| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Nieto-Miguel, C Gajate, F González-Camacho, F Mollined. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. Oncogene. vol 27. issue 12. 2008-04-22. PMID:17891170. |
edelfosine treatment recruited hsp90, c-jun n-terminal kinase (jnk) and apoptotic molecules in lipid rafts, but not the jnk regulators apoptosis signal-regulating kinase 1 (ask1) and daxx, or the survival signaling molecules extracellular signal-regulated kinase (erk) and akt. |
2008-04-22 |
2023-08-12 |
Not clear |
| X Yang, M Fraser, M R Abedini, T Bai, B K Tsan. Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18283299. |
regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by akt. |
2008-04-22 |
2023-08-12 |
Not clear |
| X Yang, M Fraser, M R Abedini, T Bai, B K Tsan. Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18283299. |
activation of the protein kinase akt, commonly observed in ovarian tumours, confers resistance to ovarian cancer cells via inhibition of caspase-dependent apoptosis. |
2008-04-22 |
2023-08-12 |
Not clear |
| X Yang, M Fraser, M R Abedini, T Bai, B K Tsan. Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18283299. |
however, the effect of akt on cisplatin-induced, caspase-independent apoptosis remains unclear. |
2008-04-22 |
2023-08-12 |
Not clear |
| X Yang, M Fraser, M R Abedini, T Bai, B K Tsan. Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18283299. |
finally, activation of akt attenuated the cisplatin-induced mitochondrial release and nuclear accumulation of aif and apoptosis in chemosensitive cells, whereas inhibition of akt activity facilitated these effects and sensitised chemoresistant cells to aif-dependent, cisplatin-induced apoptosis. |
2008-04-22 |
2023-08-12 |
Not clear |
| X Yang, M Fraser, M R Abedini, T Bai, B K Tsan. Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt. British journal of cancer. vol 98. issue 4. 2008-04-22. PMID:18283299. |
these results suggest that cisplatin-induced apoptosis proceeds, in part, via a caspase-independent mechanism involving aif, and that akt activation confers resistance to cisplatin-induced apoptosis by blocking this pathway. |
2008-04-22 |
2023-08-12 |
Not clear |
| Yun Oh, Roy S Herbst, Howard Burris, Ann Cleverly, Luna Musib, Michael Lahn, Gerold Beple. Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 26. issue 7. 2008-04-15. PMID:18309949. |
enzastaurin, an oral serine/threonine kinase inhibitor, suppresses protein kinase c (pkc) and protein kinase b/ak transforming (akt) signaling, induces tumor cell apoptosis, and inhibits proliferation and angiogenesis. |
2008-04-15 |
2023-08-12 |
Not clear |
| Hui Xing, Danhui Weng, Gang Chen, Wenming Tao, Tao Zhu, Xiaokui Yang, Li Meng, Shixuan Wang, Yunping Lu, Ding M. Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells. Cancer letters. vol 261. issue 1. 2008-04-14. PMID:18171600. |
fn adhesion promoted akt phosphorylation in highly metastatic cancer cells a2780 and mdamb231, and further brought on significant protection for tumor cells against docetaxel-induced apoptosis. |
2008-04-14 |
2023-08-12 |
Not clear |
| Eriko Tokunaga, Eiji Oki, Akinori Egashira, Noriaki Sadanaga, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehar. Deregulation of the Akt pathway in human cancer. Current cancer drug targets. vol 8. issue 1. 2008-04-14. PMID:18288941. |
numerous studies have revealed the blockage of akt signaling to result in apoptosis and growth inhibition of tumor cells. |
2008-04-14 |
2023-08-12 |
human |
| Dolores Hambardzumyan, Oren J Becher, Marc K Rosenblum, Pier Paolo Pandolfi, Katia Manova-Todorova, Eric C Hollan. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes & development. vol 22. issue 4. 2008-04-11. PMID:18281460. |
finally, inhibition of akt signaling sensitizes cells in the perivascular region to radiation-induced apoptosis. |
2008-04-11 |
2023-08-12 |
mouse |
| Amy J Johnson, Amy J Wagner, Carolyn M Cheney, Lisa L Smith, David M Lucas, Sara K Guster, Michael R Grever, Thomas S Lin, John C Byr. Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia. British journal of haematology. vol 139. issue 5. 2008-04-10. PMID:17949452. |
