| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
furthermore, treatment with gsk-3beta inhibitors reduced h2o2-induced apoptosis and abolished the death-promoting effect of akt and stat3 inhibition. |
2009-11-17 |
2023-08-12 |
mouse |
| Dmitri Kapitonov, Jeremy C Allegood, Clint Mitchell, Nitai C Hait, Jorge A Almenara, Jeffrey K Adams, Robert E Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien, Sarah Spiege. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer research. vol 69. issue 17. 2009-11-17. PMID:19723667. |
targeting sphingosine kinase 1 inhibits akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. |
2009-11-17 |
2023-08-12 |
mouse |
| Myung Jin Kim, Hyung Il Kim, Jin Chung, Tae Sung Jeong, Hae Ryoun Par. (-)-Epigallocatechin-3-gallate (EGCG) increases the viability of serum-starved A549 cells through its effect on Akt. The American journal of Chinese medicine. vol 37. issue 4. 2009-11-16. PMID:19655410. |
this study has shown that egcg protects a549 cells from apoptosis induced by serum deprivation via akt activation and this protective effect may limit the clinical use of egcg in treating and preventing nsclc. |
2009-11-16 |
2023-08-12 |
Not clear |
| R Kimura, M Okouchi, H Fujioka, A Ichiyanagi, F Ryuge, T Mizuno, K Imaeda, N Okayama, Y Kamiya, K Asai, T Jo. Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19463904. |
glp-1 protected against this mg-induced apoptosis, which corresponded to the phosphorylation of pi3k, akt, and mtor, as well as the upregulation of gclc and the restoration of the redox imbalance. |
2009-11-10 |
2023-08-12 |
Not clear |
| R Kimura, M Okouchi, H Fujioka, A Ichiyanagi, F Ryuge, T Mizuno, K Imaeda, N Okayama, Y Kamiya, K Asai, T Jo. Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19463904. |
inhibitors of pi3k (ly294002), akt (akt-i), and mtor (rapamycin) reduced the glp-1-induced gclc upregulation and its protection against mg-induced pc12 apoptosis. |
2009-11-10 |
2023-08-12 |
Not clear |
| Fazlul H Sarkar, Yiwei Li, Zhiwei Wang, Dejuan Kon. Cellular signaling perturbation by natural products. Cellular signalling. vol 21. issue 11. 2009-11-06. PMID:19298854. |
by regulating multiple important cellular signaling pathways including nf-kappab, akt, mapk, wnt, notch, p53, ar, er, etc, these natural products are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells. |
2009-11-06 |
2023-08-12 |
human |
| Fei Ye, Qinglei Gao, Tongjiang Xu, Liang Zeng, Yibo Ou, Feng Mao, Heping Wang, Yue He, Baofeng Wang, Zhengming Yang, Dongsheng Guo, Ting Le. Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. Journal of neuro-oncology. vol 94. issue 2. 2009-11-05. PMID:19300910. |
our study now clearly indicates that lrig1 indeed affects cell fate and biology behaviors of the cells in vitro by inhibiting phosphorylation of downstream mapk and akt signaling pathway, and the elevated release level of caspase-8 might contribute to the enhanced apoptosis in lrig1 transfected glioma cells. |
2009-11-05 |
2023-08-12 |
Not clear |
| Clementine Cailleteau, Bertrand Liagre, Jean-L Beneytou. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation. Journal of cellular biochemistry. vol 107. issue 4. 2009-10-26. PMID:19415684. |
for the first time, we examined kinase activation and showed that kinases including src, tor, akt, creb, rsk and chk2 may be implicated in signalling of subsequent apoptosis of mature megakaryocytes after diosgenin-induced differentiation of hel cells. |
2009-10-26 |
2023-08-12 |
human |
| Laura Calleros, Irene Sánchez-Hernández, Pablo Baquero, María José Toro, Antonio Chiloeche. Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. Carcinogenesis. vol 30. issue 10. 2009-10-26. PMID:19700418. |
the specific activation of the pi3k/akt pathway by overexpression of the (v12)rasc40 mutant or a constitutively active akt decreases the lpds plus 25-hc-induced apoptosis in ht-29 cells, whereas pi3k inhibition or abrogation of akt expression renders hct-116 sensitive to cholesterol depletion-induced apoptosis. |
2009-10-26 |
2023-08-12 |
Not clear |
| Laura Calleros, Irene Sánchez-Hernández, Pablo Baquero, María José Toro, Antonio Chiloeche. Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. Carcinogenesis. vol 30. issue 10. 2009-10-26. PMID:19700418. |
