| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Mary P Moyer, Charalabos Pothoulaki. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 6. 2007-03-22. PMID:17264209. |
vehicle-treated mice showed increased colonic akt phosphorylation and apoptosis compared with mice that received no dss. |
2007-03-22 |
2023-08-12 |
mouse |
| Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Mary P Moyer, Charalabos Pothoulaki. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 6. 2007-03-22. PMID:17264209. |
administration of cj-12,255 for 5 days post-dss suppressed akt activation, exacerbated colitis, and enhanced apoptosis, and pharmacologic inhibition of akt, either alone or together with cj-12,255, produced a similar effect. |
2007-03-22 |
2023-08-12 |
mouse |
| Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Mary P Moyer, Charalabos Pothoulaki. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 6. 2007-03-22. PMID:17264209. |
thus, sp, through nk-1r, possesses antiapoptotic effects in the colonic mucosa by activating akt, which prevents apoptosis and mediates tissue recovery during colitis. |
2007-03-22 |
2023-08-12 |
mouse |
| Caroline R Elliott-Hunt, Robert J P Pope, Penny Vanderplank, David Wynic. Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17263796. |
these findings imply that the rise in endogenous galanin observed either after brain injury or in various disease states is an adaptive response that reduces apoptosis by the activation of galr2, and hence akt and erk. |
2007-03-20 |
2023-08-12 |
Not clear |
| Bertrand Liagre, David Y Leger, Pascale Vergne-Salle, Jean Louis Beneytou. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. International journal of molecular medicine. vol 19. issue 1. 2007-03-19. PMID:17143555. |
map kinase subtypes and akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with cox-2 expression and prostanoid production. |
2007-03-19 |
2023-08-12 |
human |
| Bertrand Liagre, David Y Leger, Pascale Vergne-Salle, Jean Louis Beneytou. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. International journal of molecular medicine. vol 19. issue 1. 2007-03-19. PMID:17143555. |
in the present study, we investigated the signalling pathways involved in diosgenin-induced apoptosis in human rheumatoid arthritis (ra) fibroblast-like synoviocytes (fls) in vitro with particular interest on akt and mapks activation in relation to arachidonic acid metabolism via cox-2 pathway. |
2007-03-19 |
2023-08-12 |
human |
| Bertrand Liagre, David Y Leger, Pascale Vergne-Salle, Jean Louis Beneytou. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. International journal of molecular medicine. vol 19. issue 1. 2007-03-19. PMID:17143555. |
diosgenin-induced apoptosis in the presence of mapk or akt inhibitors was detected by a quantitative determination of dna fragmentation. |
2007-03-19 |
2023-08-12 |
human |
| Bertrand Liagre, David Y Leger, Pascale Vergne-Salle, Jean Louis Beneytou. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. International journal of molecular medicine. vol 19. issue 1. 2007-03-19. PMID:17143555. |
akt and nf-kappab are potentially required for diosgenin-induced apoptosis in human ra fls because 40 microm diosgenin abrogated akt phosphorylation which correlated with an inhibition of nf-kappab nuclear translocation. |
2007-03-19 |
2023-08-12 |
human |
| X Tang, Y Feng, K Y. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell death and differentiation. vol 14. issue 2. 2007-03-16. PMID:16841086. |
phosphatidylinositol 3-kinase enhancer-activating akt (pike-a) binds akt and upregulates its kinase activity, preventing apoptosis. |
2007-03-16 |
2023-08-12 |
mouse |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
deactivation of akt and stat3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, atiprimod. |
2007-03-16 |
2023-08-12 |
Not clear |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
in this study, we report that atiprimod selectively inhibited proliferation and induced apoptosis in hcc cells that expressed either hepatitis b virus (hbv) or hepatitis c virus, through deactivation of protein kinase b (akt) and signal transducers and activators of transcription 3 (stat3) signaling. |
