| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
expression of dominant negative p38 mapk or constitutively active akt significantly prevented cell death and mitochondrial bax translocation, implicating that p38 mapk and akt signaling pathways play crucial roles in stilbene-induced apoptosis of hl-60 cells. |
2008-06-11 |
2023-08-12 |
Not clear |
| Yu-Chieh Wang, Samuel K Kulp, Dasheng Wang, Chih-Cheng Yang, Aaron M Sargeant, Jui-Hsiang Hung, Yoko Kashida, Mamoru Yamaguchi, Geen-Dong Chang, Ching-Shih Che. Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413750. |
evidence indicates that this combination facilitates apoptosis through both akt signaling inhibition and up-regulation of endoplasmic reticulum (er) stress-induced, gadd153-mediated pathways. |
2008-06-10 |
2023-08-12 |
mouse |
| Yu-Chieh Wang, Samuel K Kulp, Dasheng Wang, Chih-Cheng Yang, Aaron M Sargeant, Jui-Hsiang Hung, Yoko Kashida, Mamoru Yamaguchi, Geen-Dong Chang, Ching-Shih Che. Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413750. |
for example, ectopic expression of constitutively active akt significantly attenuated the inhibitory effect on cell survival, and small interfering rna-mediated knockdown of gadd153 protected cells from undergoing apoptosis in response to drug cotreatments. |
2008-06-10 |
2023-08-12 |
mouse |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
cell culture assays were used to assess the effect of akt blockade (using a phosphatidylinositol 3-kinase inhibitor and a specific akt inhibitor) on sts cell growth, cell cycle, and apoptosis. |
2008-06-10 |
2023-08-12 |
mouse |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
akt inhibition decreased sts downstream target phosphorylation and growth in vitro; g(2) cell cycle arrest and apoptosis were also observed. |
2008-06-10 |
2023-08-12 |
mouse |
| Jing Wang, Limin Yang, Junhua Yang, Karen Kuropatwinski, Wang Wang, Xiao-Qiong Liu, Jennie Hauser, Michael G Brattai. Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells. Cancer research. vol 68. issue 9. 2008-06-10. PMID:18451140. |
treatment of fet dnrii cells with a pi3k inhibitor (ly294002) inhibited akt phosphorylation and reduced survivin expression resulting in increased apoptosis in fet/dnrii cells. |
2008-06-10 |
2023-08-12 |
mouse |
| Sandy Hemdan, Guillermina Almaza. Dopamine-induced toxicity is synergistically potentiated by simultaneous HSP-90 and Akt inhibition in oligodendrocyte progenitors. Journal of neurochemistry. vol 105. issue 4. 2008-06-06. PMID:18194434. |
both hsp-90 and akt play important roles in concert in the defense against da-induced apoptosis. |
2008-06-06 |
2023-08-12 |
Not clear |
| J-Y Kim, S-K Kwok, K-H Hur, H-J Kim, N S Kim, S-A Yoo, W-U Kim, C-S Ch. Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis. Clinical and experimental immunology. vol 152. issue 2. 2008-06-04. PMID:18355352. |
both extracellular regulated kinase (erk) inhibitor (pd98059) and protein kinase b (akt) inhibitor (ly294002) almost completely blocked the inhibitory effect of mif on apoptosis. |
2008-06-04 |
2023-08-12 |
Not clear |
| J-Y Kim, S-K Kwok, K-H Hur, H-J Kim, N S Kim, S-A Yoo, W-U Kim, C-S Ch. Up-regulated macrophage migration inhibitory factor protects apoptosis of dermal fibroblasts in patients with systemic sclerosis. Clinical and experimental immunology. vol 152. issue 2. 2008-06-04. PMID:18355352. |
taken together, our data suggest that mif released by activated t cells and dermal fibroblasts decreases the apoptosis of dermal fibroblasts through activation of erk, akt and bcl-2 signalling pathways, which might be associated with excessive fibrosis in ssc. |
2008-06-04 |
2023-08-12 |
Not clear |
| Carlos Sebastián, Maria Serra, Andrée Yeramian, Neus Serrat, Jorge Lloberas, Antonio Celad. Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 9. 2008-06-04. PMID:18424709. |
protection from apoptosis, which involves akt phosphorylation and p21(waf-1) expression, was not modified by tsa. |
2008-06-04 |
2023-08-12 |
Not clear |
