| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Oh Moon, Cheol Park, Moon-Soo Heo, Yeong-Min Park, Yung Hyun Choi, Gi-Young Ki. PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway. International immunopharmacology. vol 7. issue 1. 2007-02-07. PMID:17161815. |
thus, our results imply that pd98059-induced apoptosis is significantly involved in down-regulation of bcl-2, caspase-3 activity, the akt pathway, and some of the biological functions in u937 cells. |
2007-02-07 |
2023-08-12 |
human |
| Asha S Nair, Shishir Shishodia, Kwang Seok Ahn, Ajaikumar B Kunnumakkara, Gautam Sethi, Bharat B Aggarwa. Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 8. 2007-02-06. PMID:17015749. |
deguelin, an akt inhibitor, suppresses ikappabalpha kinase activation leading to suppression of nf-kappab-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. |
2007-02-06 |
2023-08-12 |
Not clear |
| Wan-Uk Kim, Soon Suk Kang, Seung-Ah Yoo, Kyung-Hee Hong, Dong-Goo Bae, Mi-Sook Lee, Seung Woo Hong, Chi-Bom Chae, Chul-Soo Ch. Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 8. 2007-02-06. PMID:17015762. |
the akt or erk inhibitor cancelled the protective effect of vegf165 on snp-induced synoviocyte apoptosis. |
2007-02-06 |
2023-08-12 |
Not clear |
| Incheol Shin, Carlos L Arteag. Expression of active Akt protects against tamoxifen-induced apoptosis in MCF-7 Cells. IUBMB life. vol 58. issue 11. 2007-02-06. PMID:17085387. |
expression of active akt protects against tamoxifen-induced apoptosis in mcf-7 cells. |
2007-02-06 |
2023-08-12 |
human |
| Driss El Kebir, Levente József, Tarek Khreiss, János G File. Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils. Cellular signalling. vol 18. issue 12. 2007-02-05. PMID:16806822. |
high extracellular k(+) (10-100 mm) did not activate extracellular signal-regulated kinase (erk) and akt, nor affected phosphorylation of p38 mapk associated with constitutive apoptosis. |
2007-02-05 |
2023-08-12 |
human |
| Birgitte B Olsen, Marina Bjørling-Poulsen, Barbara Guerr. Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action. The international journal of biochemistry & cell biology. vol 39. issue 1. 2007-02-02. PMID:17018259. |
previous published results indicated that treatment of cells with inhibitors of protein kinase ck2, such as emodin, induces apoptosis and that the anti-apoptotic effect of ck2 is partially mediated by target phosphorylation and up-regulation of akt by ck2. |
2007-02-02 |
2023-08-12 |
human |
| Xiang-Hong Peng, Prasanthi Karna, Ruth M O'Regan, Xiuju Liu, Rajesh Naithani, Robert M Moriarty, William C Wood, Ho-Young Lee, Lily Yan. Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Molecular pharmacology. vol 71. issue 1. 2007-02-01. PMID:17035597. |
we found that inhibiting akt activity with 10 to 100 nm deguelin, a small molecule derived from natural products, markedly reduced the levels of both survivin and xiap, inducing apoptosis in human breast cancer cells but not in normal cells. |
2007-02-01 |
2023-08-12 |
human |
| Chunlei Zheng, Ziyang Lin, Zhizhuang Joe Zhao, Yajun Yang, Hanben Niu, Xun She. MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17015449. |
the p38 mapk and heat shock protein 27 (hsp27) form a signaling complex with serine/threonine kinase akt and mapk-activated protein kinase-2 (mk2), which plays an important role in controlling stress-induced apoptosis and reorganizing actin cytoskeleton. |
2007-01-30 |
2023-08-12 |
mouse |
| Y Yang, T Ikezoe, C Nishioka, K Bandobashi, T Takeuchi, Y Adachi, M Kobayashi, S Takeuchi, H P Koeffler, H Taguch. NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. British journal of cancer. vol 95. issue 12. 2007-01-30. PMID:17133272. |
nfv, an hiv-1 protease inhibitor, induces growth arrest, reduced akt signalling, apoptosis and docetaxel sensitisation in nsclc cell lines. |
2007-01-30 |
2023-08-12 |
mouse |
| Guiyuan Li, Robert E Anderson, Hiroshi Tomita, Ruben Adler, Xiaochun Liu, Donald J Zack, Raju V S Rajal. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 1. 2007-01-29. PMID:17202487. |
consistent with the hypothesis that akt activity is important to circumvent stress-induced apoptosis, herein we report the novel finding that rod photoreceptor cells in akt2 knock-out mice exhibited a significantly greater sensitivity to stress-induced cell death than rods in heterozygous or wild-type mice. |
2007-01-29 |
2023-08-12 |
mouse |
| Kerstin Bellmann, Julie Martel, Dominic J P Poirier, Mireille M Labrie, Jacques Landr. Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc. Apoptosis : an international journal on programmed cell death. vol 11. issue 8. 2007-01-26. PMID:16788862. |
