| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Li, Yan Chen, Ling-Lan Zeng, Wen-Xiu Shu, Fei Zhao, Lu Wen, Yuan Li. Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells. Toxicology. vol 262. issue 2. 2009-07-28. PMID:19433130. |
ga treatment downregulated the expression of src-3 and then inhibited the activity of akt kinase and its downstream targets p70 s6 kinase 1 (s6k1) and glycogen synthase kinase 3beta (gsk3beta) without changes in total protein levels of these three proteins, which thus influenced the expression of the apoptosis related gene bcl-2 in k562 cells. |
2009-07-28 |
2023-08-12 |
human |
| Sun Joo Lee, Chung Soo Le. Combined effect of protein kinase B inhibitor or extracellular signal-regulated kinase inhibitor against farnesyltransferase inhibition-induced apoptosis in SiHa cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 3. 2009-07-24. PMID:18854983. |
farnesyltransferase inhibitor may induce apoptosis through the mitochondria-mediated process and inhibition of the mek, erk, and akt activity. |
2009-07-24 |
2023-08-12 |
human |
| Sun Joo Lee, Chung Soo Le. Combined effect of protein kinase B inhibitor or extracellular signal-regulated kinase inhibitor against farnesyltransferase inhibition-induced apoptosis in SiHa cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 3. 2009-07-24. PMID:18854983. |
inhibitors of akt and erk at low concentrations seem to prevent the farnesyltransferase inhibitor-induced apoptosis in cervical siha cells by suppressing the mitochondrial membrane permeability change that leads to cytochrome c release and caspase-3 activation. |
2009-07-24 |
2023-08-12 |
human |
| Sun Joo Lee, Chung Soo Le. Combined effect of protein kinase B inhibitor or extracellular signal-regulated kinase inhibitor against farnesyltransferase inhibition-induced apoptosis in SiHa cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 379. issue 3. 2009-07-24. PMID:18854983. |
in contrast, at higher concentrations more than 1 microm, the akt inhibitor and erk inhibitor seem to exhibit an additive toxic effect against farnesyltransferase inhibitor-induced apoptosis by increasing mitochondrial membrane permeability change and oxidative stress, which may not involve inhibition of mek, erk, and akt activity. |
2009-07-24 |
2023-08-12 |
human |
| Cheng-Yun Jin, Gi-Young Kim, Yung Hyun Cho. Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells. Journal of microbiology and biotechnology. vol 18. issue 12. 2009-07-24. PMID:19131705. |
induction of apoptosis by aqueous extract of cordyceps militaris through activation of caspases and inactivation of akt in human breast cancer mda-mb-231 cells. |
2009-07-24 |
2023-08-12 |
human |
| Cheng-Yun Jin, Gi-Young Kim, Yung Hyun Cho. Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells. Journal of microbiology and biotechnology. vol 18. issue 12. 2009-07-24. PMID:19131705. |
aecm-induced apoptosis was associated with the inhibition of akt activation in a time-dependent manner, and pretreatment with ly294002, a pi3k/akt inhibitor, significantly increased aecm-induced apoptosis. |
2009-07-24 |
2023-08-12 |
human |
| Cheng-Yun Jin, Gi-Young Kim, Yung Hyun Cho. Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells. Journal of microbiology and biotechnology. vol 18. issue 12. 2009-07-24. PMID:19131705. |
the results indicated that aecm-induced apoptosis may relate to the activation of caspase-3 and mitochondria dysfunctions that correlate with the inactivation of akt. |
2009-07-24 |
2023-08-12 |
human |
| Gabriela Domínguez-Monzón, Jorge A Benítez, Paula Vergara, Rodrigo Lorenzana, José Segovi. Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 4. 2009-07-23. PMID:19460624. |
furthermore, the over-expression of gas1 induces cell arrest, apoptosis and prevents the activation of akt, a crucial mediator of survival and cellular proliferation pathways. |
2009-07-23 |
2023-08-12 |
human |
| Joon-Yong Chung, Seung-Mo Hong, Byeong Yeob Choi, Hyungjun Cho, Eunsil Yu, Stephen M Hewit. The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 2. 2009-07-20. PMID:19147772. |
the protein kinase b (akt) pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation, and has been shown to have prognostic significance in a number of cancers. |
2009-07-20 |
2023-08-12 |
Not clear |
| W Li, Y Xie, R W-Y Sun, Q Liu, J Young, W-Y Yu, C-M Che, P K Tam, Y Re. Inhibition of Akt sensitises neuroblastoma cells to gold(III) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition. British journal of cancer. vol 101. issue 2. 2009-07-20. PMID:19550420. |
inhibition of akt sensitises neuroblastoma cells to gold(iii) porphyrin 1a, a novel antitumour drug induced apoptosis and growth inhibition. |
2009-07-20 |
2023-08-12 |
human |
| Kengo Nishimura, Peter Blume, Shigetsugu Ohgi, Bauer E Sumpi. The effect of different frequencies of stretch on human dermal keratinocyte proliferation and survival. The Journal of surgical research. vol 155. issue 1. 2009-07-16. PMID:19059608. |
