| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongna Fan, Ping Xie, Hua Zhang, Shubin Guo, Dongfeng Gu, Mingpeng She, HuiHua L. Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:18941896. |
we found that tpa treatment induced smc apoptosis through the rapid downregulation of akt phosphorylation. |
2008-12-15 |
2023-08-12 |
Not clear |
| Yongna Fan, Ping Xie, Hua Zhang, Shubin Guo, Dongfeng Gu, Mingpeng She, HuiHua L. Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:18941896. |
taken together, these results demonstrate that tpa triggers inactivation of akt, at least in part, through pkc and ubiquitin-proteasome degradation, thereby contributing to smc apoptosis. |
2008-12-15 |
2023-08-12 |
Not clear |
| Jung Hwa Oh, Tae-Jin Lee, Sang Hyun Kim, Yung Hyun Choi, Sang Han Lee, Jin Man Lee, Young-Ho Kim, Jong-Wook Park, Taeg Kyu Kwo. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:19002588. |
induction of apoptosis by withaferin a in human leukemia u937 cells through down-regulation of akt phosphorylation. |
2008-12-15 |
2023-08-12 |
human |
| Jung Hwa Oh, Tae-Jin Lee, Sang Hyun Kim, Yung Hyun Choi, Sang Han Lee, Jin Man Lee, Young-Ho Kim, Jong-Wook Park, Taeg Kyu Kwo. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:19002588. |
jnk and akt signal pathways play crucial roles in withaferin a-induced apoptosis in u937 cells. |
2008-12-15 |
2023-08-12 |
human |
| Jung Hwa Oh, Tae-Jin Lee, Sang Hyun Kim, Yung Hyun Choi, Sang Han Lee, Jin Man Lee, Young-Ho Kim, Jong-Wook Park, Taeg Kyu Kwo. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:19002588. |
furthermore, we have shown that overexpression of bcl-2 and active akt (myr-akt) in u937 cells inhibited the induction of apoptosis, activation of caspase-3, and plc-gamma1 cleavage by withaferin a. |
2008-12-15 |
2023-08-12 |
human |
| Jung Hwa Oh, Tae-Jin Lee, Sang Hyun Kim, Yung Hyun Choi, Sang Han Lee, Jin Man Lee, Young-Ho Kim, Jong-Wook Park, Taeg Kyu Kwo. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:19002588. |
taken together, our results indicated that the jnk and akt pathways and inhibition of nf-kappab activity were key regulators of apoptosis in response to withaferin a in human leukemia u937 cells. |
2008-12-15 |
2023-08-12 |
human |
| M Yuan, V Tomlinson, R Lara, D Holliday, C Chelala, T Harada, R Gangeswaran, C Manson-Bishop, P Smith, S A Danovi, O Pardo, T Crook, C A Mein, N R Lemoine, L J Jones, S Bas. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell death and differentiation. vol 15. issue 11. 2008-12-12. PMID:18617895. |
yes-associated protein (yap) has been shown to positively regulate p53 family members and to be negatively regulated by the akt proto-oncogene product in promoting apoptosis. |
2008-12-12 |
2023-08-12 |
mouse |
| R Castino, C Thepparit, N Bellio, D Murphy, C Isidor. Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression. Journal of neuroendocrinology. vol 20. issue 10. 2008-12-11. PMID:18673414. |
akt induces apoptosis in neuroblastoma cells expressing a c98x vasopressin mutant following autophagy suppression. |
2008-12-11 |
2023-08-12 |
Not clear |
| R Castino, C Thepparit, N Bellio, D Murphy, C Isidor. Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression. Journal of neuroendocrinology. vol 20. issue 10. 2008-12-11. PMID:18673414. |
in the present study, we investigated the role of the akt pro-survival signalling in the regulation of autophagy and of apoptosis linked with the handling of c98x avp. |
2008-12-11 |
2023-08-12 |
Not clear |
| Pier Luigi Tazzari, Giovanna Tabellini, Francesca Ricci, Veronica Papa, Roberta Bortul, Francesca Chiarini, Camilla Evangelisti, Giovanni Martinelli, Andrea Bontadini, Lucio Cocco, James A McCubrey, Alberto M Martell. Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer research. vol 68. issue 22. 2008-12-10. PMID:19010914. |
perifosine also synergized with trail in primary aml cells displaying constitutive activation of the akt pathway by inducing apoptosis, akt dephosphorylation, trail-r2 up-regulation, cflip-l and xiap down-regulation, and c-jun phosphorylation. |
2008-12-10 |
2023-08-12 |
human |
