| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jau-Chen Lin, Shuenn-Chen Yang, Tse-Ming Hong, Sung-Liang Yu, Qian Shi, Linyi Wei, Hsuan-Yu Chen, Pan-Chyr Yang, Kuo-Hsiung Le. Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways. Journal of medicinal chemistry. vol 52. issue 7. 2009-04-28. PMID:19284764. |
we conclude that pbt-1 induces cell cycle g2/m arrest and apoptosis by inactivating akt and by inhibiting the nf-kappab signaling pathway. |
2009-04-28 |
2023-08-12 |
Not clear |
| Ramadoss Sivakumar, Hironori Koga, Karuppaiyah Selvendiran, Michiko Maeyama, Takato Ueno, Michio Sat. Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. International journal of oncology. vol 34. issue 2. 2009-04-27. PMID:19148466. |
pp2 just attenuated the phosphorylation in akt, not through igf-ir inactivation, leading to apoptosis in slug-mdck cells. |
2009-04-27 |
2023-08-12 |
Not clear |
| Ramadoss Sivakumar, Hironori Koga, Karuppaiyah Selvendiran, Michiko Maeyama, Takato Ueno, Michio Sat. Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. International journal of oncology. vol 34. issue 2. 2009-04-27. PMID:19148466. |
of interest, the inactivation of akt by igfbp-3 was dramatically enhanced in combination with the use of pp2, resulting in a significant apoptosis in slug-mdck cells. |
2009-04-27 |
2023-08-12 |
Not clear |
| Aron Cseh, Beáta Szebeni, Balázs Szalay, Barna Vásárhely. [Akt enzyme: new therapeutic target in cancer and diabetes?]. Orvosi hetilap. vol 150. issue 8. 2009-04-24. PMID:19218147. |
proteins responsible for the regulation of apoptosis are therapeutic targets; these include the akt enzyme. |
2009-04-24 |
2023-08-12 |
Not clear |
| Aron Cseh, Beáta Szebeni, Balázs Szalay, Barna Vásárhely. [Akt enzyme: new therapeutic target in cancer and diabetes?]. Orvosi hetilap. vol 150. issue 8. 2009-04-24. PMID:19218147. |
akt is also a factor in the pathomechanism of diabetes as it determines beta-cell apoptosis of langerhans islets and insulin sensitivity of the cells. |
2009-04-24 |
2023-08-12 |
Not clear |
| Tracie A Seimon, Yibin Wang, Seongah Han, Takafumi Senokuchi, Dorien M Schrijvers, George Kuriakose, Alan R Tall, Ira A Taba. Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. The Journal of clinical investigation. vol 119. issue 4. 2009-04-24. PMID:19287091. |
in addition, inhibition of akt enhanced er stress-induced macrophage apoptosis, and expression of a constitutively active myristoylated akt blocked the enhancement of er stress-induced apoptosis that occurred with p38 inhibition in cultured cells. |
2009-04-24 |
2023-08-12 |
mouse |
| Qiaoling Sun, Yuanyuan Zheng, Qiuyan Liu, Xuetao Ca. Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation. International immunopharmacology. vol 8. issue 13-14. 2009-04-23. PMID:18789402. |
here we report that rapamycin can reverse tlr4-triggered resistance of colon cancer cells to oxaloplatin- or doxorubicin-induced apoptosis by disrupting akt and subsequent nf-kappab activation, suppressing upregulation of anti-apoptotic protein bcl-xl. |
2009-04-23 |
2023-08-12 |
Not clear |
| Qiaoling Sun, Yuanyuan Zheng, Qiuyan Liu, Xuetao Ca. Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation. International immunopharmacology. vol 8. issue 13-14. 2009-04-23. PMID:18789402. |
furthermore, akt/nf-kappab inhibitors also reverses the apoptosis resistance, accordingly, akt constitutive activation rescues nf-kappab activation and bcl-xl expression in rapamycin-pretreated colon cancer cells, suggesting akt disruption is critical to the process. |
2009-04-23 |
2023-08-12 |
Not clear |
| Hyun Sun Cho, Seung Hee Chang, Youn Sun Chung, Ji Young Shin, Sung Jin Park, Eun Sun Lee, Soon Kyung Hwang, Jung Taek Kwon, Arash Minai Tehrani, Minah Woo, Mi Sook Noh, Huda Hanifah, Hua Jin, Cheng Xiong Xu, Myung Haing Ch. Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. Journal of veterinary science. vol 10. issue 1. 2009-04-21. PMID:19255520. |
the inhibition of erk using pd98059 synergistically enhanced the tet-induced apoptosis of a549 cells whereas the inhibition of akt using ly294002 had a less significant effect. |
2009-04-21 |
2023-08-12 |
human |
| Hyun Sun Cho, Seung Hee Chang, Youn Sun Chung, Ji Young Shin, Sung Jin Park, Eun Sun Lee, Soon Kyung Hwang, Jung Taek Kwon, Arash Minai Tehrani, Minah Woo, Mi Sook Noh, Huda Hanifah, Hua Jin, Cheng Xiong Xu, Myung Haing Ch. Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. Journal of veterinary science. vol 10. issue 1. 2009-04-21. PMID:19255520. |
taken together, our results suggest that tet: i) selectively inhibits the proliferation of lung cancer cells by blocking akt activation and ii) increases apoptosis by inhibiting erk. |
2009-04-21 |
2023-08-12 |
human |
