| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Piro Lito, Bryan D Mets, Daniel M Appledorn, Veronica M Maher, J Justin McCormic. Sprouty 2 regulates DNA damage-induced apoptosis in Ras-transformed human fibroblasts. The Journal of biological chemistry. vol 284. issue 2. 2009-03-06. PMID:19008219. |
together, these data show that spry2 inhibits apoptosis in response to dna damage by regulating akt, hdm2, and p53, by a process mediated partly by rac1. |
2009-03-06 |
2023-08-12 |
human |
| Mariana G García, Laura D Alaniz, Rosalía I Cordo Russo, Elida Alvarez, Silvia E Hajo. PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines. Leukemia research. vol 33. issue 2. 2009-02-27. PMID:18640717. |
pi3k/akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated akt (p-akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or ly294002 improved apoptosis in the resistant cell lines. |
2009-02-27 |
2023-08-12 |
Not clear |
| Jasleen Shant, Kunrong Cheng, Bernard S Marasa, Jian-Ying Wang, Jean-Pierre Raufma. Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Experimental cell research. vol 315. issue 3. 2009-02-27. PMID:19056378. |
likewise, transfection with mutant akt and treatment with a chemical inhibitor of akt attenuated effects of dct on nf-kappab transcriptional activity and tnf-alpha-induced apoptosis. |
2009-02-27 |
2023-08-12 |
human |
| Jasleen Shant, Kunrong Cheng, Bernard S Marasa, Jian-Ying Wang, Jean-Pierre Raufma. Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Experimental cell research. vol 315. issue 3. 2009-02-27. PMID:19056378. |
chemical inhibitors of akt and nf-kappab activation also attenuated dct-induced rescue of h508 cells from ultraviolet radiation-induced apoptosis. |
2009-02-27 |
2023-08-12 |
human |
| Kannagi Chinnakannu, Di Chen, Yiwei Li, Zhiwei Wang, Q Ping Dou, G Prem Veer Reddy, Fazlul H Sarka. Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells. Journal of cellular physiology. vol 219. issue 1. 2009-02-27. PMID:19062173. |
recently, we have reported that a formulated dim (b-dim) induced apoptosis and inhibited growth, angiogenesis, and invasion of prostate cancer cells by regulating akt, nf-kappab, vegf and the androgen receptor (ar) signaling pathway. |
2009-02-27 |
2023-08-12 |
Not clear |
| E Petrangeli, L Lenti, B Buchetti, P Chinzari, P Sale, L Salvatori, L Ravenna, E Lococo, E Morgante, A Russo, L Frati, F Di Silverio, M A Russ. Lipido-sterolic extract of Serenoa repens (LSESr, Permixon) treatment affects human prostate cancer cell membrane organization. Journal of cellular physiology. vol 219. issue 1. 2009-02-27. PMID:19067321. |
the reduction in cholesterol content could be responsible for both membrane raft disruption and redistribution of signaling complexes, allowing for a decrease of pip2 levels, reduction of akt phosphorylation and apoptosis induction. |
2009-02-27 |
2023-08-12 |
human |
| Ivana Stanic', Annalisa Facchini, Rosa Maria Borzì, Claudio Stefanelli, Flavio Flamign. The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines. Journal of cellular physiology. vol 219. issue 1. 2009-02-27. PMID:19097065. |
denspm/chx-induced apoptosis was associated with changes in the amount or activation of signalling kinases, akt and mapks, and increased uptake of denspm. |
2009-02-27 |
2023-08-12 |
human |
| Tomohito Hirao, Yoshishige Urata, Kan Kageyama, Midori Ikezaki, Miho Kawakatsu, Michiko Matsuse, Takayuki Matsuo, Masahiro Akishita, Izumi Nagata, Takahito Kond. Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling. Free radical research. vol 42. issue 11-12. 2009-02-26. PMID:19031317. |
the results suggested that dhea increases the sensitivity of cells to gamma-ray irradiation by inducing apoptosis and cell cycle arrest through gsh-dependent regulation of the reduced form of pp2a to down-regulate the akt signalling pathway. |
2009-02-26 |
2023-08-12 |
human |
| Joe-Lin du Toit-Kohn, Louise Louw, Anna-Mart Engelbrech. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. The Journal of nutritional biochemistry. vol 20. issue 2. 2009-02-25. PMID:18479896. |
dha supplementation significantly suppressed akt phosphorylation, which also correlated with decreased cell viability and increased apoptosis in caco2 cells. |
2009-02-25 |
2023-08-12 |
Not clear |
| Joe-Lin du Toit-Kohn, Louise Louw, Anna-Mart Engelbrech. Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways. The Journal of nutritional biochemistry. vol 20. issue 2. 2009-02-25. PMID:18479896. |
dha might thus exert its beneficial effects by means of increased apoptosis and suppression of the important survival-related kinase, akt. |
2009-02-25 |
2023-08-12 |
Not clear |
| Venkateswara Rao Gogineni, Odysseas Kargiotis, Jeffrey D Klopfenstein, Meena Gujrati, Dzung H Dinh, Jasti S Ra. RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells. International journal of oncology. vol 34. issue 1. 2009-02-24. PMID:19082492. |