| Shoukang Zhu, Sarah Evans, Bin Yan, Thomas J Povsic, Victor Tapson, Pascal J Goldschmidt-Clermont, Chunming Don. Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. Circulation. vol 118. issue 21. 2008-12-09. PMID:18981303. |
transcriptional regulation of bim by foxo3a and akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. |
2008-12-09 |
2023-08-12 |
Not clear |
| Chang Hwan Park, Yoon Sook Kim, Young Hee Kim, Mee Young Choi, Ji Myong Yoo, Sang Soo Kang, Wan Sung Choi, Gyeong Jae Ch. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain research. vol 1234. 2008-12-08. PMID:18703031. |
in the present study, we investigated whether can is involved in neuronal cell apoptosis and akt dephosphorylation that occur during ischemic injury. |
2008-12-08 |
2023-08-12 |
rat |
| Chang Hwan Park, Yoon Sook Kim, Young Hee Kim, Mee Young Choi, Ji Myong Yoo, Sang Soo Kang, Wan Sung Choi, Gyeong Jae Ch. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain research. vol 1234. 2008-12-08. PMID:18703031. |
our results show that can cleavage reduced akt phosphorylation at thr308 and ser473, and led to apoptosis via dephosphorylation of the proapoptotic bcl-2 family member bad. |
2008-12-08 |
2023-08-12 |
rat |
| Chang Hwan Park, Yoon Sook Kim, Young Hee Kim, Mee Young Choi, Ji Myong Yoo, Sang Soo Kang, Wan Sung Choi, Gyeong Jae Ch. Calcineurin mediates AKT dephosphorylation in the ischemic rat retina. Brain research. vol 1234. 2008-12-08. PMID:18703031. |
these results indicate that can cleavage negatively regulates akt phosphorylation and is involved in retinal cell apoptosis after transient ischemia. |
2008-12-08 |
2023-08-12 |
rat |
| Huy Q Ta, Keena S Thomas, Randy S Schrecengost, Amy H Bouto. A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. Cancer research. vol 68. issue 21. 2008-12-08. PMID:18974122. |
based on these data, we propose that cas activates growth and survival pathways regulated by c-src, akt, and erk1/2 that lead to the inhibition of mitochondrial-mediated apoptosis in the presence of adriamycin. |
2008-12-08 |
2023-08-12 |
human |
| Dai-Wu Seo. Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18929542. |
active akt, a common mediator of cell survival signals, has been shown to inhibit apoptosis by attenuating activity of pro-apoptotic factors bad and caspase-9. |
2008-12-05 |
2023-08-12 |
human |
| Dai-Wu Seo. Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18929542. |
human prostate cancer lncap cells, known to contain constitutively activated akt as a result of a frame-shift mutation in pten, an inhibitor of pi-3k/akt pathway, were observed to be completely resistant to trail-induced apoptosis. |
2008-12-05 |
2023-08-12 |
human |
| Dai-Wu Seo. Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18929542. |
my data indicate that in addition to blocking bad and caspase-9 through akt, pi-3k also inhibits caspase-3 through up-regulating iaps, thereby attenuates apoptosis. |
2008-12-05 |
2023-08-12 |
human |
| Anne-Sophie Moreau, Xiaoying Jia, Christopher J Patterson, Aldo M Roccaro, Lian Xu, Antonio Sacco, Kelly O'Connor, Jacob Soumerai, Hai T Ngo, Evdoxia Hatjiharissi, Zachary R Hunter, Bryan Ciccarelli, Robert Manning, Irene M Ghobrial, Xavier Leleu, Steven P Treo. The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM secretion in Waldenstrom macroglobulinaemia. British journal of haematology. vol 142. issue 5. 2008-12-04. PMID:18537966. |
simvastatin-induced cytotoxicity was preceded by a decrease in akt (protein kinase b, pkb) and extracellular signal-regulated kinase (erk) mitogen-activated protein kinase (mapk) pathways at 18 h. in addition, simvastatin induced an increase in stress-activated protein kinase/c-jun n-terminal kinase (sapk/jnk) mapk followed by caspase-8, -9, -3 and poly(adp-ribose) polymerase (parp) cleavages at 18 h, leading to apoptosis. |
2008-12-04 |
2023-08-12 |
Not clear |
| Maria U Rømer, Lise Larsen, Hanne Offenberg, Nils Brünner, Ulrik A Lademan. Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway. Neoplasia (New York, N.Y.). vol 10. issue 10. 2008-12-04. PMID:18813358. |
more importantly, reintroduction of pai-1 expression in pai-1-deficient cells induced an increase in akt activity and protection against etoposide-induced apoptosis. |
2008-12-04 |
2023-08-12 |
Not clear |