| Qin Chen, Li Dong, Lian Wang, Lina Kang, Biao X. Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2. Biochemical and biophysical research communications. vol 381. issue 2. 2009-04-20. PMID:19232321. |
apoptosis, migration, and tube formation assays were used to evaluate epc function including capacity for vasculogenesis, and expression of the receptor for ages (rage), akt, endothelial nitric oxide synthase (enos), and cycloxygenase-2 (cox-2) were determined. |
2009-04-20 |
2023-08-12 |
human |
| X-R Wen, C Li, Y-Y Zong, C-Z Yu, J Xu, D Han, G-Y Zhan. Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Neuroscience. vol 156. issue 3. 2009-04-14. PMID:18773943. |
dual inhibitory roles of geldanamycin on the c-jun nh2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of akt in ischemic brain injury. |
2009-04-14 |
2023-08-12 |
rat |
| Veronica Vella, Cinzia Puppin, Giuseppe Damante, Riccardo Vigneri, Mariangela Sanfilippo, Paolo Vigneri, Gianluca Tell, Francesco Frasc. DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells. International journal of cancer. vol 124. issue 11. 2009-04-14. PMID:19173293. |
this effect of deltanp73alpha resulted in increased thyroid cancer cell proliferation and reduced apoptosis and was reverted by the pi3-kinase inhibitor ly294002, indicating the role of akt pathway in this effect. |
2009-04-14 |
2023-08-12 |
Not clear |
| Benedetta Mattioli, Luciana Giordani, Maria Giovanna Quaranta, Marina Vior. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. FEBS letters. vol 583. issue 7. 2009-04-14. PMID:19250936. |
here we found that leptin protects dcs from spontaneous, uvb and h(2)o(2)-induced apoptosis, by triggering the activation of nuclear factor-kappa b (nf-kappab) and a parallel up-regulation of bcl-2 and bcl-xl gene expression and akt activation. |
2009-04-14 |
2023-08-12 |
human |
| Benedetta Mattioli, Luciana Giordani, Maria Giovanna Quaranta, Marina Vior. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. FEBS letters. vol 583. issue 7. 2009-04-14. PMID:19250936. |
we found that leptin activates the pi3k-akt signaling pathway as demonstrated by the suppression of the effect of leptin on dc survival by wortmannin and api-2, which suppress the leptin-induced activation of akt, nf-kappab, bcl-2, bcl-xl and protection from apoptosis. |
2009-04-14 |
2023-08-12 |
human |
| Anuradha Dhanasekaran, Sreedhar Bodiga, Stephanie Gruenloh, Ying Gao, Laurel Dunn, John R Falck, J Noelle Buonaccorsi, Meetha Medhora, Elizabeth R Jacob. 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. American journal of physiology. Heart and circulatory physiology. vol 296. issue 3. 2009-04-09. PMID:19136601. |
these data suggest 20-hete-associated protection from apoptosis in bpaecs required activation of pi3-kinase and akt and generation of ros. |
2009-04-09 |
2023-08-12 |
mouse |
| Hideshi Okada, Genzou Takemura, Ken-Ichiro Kosai, Akiko Tsujimoto, Masayasu Esaki, Tomoyuki Takahashi, Satoshi Nagano, Hiromitsu Kanamori, Shusaku Miyata, Yiwen Li, Takamasa Ohno, Rumi Maruyama, Atsushi Ogino, Longhu Li, Munehiro Nakagawa, Kenshi Nagashima, Takako Fujiwara, Hisayoshi Fujiwara, Shinya Minatoguch. Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure. American journal of physiology. Heart and circulatory physiology. vol 296. issue 3. 2009-04-09. PMID:19151252. |
in vitro study using cultured myofibroblasts derived from the infarct tissue revealed that g-csf increased proliferating activity of those cells accompanying activation of akt and signal transducer and activator of transcription 3, while accelerating fas-mediated apoptosis with increasing bax-to-bcl-2 ratio. |
2009-04-09 |
2023-08-12 |
mouse |
| Yan Xu, Xiao-Yu Hou, Yong Liu, Yan-Yan Zon. Different protection of K252a and N-acetyl-L-cysteine against amyloid-beta peptide-induced cortical neuron apoptosis involving inhibition of MLK3-MKK7-JNK3 signal cascades. Journal of neuroscience research. vol 87. issue 4. 2009-04-08. PMID:18951497. |
the neuroprotective effect of k252a on abeta-induced apoptosis was partially dependent on akt activation. |
2009-04-08 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Jon B Klei. Regulation of neutrophil apoptosis by modulation of PKB/Akt activation. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273208. |
the serine/threonine kinase, akt, also known as pkb (protein kinase b) is one important signal transduction pathway that mediates the delay of neutrophil apoptosis caused by inflammatory mediators. |
2009-04-07 |
2023-08-12 |
Not clear |
| Quinten Remijsen, Tom Vanden Berghe, Eef Parthoens, Bob Asselbergh, Peter Vandenabeele, Jean Willem. Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt. Journal of leukocyte biology. vol 85. issue 3. 2009-04-06. PMID:19095734. |
inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of nadph oxidase inhibition but by lipid raft-dependent stimulation of akt. |
2009-04-06 |
2023-08-12 |
Not clear |