| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xia Liu, Qitao Zhao, Satohiko Araki, Shangli Zhang, Junying Mia. Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells. Endothelium : journal of endothelial cell research. vol 13. issue 3. 2006-09-12. PMID:16840176. |
to address this question, in this study, the authors investigated the changes of cell cycle distribution, the expression of p53, and the phosphorylation of akt when pi-plc was inhibited by its specific inhibitor compound 48/80, and they also examined the phosphorylation of akt when vec apoptosis was inhibited by d609, a specific inhibitor of pc-plc. |
2006-09-12 |
2023-08-12 |
Not clear |
| Xia Liu, Qitao Zhao, Satohiko Araki, Shangli Zhang, Junying Mia. Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells. Endothelium : journal of endothelial cell research. vol 13. issue 3. 2006-09-12. PMID:16840176. |
the results showed that suppression of pi-plc promoted vec apoptosis by inhibiting akt phosphorylation, elevating p53 expression, and affecting the cell cycle distribution. |
2006-09-12 |
2023-08-12 |
Not clear |
| Xia Liu, Qitao Zhao, Satohiko Araki, Shangli Zhang, Junying Mia. Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells. Endothelium : journal of endothelial cell research. vol 13. issue 3. 2006-09-12. PMID:16840176. |
the data suggested that pi-plc and pc-plc might control the apoptosis by jointly regulating akt phosphorylation, p53 expression, and affecting cell cycle in vecs. |
2006-09-12 |
2023-08-12 |
Not clear |
| Swati Sinha, Bikas C Pal, Shankar Jagadeesh, Partha P Banerjee, Arun Bandyopadhaya, Samir Bhattachary. Mahanine inhibits growth and induces apoptosis in prostate cancer cells through the deactivation of Akt and activation of caspases. The Prostate. vol 66. issue 12. 2006-09-08. PMID:16683271. |
mahanine inhibits growth and induces apoptosis in prostate cancer cells through the deactivation of akt and activation of caspases. |
2006-09-08 |
2023-08-12 |
Not clear |
| Yutaka Yamanaka, Katsuya Shiraki, Tomoko Inoue, Kazumi Miyashita, Hiroyuki Fuke, Yumi Yamaguchi, Norihiko Yamamoto, Keiichi Ito, Kazushi Sugimoto, Takeshi Nakan. COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. International journal of molecular medicine. vol 18. issue 1. 2006-09-05. PMID:16786154. |
these results demonstrate that cox-2 inhibitors can induce apoptosis and augment trail sensitivity by up-regulation of trail receptors and down-regulation of both survivin and akt signaling. |
2006-09-05 |
2023-08-12 |
human |
| Oliver Treeck, Birgit Wackwitz, Ulrike Haus, Olaf Ortman. Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells. Gynecologic oncology. vol 102. issue 2. 2006-08-29. PMID:16443261. |
given that akt and mtor phosphorylation also is frequently detected in ovarian and endometrial cancer, we intended to find out to what extent mtor inhibitor rad001 (everolimus) and tamoxifen add to each other's effects on growth and apoptosis of cancer cell lines derived from these tissues when given concomitantly. |
2006-08-29 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
integrin beta3-mediated src activation regulates apoptosis in iec-6 cells via akt and stat3. |
2006-08-25 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
arg-gly-asp-ser inhibited beta3, src and akt phosphorylation and sensitized polyamine-depleted cells to tumour necrosis factor alpha/cycloheximide-mediated apoptosis. |
2006-08-25 |
2023-08-12 |
Not clear |
| Junghee Kang, Adeela Kamal, Francis J Burrows, B Mark Evers, Dai H Chun. Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors. Anticancer research. vol 26. issue 3A. 2006-08-24. PMID:16827123. |
we have previously reported that geldanamycin (ga), an hsp90 inhibitor, decreases raf-1 and akt protein expressions and induces apoptosis in neuroblastoma cells. |
2006-08-24 |
2023-08-12 |
human |
| A Jin, T Kurosu, K Tsuji, D Mizuchi, A Arai, H Fujita, M Hattori, N Minato, O Miur. BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion. Oncogene. vol 25. issue 31. 2006-08-23. PMID:16518411. |
bcr/abl and il-3 activate rap1 to stimulate the b-raf/mek/erk and akt signaling pathways and to regulate proliferation, apoptosis, and adhesion. |
2006-08-23 |
2023-08-12 |
Not clear |
| Therese H Hemström, Margareta Sandström, Boris Zhivotovsk. Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells. International journal of cancer. vol 119. issue 5. 2006-08-22. PMID:16570272. |
