| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunrong Yu, Bret B Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E Kay, Christopher A Carter, Lewis R Roberts, Scott H Kaufmann, Alex A Adje. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Molecular cancer therapeutics. vol 5. issue 9. 2006-12-07. PMID:16985072. |
these findings show that sorafenib interacts synergistically with bortezomib to induce apoptosis in a broad spectrum of neoplastic cell lines and show an important role for the akt and jnk pathways in mediating synergism. |
2006-12-07 |
2023-08-12 |
human |
| John P Alao, Alexandra V Stavropoulou, Eric W-F Lam, R Charles Coombe. Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. Molecular cancer. vol 5. 2006-12-07. PMID:17018141. |
akt is an important negative regulator of gsk3beta, a kinase that has been shown to regulate apoptosis in response to various stimuli. |
2006-12-07 |
2023-08-12 |
Not clear |
| Xuesong Liu, Yan Shi, Morris J Birnbaum, Keqiang Ye, Ron De Jong, Tillman Oltersdorf, Vincent L Giranda, Yan Lu. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of biological chemistry. vol 281. issue 42. 2006-12-06. PMID:16923802. |
although several small molecule inhibitors of akt have been reported to induce apoptosis in cancer cells, these inhibitors may have additional targets. |
2006-12-06 |
2023-08-12 |
mouse |
| Xuesong Liu, Yan Shi, Morris J Birnbaum, Keqiang Ye, Ron De Jong, Tillman Oltersdorf, Vincent L Giranda, Yan Lu. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of biological chemistry. vol 281. issue 42. 2006-12-06. PMID:16923802. |
our study suggests that only a small portion of akt is active in wild-type mef cells and a threshold of akt inhibition is required to induce apoptosis by pure akt inhibitors. |
2006-12-06 |
2023-08-12 |
mouse |
| Tomoko Inoue, Katsuya Shiraki, Hiroyuki Fuke, Yutaka Yamanaka, Kazumi Miyashita, Yumi Yamaguchi, Norihiko Yamamoto, Keiichi Ito, Kazushi Sugimoto, Takeshi Nakan. Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway. Anti-cancer drugs. vol 17. issue 3. 2006-12-04. PMID:16520654. |
furthermore, mg132 downregulated phospho-akt and its downstream target phospho-bad, indicating that mg132 activated the mitochondrial apoptosis pathway by inhibiting phosphorylation of akt and bad. |
2006-12-04 |
2023-08-12 |
human |
| Tomoko Inoue, Katsuya Shiraki, Hiroyuki Fuke, Yutaka Yamanaka, Kazumi Miyashita, Yumi Yamaguchi, Norihiko Yamamoto, Keiichi Ito, Kazushi Sugimoto, Takeshi Nakan. Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway. Anti-cancer drugs. vol 17. issue 3. 2006-12-04. PMID:16520654. |
in conclusion, proteasome inhibitors induced apoptosis and augmented trail sensitivity via both the iap family and akt pathways. |
2006-12-04 |
2023-08-12 |
human |
| Weiping Yu, Ming-chieh Shun, Kristen Anderson, Hansong Chen, Bob G Sanders, Kimberly Klin. alpha-TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 10. 2006-12-04. PMID:16850165. |
knockdown of akt and erk activity using phosphoinositide- 3-kinase (pi3k) and mitogen-activated protein kinase kinase (mkk1) inhibitors enhanced alpha-tea-induced apoptosis. |
2006-12-04 |
2023-08-12 |
human |
| Emilie Sexton, Céline Van Themsche, Kim LeBlanc, Sophie Parent, Pascal Lemoine, Eric Asseli. Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Molecular cancer. vol 5. 2006-12-04. PMID:17044934. |
resveratrol interferes with akt activity and triggers apoptosis in human uterine cancer cells. |
2006-12-04 |
2023-08-12 |
human |
| Mohammad M R Bhuiyan, Yiwei Li, Sanjeev Banerjee, Fakhara Ahmed, Zhiwei Wang, Shadan Ali, Fazlul H Sarka. Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer research. vol 66. issue 20. 2006-12-04. PMID:17047070. |
these results suggest that b-dim-induced cell proliferation inhibition and apoptosis induction are partly mediated through the down-regulation of ar, akt, and nf-kappab signaling. |
2006-12-04 |
2023-08-12 |
Not clear |
| Jennifer E Skeen, Prashanth T Bhaskar, Chia-Chen Chen, William S Chen, Xiao-ding Peng, Veronique Nogueira, Annett Hahn-Windgassen, Hiroaki Kiyokawa, Nissim Ha. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer cell. vol 10. issue 4. 2006-11-29. PMID:17045205. |
akt contributes to tumorigenesis by inhibiting apoptosis. |
