| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianfeng Chen, Yum-Shing Won. Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation. Journal of agricultural and food chemistry. vol 56. issue 22. 2009-04-03. PMID:18959417. |
selenocystine induces s-phase arrest and apoptosis in human breast adenocarcinoma mcf-7 cells by modulating erk and akt phosphorylation. |
2009-04-03 |
2023-08-12 |
human |
| Tianfeng Chen, Yum-Shing Won. Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation. Journal of agricultural and food chemistry. vol 56. issue 22. 2009-04-03. PMID:18959417. |
inhibitors of erk (u0126) and akt (ly294002), but not jnk (sp600125) and p38 mapk (sb203580), suppressed sec-induced s-phase arrest and apoptosis in mcf-7 cells. |
2009-04-03 |
2023-08-12 |
human |
| Dana S Levy, Jason A Kahana, Rakesh Kuma. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. vol 113. issue 8. 2009-04-01. PMID:19064730. |
akt inhibitor, gsk690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. |
2009-04-01 |
2023-08-12 |
mouse |
| Dana S Levy, Jason A Kahana, Rakesh Kuma. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. vol 113. issue 8. 2009-04-01. PMID:19064730. |
consistent with the role of akt in cell survival, gsk690693 also induced apoptosis in sensitive all cell lines. |
2009-04-01 |
2023-08-12 |
mouse |
| Yuzhu Zheng, Ying-Lan Zhao, Xiaoqiang Deng, Shengyong Yang, Yongqiu Mao, Zhengguang Li, Peidu Jiang, Xia Zhao, Yuquan We. Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis. Cancer investigation. vol 27. issue 3. 2009-04-01. PMID:19194831. |
this effect was associated with apoptosis induction and decreased level of phosphorylated p42/44 mitogen-activated protein kinase and phosphorylated akt. |
2009-04-01 |
2023-08-12 |
mouse |
| Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Andy Tseng, Joan P Stabila, Bethany G McGonnigal, Ting C Zhao, James F Padbury, Yi-Tang Tsen. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. vol 149. issue 12. 2009-03-31. PMID:18719028. |
under physiological glucose environment (100 mg/dl), beta2ar stimulation prevented doxorubicin-induced apoptosis, which was attenuated by cotreatment with wortmannin, a phosphoinositide 3-kinase (pi3k) inhibitor, or transfection of a dominant-negative akt. |
2009-03-31 |
2023-08-12 |
Not clear |
| Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Andy Tseng, Joan P Stabila, Bethany G McGonnigal, Ting C Zhao, James F Padbury, Yi-Tang Tsen. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. vol 149. issue 12. 2009-03-31. PMID:18719028. |
these data provide in vitro evidence supporting a signaling cascade by which beta2ar exerts a protective effect against doxorubicin-induced apoptosis via sequential involvement of galphai, gbetagamma, src, pdgfr, pi3k, and akt. |
2009-03-31 |
2023-08-12 |
Not clear |
| Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi, Hsiou-Chi Lio. BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. Cell research. vol 19. issue 2. 2009-03-30. PMID:18781138. |
restoration of akt activity using a constitutive form of akt or reduction of pten to a level comparable with that seen in mature b cells rescues immature b cells from bcr-induced apoptosis. |
2009-03-30 |
2023-08-12 |
Not clear |
| Sungman Park, Jianping Guo, Donghwa Kim, Jin Q Chen. Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway. The Journal of biological chemistry. vol 284. issue 4. 2009-03-23. PMID:19056725. |
furthermore, constitutively active akt largely attenuated 24p3 expression and apoptosis in response to il-3 withdrawal. |
2009-03-23 |
2023-08-12 |
Not clear |
| Sinead Walsh, Catherine Gill, Amanda O'Neill, John M Fitzpatrick, R William G Watso. Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation. International journal of cancer. vol 124. issue 8. 2009-03-19. PMID:19142871. |
hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via akt activation. |
2009-03-19 |
2023-08-12 |
Not clear |
| Fabienne T Schulthess, Federico Paroni, Nadine S Sauter, Luan Shu, Pascale Ribaux, Leena Haataja, Robert M Strieter, Jose Oberholzer, Charles C King, Kathrin Maedle. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell metabolism. vol 9. issue 2. 2009-03-18. PMID:19187771. |