this decrease was most likely not due to apoptosis as tunel-positive cells only increased for cells treated with an akt inhibitor. |
2009-07-16 |
2023-08-12 |
human |
| Claudio Festuccia, Giovanni Luca Gravina, Anna Maria D'Alessandro, Paola Muzi, Danilo Millimaggi, Vincenza Dolo, Enrico Ricevuto, Carlo Vicentini, Mauro Bologn. Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models. Endocrine-related cancer. vol 16. issue 2. 2009-07-16. PMID:19153211. |
reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16inka, bax, bak, p21/waf1, and p27/kip1, and inhibiting the activation of akt activity and the expression of cyclin d1, bcl-2, and bcl-xl. |
2009-07-16 |
2023-08-12 |
mouse |
| Chun Shi, Lina Zhao, Bilian Zhu, Qianxi Li, David T Yew, Zhibin Yao, Jie X. Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells. Chemico-biological interactions. vol 180. issue 3. 2009-07-16. PMID:19414004. |
low doses of egb761 (50-100 microg/ml) inhibited h(2)o(2)-induced cell apoptosis via inactivation of akt, jnk and caspase 3 while high doses of egb761 (250-500 microg/ml) enhanced h(2)o(2) toxicities via inactivation of akt and enhancement of activation of jnk and caspase 3. |
2009-07-16 |
2023-08-12 |
human |
| Toshimasa Akazawa, Shawn G Kwatra, Laura E Goldsmith, Mark D Richardson, Elizabeth A Cox, John H Sampson, Madan M Kwatr. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19519779. |
linkage of nk1r to akt implicates nk1r in apoptosis of glioblastoma cells. |
2009-07-16 |
2023-08-12 |
human |
| Huahong Xie, Liucun Gao, Na Chai, Jiugang Song, Jun Wang, Zhenshun Song, Caiping Chen, Yanglin Pan, Lina Zhao, Shiren Sun, Kaichun Wu, Mark A Feitelson, Jie Liu, Daiming Fa. Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib. Molecular carcinogenesis. vol 48. issue 1. 2009-07-15. PMID:18506760. |
celecoxib also inhibited p(473ser)akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in hbx positive cells than in control cells. |
2009-07-15 |
2023-08-12 |
Not clear |
| Chen Chen Jiang, Fan Yang, Rick F Thorne, Bi Ke Zhu, Peter Hersey, Xu Dong Zhan. Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. Neoplasia (New York, N.Y.). vol 11. issue 5. 2009-07-15. PMID:19412428. |
induction of er stress resulted in the rapid activation of the pi3k/akt pathway that seemed to be important in antagonizing docetaxel and vincristine, in that inhibition of akt blocked the effect of pretreatment with tm on apoptosis induced by the drugs. |
2009-07-15 |
2023-08-12 |
human |
| Stefan Faderl, Ashutosh Pal, William Bornmann, Maher Albitar, David Maxwell, Quin Van, Zhenghong Peng, David Harris, Zhiming Liu, Inbal Hazan-Halevy, Hagop M Kantarjian, Zeev Estro. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer research. vol 69. issue 9. 2009-07-14. PMID:19383925. |
we show that (a) apck110 inhibits proliferation of the mastocytosis cell line hmc1.2 and the scf-responsive cell line oci/aml3 in a dose-dependent manner; (b) apck110 is a more potent inhibitor of oci/aml3 proliferation than the clinically used kit inhibitors imatinib and dasatinib and at least as potent as cytarabine; (c) apck110 inhibits the phosphorylation of kit, stat3, stat5, and akt in a dose-dependent fashion, showing activity of apck110 on kit and its downstream signaling pathways; (d) apck110 induces apoptosis by cleavage of caspase-3 and poly(adp-ribose) polymerase; and (e) apck110 inhibits proliferation of primary aml blasts in a clonogenic assay but does not affect proliferation of normal colony-forming cells. |
2009-07-14 |
2023-08-12 |
Not clear |
| Hiroe Toba, Naoki Sawai, Masayuki Morishita, Shoko Murata, Mamiko Yoshida, Kohei Nakashima, Yosuke Morita, Miyuki Kobara, Tetsuo Nakat. Chronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat. European journal of pharmacology. vol 612. issue 1-3. 2009-07-09. PMID:19356735. |
these results suggest that chronic treatment with rhuepo attenuated renal injury beyond hematopoiesis and regulated apoptosis and enos expression, which might be due to the activation of akt pathway. |
2009-07-09 |
2023-08-12 |
human |
| N Gallay, C Dos Santos, L Cuzin, M Bousquet, V Simmonet Gouy, C Chaussade, M Attal, B Payrastre, C Demur, C Réche. The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia. Leukemia. vol 23. issue 6. 2009-07-07. PMID:19158829. |
moreover, the specific akt inhibitor, akti-1/2, inhibited cell proliferation and clonogenic properties, and induced apoptosis in aml cells with high-risk cytogenetics, suggesting that akt may represent a therapeutic target in high-risk aml. |
2009-07-07 |
2023-08-12 |
Not clear |
| Anika Heiss, Hermann Ammer, Daniela A Eisinge. delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation. Experimental cell research. vol 315. issue 12. 2009-07-06. PMID:19362548. |
activated akt translocates to the nuclear membrane, where it promotes gsk3 phosphorylation and prevents caspase-3 cleavage, two key events mediating inhibition of cell apoptosis and enhancement of cell survival. |
2009-07-06 |
2023-08-12 |
Not clear |