2007-03-16 |
2023-08-12 |
Not clear |
| Yan Li, Junye Liu, Xinping Liu, Kefei Xing, Yun Wang, Fuyang Li, Libo Ya. Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Applied biochemistry and biotechnology. vol 135. issue 3. 2007-03-15. PMID:17299206. |
resveratrol-induced cell inhibition of growth and apoptosis in mcf7 human breast cancer cells are associated with modulation of phosphorylated akt and caspase-9. |
2007-03-15 |
2023-08-12 |
human |
| Marissa Shrader, Maria Simona Pino, Laura Lashinger, Menashe Bar-Eli, Liana Adam, Colin P N Dinney, David J McConke. Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression. Cancer research. vol 67. issue 4. 2007-03-15. PMID:17308080. |
the molecular mechanisms involved down-regulation of active akt and x-linked inhibitor of apoptosis protein (xiap) expression and were mimicked by chemical inhibitors of the phosphatidylinositol 3-kinase/akt pathway but not of the mitogen-activated protein kinase/extracellular signal-regulated kinase (erk) kinase/erk pathway. |
2007-03-15 |
2023-08-12 |
human |
| Quan-Guang Zhang, Dong-Na Wu, Dong Han, Guang-Yi Zhan. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS letters. vol 581. issue 3. 2007-03-12. PMID:17239858. |
on the contrary, activation of the protein kinase akt, which is controlled by the opposing actions of pi3k and pten, contributes to enhanced resistance to apoptosis through multiple mechanisms. |
2007-03-12 |
2023-08-12 |
Not clear |
| Yang Yang, Takayuki Ikezoe, Tamotsu Takeuchi, Yoshihiro Adachi, Yuji Ohtsuki, H Phillip Koeffler, Hirokuni Taguch. Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways. Oncology reports. vol 15. issue 6. 2007-03-08. PMID:16685399. |
zanthoxyli fructus induces growth arrest and apoptosis of lncap human prostate cancer cells in vitro and in vivo in association with blockade of the akt and ar signal pathways. |
2007-03-08 |
2023-08-12 |
mouse |
| Hong-wa Yung, Svitlana Korolchuk, Aviva M Tolkovsky, D Stephen Charnock-Jones, Graham J Burto. Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 3. 2007-03-08. PMID:17167073. |
endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of akt protein synthesis in human choriocarcinoma cells. |
2007-03-08 |
2023-08-12 |
human |
| Hong-wa Yung, Svitlana Korolchuk, Aviva M Tolkovsky, D Stephen Charnock-Jones, Graham J Burto. Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 3. 2007-03-08. PMID:17167073. |
we have identified a novel pathway in er stress-induced apoptosis after ischemia-reperfusion in vitro involving translational suppression of the survival kinase pkb/akt (akt), and elucidated an alternative protective role of antioxidants in the regulation of akt activity. |
2007-03-08 |
2023-08-12 |
human |
| Hong-wa Yung, Svitlana Korolchuk, Aviva M Tolkovsky, D Stephen Charnock-Jones, Graham J Burto. Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 3. 2007-03-08. PMID:17167073. |
transient overexpression of wild-type akt, but not kinase-dead akt, in jeg-3 cells diminished tunicamycin-ogd reoxygenation-induced apoptosis. |
2007-03-08 |
2023-08-12 |
human |
| Guo-Chang Fan, Qunying Yuan, Guojie Song, Yigang Wang, Guoli Chen, Jiang Qian, Xiaoyang Zhou, Yong J Lee, Muhammad Ashraf, Evangelia G Krania. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation research. vol 99. issue 11. 2007-03-06. PMID:17068291. |
these beneficial effects were associated with attenuation of the ask1-jnk/p38 (apoptosis signal-regulating kinase 1/c-jun nh(2)-terminal kinase/p38) signaling cascade triggered by isoproterenol, whereas there was no difference in either extracellular signal-related kinase 1/2 or akt activation. |
2007-03-06 |
2023-08-12 |
human |
| Murali Gururajan, Trivikram Dasu, Seif Shahidain, C Darrell Jennings, Darrell A Robertson, Vivek M Rangnekar, Subbarao Bondad. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 1. 2007-03-06. PMID:17182546. |
moreover, we show that overexpression of akt, a target of syk, or bcl-x(l), a target of akt can overcome curcumin-induced apoptosis of b lymphoma cells. |
2007-03-06 |
2023-08-12 |
human |