finally, we demonstrate that akt hyperactivation by oncogenic ras protects from apoptosis, preventing the activation of c-jun n-terminal kinase by cholesterol depletion. |
2009-10-26 |
2023-08-12 |
Not clear |
| Cun Li, Natalia E Schlabritz-Loutsevitch, Gene B Hubbard, Victor Han, Karen Nygard, Laura A Cox, Thomas J McDonald, Peter W Nathaniels. Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products. Endocrinology. vol 150. issue 10. 2009-10-22. PMID:19574404. |
mnr increased caspase-3, indicating apoptosis and decreased akt staining, indicating decreased nutrient sensing. |
2009-10-22 |
2023-08-12 |
Not clear |
| Jun-Qiu Song, Xu Teng, Yan Cai, Chao-Shu Tang, Yong-Fen Q. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis : an international journal on programmed cell death. vol 14. issue 9. 2009-10-21. PMID:19634012. |
imd(1-53) (1 x 10(-7) mol/l) inhibited the h/r effect in cardiomyocytes by reducing cell death by 43% and ldh leakage by 16%; diminishing cellular apoptosis; decreasing caspase 3 activity by 50%; and increasing the phosphorylated akt and gsk-3beta by 41 and 90%, respectively. |
2009-10-21 |
2023-08-12 |
rat |
| Priya Kulasekaran, Casey A Scavone, David S Rogers, Douglas A Arenberg, Victor J Thannickal, Jeffrey C Horowit. Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation. American journal of respiratory cell and molecular biology. vol 41. issue 4. 2009-10-20. PMID:19188658. |
endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via akt activation. |
2009-10-20 |
2023-08-12 |
human |
| Christina M Scifres, D Michael Nelso. Intrauterine growth restriction, human placental development and trophoblast cell death. The Journal of physiology. vol 587. issue Pt 14. 2009-10-15. PMID:19451203. |
we identify selected insults, including oxidative stress and complement activation, and key pathways that regulate apoptosis in villous trophoblast, including increased p53 activity, altered translation of akt and mtor proteins, and the stress response of the endoplasmic reticulum. |
2009-10-15 |
2023-08-12 |
human |
| Céline Van Themsche, Valérie Leblanc, Sophie Parent, Eric Asseli. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. The Journal of biological chemistry. vol 284. issue 31. 2009-10-14. PMID:19473982. |
the phosphorylation of akt has previously been shown to be promoted by x-linked inhibitor of apoptosis protein (xiap), another antiapoptotic protein dictating the fate of normal and cancer cells. |
2009-10-14 |
2023-08-12 |
mouse |
| Esther P Jane, Daniel R Premkumar, Steven O Addo-Yobo, Ian F Pollac. Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19622715. |
abrogation of mitogen-activated protein kinase and akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. |
2009-10-13 |
2023-08-12 |
human |
| Esther P Jane, Daniel R Premkumar, Steven O Addo-Yobo, Ian F Pollac. Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells. The Journal of pharmacology and experimental therapeutics. vol 331. issue 1. 2009-10-13. PMID:19622715. |
these effects were paralleled by potentiation of akt signaling inhibition and apoptosis induction. |
2009-10-13 |
2023-08-12 |
human |
| Ronald W Matheny, Martin L Adam. Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts. Biochemical and biophysical research communications. vol 389. issue 1. 2009-10-08. PMID:19703413. |
our results provide evidence for igf-i-stimulated isoform-specific actions of akt on molecules involved in promoting apoptosis. |
2009-10-08 |
2023-08-12 |
Not clear |
| Baohua Wang, Jayant Shravah, Honglin Luo, Koen Raedschelders, David D Y Chen, David M Ansle. Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation. Biochemical and biophysical research communications. vol 389. issue 1. 2009-10-08. PMID:19703415. |
the protective effect of propofol on h(2)o(2)-induced injury is reversed by pi3k inhibitor wortmannin, which effectively suppresses propofol-induced activation of akt, up-regulation of bcl-2, and protection from apoptosis. |
2009-10-08 |
2023-08-12 |
rat |
| K-H Lee, Y-L Chen, S-D Yeh, M Hsiao, J-T Lin, Y-G Goan, P-J L. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene. vol 28. issue 38. 2009-10-06. PMID:19597470. |
microrna-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through e2f1-mediated suppression of akt phosphorylation. |
2009-10-06 |
2023-08-12 |
human |