| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Song, B Kong, D Li, Q Yan. The inhibitory effect of human embryonic germ cells on ovarian cancer. Neoplasma. vol 56. issue 1. 2009-06-09. PMID:19152240. |
hegcs induced apoptosis via caspase-9 activation and akt downregulation in skov3. |
2009-06-09 |
2023-08-12 |
mouse |
| X Song, B Kong, D Li, Q Yan. The inhibitory effect of human embryonic germ cells on ovarian cancer. Neoplasma. vol 56. issue 1. 2009-06-09. PMID:19152240. |
taken together, our observations demonstrated that the hegcs could inhibit the growth of skov3 by inducing apoptosis by inhibiting akt pathway. |
2009-06-09 |
2023-08-12 |
mouse |
| Yigit S Guner, Christian J Ochoa, Jin Wang, Xiaoru Zhang, Sarah Steinhauser, Lydia Stephenson, Anatoly Grishin, Jeffrey S Upperma. Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochemical and biophysical research communications. vol 384. issue 2. 2009-06-09. PMID:19393619. |
because p38 mitogen-activated protein kinase (mapk) and serine-threonine kinase (akt) are well-characterized pro- and anti-apoptotic mediators, respectively, we hypothesized that pn could induce enterocyte apoptosis via activation of p38 and deactivation of akt. |
2009-06-09 |
2023-08-12 |
rat |
| Yigit S Guner, Christian J Ochoa, Jin Wang, Xiaoru Zhang, Sarah Steinhauser, Lydia Stephenson, Anatoly Grishin, Jeffrey S Upperma. Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochemical and biophysical research communications. vol 384. issue 2. 2009-06-09. PMID:19393619. |
these data demonstrate that pn-mediated apoptosis depends on the p38 pathway and that p38 mediates deactivation of akt survival pathways possibly by the involvement of pp2a. |
2009-06-09 |
2023-08-12 |
rat |
| Meijing Wang, Yue Wang, Brent Weil, Aaron Abarbanell, Jeremy Herrmann, Jiangning Tan, Megan Kelly, Daniel R Meldru. Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 296. issue 4. 2009-06-05. PMID:19211725. |
although estrogen-suppressed cardiomyocyte apoptosis may be mediated through the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) pathway, it is unclear whether this action is mediated via estrogen receptor beta (erbeta). |
2009-06-05 |
2023-08-12 |
mouse |
| Eva Gonzalez, Timothy E McGra. Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 17. 2009-06-05. PMID:19372382. |
the 3 akt protein kinase isoforms have critical and distinct functions in the regulation of metabolism, cell growth, and apoptosis, yet the mechanisms by which their signaling specificity is achieved remain largely unclear. |
2009-06-05 |
2023-08-12 |
Not clear |
| Miroslaw J Szczepanski, Malgorzata Czystowska, Marta Szajnik, Malgorzata Harasymczuk, Michael Boyiadzis, Aleksandra Kruk-Zagajewska, Witold Szyfter, Jan Zeromski, Theresa L Whitesid. Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer research. vol 69. issue 7. 2009-06-02. PMID:19318560. |
cell growth, apoptosis, nuclear factor-kappab (nf-kappab) translocation, and myd88 and irak-4 expression, as well as akt phosphorylation were measured following tumor cell exposure to the tlr4 ligand lipopolysaccharide (lps). |
2009-06-02 |
2023-08-12 |
human |
| Nageatte Ibrahim, Frank G Halusk. Molecular pathogenesis of cutaneous melanocytic neoplasms. Annual review of pathology. vol 4. 2009-05-28. PMID:19400696. |
this review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on cdkn2a, cdk4, mc1r, and mapk pathway targets (e.g., ras and braf), apoptosis regulators (e.g., bcl-2, akt, and apaf-1), and the tumor-suppressor genes tp53 and pten. |
2009-05-28 |
2023-08-12 |
Not clear |
| John C Dreixler, Jonathan W Hemmert, Shanti K Shenoy, Yang Shen, H Thomas Lee, Afzhal R Shaikh, Daniel M Rosenbaum, Steven Rot. The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning. Experimental eye research. vol 88. issue 3. 2009-05-26. PMID:19084003. |
interfering rna directed against akt subtypes prevented the ameliorative effect of ipc on post-ischemic apoptosis. |
2009-05-26 |
2023-08-12 |
rat |
| Dorrah Deeb, Xiaohua Gao, Hao Jiang, Scott A Dulchavsky, Subhash C Gauta. Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR. The Prostate. vol 69. issue 8. 2009-05-14. PMID:19189297. |
oleanane triterpenoid cddo-me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival akt and mtor. |
