| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Song, Yong Wu, Jian Xu, Zhonglin Xie, Yunzhou Dong, Miao Zhang, Ming-Hui Zo. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation. vol 116. issue 14. 2007-11-19. PMID:17875968. |
reactive nitrogen species induced by hyperglycemia suppresses akt signaling and triggers apoptosis by upregulating phosphatase pten (phosphatase and tensin homologue deleted on chromosome 10) in an lkb1-dependent manner. |
2007-11-19 |
2023-08-12 |
Not clear |
| Seon Young Nam, Gyung-Ah Jung, Gwong-Cheung Hur, Hee-Yong Chung, Woo Ho Kim, Dai-Wu Seol, Byung Lan Le. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer science. vol 94. issue 12. 2007-11-13. PMID:14662022. |
upregulation of flip(s) by akt, a possible inhibition mechanism of trail-induced apoptosis in human gastric cancers. |
2007-11-13 |
2023-08-12 |
human |
| Seon Young Nam, Gyung-Ah Jung, Gwong-Cheung Hur, Hee-Yong Chung, Woo Ho Kim, Dai-Wu Seol, Byung Lan Le. Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers. Cancer science. vol 94. issue 12. 2007-11-13. PMID:14662022. |
therefore, our results suggest that akt activity promotes human gastric cancer cell survival against trail-induced apoptosis via upregulation of flip(s), and that the cytotoxic effect of trail can be enhanced by modulating the akt/flip(s) pathway in human gastric cancers. |
2007-11-13 |
2023-08-12 |
human |
| Yingyu Ma, Wei-Dong Yu, Rui-Xian Kong, Donald L Trump, Candace S Johnso. Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25D3-mediated apoptosis in squamous cell carcinoma cells. Cancer research. vol 66. issue 16. 2007-11-13. PMID:16912191. |
these effects were nongenomic: they occurred rapidly and were not inhibited by cycloheximide or actinomycin d. to examine whether the nongenomic activation of akt and erk1/2 plays a role in 1,25d3-mediated apoptosis, the expression of akt or erk1/2 was reduced by small interfering rna (sirna). |
2007-11-13 |
2023-08-12 |
Not clear |
| Song Jin, Rui-Ping Pang, Jing-Nan Shen, Gang Huang, Jin Wang, Jia-Guo Zho. Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells. Apoptosis : an international journal on programmed cell death. vol 12. issue 7. 2007-11-13. PMID:17333316. |
taken together, our results suggested that grifolin is able to suppress the phosphorylation of akt and its substrates foxo transcription factor and gsk3 in osteosarcoma cells causing the suppression of proliferation and induction of mitochondria- and caspase-dependent apoptosis. |
2007-11-13 |
2023-08-12 |
human |
| Daeyoun Hwang, Sujin Seo, Yongkyu Kim, Chuelkyu Kim, Sunbo Shim, Seungwan Jee, Suhae Lee, Mikyong Jang, Minsun Kim, Suyoun Yim, Sang-Koo Lee, Byeongcheol Kang, Insurk Jang, Jungsik Ch. Selenium acts as an insulin-like molecule for the down-regulation of diabetic symptoms via endoplasmic reticulum stress and insulin signalling proteins in diabetes-induced non-obese diabetic mice. Journal of biosciences. vol 32. issue 4. 2007-11-13. PMID:17762145. |
we conclude that (i) sel treatment induced insulin-like effects in lowering serum glucose level in sel-treated nod mice, (ii) sel-treated mice had significantly decreased serum biochemical components associated with liver damage and lipid metabolism, (iii) sel treatment led to the activation of the er stress signal through the phosphorylation of jnk and eif2 protein and insulin signal mechanisms through the phosphorylation of akt and pi3 kinase, and (iv) sel-treated mice were significantly relieved apoptosis of liver tissues indicated by dna fragmentation assay in the diabetic nod group. |
2007-11-13 |
2023-08-12 |
mouse |
| Wenjuan Wu, Amir Onn, Takeshi Isobe, Satoshi Itasaka, Robert R Langley, Tomoaki Shitani, Keiko Shibuya, Ritsuko Komaki, Anderson J Ryan, Isaiah J Fidler, Roy S Herbst, Michael S O'Reill. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308046. |
in vitro, zd6474 inhibited egfr, vegfr2, mitogen-activated protein kinase and akt phosphorylation, egf- and vegf-induced proliferation, and endothelial cell tube formation and also induced apoptosis. |
2007-11-09 |
2023-08-12 |
mouse |
| Mike Failly, Serdar Korur, Viviane Egler, Jean-Louis Boulay, Maria Maddalena Lino, Roland Imber, Adrian Merl. Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells. Molecular cancer therapeutics. vol 6. issue 2. 2007-11-09. PMID:17308073. |
blocking egfr with aee788 in combination with sublethal concentrations of the microtubule stabilizer patupilone also induced apoptosis and reduced cell proliferation in glioblastoma cells, accompanied by reduced akt and erk activity. |
2007-11-09 |
2023-08-12 |
mouse |
| Suresh Varma Penumathsa, Mahesh Thirunavukkarasu, Srikanth Koneru, Bela Juhasz, Lijun Zhan, Rima Pant, Venugopal P Menon, Hajime Otani, Nilanjana Mauli. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. Journal of molecular and cellular cardiology. vol 42. issue 3. 2007-11-08. PMID:17188708. |
