| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia G Calvo, Claudia R Gentili, Ana Russo de Bolan. The early phase of programmed cell death in Caco-2 intestinal cells exposed to PTH. Journal of cellular biochemistry. vol 105. issue 4. 2009-01-12. PMID:18798227. |
taken together, our results suggest that, in caco-2 cells, the induction of apoptosis in response to pth is mediated by translocation of mitochondria to the perinuclear region, dephosphorylation of akt, dephosphorylation of bad and its movement to the mitochondria and subsequent release of cytochrome c and smac/diablo which result in activation of downstream caspase-3. |
2009-01-12 |
2023-08-12 |
human |
| S Onder Alpdogan, Sydney X Lu, Neel Patel, Suzanne McGoldrick, David Suh, Tulin Budak-Alpdogan, Odette M Smith, Jeremy Grubin, Christopher King, Gabrielle L Goldberg, Vanessa M Hubbard, Adam A Kochman, Marcel R M van den Brin. Rapidly proliferating CD44hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation. Blood. vol 112. issue 12. 2009-01-12. PMID:18815289. |
although this apoptosis was associated with a loss of bcl-2 and bcl-x(l) expression, allogeneic recipients of donor bm deficient in fas-, tumor necrosis factor-related apoptosis-inducing ligand (trail)- or bax-, or bm-overexpressing bcl-2 or akt showed no decrease in apoptosis of peripheral donor-derived t cells. |
2009-01-12 |
2023-08-12 |
Not clear |
| Gautam Sethi, Kwang Seok Ahn, Bokyung Sung, Ajaikumar B Kunnumakkara, Madan M Chaturvedi, Bharat B Aggarwa. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochemical pharmacology. vol 76. issue 11. 2009-01-09. PMID:18606397. |
sh-5, an akt inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by ikappabalpha kinase activation. |
2009-01-09 |
2023-08-12 |
Not clear |
| Gautam Sethi, Kwang Seok Ahn, Bokyung Sung, Ajaikumar B Kunnumakkara, Madan M Chaturvedi, Bharat B Aggarwa. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochemical pharmacology. vol 76. issue 11. 2009-01-09. PMID:18606397. |
thus, our results clearly demonstrate that inhibition of akt leads to potentiation of apoptosis through modulation of nf-kappab signaling. |
2009-01-09 |
2023-08-12 |
Not clear |
| Ji-Woo Kim, Mei-Hua Li, Jung-Hee Jang, Hye-Kyung Na, Na-Young Song, Chan Lee, Jeffrey A Johnson, Young-Joon Sur. 15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2. Biochemical pharmacology. vol 76. issue 11. 2009-01-09. PMID:18775681. |
15-deoxy-delta(12,14)-prostaglandin j(2) rescues pc12 cells from h2o2-induced apoptosis through nrf2-mediated upregulation of heme oxygenase-1: potential roles of akt and erk1/2. |
2009-01-09 |
2023-08-12 |
human |
| Jae-Woong Hwang, Ji-Won Jung, Yong-Soon Lee, Kyung-Sun Kan. Indole-3-carbinol prevents H(2)O(2)-induced inhibition of gap junctional intercellular communication by inactivation of PKB/Akt. The Journal of veterinary medical science. vol 70. issue 10. 2009-01-08. PMID:18981661. |
our results suggest that i3c might exert its dietary chemopreventive effects by interfering with the akt signaling pathway, which appears to be linked to modulating gjic, a cellular mechanisms regulating cell proliferation, differentiation and apoptosis. |
2009-01-08 |
2023-08-12 |
rat |
| Y Wang, M Mikhailova, S Bose, C-X Pan, R W deVere White, P M Ghos. Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. Oncogene. vol 27. issue 56. 2009-01-06. PMID:18776922. |
the effect of rapamycin on ar transcriptional activity was mediated by the phosphorylation of the serine/threonine kinase akt, which also partially mediated apoptosis induced by rapamycin and bicalutamide. |
2009-01-06 |
2023-08-12 |
Not clear |
| Veronique Nogueira, Youngkyu Park, Chia-Chen Chen, Pei-Zhang Xu, Mei-Ling Chen, Ivana Tonic, Terry Unterman, Nissim Ha. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer cell. vol 14. issue 6. 2009-01-06. PMID:19061837. |
akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. |
2009-01-06 |
2023-08-12 |
Not clear |
| Veronique Nogueira, Youngkyu Park, Chia-Chen Chen, Pei-Zhang Xu, Mei-Ling Chen, Ivana Tonic, Terry Unterman, Nissim Ha. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer cell. vol 14. issue 6. 2009-01-06. PMID:19061837. |
akt deficiency causes resistance to replicative senescence, to oxidative stress- and oncogenic ras-induced premature senescence, and to reactive oxygen species (ros)-mediated apoptosis. |
2009-01-06 |
2023-08-12 |
Not clear |
| Veronique Nogueira, Youngkyu Park, Chia-Chen Chen, Pei-Zhang Xu, Mei-Ling Chen, Ivana Tonic, Terry Unterman, Nissim Ha. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer cell. vol 14. issue 6. 2009-01-06. PMID:19061837. |
akt activation induces premature senescence and sensitizes cells to ros-mediated apoptosis by increasing intracellular ros through increased oxygen consumption and by inhibiting the expression of ros scavengers downstream of foxo, particularly sestrin 3. |