inhibiting akt in addition to enhancing p38 further exacerbate the imbalance between the death and survival signals and results in an enhanced sensitivity to apoptosis. |
2007-01-26 |
2023-08-12 |
Not clear |
| Christopher Daly, Elizabeth Pasnikowski, Elena Burova, Vivian Wong, Thomas H Aldrich, Jennifer Griffiths, Ella Ioffe, Thomas J Daly, James P Fandl, Nick Papadopoulos, Donald M McDonald, Gavin Thurston, George D Yancopoulos, John S Rudg. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 42. 2007-01-26. PMID:17030814. |
we employ rnai and blocking antibodies to show that in this setting, ang-2 unexpectedly functions as a tie2 agonist, bolstering akt activity so as to provide negative feedback on foxo1-regulated transcription and apoptosis. |
2007-01-26 |
2023-08-12 |
Not clear |
| Takeo Minaguchi, Kristin A Waite, Charis En. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178862. |
we have recently shown in mcf-7 cells that nuclear phosphatase and tensin homologue deleted on chromosome 10 (pten) down-regulates phosphorylation of p44/42 and cyclin d1 and induces g(1) cell cycle arrest, whereas cytoplasmic pten down-regulates phosphorylation of akt, up-regulates p27, and induces apoptosis. |
2007-01-25 |
2023-08-12 |
Not clear |
| Chun-Liang Lin, Jeng-Yi Wang, Yu-Ting Huang, Yu-Hsia Kuo, Kameswaran Surendran, Feng-Sheng Wan. Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. Journal of the American Society of Nephrology : JASN. vol 17. issue 10. 2007-01-23. PMID:16943306. |
suppression of gsk-3beta activation or increase in nuclear beta-catenin by transfection of wnt4 or wnt5a or stable beta-catenin (s33y) reversed akt activation and reduced the high glucose-mediated caspase-3 cleavage and cell apoptosis. |
2007-01-23 |
2023-08-12 |
rat |
| H Yokoyama, Y Ikehara, Y Kodera, S Ikehara, Y Yatabe, Y Mochizuki, M Koike, M Fujiwara, A Nakao, M Tatematsu, H Nakanish. Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis. British journal of cancer. vol 95. issue 11. 2007-01-22. PMID:17088902. |
in these her2-overexpressing glm series, protein kinase b (akt), but not extracellular signal-regulated kinase 1/2 (erk1/2), was constitutively phosphorylated, and gefitinib efficiently inhibited this akt phosphorylation, induced strong apoptosis in vitro and exhibited antitumour activity in tumour xenografts in nude mice. |
2007-01-22 |
2023-08-12 |
mouse |
| Ren-Feng Guo, Lei Sun, Hongwei Gao, Kevin X Shi, Daniel Rittirsch, Vidya J Sarma, Firas S Zetoune, Peter A War. In vivo regulation of neutrophil apoptosis by C5a during sepsis. Journal of leukocyte biology. vol 80. issue 6. 2007-01-18. PMID:16997861. |
in contrast to normal serum, septic sera induced strong phosphorylation of akt and p44/42 in neutrophils obtained from normal rats, resulting in marked resistance of these cells to apoptosis. |
2007-01-18 |
2023-08-12 |
rat |
| Ren-Feng Guo, Lei Sun, Hongwei Gao, Kevin X Shi, Daniel Rittirsch, Vidya J Sarma, Firas S Zetoune, Peter A War. In vivo regulation of neutrophil apoptosis by C5a during sepsis. Journal of leukocyte biology. vol 80. issue 6. 2007-01-18. PMID:16997861. |
c5a activated akt and p44/42 and also enhanced x-linked inhibitor of apoptosis expression in neutrophils. |
2007-01-18 |
2023-08-12 |
rat |
| James A McCubrey, Linda S Steelman, Steven L Abrams, John T Lee, Fumin Chang, Fred E Bertrand, Patrick M Navolanic, David M Terrian, Richard A Franklin, Antonio B D'Assoro, Jeffrey L Salisbury, Maria Clorinda Mazzarino, Franca Stivala, Massimo Libr. Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Advances in enzyme regulation. vol 46. 2007-01-17. PMID:16854453. |
raf is more associated with proliferation and the prevention of apoptosis while akt is more associated with the long-term clonogenicity. |
2007-01-17 |
2023-08-12 |
human |
| Gregory I Gile. The redox regulation of thiol dependent signaling pathways in cancer. Current pharmaceutical design. vol 12. issue 34. 2007-01-16. PMID:17168752. |
the effect of ros on proliferation and apoptosis will be examined by looking at interactions with transcription factors and the akt, tnf and mapk signaling pathways. |
2007-01-16 |
2023-08-12 |
Not clear |
| Nicolaas de Jonge, Marie Jose Goumans, Daan Lips, Rutger Hassink, Eva J Vlug, Roy van der Meel, Christopher Donald Emmerson, Joppe Nijman, Leon de Windt, Pieter A Doevendan. Controlling cardiomyocyte survival. Novartis Foundation symposium. vol 274. 2007-01-12. PMID:17019805. |
evidence for a key role of nuclear akt in preventing apoptosis is accumulating from various genetic and pharmacological sources. |
2007-01-12 |
2023-08-12 |
mouse |