| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahito Kondo, Makoto Hirose, Kan Kageyam. Roles of oxidative stress and redox regulation in atherosclerosis. Journal of atherosclerosis and thrombosis. vol 16. issue 5. 2010-02-01. PMID:19749495. |
the akt signaling pathway exerts effects on survival and apoptosis, and is regulated by the glutathione (gsh)/glutaredoxin (grx)-dependent redox sys-tem. |
2010-02-01 |
2023-08-12 |
Not clear |
| M R Abedini, E J Muller, R Bergeron, D A Gray, B K Tsan. Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein. Oncogene. vol 29. issue 1. 2010-02-01. PMID:19802016. |
moreover, although activated akt inhibited cddp-induced flip degradation and apoptosis in sensitive cells, these responses were facilitated by dominant-negative akt expression in chemoresistant cells. |
2010-02-01 |
2023-08-12 |
human |
| Fen Guo, Zhi-Wen Luo, Zhao-Yu Liu, Yue-Qin Li, Hong-Jian Li, Tian-Hong Zho. [Studies of effect of prosaposin on cell proliferation, cell apoptosis and its possible molecular mechanism]. Yi chuan = Hereditas. vol 31. issue 12. 2010-02-01. PMID:20042390. |
prosaposin pro-tein was proved to activate the pi3k/akt signal pathway, upregulate the phosphorylative activity of akt at serine 473, downregulate the expression of p27(kip1) gene, upregulate the expression of cyclin d1 gene and then promote the g1/s tran-sition, and upregulate the expression of survival genes ciap1 and ciap2 and then prevent cell apoptosis. |
2010-02-01 |
2023-08-12 |
Not clear |
| Bangyan L Stile. PI-3-K and AKT: Onto the mitochondria. Advanced drug delivery reviews. vol 61. issue 14. 2010-01-28. PMID:19720099. |
we reviewed the functions of akt in the mitochondrial intrinsic apoptosis pathway. |
2010-01-28 |
2023-08-12 |
Not clear |
| Wenbin Lei, Tao Jia, Zhenzhong Su, Weiping Wen, Xiaolin Zh. Combined effect of rapamycin and cisplatin on survival of Hep-2 cells in vitro. Oncology research. vol 18. issue 2-3. 2010-01-28. PMID:20066897. |
inhibition of cell growth, apoptosis, and akt, mtor, s6k, and ercc1 protein levels were assessed. |
2010-01-28 |
2023-08-12 |
Not clear |
| Paolo Spallarossa, Paola Altieri, Paolo Pronzato, Concetta Aloi, Giorgio Ghigliotti, Antonio Barsotti, Claudio Brunell. Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexrazoxane. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841470. |
data demonstrate that 1) the toxic effects of epirubicin mainly occur through nad(p)h oxidase activation; 2) the erbb2 overexpression induced by epirubicin is a redox-sensitive mechanism largely dependent on nad(p)h oxidase; 3) the loss of erbb2-related functions caused by b10 determines marginal cellular changes in untreated cells, but causes massive death by apoptosis in cells previously exposed to a prosenescent dose of epirubicin, 4) dexrazoxane promotes survival pathways, as demonstrated by the activation of akt and the pi3k-dependent erbb2 overexpression; and 5) it also prevents epirubicin-induced senescence and renders epirubicin-treated cells more resistant to treatment with b10. |
2010-01-26 |
2023-08-12 |
rat |
| Woo Young Choi, Cheng-Yun Jin, Min Ho Han, Gi-Young Kim, Nam Deuk Kim, Won Ho Lee, Se-Kwon Kim, Yung Hyun Cho. Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3. Anticancer research. vol 29. issue 11. 2010-01-26. PMID:20032392. |
sanguinarine sensitizes human gastric adenocarcinoma ags cells to trail-mediated apoptosis via down-regulation of akt and activation of caspase-3. |
2010-01-26 |
2023-08-12 |
human |
| Ha Won Kim, Husnain K Haider, Shujia Jiang, Muhammad Ashra. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. The Journal of biological chemistry. vol 284. issue 48. 2010-01-21. PMID:19721136. |
ip significantly reduced apoptosis in mscs through activation of akt (ser(473)) and erk1/2 (thr(202)/tyr(204)) and nuclear translocation of hypoxia-inducible factor-1alpha (hif-1alpha). |
2010-01-21 |
2023-08-12 |
rat |
| Kazuhiro Kunimasa, Tomomi Kobayashi, Kazuhiko Kaji, Toshiro Oht. Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVEC. The Journal of nutrition. vol 140. issue 1. 2010-01-21. PMID:19889811. |
we also demonstrated that pharmacological inhibition of erk1/2 and/or akt was enough to inhibit tube formation and induce caspase-dependent apoptosis in tube-forming huvec. |
2010-01-21 |
2023-08-12 |
human |
| Tianpeng Zhang, Dan Yang, Yongna Fan, Ping Xie, Huihua L. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19669889. |
epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via akt and mapk pathways. |
2010-01-19 |
2023-08-12 |
human |
| Tianpeng Zhang, Dan Yang, Yongna Fan, Ping Xie, Huihua L. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19669889. |
