| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Haluska, Joan M Carboni, Cynthia TenEyck, Ricardo M Attar, Xiaonan Hou, Chunrong Yu, Malvika Sagar, Tai W Wong, Marco M Gottardis, Charles Erlichma. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Molecular cancer therapeutics. vol 7. issue 9. 2008-10-22. PMID:18765823. |
furthermore, combination therapy decreased akt and extracellular signal-regulated kinase activation and increased biochemical and nuclear morphologic changes consistent with apoptosis compared with either agent alone. |
2008-10-22 |
2023-08-12 |
Not clear |
| Daruka Mahadevan, Garth Powis, Eugene A Mash, Benjamin George, Vijay M Gokhale, Shuxing Zhang, Kishore Shakalya, Lei Du-Cuny, Margareta Berggren, M Ahad Ali, Umasish Jana, Nathan Ihle, Sylvestor Moses, Chloe Franklin, Satya Narayan, Nikhil Shirahatti, Emmanuelle J Meuille. Discovery of a novel class of AKT pleckstrin homology domain inhibitors. Molecular cancer therapeutics. vol 7. issue 9. 2008-10-22. PMID:18790745. |
the compounds also inhibited akt in cells, induced apoptosis, and inhibited cancer cell proliferation. |
2008-10-22 |
2023-08-12 |
human |
| Vincenzo Cantaluppi, Luigi Biancone, Giuseppe Mauriello Romanazzi, Federico Figliolini, Silvia Beltramo, Francesco Galimi, Maria Gavina Camboni, Elisa Deriu, Piergiulio Conaldi, Antonella Bottelli, Viviana Orlandi, Maria Beatriz Herrera, Alfonso Pacitti, Giuseppe Paolo Segoloni, Giovanni Camuss. Macrophage stimulating protein may promote tubular regeneration after acute injury. Journal of the American Society of Nephrology : JASN. vol 19. issue 10. 2008-10-21. PMID:18614774. |
in vitro, msp stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating fas, mitochondrial proteins, akt, and extracellular signal-regulated kinase. |
2008-10-21 |
2023-08-12 |
mouse |
| Akito Nakamura, Mikihiko Naito, Takashi Tsuruo, Naoya Fujit. Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Molecular and cellular biology. vol 28. issue 19. 2008-10-20. PMID:18662999. |
freud-1/aki1 gene silencing decreased akt kinase activity, resulting in induction of apoptosis and increased sensitivity toward chemotherapeutic agents. |
2008-10-20 |
2023-08-12 |
Not clear |
| Kalpana K Reddy, Benjamin Lefkove, Lan Bo Chen, Baskaran Govindarajan, Arkaitz Carracedo, Guillermo Velasco, Carol O Carrillo, Sulochana S Bhandarkar, Michael J Owens, Fatima Mechta-Grigoriou, Jack L Arbise. The antidepressant sertraline downregulates Akt and has activity against melanoma cells. Pigment cell & melanoma research. vol 21. issue 4. 2008-10-20. PMID:18710373. |
one of the major reasons melanoma responds poorly to these modalities is constitutive expression of akt, which protects against apoptosis. |
2008-10-20 |
2023-08-12 |
mouse |
| Angela Zöllinger, Thorsten Stühmer, Manik Chatterjee, Stefan Gattenlöhner, Eugenia Haralambieva, Hans-Konrad Müller-Hermelink, Mindaugas Andrulis, Axel Greiner, Carmen Wesemeier, Jörg C Rath, Hermann Einsele, Ralf C Bargo. Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma. Blood. vol 112. issue 8. 2008-10-16. PMID:18635812. |
akt down-regulation with isoform-specific sirna constructs or with an akt1/2-specific pharmacologic inhibitor strongly induced apoptosis in approximately half of the primary mm samples analyzed. |
2008-10-16 |
2023-08-12 |
Not clear |
| Wim J van Blitterswijk, Marcel Verhei. Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects. Current pharmaceutical design. vol 14. issue 21. 2008-10-16. PMID:18691116. |
most important for their biological effect are the inhibition of phosphatidylcholine synthesis, the inhibition of the map-kinase/erk proliferative and phosphatidylinositol 3-kinase/ akt survival pathways and the stimulation of the stress-activated protein kinase/jnk pathway, which may lead to apoptosis in cancer cells. |
2008-10-16 |
2023-08-12 |
Not clear |
| Seigo Suzuki, Akihiro Naito, Takayuki Asano, Teresa T Evans, Shrikanth A G Reddy, Masahiro Higuch. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a. Cancer letters. vol 268. issue 1. 2008-10-14. PMID:18468786. |
constitutive activation of akt pathway inhibits tnf-induced apoptosis in mitochondrial dna-deficient human myelogenous leukemia ml-1a. |
2008-10-14 |
2023-08-12 |
human |
| Seigo Suzuki, Akihiro Naito, Takayuki Asano, Teresa T Evans, Shrikanth A G Reddy, Masahiro Higuch. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a. Cancer letters. vol 268. issue 1. 2008-10-14. PMID:18468786. |
to investigate how mitochondrial dna depletion inhibits apoptosis, we investigated akt. |
2008-10-14 |
2023-08-12 |
human |
| Seigo Suzuki, Akihiro Naito, Takayuki Asano, Teresa T Evans, Shrikanth A G Reddy, Masahiro Higuch. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a. Cancer letters. vol 268. issue 1. 2008-10-14. PMID:18468786. |