cxcl10 induced sustained activation of akt, jnk, and cleavage of p21-activated protein kinase 2 (pak-2), switching akt signals from proliferation to apoptosis. |
2009-03-18 |
2023-08-12 |
human |
| Jose Greenspon, Ruiyun Li, Lan Xiao, Jaladanki N Rao, Bernard S Marasa, Eric D Strauch, Jian-Ying Wang, Douglas J Turne. Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Digestive diseases and sciences. vol 54. issue 3. 2009-03-12. PMID:18654850. |
sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the akt signaling pathway. |
2009-03-12 |
2023-08-12 |
Not clear |
| Cheng-Gang Zou, Xiu-Zhen Cao, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xian-Yong Liu, Yan Zhang, Ke-Qin Zhan. The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I. Endocrinology. vol 150. issue 1. 2009-03-12. PMID:18801901. |
igf-i inhibited er stress-induced apoptosis by restoring the phosphorylation level of akt. |
2009-03-12 |
2023-08-12 |
Not clear |
| Cheng-Gang Zou, Xiu-Zhen Cao, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xian-Yong Liu, Yan Zhang, Ke-Qin Zhan. The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I. Endocrinology. vol 150. issue 1. 2009-03-12. PMID:18801901. |
the dephosphorylation of akt resulted in increased expression of a proapoptotic protein, p53 up-regulated modulator of apoptosis (puma), in a forkhead box o3a-dependent manner. |
2009-03-12 |
2023-08-12 |
Not clear |
| Konrad Kleszczyński, Piotr Stepnowski, Andrzej C Składanowsk. Mechanism of cytotoxic action of perfluorinated acids II. Disruption of mitochondrial bioenergetics. Toxicology and applied pharmacology. vol 235. issue 2. 2009-03-12. PMID:19135466. |
synchronized removal of the phosphorylated state of akt, erk1/2 and pkcdelta/theta kinases by cf(10) suggests presence of concerted action to uninhibit bad protein activation and a cascade of intrinsic pathway of apoptosis. |
2009-03-12 |
2023-08-12 |
human |
| Mohini Rajasagi, Mario Vitacolonna, Bojan Benjak, Rachid Marhaba, Margot Zölle. CD44 promotes progenitor homing into the thymus and T cell maturation. Journal of leukocyte biology. vol 85. issue 2. 2009-03-11. PMID:18955544. |
cd44v6-induced apoptosis resistance, most strong in double-negative (dn) thymocytes, is accompanied by akt activation. |
2009-03-11 |
2023-08-12 |
Not clear |
| Kang Fang, Shih-Ping Chen, Chia-Wei Lin, Wan-Chun Cheng, Hwei-Tien Huan. Ellipticine-induced apoptosis depends on Akt translocation and signaling in lung epithelial cancer cells. Lung cancer (Amsterdam, Netherlands). vol 63. issue 2. 2009-03-10. PMID:18619705. |
ellipticine-induced apoptosis depends on akt translocation and signaling in lung epithelial cancer cells. |
2009-03-10 |
2023-08-12 |
human |
| Xiu Feng Hu, Jie Li, Scott Vandervalk, Zeping Wang, Nancy S Magnuson, Pei Xiang Xin. PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. The Journal of clinical investigation. vol 119. issue 2. 2009-03-10. PMID:19147983. |
pim-1-specific mab suppresses human and mouse tumor growth by decreasing pim-1 levels, reducing akt phosphorylation, and activating apoptosis. |
2009-03-10 |
2023-08-12 |
mouse |
| Maria H V M Jacob, Daiane da R Janner, Adriane Belló-Klein, Susana F Llesuy, Maria F M Ribeir. Dehydroepiandrosterone modulates antioxidant enzymes and Akt signaling in healthy Wistar rat hearts. The Journal of steroid biochemistry and molecular biology. vol 112. issue 1-3. 2009-03-06. PMID:18848627. |
akt signaling pathway is one of the anti-proliferative mechanisms of dhea (y. jiang, t. miyazaki, a. honda, t. hirayama, s. yoshida, n. tanaka, y. matsuzaki, apoptosis and inhibition of the phosphatidylinositol 3-kinase/akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone, j. gastroenterol. |
2009-03-06 |
2023-08-12 |
rat |
| Piro Lito, Bryan D Mets, Daniel M Appledorn, Veronica M Maher, J Justin McCormic. Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. The Journal of biological chemistry. vol 284. issue 2. 2009-03-06. PMID:19008219. |
silencing spry2 in this context resulted in increased apoptosis, associated with decreased akt activation and decreased phosphorylation of hdm2 at ser-166, which has been shown to stabilize hdm2. |
2009-03-06 |
2023-08-12 |
human |