| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Yang Liou, David P Ellent, Sang Lee, Jennifer Goldsby, Bor-Sheng Ko, Nena Matijevic, Jaou-Chen Huang, Kenneth K W. Cyclooxygenase-2-derived prostaglandin e2 protects mouse embryonic stem cells from apoptosis. Stem cells (Dayton, Ohio). vol 25. issue 5. 2007-05-16. PMID:17234991. |
these results indicate that mes cells constitutively express cox-2 and pge synthases and produce pge(2), which confers resistance to apoptosis via ep2-mediated activation of pi-3k to the akt pathway. |
2007-05-16 |
2023-08-12 |
mouse |
| Michele Caraglia, Monica Marra, Carlo Leonetti, Giuseppina Meo, Anna Maria D'Alessandro, Alfonso Baldi, Daniele Santini, Giuseppe Tonini, Raffaello Bertieri, Gabriella Zupi, Alfredo Budillon, Alberto Abbruzzes. R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. Journal of cellular physiology. vol 211. issue 2. 2007-05-15. PMID:17192846. |
these effects were paralleled by enhanced apoptosis and inactivation of both erk and akt. |
2007-05-15 |
2023-08-12 |
mouse |
| Zhang Xiaoyu, Biswas Payal, Owraghi Melissa, Laura P Zanell. 1alpha,25(OH)2-vitamin D3 membrane-initiated calcium signaling modulates exocytosis and cell survival. The Journal of steroid biochemistry and molecular biology. vol 103. issue 3-5. 2007-05-11. PMID:17208437. |
at the tissue level, 1,25d protects osteoblasts from apoptosis via a ca(2+)-dependent akt pathway. |
2007-05-11 |
2023-08-12 |
Not clear |
| Jin-Hua Shen, Ye Zhang, Ning-Hua Wu, Yu-Fei She. Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. Neuroscience letters. vol 414. issue 2. 2007-05-08. PMID:17293044. |
treatment of the cells with all trans retinoic acid (ra) generates a neuron-like, morphological change of differentiation, and results in the activation of erk and akt pathways, an inhibition of the nuclear translocation of p53 induced by ga, and induces higher resistance to the ga-induced apoptosis. |
2007-05-08 |
2023-08-12 |
human |
| Xia Wang, Wenshu Chen, Yong Li. Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways. Biochemical and biophysical research communications. vol 355. issue 3. 2007-05-08. PMID:17316570. |
blockage of either nuclear factor-kappab (nf-kappab) or akt sensitizes cancer cells to tnf-induced apoptosis. |
2007-05-08 |
2023-08-12 |
Not clear |
| X F Hu, J Li, E Yang, S Vandervalk, P X Xin. Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways. British journal of cancer. vol 96. issue 6. 2007-05-08. PMID:17342096. |
we demonstrated that anti-cripto mab-induced cem/a7r cell apoptosis, which was associated with an enhanced activity of the c-jun n-terminal kinase/stress-activated protein kinase and inhibition of akt phosphorylation, resulting in an activation of mitochondrial apoptosis pathway as evidenced by dephosphorylation of bad at ser136, bcl-2 at ser70 and a cleaved caspase-9. |
2007-05-08 |
2023-08-12 |
mouse |
| John Brognard, Emma Sierecki, Tianyan Gao, Alexandra C Newto. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molecular cell. vol 25. issue 6. 2007-05-08. PMID:17386267. |
here we describe a second family member, phlpp2, which also inactivates akt, inhibits cell-cycle progression, and promotes apoptosis. |
2007-05-08 |
2023-08-12 |
Not clear |
| Su-Hyeong Kim, Yong-Sung Juhnn, Yong-Sang Son. Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404021. |
akt mediates survival signals which preserve various cancer cells from apoptosis pathway. |
2007-05-08 |
2023-08-12 |
human |
| Su-Hyeong Kim, Yong-Sung Juhnn, Yong-Sang Son. Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404021. |
here, we demonstrated that inhibition of akt increases the efficacy of the paclitaxel-induced apoptosis in skov3 and pa-1 human ovarian cancer cells. |
2007-05-08 |
2023-08-12 |
human |
| Su-Hyeong Kim, Yong-Sung Juhnn, Yong-Sang Son. Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404021. |
to further elucidate the mechanism of apoptosis by paclitaxel, we compared the levels of phosphorylation of akt between paclitaxel-resistant skov3 cells and paclitaxel-sensitive pa-1 cells. |
2007-05-08 |
2023-08-12 |
human |
| Su-Hyeong Kim, Yong-Sung Juhnn, Yong-Sang Son. Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404021. |
furthermore, inhibition of akt by specific phosphatidyinositol-3-kinase (pi3k)-akt inhibitors (wortmannin, and ly294002) synergistically increased the efficacy of the paclitaxel-induced apoptosis in both cell lines. |
2007-05-08 |
2023-08-12 |
human |
| Giordano Bianchi, Fabrizio Montecucco, Maria Bertolotto, Franco Dallegri, Luciano Ottonell. Immune complexes induce monocyte survival through defined intracellular pathways. Annals of the New York Academy of Sciences. vol 1095. 2007-05-08. PMID:17404034. |
