| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Freilinger, M Rosner, G Krupitza, M Nishino, G Lubec, S J Korsmeyer, M Hengstschläge. Tuberin activates the proapoptotic molecule BAD. Oncogene. vol 25. issue 49. 2006-11-09. PMID:16702951. |
akt phosphorylation negatively regulates tuberin's potential to trigger apoptosis. |
2006-11-09 |
2023-08-12 |
human |
| Dongmei Lu, Jie Huang, Alakananda Bas. Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death. The Journal of biological chemistry. vol 281. issue 32. 2006-11-08. PMID:16785234. |
furthermore, we report for the first time that dna-pk can regulate receptor-initiated apoptosis via akt. |
2006-11-08 |
2023-08-12 |
Not clear |
| Georgios V Georgakis, Yang Li, Anas Youne. The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9. British journal of haematology. vol 135. issue 1. 2006-11-06. PMID:16925576. |
the heat shock protein 90 inhibitor 17-aag induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin d1, akt, bid and activating caspase 9. |
2006-11-06 |
2023-08-12 |
Not clear |
| Riccardo Alessandro, Maria Antonietta Di Bella, Anna Maria Flugy, Simona Fontana, Francesca Damiani, Chiara Corrado, Paolo Colomba, Matilde Todaro, Domenica Russo, Alessandra Santoro, Elise C Kohn, Giacomo De Le. Comparative study of T84 and T84SF human colon carcinoma cells: in vitro and in vivo ultrastructural and functional characterization of cell culture and metastasis. Virchows Archiv : an international journal of pathology. vol 449. issue 1. 2006-11-02. PMID:16612624. |
these morphological differences were also coupled with biochemical data showing a distinct tyrosine phosphorylation-based signaling, an altered localization of beta-catenin, mapk, and akt activation, as well as an increased expression in t84sf cells of bcl-x(l), a major regulator of apoptosis. |
2006-11-02 |
2023-08-12 |
human |
| Rhona Stein, Zhengxing Qu, Susan Chen, David Solis, Hans J Hansen, David M Goldenber. Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab. Blood. vol 108. issue 8. 2006-11-02. PMID:16778139. |
in vitro studies show that replacing the fc region of hl243gamma1, a humanized igg1 anti-hla-dr mab, with the igg4 isotype abrogates the effector cell functions of the antibody (adcc and cdc) while retaining its antigen-binding properties, antiproliferative capacity (in vitro and in vivo), and the ability to induce apoptosis concurrent with activation of the akt survival pathway. |
2006-11-02 |
2023-08-12 |
Not clear |
| Makoto Hiromura, Futoshi Suizu, Masumi Narita, Keiichi Kinowaki, Masayuki Noguch. Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element. The Journal of biological chemistry. vol 281. issue 38. 2006-11-02. PMID:16835233. |
nur77/ngfi-b, an orphan receptor superfamily transcription factor implicated in t-cell apoptosis, is a substrate for akt. |
2006-11-02 |
2023-08-12 |
human |
| Mingyue Li, Tak W Lee, Anthony P C Yim, Tony S K Mok, George G Che. Apoptosis induced by troglitazone is both peroxisome proliferator-activated receptor-gamma- and ERK-dependent in human non-small lung cancer cells. Journal of cellular physiology. vol 209. issue 2. 2006-10-26. PMID:16883598. |
however, the inhibition of akt promoted the release of cytochrome c, suggesting the activation of akt may have a negative effect on apoptosis induced by tgz. |
2006-10-26 |
2023-08-12 |
human |
| Ya-Min Fu, Hui Zhang, Mingjie Ding, Yi-Qi Li, Xing Fu, Zu-Xi Yu, Gary G Meadow. Selective amino acid restriction targets mitochondria to induce apoptosis of androgen-independent prostate cancer cells. Journal of cellular physiology. vol 209. issue 2. 2006-10-26. PMID:16897757. |
