| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lourdes A Gomez, Alicia de Las Pozas, Carlos Perez-Stabl. Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731754. |
sequential combination of flavopiridol and docetaxel reduces the levels of x-linked inhibitor of apoptosis and akt proteins and stimulates apoptosis in human lncap prostate cancer cells. |
2006-08-14 |
2023-08-12 |
human |
| Lourdes A Gomez, Alicia de Las Pozas, Carlos Perez-Stabl. Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731754. |
androgen ablation in androgen-independent lncap cells increased activated akt and chemoresistance to apoptosis after treatment with fd. |
2006-08-14 |
2023-08-12 |
human |
| Lourdes A Gomez, Alicia de Las Pozas, Carlos Perez-Stabl. Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731754. |
the proteasome inhibitor mg-132 blocked fd-mediated reduction of xiap and akt and antagonized apoptosis, suggesting that the activation of the proteasome pathway is one of the mechanisms involved. |
2006-08-14 |
2023-08-12 |
human |
| Lourdes A Gomez, Alicia de Las Pozas, Carlos Perez-Stabl. Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731754. |
overall, our data suggest that the docetaxel and flavopiridol combination requires a maximal effect on cyclin b1-dependent kinase activity and a reduction of xiap and akt prosurvival proteins for augmentation of apoptosis in lncap cells. |
2006-08-14 |
2023-08-12 |
human |
| Antonella di Palma, Giuseppe Matarese, Vincenza Leone, Tiziana Di Matola, Fabio Acquaviva, Angela Maria Acquaviva, Paolo Ricch. Aspirin reduces the outcome of anticancer therapy in Meth A-bearing mice through activation of AKT-glycogen synthase kinase signaling. Molecular cancer therapeutics. vol 5. issue 5. 2006-08-14. PMID:16731765. |
we found that cotreatment with aspirin reduced vp-16-induced apoptosis and activated akt in vitro and in vivo. |
2006-08-14 |
2023-08-12 |
mouse |
| Marta Volosin, Wenyu Song, Ramiro D Almeida, David R Kaplan, Barbara L Hempstead, Wilma J Friedma. Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 29. 2006-08-14. PMID:16855103. |
however, activation of pi3k (phosphatidylinositol 3-kinase)/akt and mek (mitogen-activated protein kinase kinase)/erk pathways prevented pro-ngf-induced apoptosis, revealing a novel critical checkpoint in survival versus apoptotic signaling downstream of trk activation, and suggesting that pro-ngf blocks survival signaling by preventing akt and erk activation. |
2006-08-14 |
2023-08-12 |
Not clear |
| Wenjun Li, Shaohui Cai, Lu Cai, Xiaokun L. Anti-apoptotic effect of hepatocyte growth factor from actinomycin D in hepatocyte-derived HL7702 cells is associated with activation of PI3K/Akt signaling. Toxicology letters. vol 165. issue 2. 2006-08-10. PMID:16616440. |
hgf was found to significantly activate akt phosphorylation while pre-treatment with pi3k specific inhibitor wortmannin further enhanced actd-induced apoptotic effect, and also significantly prevented hgf's protection against actd-induced apoptosis. |
2006-08-10 |
2023-08-12 |
human |
| Chit Chow, Angi Y Liu, Wai S Chan, Kenny I K Lei, Wing Y Chan, Anthony W I L. AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type. Haematologica. vol 90. issue 2. 2006-08-09. PMID:15710591. |
either interleukin-2 (il-2) or interleukin-15 (il-15) could prevent akt dephosphorylation and apoptosis in the nk-92 cell line model. |
2006-08-09 |
2023-08-12 |
Not clear |
| T Mochizuki, S Furuta, J Mitsushita, W H Shang, M Ito, Y Yokoo, M Yamaura, S Ishizone, J Nakayama, A Konagai, K Hirose, K Kiyosawa, T Kamat. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16532036. |
furthermore, akt phosphorylation of apoptosis signal-regulating kinase 1 (ask1) on ser-83 was reduced by dpi and sinox4rnas. |
2006-08-08 |
2023-08-12 |
human |
| T Mochizuki, S Furuta, J Mitsushita, W H Shang, M Ito, Y Yokoo, M Yamaura, S Ishizone, J Nakayama, A Konagai, K Hirose, K Kiyosawa, T Kamat. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16532036. |
when ask1ser83ala (an akt phosphorylation-defective ask1 mutant) was introduced into panc-1 cells, this mutant alone induced apoptosis. |
2006-08-08 |
2023-08-12 |
human |
| Y-Y He, J Pi, J-L Huang, B A Diwan, M P Waalkes, C F Chignel. Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene. vol 25. issue 26. 2006-08-08. PMID:16682958. |
the resistance of ulth cells to uva-induced apoptosis was reversed by either inhibition of phosphatidylinositol 3-kinase (pi-3k) or adenovirus expression of pten or dominant negative akt. |
2006-08-08 |
2023-08-12 |
mouse |
| An-Chin Cheng, Tzou-Chi Huang, Ching-Shu Lai, Jen-Min Kuo, Ying-Tang Huang, Chih-Yu Lo, Chi-Tang Ho, Min-Hsiung Pa. Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells. Journal of agricultural and food chemistry. vol 54. issue 12. 2006-08-08. PMID:16756349. |
pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of akt and caspase-9 in human leukemia hl-60 cells. |
