| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sungwon Hong, Byoung-Ho Moon, Yeonjoong Yong, Soon Young Shin, Young Han Lee, Yoongho Li. Inhibitory effect against Akt of cyclic dipeptides isolated from Bacillus sp. Journal of microbiology and biotechnology. vol 18. issue 4. 2008-08-06. PMID:18467861. |
since akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. |
2008-08-06 |
2023-08-12 |
Not clear |
| Gianrico Spagnuolo, Vincenzo D'Antò, Rosa Valletta, Caterina Strisciuglio, Gottfried Schmalz, Helmut Schweikl, Sandro Reng. Effect of 2-hydroxyethyl methacrylate on human pulp cell survival pathways ERK and AKT. Journal of endodontics. vol 34. issue 6. 2008-08-05. PMID:18498889. |
mitogen-activated protein kinase (mapk) and protein kinase b (akt) might mediate cell responses as well as cell survival and apoptosis. |
2008-08-05 |
2023-08-12 |
human |
| Edgar Gil Rizzatti, Helena Mora-Jensen, Marc Andrée Weniger, Federica Gibellini, Elinor Lee, Masanori Daibata, Raymond Lai, Adrian Wiestne. Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways. Leukemia & lymphoma. vol 49. issue 4. 2008-08-04. PMID:18398749. |
noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the akt and nf-kappab pathways. |
2008-08-04 |
2023-08-12 |
Not clear |
| Naghma Khan, Farrukh Afaq, Deeba N Syed, Hasan Mukhta. Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. Carcinogenesis. vol 29. issue 5. 2008-08-01. PMID:18359761. |
fisetin treatment also resulted in induction of apoptosis, poly (adp-ribose) polymerase (parp) cleavage, modulation in the expressions of bcl-2 family proteins, inhibition of phosphatidyl inositol 3-kinase and phosphorylation of akt at ser(473) and thr(308). |
2008-08-01 |
2023-08-12 |
human |
| Subbareddy Maddika, Sudharsana Rao Ande, Emilia Wiechec, Lise Lotte Hansen, Sebastian Wesselborg, Marek Lo. Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis. Journal of cell science. vol 121. issue Pt 7. 2008-07-31. PMID:18354084. |
here, we show that cdk2, an s-phase cyclin-dependent kinase, is a novel target for akt during cell cycle progression and apoptosis. |
2008-07-31 |
2023-08-12 |
Not clear |
| Nizar J Bahlis, Yanling Miao, Omer N Koc, Kelvin Lee, Lawrence H Boise, Stanton L Gerso. N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leukemia & lymphoma. vol 46. issue 6. 2008-07-29. PMID:16019536. |
n-benzoylstaurosporine (pkc412) inhibits akt kinase inducing apoptosis in multiple myeloma cells. |
2008-07-29 |
2023-08-12 |
Not clear |
| Nizar J Bahlis, Yanling Miao, Omer N Koc, Kelvin Lee, Lawrence H Boise, Stanton L Gerso. N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leukemia & lymphoma. vol 46. issue 6. 2008-07-29. PMID:16019536. |
in summary, our results demonstrate that pkc412 suppresses akt kinase activation and induces apoptosis in myeloma cell lines, as well as primary resistant cells. |
2008-07-29 |
2023-08-12 |
Not clear |
| Weiguo Liu, David A Bloom, William G Cance, Elena V Kurenova, Vita M Golubovskaya, Steven N Hochwal. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. vol 29. issue 6. 2008-07-29. PMID:18263593. |
inhibition of both tyrosine kinase activities via a novel single small molecular inhibitor (tae 226), at low doses specific for fak and igf-1r, resulted in significant inhibition of cell viability, decrease in phosphorylation of erk and akt and increase in apoptosis accompanied by cleavage of poly (adp-ribose) polymerase (parp) and activation of caspase-3 in pancreatic cancer cells. |
2008-07-29 |
2023-08-12 |
human |
| Hongwei Shao, Yaohong Tan, Darwin Eton, Zhe Yang, M Georgina Uberti, Sen Li, Andrew Schulick, Hong Y. Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels. Stem cells (Dayton, Ohio). vol 26. issue 5. 2008-07-28. PMID:18308946. |
in vitro mono-treatment with either fluvastatin (100 nm) or sdf-1 (100 ng/ml) facilitated epc proliferation and migration, inhibited epc apoptosis, enhanced expression of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9), and increased akt phosphorylation and nitric oxide production. |
2008-07-28 |
2023-08-12 |
mouse |
| Teresa Puig, Alejandro Vázquez-Martín, Joana Relat, Jordi Pétriz, Javier A Menéndez, Rut Porta, Gemma Casals, Pedro F Marrero, Diego Haro, Joan Brunet, Ramon Colome. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast cancer research and treatment. vol 109. issue 3. 2008-07-24. PMID:17902053. |
