| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benjamin Y Klein, Zohar Kerem, Nathan Rojansk. LDL induces Saos2 osteoblasts death via Akt pathways responsive to a neutral sphingomyelinase inhibitor. Journal of cellular biochemistry. vol 98. issue 3. 2006-06-14. PMID:16440306. |
taken together, the results indicate that nldl has induced apoptosis in saos2 osteoblasts by inactivation of the pathway downstream to akt using nsmase, and by involvement of src kinase. |
2006-06-14 |
2023-08-12 |
Not clear |
| Lamine Aoudjit, Anna Potapov, Tomoko Takan. Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor. American journal of physiology. Renal physiology. vol 290. issue 6. 2006-06-12. PMID:16396944. |
induction of cox-2 and addition of exogenous pge2 both lead to decreased serum deprivation-induced apoptosis, which was accompanied by activation of the survival kinase akt. |
2006-06-12 |
2023-08-12 |
rat |
| Dong Ju Son, Seong Jong Ha, Ho Sueb Song, Yong Lim, Yeo Pyo Yun, Jae Woong Lee, Dong Cheul Moon, Young Hyun Park, Byeoung Soo Park, Min Jong Song, Jin Tae Hon. Melittin inhibits vascular smooth muscle cell proliferation through induction of apoptosis via suppression of nuclear factor-kappaB and Akt activation and enhancement of apoptotic protein expression. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16401728. |
melittin inhibits vascular smooth muscle cell proliferation through induction of apoptosis via suppression of nuclear factor-kappab and akt activation and enhancement of apoptotic protein expression. |
2006-06-09 |
2023-08-12 |
rat |
| Dong Ju Son, Seong Jong Ha, Ho Sueb Song, Yong Lim, Yeo Pyo Yun, Jae Woong Lee, Dong Cheul Moon, Young Hyun Park, Byeoung Soo Park, Min Jong Song, Jin Tae Hon. Melittin inhibits vascular smooth muscle cell proliferation through induction of apoptosis via suppression of nuclear factor-kappaB and Akt activation and enhancement of apoptotic protein expression. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16401728. |
these results suggest the antiproliferative effects of bv and melittin in vsmc through induction of apoptosis via suppressions of nf-kappab and akt activation and enhancement of apoptotic signaling pathway. |
2006-06-09 |
2023-08-12 |
rat |
| Markus J Leskinen, Hanna M Heikkilä, Mei Y Speer, Jukka K Hakala, Mika Laine, Petri T Kovanen, Ken A Lindsted. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16460729. |
chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (smcs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and akt dephosphorylation, which are necessary for cell adhesion and survival. |
2006-06-08 |
2023-08-12 |
human |
| Markus J Leskinen, Hanna M Heikkilä, Mei Y Speer, Jukka K Hakala, Mika Laine, Petri T Kovanen, Ken A Lindsted. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16460729. |
however, the molecular mechanisms of chymase-mediated apoptosis downstream of akt have remained elusive. |
2006-06-08 |
2023-08-12 |
human |
| Xiu-Huai Liu, Erik Z Yu, Ying-Yue Li, Florence M Rollwagen, Elliott Kaga. RNA interference targeting Akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells. Brain research. vol 1070. issue 1. 2006-06-06. PMID:16405925. |
rna interference targeting akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells. |
2006-06-06 |
2023-08-12 |
human |
| Yangxin Li, Yao-Hua Song, Jessica Mohler, Patrick Delafontain. ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression. American journal of physiology. Heart and circulatory physiology. vol 290. issue 5. 2006-06-01. PMID:16339840. |
ang ii induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of akt phosphorylation and increased fasl expression. |
2006-06-01 |
2023-08-12 |
human |
| Yangxin Li, Yao-Hua Song, Jessica Mohler, Patrick Delafontain. ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression. American journal of physiology. Heart and circulatory physiology. vol 290. issue 5. 2006-06-01. PMID:16339840. |
ang ii-induced apoptosis was characterized by marked inhibition of akt phosphorylation and stimulation of membrane fas ligand (fasl) expression, caspase-8 activation, and a reduction in soluble fasl expression. |
2006-06-01 |
2023-08-12 |
human |
| Yangxin Li, Yao-Hua Song, Jessica Mohler, Patrick Delafontain. ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression. American journal of physiology. Heart and circulatory physiology. vol 290. issue 5. 2006-06-01. PMID:16339840. |
adenovirally mediated overexpression of akt rescued hvsmc from ang ii-induced apoptosis. |
2006-06-01 |
2023-08-12 |
human |
