| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin A Janes, John G Albeck, Lili X Peng, Peter K Sorger, Douglas A Lauffenburger, Michael B Yaff. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & cellular proteomics : MCP. vol 2. issue 7. 2006-07-27. PMID:12832460. |
when applied to a model of sepsis-induced colon epithelial apoptosis, this approach identified a late phase of akt activity as a critical mediator of cell survival that quantitatively contributed to the efficacy of insulin as an anti-apoptotic cue. |
2006-07-27 |
2023-08-12 |
human |
| Manila Boca, Gianfranco Distefano, Feng Qian, Anil K Bhunia, Gregory G Germino, Alessandra Bolett. Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway. Journal of the American Society of Nephrology : JASN. vol 17. issue 3. 2006-07-27. PMID:16452497. |
in addition, it is shown that dominant negative akt can revert pc-1-induced protection from apoptosis. |
2006-07-27 |
2023-08-12 |
Not clear |
| Lanxi Song, Mark Morris, Tapan Bagui, Francis Y Lee, Richard Jove, Eric B Haur. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740687. |
the induction of apoptosis in these egfr-mutant cell lines corresponds to down-regulation of activated akt and stat3 survival proteins. |
2006-07-27 |
2023-08-12 |
human |
| Alberto M Martelli, Irene Faenza, Anna Maria Billi, Lucia Manzoli, Camilla Evangelisti, Federica Falà, Lucio Cocc. Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cellular signalling. vol 18. issue 8. 2006-07-26. PMID:16516442. |
intranuclear 3'-phosphoinositide metabolism and akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? |
2006-07-26 |
2023-08-12 |
Not clear |
| Alberto M Martelli, Irene Faenza, Anna Maria Billi, Lucia Manzoli, Camilla Evangelisti, Federica Falà, Lucio Cocc. Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cellular signalling. vol 18. issue 8. 2006-07-26. PMID:16516442. |
pi3k, its lipid product phosphatidylinositol (3,4,5) trisphosphate (ptdins(3,4,5)p3), and akt have been identified within the nucleus and recent data suggest that they counteract apoptosis also by operating in this cell compartment through a block of caspase-activated dnase and inhibition of chromatin condensation. |
2006-07-26 |
2023-08-12 |
Not clear |
| Jee-Yin Ahn, Xia Liu, Zhixue Liu, Lorena Pereira, Dongmei Cheng, Junmin Peng, Paul A Wade, Anne W Hamburger, Keqiang Y. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. The EMBO journal. vol 25. issue 10. 2006-07-21. PMID:16642037. |
ebp1 (s360a), which cannot be phosphorylated by pkc, barely binds akt or inhibits dna fragmentation, whereas ebp1 s360d, which mimics phosphorylation, strongly binds akt and suppresses apoptosis. |
2006-07-21 |
2023-08-12 |
Not clear |
| Jee-Yin Ahn, Xia Liu, Zhixue Liu, Lorena Pereira, Dongmei Cheng, Junmin Peng, Paul A Wade, Anne W Hamburger, Keqiang Y. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. The EMBO journal. vol 25. issue 10. 2006-07-21. PMID:16642037. |
thus, nuclear akt might contribute to suppressing apoptosis through interaction with ebp1. |
2006-07-21 |
2023-08-12 |
Not clear |
| Philippe Verbeke, Lynn Welter-Stahl, Songmin Ying, Jon Hansen, Georg Häcker, Toni Darville, David M Ojciu. Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival. PLoS pathogens. vol 2. issue 5. 2006-07-20. PMID:16710454. |
depletion of akt through short-interfering rna reverses the resistance to apoptosis of c. trachomatis-infected cells. |
2006-07-20 |
2023-08-12 |
Not clear |
| Uma Kant Misra, Rohit Deedwania, Salvatore Vincent Pizz. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16543232. |
we have now examined the interplay between akt activation, regulation of apoptosis, the unfolded protein response, and activation of nf-kappab in alpha2m*-induced proliferation of 1-ln cells. |
2006-07-18 |
2023-08-12 |
human |
| Xinqun Li, Yang Lu, Weidong Jin, Ke Liang, Gordon B Mills, Zhen Fa. Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16549426. |
compared with wild-type akt, akt/t72a/s246a mutant exhibited markedly reduced basal akt kinase activity and response to cellular stimulation by insulin-like growth factor-1, and also conferred less cellular resistance to doxorubicin-induced apoptosis. |