treatment of c19 with ly294002, which inhibits pi-3 kinase and inhibits akt, significantly increased apoptosis induction by tnf plus cycloheximide and eliminated phosphorylation of akt. |
2008-10-14 |
2023-08-12 |
human |
| Seigo Suzuki, Akihiro Naito, Takayuki Asano, Teresa T Evans, Shrikanth A G Reddy, Masahiro Higuch. Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a. Cancer letters. vol 268. issue 1. 2008-10-14. PMID:18468786. |
these results indicate that akt activation was induced by the depletion of mtdna and inhibited tnf-induced apoptosis. |
2008-10-14 |
2023-08-12 |
human |
| Sanjeev Banerjee, Yiwei Li, Zhiwei Wang, Fazlul H Sarka. Multi-targeted therapy of cancer by genistein. Cancer letters. vol 269. issue 2. 2008-10-14. PMID:18492603. |
it has been shown that genistein inhibits the activation of nf-kappab and akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. |
2008-10-14 |
2023-08-12 |
human |
| Liyun Cao, Daniela N Petrusca, Minati Satpathy, Harikrishna Nakshatri, Irina Petrache, Daniela Mate. Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling. Carcinogenesis. vol 29. issue 10. 2008-10-14. PMID:18667446. |
overexpression of the constitutively active p65 subunit of nf-kappab, but not constitutively active akt, rescued cells with diminished tg2 expression from cisplatin-induced apoptosis. |
2008-10-14 |
2023-08-12 |
Not clear |
| Diansheng Zhong, Xiuju Liu, Fadlo R Khuri, Shi-Yong Sun, Paula M Vertino, Wei Zho. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer research. vol 68. issue 18. 2008-10-14. PMID:18794113. |
because the phosphorylation of these sites by akt suppresses apoptosis, the requirement of lkb1 suggests that lkb1 may have an antiapoptotic role in tumor cells with constitutively active akt. |
2008-10-14 |
2023-08-12 |
Not clear |
| Diansheng Zhong, Xiuju Liu, Fadlo R Khuri, Shi-Yong Sun, Paula M Vertino, Wei Zho. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer research. vol 68. issue 18. 2008-10-14. PMID:18794113. |
indeed, we found that the suppression of lkb1 expression led to apoptosis in three cell lines in which akt is constitutively active but not in two cell lines without akt activation. |
2008-10-14 |
2023-08-12 |
Not clear |
| F Dean Jousan, Lilian J Oliveira, Peter J Hanse. Short-Term culture of in vitro produced bovine preimplantation embryos with insulin-like growth factor-i prevents heat shock-induced apoptosis through activation of the Phosphatidylinositol 3-Kinase/Akt pathway. Molecular reproduction and development. vol 75. issue 4. 2008-10-09. PMID:18161856. |
this action of igf-i to block heat shock-induced apoptosis was eliminated if embryos were cultured with either a phosphatidylinositol 3-kinase (pi3k) inhibitor (wortmannin) or an akt inhibitor (1l-6-hydroxymethyl-chiro-inositol 2-(r)-2-o-methyl-3-o-octadecylcarbonate). |
2008-10-09 |
2023-08-12 |
cattle |
| F Dean Jousan, Lilian J Oliveira, Peter J Hanse. Short-Term culture of in vitro produced bovine preimplantation embryos with insulin-like growth factor-i prevents heat shock-induced apoptosis through activation of the Phosphatidylinositol 3-Kinase/Akt pathway. Molecular reproduction and development. vol 75. issue 4. 2008-10-09. PMID:18161856. |
in conclusion, short-term treatment of embryos with igf-i can block induction of apoptosis caused by heat shock through signaling events requiring pi3k and akt. |
2008-10-09 |
2023-08-12 |
cattle |
| Anne Gingery, Elizabeth W Bradley, Larry Pederson, Ming Ruan, Nikki J Horwood, Merry Jo Oursle. TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Experimental cell research. vol 314. issue 15. 2008-10-07. PMID:18586026. |
adenoviral-mediated tak1 or mek inhibition eliminated tgf-beta-mediated kinase pathway activation and constitutively active akt expression overcame apoptosis induction following mek inhibition. |
2008-10-07 |
2023-08-12 |
Not clear |
| Julie L Wilsbacher, Qian Zhang, Lora A Tucker, Robert D Hubbard, George S Sheppard, Nwe Y Bamaung, Steve D Fidanze, Gary T Wang, Xiaoming Hu, Steven K Davidsen, Randy L Bell, Jieyi Wan. Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation. The Journal of biological chemistry. vol 283. issue 35. 2008-10-03. PMID:18559346. |
thus, targeting both igf-1r and erbb receptors simultaneously results in cell cycle arrest and apoptosis through combined effects on akt, cyclin d1, and bax activation. |
2008-10-03 |
2023-08-12 |
Not clear |
| Katharine D Grugan, Chunguang Ma, Seema Singhal, Nancy L Krett, Steven T Rose. Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma. The Journal of steroid biochemistry and molecular biology. vol 110. issue 3-5. 2008-10-01. PMID:18499442. |
the combination of dexamethasone (dex) and ly294002, wortmannin, triciribine, or akt inhibitor viii dramatically up regulated gilz levels and enhanced apoptosis. |
2008-10-01 |
2023-08-12 |
Not clear |