| Yangxin Li, Yao-Hua Song, Jessica Mohler, Patrick Delafontain. ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression. American journal of physiology. Heart and circulatory physiology. vol 290. issue 5. 2006-06-01. PMID:16339840. |
in conclusion, ang ii-induced apoptosis of hvsmc is characterized by marked inhibition of akt phosphorylation and stimulation of an extrinsic cell death signaling pathway via upregulation of membrane fasl expression, caspase-8 activation, and a reduction in soluble fasl expression. |
2006-06-01 |
2023-08-12 |
human |
| Deepa Sampath, Jorge Cortes, Zeev Estrov, Min Du, Zheng Shi, Michael Andreeff, Varsha Gandhi, William Plunket. Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. vol 107. issue 6. 2006-05-31. PMID:16293603. |
however, inhibition of chk1 by ucn-01 in s-phase-arrested cells resulted in an abrogation of the checkpoint, inhibition of akt, activation of jnk, and a rapid induction of apoptosis. |
2006-05-31 |
2023-08-12 |
Not clear |
| Jennifer L Gilmore, Richard M Gallo, David J Ries. The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events. The Biochemical journal. vol 396. issue 1. 2006-05-31. PMID:16445385. |
finally, the egfr-s442f mutant constitutively suppresses apoptosis via phosphoinositide 3-kinase and akt signalling but is not highly tyrosine phosphorylated in the absence of ligand. |
2006-05-31 |
2023-08-12 |
human |
| S M Quirk, R G Cowan, R M Harman, C-L Hu, D A Porte. Ovarian follicular growth and atresia: the relationship between cell proliferation and survival. Journal of animal science. vol 82 E-Suppl. 2006-05-30. PMID:15471814. |
constitutive activation of akt by the infection of granulosa cells with a recombinant akt adenovirus protected against apoptosis, and this effect also depended on cell cycle progression. |
2006-05-30 |
2023-08-12 |
cattle |
| Jianhai Jiang, Xiaoning Chen, Jialin Shen, Yuanyan Wei, Tao Wu, Yanzhong Yang, Hanzhou Wang, Hongliang Zong, Junwu Yang, Si Zhang, Jianhui Xie, Xiangfei Kong, Weicheng Liu, Jianxin G. Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. The Journal of biological chemistry. vol 281. issue 14. 2006-05-30. PMID:16461357. |
furthermore, decreasing the expression of galt v in glioma cells promoted apoptosis, inhibited the invasion and migration and the ability of tumor formation in vivo, and reduced the activation of akt. |
2006-05-30 |
2023-08-12 |
Not clear |
| Fazlul H Sarkar, Shreelekha Adsule, Subhash Padhye, Sudhir Kulkarni, Yiwei L. The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini reviews in medicinal chemistry. vol 6. issue 4. 2006-05-30. PMID:16613577. |
it has been reported that genistein induces apoptosis and inhibits activation of nf-kappab and akt signaling pathways, both of which are known to maintain a balance between cell survival and apoptosis. |
2006-05-30 |
2023-08-12 |
Not clear |
| Xuesong Liu, Yan Shi, Vincent L Giranda, Yan Lu. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546963. |
treatment of cells with cerulenin and ly294002 down-regulated the protein levels of x chromosome-linked inhibitor of apoptosis (xiap), cellular inhibitor of apoptosis 1 (ciap-1), and akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic bcl-2 family proteins (bcl-2 and bcl-xl) did not change. |
2006-05-26 |
2023-08-12 |
human |
| Xuesong Liu, Yan Shi, Vincent L Giranda, Yan Lu. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546963. |
in conclusion, these studies show that inhibition of pi3k can sensitize cerulenin-induced apoptosis in mba-mb468 breast cancer cells via activation of caspases, down-regulation of antiapoptotic proteins, such as xiap, ciap-1 and akt, and possibly, activation of bak in mitochondria. |
2006-05-26 |
2023-08-12 |
human |
| Naoto Ohi, Yuji Nishikawa, Takuo Tokairin, Yohei Yamamoto, Yuko Doi, Yasufumi Omori, Katsuhiko Enomot. Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo. The American journal of pathology. vol 168. issue 4. 2006-05-25. PMID:16565486. |
sec apoptosis in vivo was associated with dephosphorylation of bad, akt, and extracellular signal-regulated protein kinase, which was blocked by ov treatment. |
2006-05-25 |
2023-08-12 |
rat |
| Ying Chun Li, Mi Jung Park, Sang-Kyu Ye, Chul-Woo Kim, Yong-Nyun Ki. Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. The American journal of pathology. vol 168. issue 4. 2006-05-25. PMID:16565487. |
here, we report that cholesterol depletion using methyl-beta cyclodextrin caused anoikis-like apoptosis, which in a431 cells involved decreased raft levels, bcl-xl down-regulation, caspase-3 activation, and akt inactivation regardless of epidermal growth factor receptor activation. |
2006-05-25 |
2023-08-12 |
human |