| Véronique Gagnon, Céline Van Themsche, Steve Turner, Valérie Leblanc, Eric Asseli. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis : an international journal on programmed cell death. vol 13. issue 2. 2008-06-03. PMID:18071906. |
the three drugs decreased akt and xiap content and induced apoptosis in p-akt-negative hela cells. |
2008-06-03 |
2023-08-12 |
human |
| Véronique Gagnon, Céline Van Themsche, Steve Turner, Valérie Leblanc, Eric Asseli. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis : an international journal on programmed cell death. vol 13. issue 2. 2008-06-03. PMID:18071906. |
p-akt1/2/3-positive kle cells showed maximum chemoresistance as xiap and akt levels/phosphorylation remained stable in response to the three drugs, and only cisplatin could significantly induce apoptosis. |
2008-06-03 |
2023-08-12 |
human |
| Martin Schiller, Sandra Franz, Petra Heyder, Reinhard E Voll, Udo S Gaipl, Hanns-Martin Lorenz, Joachim R Kalden, Martin Herrman. Hypothesis: human serum-borne albumin bound lipids promote cellular survival after apoptosis induction by a variety of stimuli. Apoptosis : an international journal on programmed cell death. vol 13. issue 2. 2008-06-03. PMID:18080861. |
the activity prevented akt dephosphorylation and degradation, after apoptosis induction by staurosporine and the production of reactive oxygen species after uv-b irradiation. |
2008-06-03 |
2023-08-12 |
human |
| Alexandra d'Anglemont de Tassigny, Alain Berdeaux, Rachid Souktani, Patrick Henry, Bijan Ghale. The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. European journal of heart failure. vol 10. issue 1. 2008-06-03. PMID:18164246. |
the volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through pi3kinase, akt and erk 1/2. |
2008-06-03 |
2023-08-12 |
Not clear |
| Lin Ji, Jack A Rot. Tumor suppressor FUS1 signaling pathway. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 3. issue 4. 2008-05-27. PMID:18379348. |
here we present recent findings indicating that fus1 induces apoptosis through the activation of the intrinsic mitochondrial-dependent and apaf-1-associated pathways and inhibits the function of protein tyrosine kinases including egfr, pdgfr, akt, c-abl, and c-kit. |
2008-05-27 |
2023-08-12 |
human |
| Seung Hyun Oh, Quanri Jin, Edward S Kim, Fadlo R Khuri, Ho-Young Le. Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 14. issue 5. 2008-05-23. PMID:18316583. |
inhibition of igf-ir, akt, or mtor or the knockdown of survivin expression abolished resistance to sch66336 and induced apoptosis in the cells. |
2008-05-23 |
2023-08-12 |
Not clear |
| Yukiyasu Ozawa, Ann H Williams, Myka L Estes, Norimasa Matsushita, Frank Boschelli, Richard Jove, Alan F Lis. Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT). Leukemia research. vol 32. issue 6. 2008-05-22. PMID:18179820. |
akt phosphorylation and mcl-1 expression decreased after sfk inhibition accompanied by apoptosis induction. |
2008-05-22 |
2023-08-12 |
Not clear |
| Abdelkarim Sabri, Khadija Rafiq, Rachid Seqqat, Mikhail A Kolpakov, Ray Dillon, Louis J Dell'itali. Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog. Circulation research. vol 102. issue 9. 2008-05-22. PMID:18356543. |
there was increased phosphorylation of stress related molecules p38 mitogen-activated protein kinase (mapk) and hsp27 and survival signaling kinases extracellular signal-regulated kinase 1/2 and akt, with no evidence of cardiomyocyte apoptosis. |
2008-05-22 |
2023-08-12 |
dog |
| Sabine Rottmann, Stefanie Speckgens, Juliane Lüscher-Firzlaff, Bernhard Lüsche. Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:17998413. |
interfering with akt function affected the control of fas-induced apoptosis by mad1. |
2008-05-16 |
2023-08-12 |
human |
| Adrián M Ramos, Patricio Alle. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18359480. |
as an exception, ato plus quercetin failed to elicit akt de-phosphorylation and gsh depletion in nb4 acute promyelocytic leukemia cells, and correspondingly exhibited low cooperative effect in inducing apoptosis in this cell line. |
2008-05-16 |
2023-08-12 |
human |