here we show that ic-activated monocytes underwent apoptosis at a rate comparable to that of resting monocytes in the presence of ly294002, a selective inhibitor of pi3k, as well in the presence of akt inhibitor, pd98059 inhibitor of erk1/2, and sb203580 inhibitor of p38. |
2007-05-08 |
2023-08-12 |
Not clear |
| Sharmila Shankar, Rakesh K Srivastav. Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. International journal of oncology. vol 30. issue 4. 2007-05-04. PMID:17332930. |
downregulation of akt by inhibitors of pi3k (wortmannin and ly294002) and akt, or by dominant negative akt increased curcumin-induced apoptosis, whereas transfection of constitutively active akt attenuated this effect. |
2007-05-04 |
2023-08-12 |
human |
| Fatih Kircelli, Cagla Akay, Yair Gazit. Arsenic trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53: MAP kinase pathway is preferentially activated in cells expressing inactivated p53. International journal of oncology. vol 30. issue 4. 2007-05-04. PMID:17332940. |
we also observed in these cells activation of the extrinsic apoptotic pathway through upregulation of apo2/trail and apo2/trail-r2, activation of caspase 8, degradation of flip-l and release of apoptosis inducing factors from mitochondria, instead of cytochrome c. in addition, we observed marked activation of the map kinase pathway and dephosphorylation of akt in p53 or p21 silenced cells. |
2007-05-04 |
2023-08-12 |
Not clear |
| Chi Bun Chan, Keqiang Y. PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. Journal of cellular and molecular medicine. vol 11. issue 1. 2007-05-04. PMID:17367500. |
because both pi3k and akt are important effectors in the growth factor-mediated signaling which triggers cellular growth and acts against apoptosis, pikes therefore serve as the molecular switch that their activation are crucial for growth factors to exert their physiological functions. |
2007-05-04 |
2023-08-12 |
Not clear |
| Julie Chao, Hang Yin, Yu-Yu Yao, Bo Shen, Robert S Smith, Lee Cha. Novel role of kallistatin in protection against myocardial ischemia-reperfusion injury by preventing apoptosis and inflammation. Human gene therapy. vol 17. issue 12. 2007-05-03. PMID:17081080. |
moreover, kallistatin reduced the phosphorylation of apoptosis signal-regulating kinase-1 and mitogen-activated protein kinases (mapks), but increased akt and glycogen synthase kinase-3beta phosphorylation. |
2007-05-03 |
2023-08-12 |
human |
| Catherine Alexia, Marlène Bras, Guillaume Fallot, Nathalie Vadrot, Fanny Daniel, Malika Lasfer, Houda Tamouza, André Groye. Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis. Annals of the New York Academy of Sciences. vol 1090. 2007-04-26. PMID:17384242. |
altogether, the data emphasize the crucial role of pi-3'k/akt signaling (i) in basal as well as igf-ir-stimulated hepg2 cell proliferation and (ii) in controlling both doxorubicin-induced apoptosis (e.g., drug-induced cleavage of akt) and its reversal by igf-i (protection against apoptosis parallels the extent of akt phosphorylation). |
2007-04-26 |
2023-08-12 |
mouse |
| Moonkyoung Um, Alec W Gross, Harvey F Lodis. A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cellular signalling. vol 19. issue 3. 2007-04-20. PMID:17045782. |
here we show that epo prevents staurosporine-induced apoptosis of differentiated human neuroblastoma sh-sy5y cells, and activates the stat5, akt and mapk signaling pathways. |
2007-04-20 |
2023-08-12 |
human |
| Melissa H Pespeni, Maki Hodnett, Keith S Abayasiriwardana, Jérémie Roux, Marybeth Howard, V Courtney Broaddus, Jean-François Pitte. Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway. Cancer research. vol 67. issue 6. 2007-04-19. PMID:17363610. |
the role of hsp90 and the akt pathway was confirmed by showing that inhibitors of hsp90 and the phosphatidyilinositol-3 kinase/akt pathway reproduced the effect of heat stress on trail-induced apoptosis and that the effect of inhibiting hsp90 on trail-induced apoptosis could be overcome by activating the akt pathway with a constitutively active construct of the akt kinase pdk-1. |
2007-04-19 |
2023-08-12 |
Not clear |
| Melissa H Pespeni, Maki Hodnett, Keith S Abayasiriwardana, Jérémie Roux, Marybeth Howard, V Courtney Broaddus, Jean-François Pitte. Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway. Cancer research. vol 67. issue 6. 2007-04-19. PMID:17363610. |
in summary, these results support the novel concept that heat stress inhibits the akt pathway by dissociating pdk-1 from its chaperone hsp90, leading to potentiation of trail-induced apoptosis in resistant malignant cells. |
2007-04-19 |
2023-08-12 |
Not clear |