treating cancer cells with egcg or c75 induced apoptosis and caused a decrease in the active forms of oncoprotein her2, akt and erk1/2 to a similar degree. |
2008-07-24 |
2023-08-12 |
human |
| Dong-Yun Shi, Hong-Lei Liu, Jeremy S Stern, Pei-Zhong Yu, Shan-Lin Li. Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway. FEBS letters. vol 582. issue 12. 2008-07-24. PMID:18435927. |
prior to cell apoptosis, pten was activated and its downstream target akt was inhibited. |
2008-07-24 |
2023-08-12 |
human |
| Chi Tarn, Lori Rink, Erin Merkel, Douglas Flieder, Harsh Pathak, Daphne Koumbi, Joseph R Testa, Burton Eisenberg, Margaret von Mehren, Andrew K Godwi. Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 24. 2008-07-18. PMID:18550829. |
inhibition of igf1r activity in vitro with nvp-aew541 or down-regulation of expression with siigf1r led to cytotoxicity and induced apoptosis in gist cell lines via akt and mapk signaling. |
2008-07-18 |
2023-08-12 |
Not clear |
| Dorrah Deeb, Xiaohua Gao, Scott A Dulchavsky, Subhash C Gauta. CDDO-Me inhibits proliferation, induces apoptosis, down-regulates Akt, mTOR, NF-kappaB and NF-kappaB-regulated antiapoptotic and proangiogenic proteins in TRAMP prostate cancer cells. Journal of experimental therapeutics & oncology. vol 7. issue 1. 2008-07-17. PMID:18472640. |
cddo-me inhibits proliferation, induces apoptosis, down-regulates akt, mtor, nf-kappab and nf-kappab-regulated antiapoptotic and proangiogenic proteins in tramp prostate cancer cells. |
2008-07-17 |
2023-08-12 |
mouse |
| Rajesh L Thangapazham, Neena Passi, Radha K Maheshwar. Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells. Cancer biology & therapy. vol 6. issue 12. 2008-07-16. PMID:18059161. |
for the first time we report the connection of beta-catenin and akt modulation by gtp and egcg as a possible mechanism for the induction of apoptosis in human breast cancer cells and also inhibition in their invasive capacity. |
2008-07-16 |
2023-08-12 |
human |
| Melanie van der Heijden, Amanda M G Versteilen, Pieter Sipkema, Geerten P van Nieuw Amerongen, Rene J P Musters, A B Johan Groenevel. Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 3. 2008-07-15. PMID:18165899. |
y-27632 treatment reduced i/r-induced apoptosis by 31% (p < 0.01) and maintained akt activity. |
2008-07-15 |
2023-08-12 |
human |
| Melanie van der Heijden, Amanda M G Versteilen, Pieter Sipkema, Geerten P van Nieuw Amerongen, Rene J P Musters, A B Johan Groenevel. Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 3. 2008-07-15. PMID:18165899. |
apoptosis and akt activity were inversely correlated (r (2) = 0.68, p < 0.05). |
2008-07-15 |
2023-08-12 |
human |
| Melanie van der Heijden, Amanda M G Versteilen, Pieter Sipkema, Geerten P van Nieuw Amerongen, Rene J P Musters, A B Johan Groenevel. Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 3. 2008-07-15. PMID:18165899. |
in conclusion, prevention of f-actin rearrangement by rho-kinase inhibition or by cytochalasind treatment attenuated i/r-induced endothelial cell apoptosis by maintaining pi3-kinase and akt activity. |
2008-07-15 |
2023-08-12 |
human |
| Letizia Penolazzi, Barbara Pocaterra, Elisa Tavanti, Elisabetta Lambertini, Fortunato Vesce, Roberto Gambari, Roberta Piv. Human osteoclasts differentiated from umbilical cord blood precursors are less prone to apoptotic stimuli than osteoclasts from peripheral blood. Apoptosis : an international journal on programmed cell death. vol 13. issue 4. 2008-07-15. PMID:18307044. |
the resistance to apoptosis seems to be not correlated with nf-kb, nfatc1, or eralpha expression level, or with the activation of erk and akt proteins. |
2008-07-15 |
2023-08-12 |
human |
| Tamara N Fitzgerald, Benjamin R Shepherd, Hidenori Asada, Desarom Teso, Akihito Muto, Tiffany Fancher, Jose M Pimiento, Stephen P Maloney, Alan Dardi. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. Journal of cellular physiology. vol 216. issue 2. 2008-07-08. PMID:18247368. |
laminar shear stress stimulates vascular smooth muscle cell apoptosis via the akt pathway. |
2008-07-08 |
2023-08-12 |
cattle |
| Tamara N Fitzgerald, Benjamin R Shepherd, Hidenori Asada, Desarom Teso, Akihito Muto, Tiffany Fancher, Jose M Pimiento, Stephen P Maloney, Alan Dardi. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. Journal of cellular physiology. vol 216. issue 2. 2008-07-08. PMID:18247368. |
cells transduced with constitutively-active akt had twofold decreased apoptosis (n = 3, p < 0.002). |
2008-07-08 |
2023-08-12 |
cattle |