2009-05-14 |
2023-08-12 |
human |
| Sun Ok Hwang, Gyun Min Le. Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells. Journal of biotechnology. vol 139. issue 1. 2009-05-11. PMID:18983878. |
in this study, to determine the effect of akt, which is known to regulate both apoptosis and autophagy, on cell survival and foreign protein production, constitutively active akt was overexpressed in antibody-producing cells. |
2009-05-11 |
2023-08-12 |
Not clear |
| Sun Ok Hwang, Gyun Min Le. Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells. Journal of biotechnology. vol 139. issue 1. 2009-05-11. PMID:18983878. |
compared with the control cells, akt overexpressing cells showed delayed onset of apoptosis and autophagy during batch culture. |
2009-05-11 |
2023-08-12 |
Not clear |
| Naoya Fujit. [Drug resistance mediated by survival- and growth-promoting signaling pathways]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 36. issue 4. 2009-05-08. PMID:19381028. |
in future, new therapy targeting akt and pim signaling pathways will be developed to selectively induce apoptosis in cancer cells and to overcome drug resistance. |
2009-05-08 |
2023-08-12 |
Not clear |
| Anita Goel, Ashok K Prasad, Virinder S Parmar, Balaram Ghosh, Neeru Sain. Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway. Chemico-biological interactions. vol 179. issue 2-3. 2009-05-06. PMID:19061872. |
results of present study suggest that downregulation of bcl-xl, cox-2 and mitogen activated protein kinase pathway and upregulation of p53, akt and nf-kappab pathway are involved in the underlying molecular mechanism of apoptosis induction by damc and damtc in a549 cells. |
2009-05-06 |
2023-08-12 |
human |
| Jean-Marc Navenot, Nobutaka Fujii, Stephen C Peipe. KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Molecular pharmacology. vol 75. issue 5. 2009-05-05. PMID:19201817. |
kiss1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to akt, tumor necrosis factor family ligand expression, and apoptosis. |
2009-05-05 |
2023-08-12 |
Not clear |
| Fazlul H Sarkar, Yi-wei L. Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy. Acta pharmacologica Sinica. vol 28. issue 9. 2009-05-04. PMID:17723164. |
growing evidence has shown that chemopreventive agents potentiate the efficacy of chemotherapy and radiotherapy through the regulation of multiple signaling pathways, including akt, nf-kappab, c-myc, cyclooxygenase-2, apoptosis, and others, suggesting a multitargeted nature of chemopreventive agents. |
2009-05-04 |
2023-08-12 |
Not clear |
| S Gobessi, L Laurenti, P G Longo, L Carsetti, V Berno, S Sica, G Leone, D G Efremo. Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells. Leukemia. vol 23. issue 4. 2009-05-04. PMID:19092849. |
treatment with r406 induced leukemic cell apoptosis in the majority of investigated cases and affected the basal activity or expression of several pro-survival molecules regulated by syk, including the akt and extracellular signal-regulated (erk) kinases, and the anti-apoptotic protein mcl-1. |
2009-05-04 |
2023-08-12 |
Not clear |
| Kyung Hee Noh, Tae Heung Kang, Jin Hee Kim, Sara I Pai, Ken Y Lin, Chien-Fu Hung, T-C Wu, Tae Woo Ki. Activation of Akt as a mechanism for tumor immune evasion. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 3. 2009-05-01. PMID:19107122. |
retroviral transfer of a constitutively active form of akt into the parental tumor significantly increased its resistance against e7-specific cd8(+) t-cell mediated apoptosis. |
2009-05-01 |
2023-08-12 |
human |
| Pil-Jae Kong, Myung-Og Kil, Heejae Lee, Sung-Soo Kim, Gail V W Johnson, Wanjoo Chu. Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line. Neurological research. vol 31. issue 1. 2009-04-30. PMID:18691453. |
these data suggest that the presence of mutant huntingtin causes transcriptional dysregulation favoring apoptosis and that akt pro-survival pathway in sthdh(q111) is not compromised due to the presence of mutant huntingtin. |
2009-04-30 |
2023-08-12 |
Not clear |
| Peter Y Chuang, John C H. Signaling in regulation of podocyte phenotypes. Nephron. Physiology. vol 111. issue 2. 2009-04-30. PMID:19142027. |
phosphoinositide 3-kinase and its downstream target akt protect podocytes from apoptosis. |
2009-04-30 |
2023-08-12 |
human |