in du145, tyr/phe or met restriction reduces activity of akt, mitochondrial distribution of phosphorylated raf and apoptosis inducing factor (aif), and increases mitochondrial distribution of bak. |
2006-10-26 |
2023-08-12 |
Not clear |
| Ya-Min Fu, Hui Zhang, Mingjie Ding, Yi-Qi Li, Xing Fu, Zu-Xi Yu, Gary G Meadow. Selective amino acid restriction targets mitochondria to induce apoptosis of androgen-independent prostate cancer cells. Journal of cellular physiology. vol 209. issue 2. 2006-10-26. PMID:16897757. |
we conclude that specific amino acid restriction differentially interferes with homeostasis/balance between the raf and akt survival pathways and with the interaction of raf and bcl-2 family proteins in mitochondria to induce apoptosis of du145 and pc3 cells. |
2006-10-26 |
2023-08-12 |
Not clear |
| Corinne Sonnet, Peggy Lafuste, Ludovic Arnold, Madly Brigitte, Françoise Poron, Françoise-Jérôme Authier, Fabrice Chrétien, Romain K Gherardi, Bénédicte Chazau. Human macrophages rescue myoblasts and myotubes from apoptosis through a set of adhesion molecular systems. Journal of cell science. vol 119. issue Pt 12. 2006-10-25. PMID:16720640. |
we demonstrated that: (1) macrophage influx is temporally correlated with the disappearance of tunel-positive apoptotic myogenic cells during post-injury muscle regeneration in mice; (2) direct cell-cell contacts between human macrophages and myogenic cells rescue myogenic cells from apoptosis, as assessed by decreased annexin v labelling and caspase-3 activity, and by increased dioc-6 staining, bcl-2 expression and phosphorylation of akt and erk1/2 survival pathways; (3) four pro-survival cell-cell adhesion molecular systems detected by dna macroarray are expressed by macrophages and myogenic cells in vitro and in vivo - vcam-1-vla-4, icam-1-lfa-1, pecam-1-pecam-1 and cx3cl1-cx3cr1; (4) macrophages deliver anti-apoptotic signals through all four adhesion systems, as assessed by functional analyses with blocking antibodies; and (5) macrophages more strongly rescue differentiated myotubes, which must achieve adhesion-induced stabilisation of their structure to survive. |
2006-10-25 |
2023-08-12 |
mouse |
| Roger S Y Foo, Richard C M Siow, Morris J Brown, Martin R Bennet. Heme oxygenase-1 gene transfer inhibits angiotensin II-mediated rat cardiac myocyte apoptosis but not hypertrophy. Journal of cellular physiology. vol 209. issue 1. 2006-10-20. PMID:16826603. |
inhibition of phosphotidylinositol-3-kinase enhanced myocyte apoptosis elicited by ang ii, however, p38mapk inhibition had no effect, suggesting that overexpression of ho-1 protects myocytes via augmented akt activation and not through modulation of p38mapk activation. |
2006-10-20 |
2023-08-12 |
rat |
| Janet Lau, Laura A Castelli, Emme C K Lin, S Lance Macaula. Identification of elongation factor 1alpha as a potential associated binding partner for Akt2. Molecular and cellular biochemistry. vol 286. issue 1-2. 2006-10-19. PMID:16652225. |
akt protein kinase has been shown to play a pivotal role in diverse cell functions, including motility, apoptosis, growth and metabolism. |
2006-10-19 |
2023-08-12 |
Not clear |
| Qingquan Chen, Bruno Casali, Laura Pattacini, Luigi Boiardi, Carlo Salvaran. Tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction. The Journal of rheumatology. vol 33. issue 6. 2006-10-19. PMID:16755653. |
tumor necrosis factor-alpha protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase akt signal transduction. |
2006-10-19 |
2023-08-12 |
human |