we demonstrate that at biologically active and clinically attainable levels (1 mumol/l), 17-aag treatment of cll b cells in vitro causes modest apoptosis as well as decreased akt protein levels. |
2008-04-10 |
2023-08-12 |
Not clear |
| Paul C McDonald, Arusha Oloumi, Julia Mills, Iveta Dobreva, Mykola Maidan, Virginia Gray, Elizabeth D Wederell, Marcel B Bally, Leonard J Foster, Shoukat Dedha. Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339839. |
depletion of ilk and rictor in breast and prostate cancer cell lines resulted in inhibition of akt ser(473) phosphorylation and induction of apoptosis, whereas, in several cell lines, depletion of mtor increased akt phosphorylation. |
2008-04-09 |
2023-08-12 |
Not clear |
| Keun-Wook Lee, Sang Gyun Kim, Hwang-Phill Kim, Euna Kwon, Jiran You, Hyung-Jun Choi, Jung-Hyun Park, Byeong-Cheol Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Yung-Jue Ban. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339873. |
although enzastaurin was initially advanced to the clinic based on its antiangiogenic activity, it is also known to have a direct effect on a variety of human cancer cells, inducing apoptosis by inhibiting the akt signal pathway. |
2008-04-09 |
2023-08-12 |
human |
| Keun-Wook Lee, Sang Gyun Kim, Hwang-Phill Kim, Euna Kwon, Jiran You, Hyung-Jun Choi, Jung-Hyun Park, Byeong-Cheol Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Yung-Jue Ban. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer research. vol 68. issue 6. 2008-04-09. PMID:18339873. |
these data suggest that enzastaurin induces apoptosis through rsk-mediated and bad-mediated pathways, besides inhibiting the akt signal cascade. |
2008-04-09 |
2023-08-12 |
human |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
ceramide induces p38 mapk-dependent apoptosis and bax translocation via inhibition of akt in hl-60 cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| Hae Jong Kim, Ji Eun Oh, Sang Woo Kim, Young Jin Chun, Mie Young Ki. Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer letters. vol 260. issue 1-2. 2008-04-08. PMID:18054155. |
overexpression of akt also led to suppression of bax translocation to mitochondria during ceramide-induced apoptosis in hl-60 cells. |
2008-04-08 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
pharmacological interaction was studied using the combination index (ci) method, whereas cell cycle, apoptosis induction, and egfr, extracellular signal-regulated kinases 1 and 2, and akt phosphorylation were studied by flow cytometry, fluorescence microscopy, and enzyme-linked immunosorbent assays. |
2008-04-03 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Clara Lemos, Christina Tekle, Kees Smid, Sara Nannizzi, José A Rodriguez, Simona Ricciardi, Romano Danesi, Giuseppe Giaccone, Godefridus J Peter. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Molecular pharmacology. vol 73. issue 4. 2008-04-03. PMID:18187583. |
induction of apoptosis, modulation of egfr and akt phosphorylation, and changes in the expression of critical genes involved in pemetrexed activity contribute to this synergistic interaction and support the clinical investigation of these markers. |
2008-04-03 |
2023-08-12 |
Not clear |
| Babli Halder, Udayan Bhattacharya, Sibabrata Mukhopadhyay, Ashok K Gir. Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade. Carcinogenesis. vol 29. issue 1. 2008-03-31. PMID:17984116. |
our intricate investigations on apoptosis also explained that tf and tr augmented bax:bcl2 ratio, up-regulated the expression of p53 as well as p21 and inhibited phosphorylation of the cell survival protein akt. |
2008-03-31 |
2023-08-12 |
human |
| Anuradha Dhanasekaran, Stephanie K Gruenloh, J Noelle Buonaccorsi, Rong Zhang, Garrett J Gross, John R Falck, Paresh K Patel, Elizabeth R Jacobs, Meetha Medhor. Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. American journal of physiology. Heart and circulatory physiology. vol 294. issue 2. 2008-03-31. PMID:18055514. |
in fact, cardiomyocytes pretreated with eet and exposed to h/r exhibited antiapoptotic changes in at least five downstream effectors of pi3k, protein kinase b (akt), bcl-x(l)/bcl-2-associated death promoter, caspases-9 and -3 activities, and the expression of the x-linked inhibitor of apoptosis, compared with vehicle-treated controls. |
2008-03-31 |
2023-08-12 |
mouse |