increased phosphorylation of akt and enos was also observed in all the treatment groups resulting in decreased extent of cardiomyocyte apoptosis but the extent of reduction in apoptosis was more significant in hcrs group compared to all other groups. |
2007-11-08 |
2023-08-12 |
rat |
| Oleg P Zhirnov, Hans-Dieter Klen. Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis : an international journal on programmed cell death. vol 12. issue 8. 2007-11-08. PMID:17468837. |
control of apoptosis in influenza virus-infected cells by up-regulation of akt and p53 signaling. |
2007-11-08 |
2023-08-12 |
human |
| Oleg P Zhirnov, Hans-Dieter Klen. Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis : an international journal on programmed cell death. vol 12. issue 8. 2007-11-08. PMID:17468837. |
virus-induced apoptosis and signaling of akt and p53 developed in ifn-deficient vero cells with similar kinetics as in ifn-competent cv1-infected cells indicating that these processes were endocrine ifn-independent. |
2007-11-08 |
2023-08-12 |
human |
| Oleg P Zhirnov, Hans-Dieter Klen. Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis : an international journal on programmed cell death. vol 12. issue 8. 2007-11-08. PMID:17468837. |
apoptosis in influenza-infected cv-1 and mdck cells was akt-dependent and was accelerated by ly294002, a specific inhibitor of pi3k-akt signaling, and down-regulated by the viral protein ns1, an inducer of host akt. |
2007-11-08 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Liyue Tong, Shilpa Vishwanath, Anna Bratasz, Nancy J Trigg, Vijay K Kutala, Kalman Hideg, Periannan Kuppusam. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17684018. |
suppression of pten expression with sirna significantly reduced the p53 and p21 levels and activated akt phosphorylation at ser(473) and thr(308), resulting in decreased apoptosis and increased cell survival. |
2007-11-08 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Liyue Tong, Shilpa Vishwanath, Anna Bratasz, Nancy J Trigg, Vijay K Kutala, Kalman Hideg, Periannan Kuppusam. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17684018. |
the up-regulation of pten inhibited akt and mdm2, which enhanced the level of p53, thereby inducing g(2)/m arrest and apoptosis. |
2007-11-08 |
2023-08-12 |
human |
| S-I Harashima, C Harashima, T Nishimura, Y Hu, A L Notkin. Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction. Clinical and experimental immunology. vol 150. issue 1. 2007-11-08. PMID:17725654. |
a search for ia-2 interacting proteins revealed that ia-2 interacts with sorting nexin (snx)19 and that snx19, but not ia-2, inhibits the conversion of ptdins(4,5)p2 to ptdins(3,4,5)p3 and thereby suppresses the phosphorylation of proteins in the akt signalling pathway resulting in apoptosis. |
2007-11-08 |
2023-08-12 |
mouse |
| Keishi Fujiwara, Eiji Iwado, Gordon B Mills, Raymond Sawaya, Seiji Kondo, Yasuko Kond. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. International journal of oncology. vol 31. issue 4. 2007-11-08. PMID:17786305. |
in terms of the mechanism, the akt inhibitor decreased phosphorylated p70s6 kinase, a downstream target of akt, and induced autophagy, but not apoptosis. |
2007-11-08 |
2023-08-12 |
Not clear |
| Nhu-An Pham, Ming-Sound Tsao, Pinjiang Cao, David William Hedle. Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models. Pancreas. vol 35. issue 3. 2007-11-07. PMID:17895832. |
to understand the impact of protein kinase b (pkb; akt) signaling on growth and protection from apoptosis in pancreatic ductal adenocarcinoma models demonstrating differences in pkb activity. |
2007-11-07 |
2023-08-12 |
Not clear |
| Claudia P Schroeder, Humam Kadara, Dafna Lotan, Jong K Woo, Ho-Young Lee, Waun Ki Hong, Reuben Lota. Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. Cancer research. vol 66. issue 19. 2007-11-06. PMID:17018636. |
involvement of mitochondrial and akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and n-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. |
2007-11-06 |
2023-08-12 |
human |
| Claudia P Schroeder, Humam Kadara, Dafna Lotan, Jong K Woo, Ho-Young Lee, Waun Ki Hong, Reuben Lota. Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. Cancer research. vol 66. issue 19. 2007-11-06. PMID:17018636. |
accordingly, overexpression of constitutively active akt protected bronchial epithelial cells from undergoing apoptosis after incubation with both celecoxib and 4hpr. |
2007-11-06 |
2023-08-12 |
human |
| Claudia P Schroeder, Humam Kadara, Dafna Lotan, Jong K Woo, Ho-Young Lee, Waun Ki Hong, Reuben Lota. Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. Cancer research. vol 66. issue 19. 2007-11-06. PMID:17018636. |
these findings indicate that activation of the mitochondrial apoptosis pathway and suppression of the akt survival pathway mediate the augmented apoptosis and suggest that this combination may be useful for lung cancer chemoprevention. |
2007-11-06 |
2023-08-12 |
human |