| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Wu, Hina Kausar, Paul Johnson, Diego E Montoya-Durango, Michael Merchant, Madhavi J Ran. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. The Journal of biological chemistry. vol 282. issue 30. 2007-09-20. PMID:17510053. |
these studies collectively define a novel role of hsp27 in regulating akt activation and cellular apoptosis by mediating interaction between akt and its upstream activator mk2. |
2007-09-20 |
2023-08-12 |
Not clear |
| Traci R Lyons, Jackie Thorburn, Philip W Ryan, Andrew Thorburn, Steven M Anderson, C Kenneth Kassenbroc. Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. The Journal of biological chemistry. vol 282. issue 30. 2007-09-20. PMID:17535800. |
overexpression of posh induces apoptosis in a variety of cell types, but apoptosis can be prevented by co-expressing the pro-survival protein kinase akt. |
2007-09-20 |
2023-08-12 |
Not clear |
| Olivier Dormond, Joren C Madsen, David M Brisco. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. The Journal of biological chemistry. vol 282. issue 32. 2007-09-19. PMID:17553806. |
furthermore, inhibition of akt activity by rapamycin increased the number of endothelial cells undergoing apoptosis after serum withdrawal as well as after stimulation by vascular endothelial growth factor or tumor necrosis factor. |
2007-09-19 |
2023-08-12 |
Not clear |
| Tao Shen, Ming Zheng, Chunmei Cao, Chunlei Chen, Jian Tang, Wanrui Zhang, Heping Cheng, Kuang-Hueih Chen, Rui-Ping Xia. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. The Journal of biological chemistry. vol 282. issue 32. 2007-09-19. PMID:17562700. |
second, overexpression of mfn-2 to a level similar to that induced by h(2)o(2) was sufficient to trigger myocyte apoptosis, which is associated with profound inhibition of akt activation without altering erk1/2 signaling. |
2007-09-19 |
2023-08-12 |
rat |
| Tao Shen, Ming Zheng, Chunmei Cao, Chunlei Chen, Jian Tang, Wanrui Zhang, Heping Cheng, Kuang-Hueih Chen, Rui-Ping Xia. Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. The Journal of biological chemistry. vol 282. issue 32. 2007-09-19. PMID:17562700. |
furthermore, mfn-2-induced myocyte apoptosis was abrogated by inhibition of caspase-9 (but not caspase-8) and by overexpression of bcl-x(l) or enhanced activation of phosphatidylinositol 3-kinase-akt, suggesting that inhibition of akt signaling and activation of the mitochondrial death pathway are essentially involved in mfn-2-induced heart muscle cell apoptosis. |
2007-09-19 |
2023-08-12 |
rat |
| Heath A Elrod, Yi-Dan Lin, Ping Yue, Xuerong Wang, Sagar Lonial, Fadlo R Khuri, Shi-Yong Su. The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Molecular cancer therapeutics. vol 6. issue 7. 2007-09-19. PMID:17604333. |
the alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of akt and activation of the extrinsic apoptotic pathway. |
2007-09-19 |
2023-08-12 |
human |
| Heath A Elrod, Yi-Dan Lin, Ping Yue, Xuerong Wang, Sagar Lonial, Fadlo R Khuri, Shi-Yong Su. The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Molecular cancer therapeutics. vol 6. issue 7. 2007-09-19. PMID:17604333. |
importantly, enforced activation of akt attenuated perifosine-induced apoptosis. |
2007-09-19 |
2023-08-12 |
human |
| Heath A Elrod, Yi-Dan Lin, Ping Yue, Xuerong Wang, Sagar Lonial, Fadlo R Khuri, Shi-Yong Su. The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway. Molecular cancer therapeutics. vol 6. issue 7. 2007-09-19. PMID:17604333. |
these results indicate that akt inhibition is necessary for perifosine-induced apoptosis. |
2007-09-19 |
2023-08-12 |
human |
| Laura Rosanò, Valeriana Di Castro, Francesca Spinella, Maria Rita Nicotra, Pier Giorgio Natali, Anna Bagnat. ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. Molecular cancer therapeutics. vol 6. issue 7. 2007-09-19. PMID:17620430. |
in the human ovarian cancer et(a)r-positive cell lines hey, ovca 433, skov-3, and a-2780, zd4054 effectively inhibited the basal and et-1-induced cell proliferation, associated with the inhibition of akt and p42/44mapk phosphorylation, and with increased apoptosis, through the inhibition of bcl-2 and activation of caspase-3 and poly(adp-ribose) polymerase proteins. |
2007-09-19 |
2023-08-12 |
mouse |
| C M Logar, P T Brinkkoetter, R D Krofft, J W Pippin, S J Shanklan. Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney international. vol 72. issue 4. 2007-09-18. PMID:17554257. |
pretreatment with darbepoetin alfa significantly reduced podocyte apoptosis with this effect involving intact janus family protein kinase-2 (jak2) and akt signaling pathways. |
2007-09-18 |
2023-08-12 |
mouse |
| Sung-E Choi, Hyo-Eun Kim, Ha-Chul Shin, Hyun-Ju Jang, Kwan-Woo Lee, Youngsoo Kim, Sang Sun Kang, Jaesun Chun, Yup Kan. Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death. Molecular and cellular endocrinology. vol 272. issue 1-2. 2007-09-17. PMID:17507155. |