2006-07-18 |
2023-08-12 |
Not clear |
| Yoshishige Urata, Yoshito Ihara, Hiroaki Murata, Shinji Goto, Takehiko Koji, Junji Yodoi, Satoshi Inoue, Takahito Kond. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16549430. |
the gsh/glutaredoxin (grx) system is involved in the redox regulation of certain enzyme activities, and this system protects cells from h2o2-induced apoptosis by regulating the redox state of akt (murata, h., ihara, y., nakamura, h., yodoi, j., sumikawa, k., and kondo, t. (2003) j. biol. |
2006-07-18 |
2023-08-12 |
Not clear |
| Yoshishige Urata, Yoshito Ihara, Hiroaki Murata, Shinji Goto, Takehiko Koji, Junji Yodoi, Satoshi Inoue, Takahito Kond. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. The Journal of biological chemistry. vol 281. issue 19. 2006-07-18. PMID:16549430. |
in the present study, we demonstrated that e2 protected cardiac h9c2 cells, expressing erbeta from h2o2-induced apoptosis concomitant with an increase in the activity of akt. |
2006-07-18 |
2023-08-12 |
Not clear |
| Carole Sourbier, Véronique Lindner, Hervé Lang, Abdelali Agouni, Eric Schordan, Sabrina Danilin, Sylvie Rothhut, Didier Jacqmin, Jean-Jacques Helwig, Thierry Massfelde. The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707436. |
exposure to ly294002 or wortmannin decreased akt activation and gsk-3 phosphorylation and reduced cell growth by up to 70% through induction of cell apoptosis. |
2006-07-18 |
2023-08-12 |
mouse |
| Chi Tarn, Yuliya V Skorobogatko, Takahiro Taguchi, Burton Eisenberg, Margaret von Mehren, Andrew K Godwi. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707477. |
importantly, expression of constitutively active akt1 or akt2 does not rescue cells from the imatinib-mediated apoptosis although glucose uptake was not blocked, suggesting that the potential therapeutic effect of imatinib is independent of akt activity and glucose deprivation. |
2006-07-18 |
2023-08-12 |
Not clear |
| Marie P Piechocki, George H Yoo, Susan K Dibbley, Esmael H Amjad, Fulvio Lonard. Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neu. International journal of cancer. vol 119. issue 2. 2006-07-14. PMID:16470840. |
higher doses of iressa diminished phosphorylation of akt slightly, but failed to induce apoptosis. |
2006-07-14 |
2023-08-12 |
mouse |
| Bin Lu, Liying Wang, Christian Stehlik, Djordje Medan, Chuanshu Huang, Shuiying Hu, Fei Chen, Xianglin Shi, Yon Rojanasaku. Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 11. 2006-07-13. PMID:16709838. |
inhibition of pi3k/akt by dominant-negative overexpression of pi3k (deltap85) and akt (akt-t308a/s473a) protects the cells from apoptosis, indicating an unexpected proapoptotic role of pi3k/akt in the fas signaling process. |
2006-07-13 |
2023-08-12 |
human |
| Huang-Ge Zhang, Cunren Liu, Kaihong Su, Kaihun Su, Shaohua Yu, Liming Zhang, Shuangqin Zhang, Jianhua Wang, Xu Cao, William Grizzle, Robert P Kimberl. A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. Journal of immunology (Baltimore, Md. : 1950). vol 176. issue 12. 2006-07-13. PMID:16751383. |
exosomes can transmit signals between cells, and rasf exosomes, effectively taken up by anti-cd3-activated t cells, activated akt and nf-kappab and rendered these activated t cells resistant to apoptosis. |
2006-07-13 |
2023-08-12 |
Not clear |
| Yiwei Li, Sreenivasa R Chinni, Fazlul H Sarka. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574364. |
we have previously shown that i3c induces apoptosis and inhibits the activation of nf-kappab pathway, which could be mediated via akt signaling pathway. |
2006-07-07 |
2023-08-12 |
human |
| Yiwei Li, Sreenivasa R Chinni, Fazlul H Sarka. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574364. |
in this study, we investigated whether there is any cross-talk between akt and nf-kappab during dim-induced apoptosis in pc-3 prostate cancer cells. |
2006-07-07 |
2023-08-12 |
human |
| Yiwei Li, Sreenivasa R Chinni, Fazlul H Sarka. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574364. |
dim treatment also showed significant induction of apoptosis in non-transfected cells compared to akt and akt-myr transfected prostate cancer cells. |
2006-07-07 |
2023-08-12 |
human |