Shibu Thomas, Girish Sha. Calcitonin induces apoptosis resistance in prostate cancer cell lines against cytotoxic drugs via the Akt/survivin pathway. Cancer biology & therapy. vol 4. issue 11. 2006-06-22. PMID:16222118. |
since the role of akt and inhibitors of apoptosis proteins (iaps) in chemoresistance of advanced prostate cancers has been established, we tested the effect of ct on phospho-akt and survivin levels in pc-3m cells. |
2006-06-22 |
2023-08-12 |
Not clear |
| Xiuli Lu, Fukushi Kambe, Xia Cao, Taemi Yoshida, Sachiko Ohmori, Kohji Murakami, Takahide Kaji, Takehisa Ishii, David Zadworny, Hisao Se. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology. vol 147. issue 6. 2006-06-22. PMID:16513830. |
however, the inhibition of external cholesterol supply by serum withdrawal induced apoptosis of dhcr24(-/-) mefs, which was associated with a marked decrease in the intracellular and plasma membrane cholesterol levels, akt inactivation, and bad dephosphorylation. |
2006-06-22 |
2023-08-12 |
mouse |
| Xiuli Lu, Fukushi Kambe, Xia Cao, Taemi Yoshida, Sachiko Ohmori, Kohji Murakami, Takahide Kaji, Takehisa Ishii, David Zadworny, Hisao Se. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology. vol 147. issue 6. 2006-06-22. PMID:16513830. |
however, this impairment was partial because treatment of the mefs with insulin restored akt activation and prevented apoptosis. |
2006-06-22 |
2023-08-12 |
mouse |
| Tahira Khan, Jimmy K Stauffer, Rebecca Williams, Julie A Hixon, Rosalba Salcedo, Erin Lincoln, Timothy C Back, Douglas Powell, Stephen Lockett, Alma C Arnold, Thomas J Sayers, Jon M Wigginto. Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 10. 2006-06-22. PMID:16670342. |
the present studies provide the first evidence that bortezomib, a newly approved inhibitor of proteasome function, inhibits phosphorylation of akt, induces the translocation of proapoptotic bid, and potently enhances the apoptosis of murine neuroblastoma tumor cells in vitro. |
2006-06-22 |
2023-08-12 |
mouse |
| Tahira Khan, Jimmy K Stauffer, Rebecca Williams, Julie A Hixon, Rosalba Salcedo, Erin Lincoln, Timothy C Back, Douglas Powell, Stephen Lockett, Alma C Arnold, Thomas J Sayers, Jon M Wigginto. Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 10. 2006-06-22. PMID:16670342. |
furthermore, in that inhibitors of the akt pathway can sensitize otherwise resistant tbj/neuro-2a cells to apoptosis induced by ifn-gamma plus tnf-alpha, we hypothesized that bortezomib also could sensitize these cells to ifn-gamma plus tnf-alpha. |
2006-06-22 |
2023-08-12 |
mouse |
| Nauman Ahmad, Yigang Wang, Khawaja Husnain Haider, Boyu Wang, Zeeshan Pasha, Ozge Uzun, Muhammad Ashra. Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. American journal of physiology. Heart and circulatory physiology. vol 290. issue 6. 2006-06-22. PMID:16687609. |
moreover, bms and de accelerated akt phosphorylation in cardiac tissue as determined by western blot analysis and also significantly reduced apoptosis compared with ischemic control. |
2006-06-22 |
2023-08-12 |
mouse |
| Nauman Ahmad, Yigang Wang, Khawaja Husnain Haider, Boyu Wang, Zeeshan Pasha, Ozge Uzun, Muhammad Ashra. Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. American journal of physiology. Heart and circulatory physiology. vol 290. issue 6. 2006-06-22. PMID:16687609. |
wtn significantly suppressed bms-induced akt phosphorylation, whereas 5-hd had no effect on akt phosphorylation in cytosol, and the effect of bms on apoptosis was abolished. |
2006-06-22 |
2023-08-12 |
mouse |
| Victor T Solovyan, Jorma Keski-Oj. Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells. Journal of cellular physiology. vol 207. issue 2. 2006-06-21. PMID:16447253. |
potentiation of cell death by activated tgf-beta was associated with downregulation of akt and p38 mapk, which were both activated at the initial stages of mv1lu apoptosis and were suppressed by exogenous tgf-beta. |
2006-06-21 |
2023-08-12 |
Not clear |
| F Guan, G Villegas, J Teichman, P Mundel, A Tufr. Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival. Kidney international. vol 69. issue 9. 2006-06-21. PMID:16541019. |
sema 3a induced a 10-fold increase in podocyte apoptosis and significantly decreased the activity of the akt survival pathway. |
2006-06-21 |
2023-08-12 |
mouse |
| B Hohenstein, B Hausknecht, K Boehmer, R Riess, R A Brekken, C P M Hug. Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man. Kidney international. vol 69. issue 9. 2006-06-21. PMID:16541023. |
glomerulosclerosis, capillary rarefaction, glomerular and endothelial cell proliferation, apoptosis, vegf expression, as well as receptor-bound vegf indicating local vegf activity, and phosphorylation of the signal transduction molecule akt were investigated. |
2006-06-21 |
2023-08-12 |
human |
| S Semba, F Trapasso, M Fabbri, K A McCorkell, S Volinia, T Druck, D Iliopoulos, Y Pekarsky, H Ishii, P N Garrison, L D Barnes, C M Croce, K Huebne. Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential. Oncogene. vol 25. issue 20. 2006-06-20. PMID:16407838. |
in addition, fhit inhibited activity of akt, a key effector in the phosphatidylinositol 3-oh kinase (pi3k) pathway; loss of endogenous fhit expression caused increased akt activity in vitro and in vivo, and overexpression of constitutively active akt inhibited fhit-induced apoptosis. |
2006-06-20 |
2023-08-12 |
human |
| Donghwa Kim, George Z Cheng, Craig W Lindsley, Hua Yang, Jin Q Chen. Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer. Current opinion in investigational drugs (London, England : 2000). vol 6. issue 12. 2006-06-19. PMID:16370391. |
inhibition of pi3k/akt signaling induces apoptosis and inhibits the growth of tumor cells that have elevated akt levels. |
2006-06-19 |
2023-08-12 |
mouse |
| Ian L P Beales, O Ogunwob. Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways. Molecular and cellular endocrinology. vol 247. issue 1-2. 2006-06-15. PMID:16442704. |
glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of akt and jnk pathways. |
2006-06-15 |
2023-08-12 |
Not clear |
| A R Hussain, M Al-Rasheed, P S Manogaran, K A Al-Hussein, L C Platanias, K Al Kuraya, S Uddi. Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502262. |
taken together, our finding suggest that curcumin suppresses constitutively activated targets of pi3'-kinase (akt, foxo and gsk3) in t cells leading to the inhibition of proliferation and induction of caspase-dependent apoptosis. |
2006-06-15 |
2023-08-12 |
Not clear |