Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jialin Shen, Jianhai Jiang, Yuanyan Wei, Lei Zhou, Dan Liu, Jin Zhou, Jianxin G. Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17557191. |
in this study, we reported that constitutively active akt protein (myr-akt) inhibited chx-induced apoptosis in smmc-7721 cells through down-regulating beta1,4gt1. |
2008-02-05 |
2023-08-12 |
human |
Jialin Shen, Jianhai Jiang, Yuanyan Wei, Lei Zhou, Dan Liu, Jin Zhou, Jianxin G. Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17557191. |
moreover, we found that chx accentuated beta1,4gt1 through down-regulating akt expression to mediate smmc-7721 cells apoptosis. |
2008-02-05 |
2023-08-12 |
human |
David C New, Kelvin Wu, Alice W S Kwok, Yung H Won. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. The FEBS journal. vol 274. issue 23. 2008-02-05. PMID:17949438. |
g protein-coupled receptor-induced akt activity in cellular proliferation and apoptosis. |
2008-02-05 |
2023-08-12 |
Not clear |
David C New, Kelvin Wu, Alice W S Kwok, Yung H Won. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. The FEBS journal. vol 274. issue 23. 2008-02-05. PMID:17949438. |
akt plays a particularly prominent part in signaling networks that result in the modulation of cellular proliferation, apoptosis and survival. |
2008-02-05 |
2023-08-12 |
Not clear |
David C New, Kelvin Wu, Alice W S Kwok, Yung H Won. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. The FEBS journal. vol 274. issue 23. 2008-02-05. PMID:17949438. |
thus, the overexpression of akt subtypes has been measured in a number of cancer types, and dominant-negative forms of akt can trigger apoptosis and reduce the survival of cancer cells. |
2008-02-05 |
2023-08-12 |
Not clear |
David C New, Kelvin Wu, Alice W S Kwok, Yung H Won. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. The FEBS journal. vol 274. issue 23. 2008-02-05. PMID:17949438. |
in this review, we shall document how g protein-coupled receptors are able to control akt activity and examine the resulting biochemical and physiological changes, with particular emphasis on cellular proliferation, apoptosis and survival. |
2008-02-05 |
2023-08-12 |
Not clear |
Li Liu, Xiao-jin Zhang, Su-rong Jiang, Zheng-nian Ding, Guo-xian Ding, Jun Huang, Yun-lin Chen. Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation. Chinese medical journal. vol 120. issue 24. 2008-02-05. PMID:18167217. |
heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and akt activation. |
2008-02-05 |
2023-08-12 |
Not clear |
Chiung-Ho Liao, Shengmin Sang, Chi-Tang Ho, Jen-Kun Li. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Journal of cellular biochemistry. vol 96. issue 1. 2008-02-01. PMID:16052481. |
garcinol modulates tyrosine phosphorylation of fak and subsequently induces apoptosis through down-regulation of src, erk, and akt survival signaling in human colon cancer cells. |
2008-02-01 |
2023-08-12 |
human |
Alexander Jacob, Lauren K Hensley, Bryan D Safratowich, Richard J Quigg, Jessy J Alexande. The role of the complement cascade in endotoxin-induced septic encephalopathy. Laboratory investigation; a journal of technical methods and pathology. vol 87. issue 12. 2008-02-01. PMID:17922019. |
consistent with the capacity of these inflammatory mediators, there was increased apoptosis as determined by dna fragmentation and tunel staining on lps treatment, which occurred through the akt pathway. |
2008-02-01 |
2023-08-12 |
mouse |
Tracy Haynes, Christian Gutierrez, Juan-Carlos Aycinena, Panagiotis A Tsonis, Katia Del Rio-Tsoni. BMP signaling mediates stem/progenitor cell-induced retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18093961. |
by 7d pr, it induces apoptosis by activating p38 (a noncanonical bmp pathway) and down-regulating fgf signaling (by both mapk and akt pathways). |
2008-01-28 |
2023-08-12 |
chicken |
Alok S Pachori, Anthony Smith, Patricia McDonald, Lunan Zhang, Victor J Dzau, Luis G Mel. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. Journal of molecular and cellular cardiology. vol 43. issue 5. 2008-01-23. PMID:17920074. |
ho-1 overexpression increased phosphorylation of the regulatory subunit of the pi3k (p85alpha) and downstream effector akt in h9c2 cells, leading to decreased ros and apoptosis. |