| Michael F Azari, Christos Profyris, Tara Karnezis, Claude C Bernard, David H Small, Surindar S Cheema, Ezgi Ozturk, Irene Hatzinisiriou, Steven Petrato. Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury. Journal of neuropathology and experimental neurology. vol 65. issue 9. 2006-10-18. PMID:16957585. |
we report that leukemia inhibitory factor (lif) can prevent oligodendrocyte apoptosis, notably contralateral to the spinal cord lesion, through the induction of the jak/stat and akt signaling pathways as well as by potentiating the expression of the antiapoptotic molecule, ciap2. |
2006-10-18 |
2023-08-12 |
Not clear |
| Manoranjan Santra, Mark Katakowski, Rui Lan Zhang, Zheng Gang Zhang, He Meng, Feng Jiang, Michael Chop. Protection of adult mouse progenitor cells and human glioma cells by de novo decorin expression in an oxygen- and glucose-deprived cell culture model system. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 10. 2006-10-11. PMID:16467781. |
our data indicate that induction of p21, p27, ras, akt, and phosphorylated akt by decorin inhibits apoptosis and protects u-87 and svz cells against ogd. |
2006-10-11 |
2023-08-12 |
mouse |
| Mujahid A Rizvi, Kulsoom Ghias, Katharine M Davies, Chunguang Ma, Frank Weinberg, Hidayatullah G Munshi, Nancy L Krett, Steven T Rose. Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Molecular cancer therapeutics. vol 5. issue 7. 2006-10-10. PMID:16891464. |
enzastaurin (ly317615), a protein kinase cbeta inhibitor, inhibits the akt pathway and induces apoptosis in multiple myeloma cell lines. |
2006-10-10 |
2023-08-12 |
Not clear |
| Mujahid A Rizvi, Kulsoom Ghias, Katharine M Davies, Chunguang Ma, Frank Weinberg, Hidayatullah G Munshi, Nancy L Krett, Steven T Rose. Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines. Molecular cancer therapeutics. vol 5. issue 7. 2006-10-10. PMID:16891464. |
these data indicate that enzastaurin induces apoptosis in mm cell lines in a caspase-independent manner and that enzastaurin exerts its antimyeloma effect by inhibiting signaling through the akt pathway. |
2006-10-10 |
2023-08-12 |
Not clear |
| Wei-Qun Ding, Bolin Liu, Joshua L Vaught, Richard D Palmiter, Stuart E Lin. Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Molecular cancer therapeutics. vol 5. issue 7. 2006-10-10. PMID:16891473. |
clioquinol exhibited a synergistic interaction with dha in reducing nuclear factor-kappab activity and inducing apoptosis, and the combination reduced the level of several molecules that promote cell survival, including akt, p65, and bcl-2. |
2006-10-10 |
2023-08-12 |
human |
| Melanie Weigand, Pia Hantel, Rolf Kreienberg, Johannes Waltenberge. Autocrine vascular endothelial growth factor signalling in breast cancer. Evidence from cell lines and primary breast cancer cultures in vitro. Angiogenesis. vol 8. issue 3. 2006-10-05. PMID:16328160. |
in addition, vegf-a leads to increased phosphorylation of erk1/2 and akt indicating that vegf-a stimulation plays a crucial role in the regulation of cell growth, apoptosis, survival and differentiation. |
2006-10-05 |
2023-08-12 |
Not clear |
| Martina Rudelius, Stefania Pittaluga, Satoshi Nishizuka, Trinh H-T Pham, Falko Fend, Elaine S Jaffe, Leticia Quintanilla-Martinez, Mark Raffel. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood. vol 108. issue 5. 2006-10-05. PMID:16645163. |
inhibition of the pi3k/akt pathway in the mcl cell lines abrogated or reduced the phosphorylation of akt, p27(kip1), frkhl-1, mdm2, bad, mtor, gsk-3beta, ikappab, and led to cell-cycle arrest and apoptosis. |
2006-10-05 |
2023-08-12 |
Not clear |