| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunrong Yu, Bret B Friday, Jin-Ping Lai, Andrea McCollum, Peter Atadja, Lewis R Roberts, Alex A Adje. Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 13. issue 4. 2007-07-18. PMID:17317822. |
abrogation of mapk and akt signaling by aee788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation. |
2007-07-18 |
2023-08-12 |
Not clear |
| Kyung Mi Woo, Jihye Seo, Ruiyun Zhang, Peter X M. Suppression of apoptosis by enhanced protein adsorption on polymer/hydroxyapatite composite scaffolds. Biomaterials. vol 28. issue 16. 2007-07-18. PMID:17320948. |
furthermore, beta1 and beta3 integrins and phosphorylation of fak and akt proteins in the cells on the plla/hap scaffolds were significantly more abundent than those on plla scaffolds, which suggest that enhanced adsorption of serum adhesion proteins to plla/hap scaffolds protect the cells from apoptosis possibly through the integrin-fak-akt pathway. |
2007-07-18 |
2023-08-12 |
Not clear |
| Makiko Uchida, Masayasu Iwase, Sayaka Takaoka, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagumo, Satoru Shintan. Enhanced susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with phosphatidylinositol 3-kinase inhibitors. International journal of oncology. vol 30. issue 5. 2007-07-17. PMID:17390018. |
the pi 3-k inhibitors wortmannin and ly294002 markedly suppressed phosphorylation of akt and accelerated trail-mediated apoptosis in oscc cells. |
2007-07-17 |
2023-08-12 |
Not clear |
| Ian L P Beales, Olorunseun Ogunwobi, Ewen Cameron, Khalid El-Amin, Gabriel Mutungi, Mark Wilkinso. Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study. BMC cancer. vol 7. 2007-07-12. PMID:17559672. |
activation of akt is increased in the dysplasia-carcinoma sequence in barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study. |
2007-07-12 |
2023-08-12 |
Not clear |
| Ian L P Beales, Olorunseun Ogunwobi, Ewen Cameron, Khalid El-Amin, Gabriel Mutungi, Mark Wilkinso. Activation of Akt is increased in the dysplasia-carcinoma sequence in Barrett's oesophagus and contributes to increased proliferation and inhibition of apoptosis: a histopathological and functional study. BMC cancer. vol 7. 2007-07-12. PMID:17559672. |
the serine-threonine protein kinase and proto-oncogene akt has been reported to regulate proliferation and apoptosis in several tissues but there are no data on the involvement of akt in oesophageal carcinogenesis. |
2007-07-12 |
2023-08-12 |
Not clear |
| O Kosmider, N Denis, P Dubreuil, F Moreau-Gacheli. Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate. Oncogene. vol 26. issue 26. 2007-07-09. PMID:17173066. |
using these cells in vitro, we demonstrate that the tyrosine kinase inhibitor su5416 (semaxinib) induces growth arrest and apoptosis independent of the mutation type by inhibiting the functions of kit, including kit autophosphorylation and activation of akt, erk1/erk2 and stat3 downstream signaling pathways. |
2007-07-09 |
2023-08-12 |
mouse |
| Cheung-Yun Jin, Dong-Oh Moon, Jae-Dong Lee, Moon-Soo Heo, Yung Hyun Choi, Chang-Min Lee, Yeong-Min Park, Gi-Young Ki. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis. vol 28. issue 5. 2007-07-09. PMID:17183064. |
sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of erk and akt in lung adenocarcinoma a549 cells. |
2007-07-09 |
2023-08-12 |
human |
| Cheung-Yun Jin, Dong-Oh Moon, Jae-Dong Lee, Moon-Soo Heo, Yung Hyun Choi, Chang-Min Lee, Yeong-Min Park, Gi-Young Ki. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis. vol 28. issue 5. 2007-07-09. PMID:17183064. |
these results indicate that caspase-3 is a key regulator of apoptosis in response to combined sfn and trail in human lung adenocarcinoma a549 cells through downregulation of erk and akt. |
2007-07-09 |
2023-08-12 |
human |
| Arisa Imsumran, Yasushi Adachi, Hiroyuki Yamamoto, Rong Li, Yu Wang, Yongfen Min, Wenhua Piao, Katsuhiko Nosho, Yoshiaki Arimura, Yasuhisa Shinomura, Masao Hosokawa, Choon-Taek Lee, David P Carbone, Kohzoh Ima. Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma. Carcinogenesis. vol 28. issue 5. 2007-07-09. PMID:17183068. |
igf-ir/dn suppressed proliferation and motility as well as upregulating chemotherapy-induced apoptosis through blocking ligand-induced akt activation. |
2007-07-09 |
2023-08-12 |
human |
| Gina Lee, Jongkyeong Chun. Discrete functions of rictor and raptor in cell growth regulation in Drosophila. Biochemical and biophysical research communications. vol 357. issue 4. 2007-07-09. PMID:17462592. |
furthermore, foxo-dependent apoptosis, which is inhibited by akt, was augmented in the rictor-null background, indicating that rictor is essential for the akt-foxo signaling module. |
2007-07-09 |
2023-08-12 |
drosophila_melanogaster |