taken together, our study for the first time suggest that egcg is able to enhance growth arrest and apoptosis of huvecs during i/r injury, at least in part, through inhibition of akt and erk1/2 and activation of jnk1/2 signaling pathways. |
2010-01-19 |
2023-08-12 |
human |
| Gaoliang Ouyang, Luming Yao, Kai Ruan, Gang Song, Yubin Mao, Shideng Ba. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell biology international. vol 33. issue 12. 2010-01-19. PMID:19732843. |
moreover, genistein enhances the phosphorylation and activation of p53, while decreases the ratio of bcl-2/bax and bcl-xl/bax and the level of phosphorylated akt, which result in cells undergoing apoptosis. |
2010-01-19 |
2023-08-12 |
human |
| Jiachi Ma, Hirozumi Sawai, Nobuo Ochi, Yoichi Matsuo, Donghui Xu, Akira Yasuda, Hiroki Takahashi, Takehiro Wakasugi, Hiromitsu Takeyam. PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Molecular and cellular biochemistry. vol 331. issue 1-2. 2010-01-18. PMID:19437103. |
phosphoinositide 3-kinase (pi3k) pathway exerts its effects through akt, its downstream target molecule, and thereby regulates various cell functions including cell proliferation, cell transformation, apoptosis, tumor growth, and angiogenesis. |
2010-01-18 |
2023-08-12 |
human |
| b' Thomas De Luca, Elena Bosneaga, Dorothy M Morr\\xc3\\xa9, D James Morr\\xc3\\xa. Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol. BioFactors (Oxford, England). vol 34. issue 3. 2010-01-15. PMID:19734127.' |
the prevailing hypothesis is that products of akt activation, c-flip and xiap, which exhibit anticaspase activities to block fas signaling when sphingosine-1-phospate is elevated, are down regulated to permit apoptosis when sphingosine-1-phosphate is decreased by inhibition of sphingosine kinase under conditions of elevated cytosolic nadh associated with anticancer drug inhibition of enox2. |
2010-01-15 |
2023-08-12 |
Not clear |
| Yosuke Osawa, Ekihiro Seki, Masayuki Adachi, Atsushi Suetsugu, Hiroyasu Ito, Hisataka Moriwaki, Mitsuru Seishima, Masahito Nagak. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology (Baltimore, Md.). vol 51. issue 1. 2010-01-15. PMID:19821528. |
in cholestatic liver injury, the remaining viable cells represented tolerance for tumor necrosis factor alpha (tnf-alpha)-induced hepatocyte apoptosis and regenerative features along with akt activation. |
2010-01-15 |
2023-08-12 |
mouse |
| Yosuke Osawa, Ekihiro Seki, Masayuki Adachi, Atsushi Suetsugu, Hiroyasu Ito, Hisataka Moriwaki, Mitsuru Seishima, Masahito Nagak. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology (Baltimore, Md.). vol 51. issue 1. 2010-01-15. PMID:19821528. |
in these mice, akt activation, the tolerance for tnf-alpha-induced apoptosis, and the regenerative responses were attenuated in hepatocytes after bdl. |
2010-01-15 |
2023-08-12 |
mouse |
| Shahab Uddin, Maqbool Ahmed, Azhar Hussain, Lina Assad, Fouad Al-Dayel, Prashant Bavi, Khawla S Al-Kuraya, Adnan Munkara. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. International journal of cancer. vol 126. issue 2. 2010-01-13. PMID:19621391. |
our in vitro data using eoc cell line showed that inhibition of cox-2 by aspirin, selective inhibitor ns398 and gene silencing by cox-2 specific sirna impaired phosphorylation of akt resulting decreased downstream signaling leading to cell growth inhibition and induction of apoptosis. |
2010-01-13 |
2023-08-12 |
mouse |
| Madhavi J Rane, Ye Song, Shunying Jin, Michelle T Barati, Rui Wu, Hina Kausar, Yi Tan, Yuehui Wang, Guihua Zhou, Jon B Klein, Xiaokun Li, Lu Ca. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. American journal of physiology. Renal physiology. vol 298. issue 1. 2010-01-11. PMID:19726550. |
interplay between akt and p38 mapk pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. |
2010-01-11 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Ye Song, Shunying Jin, Michelle T Barati, Rui Wu, Hina Kausar, Yi Tan, Yuehui Wang, Guihua Zhou, Jon B Klein, Xiaokun Li, Lu Ca. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. American journal of physiology. Renal physiology. vol 298. issue 1. 2010-01-11. PMID:19726550. |
overexpression of constitutively active akt abrogated hg-induced p38 mapk phosphorylation and rptc apoptosis. |
2010-01-11 |
2023-08-12 |
Not clear |
| Madhavi J Rane, Ye Song, Shunying Jin, Michelle T Barati, Rui Wu, Hina Kausar, Yi Tan, Yuehui Wang, Guihua Zhou, Jon B Klein, Xiaokun Li, Lu Ca. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. American journal of physiology. Renal physiology. vol 298. issue 1. 2010-01-11. PMID:19726550. |
these results collectively suggest that downregulation of akt activation during long-term hyperglycemia contributes to enhanced p38 mapk activation and rptc apoptosis. |
2010-01-11 |
2023-08-12 |
Not clear |