2006-11-29 |
2023-08-12 |
mouse |
| Alison M Karst, Derek L Dai, Jin Q Cheng, Gang L. Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer research. vol 66. issue 18. 2006-11-28. PMID:16982766. |
role of p53 up-regulated modulator of apoptosis and phosphorylated akt in melanoma cell growth, apoptosis, and patient survival. |
2006-11-28 |
2023-08-12 |
mouse |
| Alison M Karst, Derek L Dai, Jin Q Cheng, Gang L. Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer research. vol 66. issue 18. 2006-11-28. PMID:16982766. |
here, we show that aberrant expression of two proteins, p53 up-regulated modulator of apoptosis (puma) and phosphorylated akt (p-akt), is associated with poor patient survival. |
2006-11-28 |
2023-08-12 |
mouse |
| Patrick Laplante, Marc-André Raymond, Andrée Labelle, Jun-Ichi Abe, Renato V Iozzo, Marie-Josée Héber. Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16882656. |
neutralizing alpha2beta1 integrin activity in fibroblasts exposed to either medium conditioned by apoptotic ec (ssc) or a recombinant perlecan c-terminal fragment (lg3) prevented resistance to apoptosis and is associated with decreased levels of akt phosphorylation. |
2006-11-27 |
2023-08-12 |
Not clear |
| Xiaoxian Zhao, Dongmei Wang, Zhenwen Zhao, Yingyi Xiao, Saubhik Sengupta, Yijin Xiao, Renliang Zhang, Kirsten Lauber, Sebastian Wesselborg, Li Feng, Tyler M Rose, Yue Shen, Junjie Zhang, Glenn Prestwich, Yan X. Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16882668. |
lysophosphatidic acid activates akt that in turn acts in a feedback loop to block the cleavage of poly-(adp-ribose) polymerase and dna fragmentation factor as well as prevent apoptosis. |
2006-11-27 |
2023-08-12 |
human |
| Jason W Triplett, Fredrick M Pavalk. Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. American journal of physiology. Cell physiology. vol 291. issue 5. 2006-11-24. PMID:16807302. |
increases in both erk and akt phosphorylation were also observed in rod-gfp-expressing cells, although inhibition of either erk or akt individually or together failed to induce apoptosis. |
2006-11-24 |
2023-08-12 |
Not clear |
| Ji-Young Jang, Choong-Eun Le. IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. Cellular immunology. vol 241. issue 1. 2006-11-14. PMID:16930576. |
in fact, il-4 induced specific activation of nf-kappab, akt, and erk in jurkat t cells and partially rescued these cells from dexamethasone-induced apoptosis. |
2006-11-14 |
2023-08-12 |
human |
| Natsuo Oka, Shuji Tanimoto, Ryuichi Taue, Hiroyoshi Nakatsuji, Tomoteru Kishimoto, Hirofumi Izaki, Tomoharu Fukumori, Masayuki Takahashi, Masaaki Nishitani, Hiro-omi Kanayam. Role of phosphatidylinositol-3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer science. vol 97. issue 10. 2006-11-14. PMID:16984382. |
however, transfecting constitutively active akt into rt4 cells increased akt activity and inhibited trail-induced apoptosis. |
2006-11-14 |
2023-08-12 |
human |
| Natsuo Oka, Shuji Tanimoto, Ryuichi Taue, Hiroyoshi Nakatsuji, Tomoteru Kishimoto, Hirofumi Izaki, Tomoharu Fukumori, Masayuki Takahashi, Masaaki Nishitani, Hiro-omi Kanayam. Role of phosphatidylinositol-3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer science. vol 97. issue 10. 2006-11-14. PMID:16984382. |
these results suggest that elevated akt activity protects um-uc-3 and t24 cells from trail-induced apoptosis, and the pi3k/akt signaling might inhibit apoptotic signals. |
2006-11-14 |
2023-08-12 |
human |
| Hua Yang, Lili He, Patricia Kruk, Santo V Nicosia, Jin Q Chen. Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian cancer cells. International journal of cancer. vol 119. issue 10. 2006-11-13. PMID:16894566. |
here we report that aurora-a protects ovarian cancer cells from apoptosis induced by chemotherapeutic agent and activates akt pathway in a p53-dependent manner. |
2006-11-13 |
2023-08-12 |
human |
| Xian Zhong, Yongliang Zhu, Qinghua Lu, Jiawei Zhang, Zhen Ge, Shu Zhen. Silymarin causes caspases activation and apoptosis in K562 leukemia cells through inactivation of Akt pathway. Toxicology. vol 227. issue 3. 2006-11-13. PMID:16949716. |
silymarin causes caspases activation and apoptosis in k562 leukemia cells through inactivation of akt pathway. |
2006-11-13 |
2023-08-12 |
human |