| Katrin Nowak, Katrin Killmer, Christine Gessner, Werner Lut. E2F-1 regulates expression of FOXO1 and FOXO3a. Biochimica et biophysica acta. vol 1769. issue 4. 2007-07-06. PMID:17482685. |
in addition, both e2f-induced apoptosis and foxo function are inhibited by the kinase akt. |
2007-07-06 |
2023-08-12 |
Not clear |
| David Chi-Leung Lam, Luc Girard, Ruben Ramirez, Wing-Shun Chau, Wai-sing Suen, Shelley Sheridan, Vicky P C Tin, Lap-ping Chung, Maria P Wong, Jerry W Shay, Adi F Gazdar, Wah-kit Lam, John D Minn. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer research. vol 67. issue 10. 2007-07-03. PMID:17510389. |
nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nachr) on bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the akt pathway. |
2007-07-03 |
2023-08-12 |
human |
| Ann Zeuner, Michele Signore, Daniela Martinetti, Monica Bartucci, Cesare Peschle, Ruggero De Mari. Chemotherapy-induced thrombocytopenia derives from the selective death of megakaryocyte progenitors and can be rescued by stem cell factor. Cancer research. vol 67. issue 10. 2007-07-03. PMID:17510405. |
interfering with akt activation abrogated the antiapoptotic effects of scf, whereas exogenous expression of constitutively active akt inhibited drug-induced apoptosis of primary megakaryocytes, indicating the akt pathway as primarily responsible for scf-mediated protection of megakaryocyte progenitors. |
2007-07-03 |
2023-08-12 |
human |
| D L Vesely, B Hoffman, D A Lieberman. Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells. Oncogene. vol 26. issue 21. 2007-06-25. PMID:17099722. |
taken together, this work supports a novel model for leukemic progression where cells that acquire the ability to produce an autocrine survival factor, such as il-6, can bypass normal p53 surveillance function by targeting akt, which in turn can exert effects on the regulators of apoptosis, such as the fas/cd95 pathway, the mitochondria and nf-kappab. |
2007-06-25 |
2023-08-12 |
Not clear |
| Chi-Chun Fong, Qi Zhang, Yue-Feng Shi, Rudolf S S Wu, Wang-Fun Fong, Mengsu Yan. Effect of hypoxia on RAW264.7 macrophages apoptosis and signaling. Toxicology. vol 235. issue 1-2. 2007-06-22. PMID:17416447. |
the result of western blotting showed that the expression of apoptosis related signaling molecules, such as akt and jnk was activated under hypoxia. |
2007-06-22 |
2023-08-12 |
Not clear |
| Gen Kondo, Masayasu Iwase, Hitoshi Watanabe, Makiko Uchida, Sayaka Takaoka, Masaru Ohashi, Masao Nagum. Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by phosphatidylinositol 3-kinase inhibitor. Oral oncology. vol 42. issue 7. 2007-06-21. PMID:16527514. |
we found that both pi 3-k inhibitors, wortmannin and ly294002, markedly suppressed the phosphorylation of akt and accelerated fas-mediated apoptosis in oscc cells. |
2007-06-21 |
2023-08-12 |
Not clear |
| M Graessmann, B Berg, B Fuchs, A Klein, A Graessman. Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. Oncogene. vol 26. issue 20. 2007-06-20. PMID:17160024. |
its signaling involves mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) kinase (mek)1/2 as the kinase inhibitor pd98059 restores apoptosis but not the akt inhibitor. |
2007-06-20 |
2023-08-12 |
mouse |
| Hiroo Nakajima, Koichi Sakaguchi, Ikuya Fujiwara, Mitsuhiko Mizuta, Mie Tsuruga, Junji Magae, Naruhiko Mizut. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Biochemical and biophysical research communications. vol 356. issue 1. 2007-06-20. PMID:17350598. |
a survival kinase, akt, is a downstream factor in the phosphatidylinositide-3'-kinase-dependent pathway, which mediates many biological responses including glucose uptake, protein synthesis and the regulation of proliferation and apoptosis, which is assumed to contribute to acquisition of malignant properties of human cancers. |
2007-06-20 |
2023-08-12 |
human |
| Hiroo Nakajima, Koichi Sakaguchi, Ikuya Fujiwara, Mitsuhiko Mizuta, Mie Tsuruga, Junji Magae, Naruhiko Mizut. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Biochemical and biophysical research communications. vol 356. issue 1. 2007-06-20. PMID:17350598. |
the apoptosis is accompanied by the activation of a proteolytic cascade of caspases including caspase-3 and -9, and concomitantly decreases phosphorylation of akt, pdk1, and pten, a tumor suppressor that regulates the activity of akt through the dephosphorylation of polyphosphoinositides. |
2007-06-20 |
2023-08-12 |
human |
| Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L Madden, Michael Andreef. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483332. |
in vitro, after treatment of 4t1 cells with 500 nmol/l cddo-me for 2 h, we found (a) inactivation of stat3, (b) inactivation of src and akt, (c) 4-fold reduction of c-myc mrna levels, (d) accumulation of cells in g(2)-m cell cycle phase, (e) abrogation of invasive growth of 4t1 cells, and (f) lack of apoptosis induction. |
2007-06-18 |
2023-08-12 |
mouse |