2006-08-08 |
2023-08-12 |
human |
| An-Chin Cheng, Tzou-Chi Huang, Ching-Shu Lai, Jen-Min Kuo, Ying-Tang Huang, Chih-Yu Lo, Chi-Tang Ho, Min-Hsiung Pa. Pyrrolidine dithiocarbamate inhibition of luteolin-induced apoptosis through up-regulated phosphorylation of Akt and caspase-9 in human leukemia HL-60 cells. Journal of agricultural and food chemistry. vol 54. issue 12. 2006-08-08. PMID:16756349. |
therefore, not only was pdtc able to stop the apoptosis of hl-60 cells treated with luteolin, it was also found to increase phosphorylation of akt and caspase-9. |
2006-08-08 |
2023-08-12 |
human |
| Ryoji Yanai, Naoyuki Yamada, Makoto Inui, Teruo Nishid. Correlation of proliferative and anti-apoptotic effects of HGF, insulin, IGF-1, IGF-2, and EGF in SV40-transformed human corneal epithelial cells. Experimental eye research. vol 83. issue 1. 2006-08-07. PMID:16530761. |
the growth factors examined could be classified into three groups on the basis of their effects on the proliferation and apoptosis of human corneal epithelial cells: hepatocyte growth factor (hgf), insulin, insulin-like growth factor (igf)-1, igf-2, and epidermal growth factor (egf) each increased cell proliferation, inhibited the induction of apoptosis by sodium nitroprusside, and elicited the activation of akt; transforming growth factor-beta1 and -beta2 inhibited [3h]thymidine incorporation but had no effect on sodium nitroprusside-induced apoptosis or on akt activity; and platelet-derived growth factor-bb had no effects on the measured parameters. |
2006-08-07 |
2023-08-12 |
human |
| Y Liu, L Chen, T C Ko, A P Fields, E A Thompso. Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Oncogene. vol 25. issue 25. 2006-08-03. PMID:16462766. |
however, evi1 did inhibit tgfbeta-mediated apoptosis by a process that involves phosphoinositide-3-kinase (pi3k) and its downstream effector akt. |
2006-08-03 |
2023-08-12 |
human |
| Y Liu, L Chen, T C Ko, A P Fields, E A Thompso. Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Oncogene. vol 25. issue 25. 2006-08-03. PMID:16462766. |
knockdown of evi1 by sirna inhibited akt phosphorylation in ht-29 human colon cancer cells and increased their sensitivity to taxol-mediated apoptosis. |
2006-08-03 |
2023-08-12 |
human |
| Kohjiro Ueki, Terumasa Okada, Jiang Hu, Chong Wee Liew, Anke Assmann, Gabriella M Dahlgren, Jennifer L Peters, Jonathan G Shackman, Min Zhang, Isabella Artner, Leslie S Satin, Roland Stein, Martin Holzenberger, Robert T Kennedy, C Ronald Kahn, Rohit N Kulkarn. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nature genetics. vol 38. issue 5. 2006-08-01. PMID:16642022. |
normoglycemic 2-week-old betadko mice manifest reduced beta cell mass, reduced expression of phosphorylated akt and the transcription factor mafa, increased apoptosis in islets and severely compromised beta cell function. |
2006-08-01 |
2023-08-12 |
mouse |
| Christiane Querfeld, Mujahid A Rizvi, Timothy M Kuzel, Joan Guitart, Alfred Rademaker, Simran S Sabharwal, Nancy L Krett, Steven T Rose. The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. The Journal of investigative dermatology. vol 126. issue 7. 2006-08-01. PMID:16645590. |
the selective protein kinase c beta inhibitor enzastaurin induces apoptosis in cutaneous t-cell lymphoma cell lines through the akt pathway. |
2006-08-01 |
2023-08-12 |
Not clear |
| Christiane Querfeld, Mujahid A Rizvi, Timothy M Kuzel, Joan Guitart, Alfred Rademaker, Simran S Sabharwal, Nancy L Krett, Steven T Rose. The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. The Journal of investigative dermatology. vol 126. issue 7. 2006-08-01. PMID:16645590. |
these results demonstrate that enzastaurin, at clinically achievable concentrations, induces apoptosis and affects akt signaling, and provide a rationale for further in vivo studies addressing the therapeutic efficacy in cutaneous t-cell lymphoma patients. |
2006-08-01 |
2023-08-12 |
Not clear |
| Zoltán Derdák, Péter Fülöp, Edmond Sabo, Rose Tavares, Eric P Berthiaume, Murray B Resnick, György Paragh, Jack R Wands, György Baff. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis. vol 27. issue 5. 2006-07-31. PMID:16401637. |
this effect is primarily seen in the proximal colon of ucp2-/- mice (p < 0.05), in association with changes indicative of increased oxidative stress (increased staining for malondialdehyde and inducible nitric oxide synthase), enhanced nf-kappab activation (increased levels of phosphorylated ikappab and increased nuclear presence of p65) and a disrupted balance between intestinal epithelial cell proliferation (greater 5-bromo-2'-deoxy-uridine incorporation rates and increased phosphorylation of erk1/2 and akt) and apoptosis (decreased number of terminal deoxynucleotidyltransferase-mediated nick-end-labeling (tunel)-positive cells and increased expression of bcl-2). |
2006-07-31 |
2023-08-12 |
mouse |