2009-01-06 |
2023-08-12 |
Not clear |
| Veronique Nogueira, Youngkyu Park, Chia-Chen Chen, Pei-Zhang Xu, Mei-Ling Chen, Ivana Tonic, Terry Unterman, Nissim Ha. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer cell. vol 14. issue 6. 2009-01-06. PMID:19061837. |
this uncovers an achilles' heel of akt, since in contrast to its ability to inhibit apoptosis induced by multiple apoptotic stimuli, akt could not inhibit ros-mediated apoptosis. |
2009-01-06 |
2023-08-12 |
Not clear |
| Veronique Nogueira, Youngkyu Park, Chia-Chen Chen, Pei-Zhang Xu, Mei-Ling Chen, Ivana Tonic, Terry Unterman, Nissim Ha. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer cell. vol 14. issue 6. 2009-01-06. PMID:19061837. |
furthermore, treatment with rapamycin that led to further akt activation and resistance to etoposide hypersensitized cancer cells to ros-mediated apoptosis. |
2009-01-06 |
2023-08-12 |
Not clear |
| Natalia Tkachuk, Julia Kiyan, Sergey Tkachuk, Roman Kiyan, Nelli Shushakova, Hermann Haller, Inna Dumle. Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus. The Biochemical journal. vol 415. issue 2. 2009-01-05. PMID:18564064. |
studies on the underlying signalling indicate that the erk1/2 (extracellular-signal-regulated kinase 1/2), akt and bad (bcl-2/bcl-x(l)-antagonist, causing cell death) protein were involved in regulation of apoptosis by upa in mcs. |
2009-01-05 |
2023-08-12 |
human |
| Claude A Piantadosi, Martha Sue Carraway, Abdelwahid Babiker, Hagir B Sulima. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circulation research. vol 103. issue 11. 2008-12-31. PMID:18845810. |
in cardiac cells, akt silencing exacerbates doxorubicin-induced apoptosis, and in vivo co rescues wild-type but not akt1(-/-) mice from doxorubicin cardiomyopathy. |
2008-12-31 |
2023-08-12 |
mouse |
| Meng Qiao, Shijie Sheng, Arthur B Parde. Metastasis and AKT activation. Cell cycle (Georgetown, Tex.). vol 7. issue 19. 2008-12-24. PMID:18818526. |
the activated akt kinase is necessary for many events of the metastatic pathway including escape of cells from the tumor's environment, into and then out of the circulation, activation of proliferation, blockage of apoptosis, and activation of angiogenesis. |
2008-12-24 |
2023-08-12 |
Not clear |
| Xia Qian, Jing Li, Jianhua Ding, Zhiyuan Wang, Lei Duan, Gang H. Glibenclamide exerts an antitumor activity through reactive oxygen species-c-jun NH2-terminal kinase pathway in human gastric cancer cell line MGC-803. Biochemical pharmacology. vol 76. issue 12. 2008-12-24. PMID:18840412. |
furthermore, glibenclamide greatly decreased the cellular viability, induced apoptosis and inhibited akt activation in wild-type mouse embryonic fibroblast (mef) cells but not in jnk1-/- or jnk2-/- mef cells. |
2008-12-24 |
2023-08-12 |
mouse |
| Adrian Harold Box, Carol Yuen, Dragana Ponjevic, Gordon H Fick, Douglas James Demetric. Signaling and apoptosis differences between severe hypoxia and desferoxamine treatment of human epithelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 86. issue 5. 2008-12-16. PMID:18923544. |
hypoxia-induced apoptosis in hela was associated with decreases of both phospho-s473- and -t308-akt and loss of akt function, whereas hep3b cells were resistant to hypoxia-induced apoptosis and did not lose phospho-akt or akt function. |
2008-12-16 |
2023-08-12 |
human |
| Adrian Harold Box, Carol Yuen, Dragana Ponjevic, Gordon H Fick, Douglas James Demetric. Signaling and apoptosis differences between severe hypoxia and desferoxamine treatment of human epithelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 86. issue 5. 2008-12-16. PMID:18923544. |
interestingly, in these cell lines, there was a complete correlation between loss of phospho-akt and (or) total akt, and susceptibility to hypoxia-induced apoptosis. |
2008-12-16 |
2023-08-12 |
human |
| Adrian Harold Box, Carol Yuen, Dragana Ponjevic, Gordon H Fick, Douglas James Demetric. Signaling and apoptosis differences between severe hypoxia and desferoxamine treatment of human epithelial cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 86. issue 5. 2008-12-16. PMID:18923544. |
our data suggests a model in which regulated loss of active akt at a precise time point in hypoxia may be associated with apoptosis in susceptible cells. |
2008-12-16 |
2023-08-12 |
human |
| Yongna Fan, Ping Xie, Hua Zhang, Shubin Guo, Dongfeng Gu, Mingpeng She, HuiHua L. Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. Apoptosis : an international journal on programmed cell death. vol 13. issue 12. 2008-12-15. PMID:18941896. |
proteasome-dependent inactivation of akt is essential for 12-o-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. |
2008-12-15 |
2023-08-12 |
Not clear |