the transient expression of catalytically active akt prevented min6n8a cells from palmitate-induced apoptosis. |
2007-09-17 |
2023-08-12 |
Not clear |
| Sung-E Choi, Hyo-Eun Kim, Ha-Chul Shin, Hyun-Ju Jang, Kwan-Woo Lee, Youngsoo Kim, Sang Sun Kang, Jaesun Chun, Yup Kan. Involvement of Ca2+-mediated apoptotic signals in palmitate-induced MIN6N8a beta cell death. Molecular and cellular endocrinology. vol 272. issue 1-2. 2007-09-17. PMID:17507155. |
deltamethrin, an inhibitor of ca(2+)-activated phosphatase, delayed akt and bad dephosphorylations, and then protected min6n8a cells from palmitate-induced apoptosis. |
2007-09-17 |
2023-08-12 |
Not clear |
| Yiwei Li, Zhiwei Wang, Dejuan Kong, Shalini Murthy, Q Ping Dou, Shijie Sheng, G Prem Veer Reddy, Fazlul H Sarka. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. The Journal of biological chemistry. vol 282. issue 29. 2007-09-17. PMID:17522055. |
we found that b-dim significantly inhibited the phosphorylation of akt and foxo3a and increased the phosphorylation of beta-catenin, leading to the inhibition of cell growth and induction of apoptosis. |
2007-09-17 |
2023-08-12 |
Not clear |
| Yuwei Zhang, Binwu Ying, LiXin Shi, Hong Fan, Dongmei Yang, Dan Xu, Yonggang Wei, Xiaobo Hu, Yonggang Zhang, Xiaohong Zhang, Tao Wang, Daishun Liu, Liyang Dou, Guo Chen, Fei Jiang, Fuqiang We. Ghrelin inhibit cell apoptosis in pancreatic beta cell line HIT-T15 via mitogen-activated protein kinase/phosphoinositide 3-kinase pathways. Toxicology. vol 237. issue 1-3. 2007-09-17. PMID:17602820. |
our findings suggest that ghrelin may act as a survival factor that inhibits the apoptotics pathways, and the mapks, akt pathways could be key roles in the apoptosis of pancreatic beta cells. |
2007-09-17 |
2023-08-12 |
Not clear |
| Shoucheng Ning, Zhijian Chen, Amie Dirks, Bryan Husbeck, Mark Hsu, Barbara Bedogni, Melony O'Neill, Marianne Broome Powell, Susan J Kno. Targeting integrins and PI3K/Akt-mediated signal transduction pathways enhances radiation-induced anti-angiogenesis. Radiation research. vol 168. issue 1. 2007-09-14. PMID:17722999. |
treatment with ly294002 effectively inhibited radiation- and crgd-induced akt phosphorylation and up-regulation of cox2 and increased apoptosis of huvecs. |
2007-09-14 |
2023-08-12 |
human |
| N L P Barnes, F Warnberg, G Farnie, D White, W Jiang, E Anderson, N J Bundre. Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer. British journal of cancer. vol 96. issue 4. 2007-09-13. PMID:17285134. |
celecoxib increased apoptosis in mcf7/her2-18 tumours (tunel 0.52% control vs 0.73% treated, p=0.0004) via inactivation of akt (median pakt(ser473) 57.3% control vs 35.5% treated, p=0.0001--confirmed at western blotting). |
2007-09-13 |
2023-08-12 |
mouse |
| Kiyotaka Nakagawa, Akira Shibata, Shinji Yamashita, Tsuyoshi Tsuzuki, Jun Kariya, Shinichi Oikawa, Teruo Miyazaw. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. The Journal of nutrition. vol 137. issue 8. 2007-09-13. PMID:17634267. |
western blot analysis revealed that delta-t3 suppressed the phosphorylation of phosophoinositide-dependent protein kinase (pdk) and akt, and increased the phosphorylation of apoptosis signal-regulating kinase and p38 in fibroblast growth factor-treated huvec, indicating that the antiangiogenic effects of t3 are associated with changes in growth factor-dependent phosphatidylinositol-3 kinase /pdk/akt signaling as well as induction of apoptosis in endothelial cells. |
2007-09-13 |
2023-08-12 |
mouse |
| Long He, Bo Yeon Kim, Kyoung A Kim, Osong Kwon, Sun Ok Kim, Eun Young Bae, Myung Sun Lee, Min Soo Kim, Mira Jung, A Moon, Kihwan Bae, Jong Seog Ah. NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin. Cellular signalling. vol 19. issue 8. 2007-09-12. PMID:17462862. |
given the accumulating evidences demonstrating akt as a promising anticancer therapeutic target, all these results suggest that dna damage induced apoptosis could be regulated by atm-mediated nf-kappab activation, and that akt1 degradation be necessarily required for this apoptotic process. |
2007-09-12 |
2023-08-12 |
Not clear |
| Shih-Horng Huang, Ying Chen, Po-Yuan Tung, Jiahn-Chun Wu, Kuo-Hsin Chen, Jiann-Ming Wu, Seu-Mei Wan. Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells. Journal of cellular biochemistry. vol 101. issue 4. 2007-09-11. PMID:17390340. |
these data suggest that magnolol promoted apoptosis probably by alleviating the inhibitory effect of akt on caspase 9. |
2007-09-11 |
2023-08-12 |
Not clear |
| Song Jin, Jing-Nan Shen, Jin Wang, Gang Huang, Jia-Guo Zho. Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. Cancer biology & therapy. vol 6. issue 2. 2007-08-31. PMID:17218775. |
oridonin induced apoptosis through akt and mapks signaling pathways in human osteosarcoma cells. |
2007-08-31 |
2023-08-12 |
human |