2008-01-23 |
2023-08-12 |
Not clear |
Alok S Pachori, Anthony Smith, Patricia McDonald, Lunan Zhang, Victor J Dzau, Luis G Mel. Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. Journal of molecular and cellular cardiology. vol 43. issue 5. 2008-01-23. PMID:17920074. |
in addition, knockdown of biliverdin reductase (bvr) expression with sirna attenuated ho-1-induced akt phosphorylation and increased h/r-induced apoptosis of h9c2 cells. |
2008-01-23 |
2023-08-12 |
Not clear |
Ruiqiong Ran, Ruiqin Pan, Aigang Lu, Huichun Xu, Ryan R Davis, Frank R Shar. A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Molecular and cellular neurosciences. vol 36. issue 3. 2008-01-22. PMID:17888676. |
a novel 165-kda golgin protein induced by brain ischemia and phosphorylated by akt protects against apoptosis. |
2008-01-22 |
2023-08-12 |
rat |
Ruiqiong Ran, Ruiqin Pan, Aigang Lu, Huichun Xu, Ryan R Davis, Frank R Shar. A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. Molecular and cellular neurosciences. vol 36. issue 3. 2008-01-22. PMID:17888676. |
these data show that akt phosphorylation of iigp165 protects against apoptotic cell death, and add to evidence that the golgi apparatus also plays a role in regulating apoptosis. |
2008-01-22 |
2023-08-12 |
rat |
Michael Fraser, Tao Bai, Benjamin K Tsan. Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function. International journal of cancer. vol 122. issue 3. 2008-01-22. PMID:17918180. |
overexpression/activation of the phosphatidylinositol-3-kinase/akt pathway is commonly observed in ovarian cancer, and akt activation is a determinant of chemoresistance in ovarian cancer cells, an effect that may be due, in part, to its inhibitory actions on p53-dependent apoptosis. |
2008-01-22 |
2023-08-12 |
human |
Michael Fraser, Tao Bai, Benjamin K Tsan. Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function. International journal of cancer. vol 122. issue 3. 2008-01-22. PMID:17918180. |
furthermore, activation of akt inhibited the cisplatin-induced upregulation of puma, and suppressed cisplatin-induced p53 phosphorylation, while inhibition of akt increased total and phospho-p53 contents and sensitized p53 wild-type, chemoresistant cells to cisplatin-induced apoptosis. |
2008-01-22 |
2023-08-12 |
human |
Michael Fraser, Tao Bai, Benjamin K Tsan. Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function. International journal of cancer. vol 122. issue 3. 2008-01-22. PMID:17918180. |
these results support the hypothesis that p53 is a determinant of cddp sensitivity, and suggest that akt contributes to chemoresistance, in part, by attenuating p53-mediated puma upregulation and phosphorylation of p53, which are essential, but independent determinants of sensitivity to cddp-induced apoptosis. |
2008-01-22 |
2023-08-12 |
human |
Kyoung-Han Kim, Gavin Y Oudit, Peter H Back. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. The Journal of pharmacology and experimental therapeutics. vol 324. issue 1. 2008-01-18. PMID:17928571. |
indeed, preventing akt and gsk-3beta phosphorylations by phosphatidylinositol 3-kinase (pi3k) inhibition abolished protection by epo against cardiomyocyte loss, apoptosis, and oxidative stress. |
2008-01-18 |
2023-08-12 |
mouse |
Jingbo Pan, Zhaorui Lian, Sarah Wallet, Mark A Feitelso. The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. The Journal of general virology. vol 88. issue Pt 12. 2008-01-17. PMID:18024896. |
given that akt and hbxag also activate beta-catenin, experiments were designed to determine whether urg7 blocked apoptosis via activation of beta-catenin. |
2008-01-17 |
2023-08-12 |
cat |
Akira Takemura, Akihiko Gemma, Masahiko Shibuya, Kuniko Matsuda, Tetsuya Okano, Michiya Nara, Rintarou Noro, Yuji Minegishi, Akinobu Yoshimura, Shoji Kudo. Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib. International journal of oncology. vol 31. issue 6. 2008-01-15. PMID:17982658. |
the combination of anti-cancer drugs and inhibition of the molecules related with apoptosis and/or akt pathway might be beneficial in the treatment of metastatic nsclc. |
2008-01-15 |
2023-08-12 |
human |