rnai-mediated downregulation of radiation-induced mmp-9 leads to apoptosis via activation of erk and akt in iomm-lee cells. |
2009-02-24 |
2023-08-12 |
Not clear |
| Shanhong Ling, Ruizhi Luo, Aozhi Dai, Zhixin Guo, Ruoling Guo, Paul A Komesarof. A pharmaceutical preparation of Salvia miltiorrhiza protects cardiac myocytes from tumor necrosis factor-induced apoptosis and reduces angiotensin II-stimulated collagen synthesis in fibroblasts. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 16. issue 1. 2009-02-23. PMID:19010649. |
it was found that (1) at therapeutic (50 microg/ml) and double therapeutic (100 microg/ml) concentrations, cp did not significantly affect normal dna synthesis and cell growth in these cardiac cells, while at higher (over 4-fold therapeutic) concentrations (200-800 microg/ml), cp decreased dna synthesis and cell growth and increased cell death; (2) cp treatment (50 microg/ml) significantly inhibited tnfalpha-induced apoptosis in myocytes, with 12.3+/-1.46% cells being apoptosis in cp treatment group and 37.0+/-7.34% in the control (p<0.01), and simultaneously, expression of activated (phosphorylated) akt protein was increased by about 2 folds in the cp-treated cells; and (3) in cultured fibroblasts, cp significantly reduced aii-induced collagen synthesis in a concentration-dependent manner (by approximately 50% and approximately 90% reduction of aii-induced collagen synthesis at 50 and 100 microg/ml, respectively). |
2009-02-23 |
2023-08-12 |
rat |
| Hiroshi Yagi, Fusanori Yotsumoto, Kenzo Sonoda, Masahide Kuroki, Eisuke Mekada, Shingo Miyamot. Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. International journal of cancer. vol 124. issue 6. 2009-02-23. PMID:19048624. |
the combination of paclitaxel with crm197 had an inhibitory effect on cell proliferation and enhanced apoptosis via the inhibition of erk and akt activation and the stimulation of p38 and jnk activation. |
2009-02-23 |
2023-08-12 |
mouse |
| Tatsuya Kawase, Rieko Ohki, Tatsuhiro Shibata, Shuichi Tsutsumi, Naoko Kamimura, Johji Inazawa, Tsutomu Ohta, Hitoshi Ichikawa, Hiroyuki Aburatani, Fumio Tashiro, Yoichi Tay. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell. vol 136. issue 3. 2009-02-23. PMID:19203586. |
ablation of endogenous phlda3 results in enhanced akt activity and decrease of p53-dependent apoptosis. |
2009-02-23 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
palmitate treatment of several cell lines in vitro results in apoptosis and inhibits protein kinase b (akt) activity in response to insulin. |
2009-02-11 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
these data show that palmitate induces bax-mediated apoptosis in c(2)c(12) myotubes and that this effect corresponds to reductions in akt(ser473) phosphorylation. |
2009-02-11 |
2023-08-12 |
Not clear |
| Cynthia A Warren, Kimberly J Paulhill, Laurie A Davidson, Joanne R Lupton, Stella S Taddeo, Mee Young Hong, Raymond J Carroll, Robert S Chapkin, Nancy D Turne. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. The Journal of nutrition. vol 139. issue 1. 2009-02-11. PMID:19056647. |
the colon was resected 4 wk after the last aom injection and samples were used to determine high multiplicity ac foci (hmacf; foci with >4 ac) number, colonocyte proliferation and apoptosis by immunohistochemistry, expression of pi 3-kinase (p85 and p85alpha subunits) and akt by immunoblotting, and cox-1, cox-2, and inos expression by real time rt-pcr. |
2009-02-11 |
2023-08-12 |
rat |
| Máté Maus, Dávid Medgyesi, Dorottya Kövesdi, Dorottya Csuka, Gábor Koncz, Gabriella Sárma. Grb2 associated binder 2 couples B-cell receptor to cell survival. Cellular signalling. vol 21. issue 2. 2009-02-10. PMID:18950707. |
accordingly to the elevated akt phosphorylation, overexpression of wild-type gab2 in a20 cells suppressed fas-mediated apoptosis, and enhanced bcr-mediated rescue from fas-induced cell death. |
2009-02-10 |
2023-08-12 |
Not clear |
| Kumudha Balakrishnan, Jan A Burger, William G Wierda, Varsha Gandh. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood. vol 113. issue 1. 2009-02-06. PMID:18836097. |
stromal cells expressed undetectable levels of antiapoptotic but high levels of activated erk and akt proteins and had low or no apoptosis with at-101. |
2009-02-06 |
2023-08-12 |
Not clear |
| Michela Garofalo, Cristina Quintavalle, Ciro Zanca, Assunta De Rienzo, Giulia Romano, Mario Acunzo, Loredana Puca, Mariarosaria Incoronato, Carlo M Croce, Gerolama Condorell. Akt regulates drug-induced cell death through Bcl-w downregulation. PloS one. vol 3. issue 12. 2009-02-05. PMID:19114998. |
akt is a serine threonine kinase with a major role in transducing survival signals and regulating proteins involved in apoptosis. |
2009-02-05 |
2023-08-12 |
human |