recently (hemström et al., exp cell res 2005;305:200-13) we showed that apoptosis of u1810 nsclc cells induced by the staurosporine analog pkc 412 correlated with inhibition of akt and erk1/2, suggesting the involvement of these kinases in cell survival. |
2006-08-22 |
2023-08-12 |
Not clear |
| Diane L M Hickson-Bick, Chad Jones, L Maximilian Buj. The response of neonatal rat ventricular myocytes to lipopolysaccharide-induced stress. Shock (Augusta, Ga.). vol 25. issue 5. 2006-08-22. PMID:16680021. |
however, high doses of lps are unable to induce apoptosis in these cells, and protection is not a function of akt activation. |
2006-08-22 |
2023-08-12 |
rat |
| Michelle T Barati, Madhavi J Rane, Jon B Klein, Kenneth R McLeis. A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells. Journal of proteome research. vol 5. issue 7. 2006-08-22. PMID:16823971. |
the serine-threonine kinase akt regulates mesangial cell apoptosis, proliferation, and hypertrophy. |
2006-08-22 |
2023-08-12 |
rat |
| Florence Lefranc, Robert Kis. Autophagy, the Trojan horse to combat glioblastomas. Neurosurgical focus. vol 20. issue 4. 2006-08-18. PMID:16709038. |
migrating gbm cells are resistant to apoptosis (type i programmed cell death), and thus to radiotherapy and conventional chemotherapy, because of the constitutive activation of several intracellular signaling pathways, of which the most important identified to date are the pathways controlled by phosphatidylinositol 3-kinase, akt, and the mammalian target of rapamycin (mtor). |
2006-08-18 |
2023-08-12 |
Not clear |
| Pradeep Reddy, Lijun Shen, Chong Ren, Karin Boman, Eva Lundin, Ulrika Ottander, Peter Lindgren, Yi-Xun Liu, Qing-Yuan Sun, Kui Li. Activation of Akt (PKB) and suppression of FKHRL1 in mouse and rat oocytes by stem cell factor during follicular activation and development. Developmental biology. vol 281. issue 2. 2006-08-16. PMID:15893970. |
in this study, by using ovaries and isolated oocytes from postnatal mice and rats, we demonstrated for the first time that components of the pi3 kinase pathway, the serine/threonine kinase akt (pkb) which enhances cellular proliferation and survival, and an akt substrate fkhrl1 which is a transcription factor that leads to apoptosis and cell cycle arrest, are expressed in mammalian oocytes. |
2006-08-16 |
2023-08-12 |
mouse |
| Keqiang Y. PIKE GTPase-mediated nuclear signalings promote cell survival. Biochimica et biophysica acta. vol 1761. issue 5-6. 2006-08-16. PMID:16567124. |
nuclear akt regulation of apoptosis is dependent on its phosphorylation of key substrates in the nucleus, but the identities of these substrates are unknown. |
2006-08-16 |
2023-08-12 |
Not clear |
| Amy L Howes, Shigeki Miyamoto, John W Adams, Elizabeth A Woodcock, Joan Heller Brow. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. Journal of molecular and cellular cardiology. vol 40. issue 5. 2006-08-14. PMID:16466740. |
as demonstrated here, galphaq expression protects cardiomyocytes against apoptosis induced by treatment with 2-deoxyglucose (2dog) and this protection is lost when akt activation is prevented by treatment with ly294002 (an inhibitor of pi3k). |
2006-08-14 |
2023-08-12 |
rat |
| Andrew E Schade, Jennifer J Powers, Marcin W Wlodarski, Jaroslaw P Maciejewsk. Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis. Blood. vol 107. issue 12. 2006-08-14. PMID:16484592. |
given the importance of the phosphatidylinositol-3 kinase (pi3k)-akt pathway in regulating the balance between survival and apoptosis, we analyzed akt activity in t-lgl cells. |
2006-08-14 |
2023-08-12 |
Not clear |
| Jacob Raphael, Suzan Abedat, Julia Rivo, Karen Meir, Ronen Beeri, Thea Pugatsch, Zhiyi Zuo, Yaacov Goza. Volatile anesthetic preconditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via Akt signaling and modulation of Bcl-2 family proteins. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16551837. |
volatile anesthetic preconditioning attenuates myocardial apoptosis in rabbits after regional ischemia and reperfusion via akt signaling and modulation of bcl-2 family proteins. |
2006-08-14 |
2023-08-12 |
Not clear |
| Jason Ramos, Mint Sirisawad, Richard Miller, Louie Naumovsk. Motexafin gadolinium modulates levels of phosphorylated Akt and synergizes with inhibitors of Akt phosphorylation. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731749. |
these data point to a potential protective role for pakt in mgd-induced apoptosis and suggest that mgd activity may be enhanced by combining it with agents that inhibit akt phosphorylation. |
2006-08-14 |
2023-08-12 |
Not clear |