| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Subhra Mohapatra, Baoky Chu, Xiuhua Zhao, Julie Djeu, Jin Q Cheng, W Jackson Pledge. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. The international journal of biochemistry & cell biology. vol 41. issue 3. 2009-12-07. PMID:18708158. |
apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and akt inhibitors. |
2009-12-07 |
2023-08-12 |
Not clear |
| Subhra Mohapatra, Baoky Chu, Xiuhua Zhao, Julie Djeu, Jin Q Cheng, W Jackson Pledge. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. The international journal of biochemistry & cell biology. vol 41. issue 3. 2009-12-07. PMID:18708158. |
toward this goal, we show apoptosis and impaired long-term survival of androgen-independent prostate cancer cells (pc3 and pc3 derivatives) co-treated with the cyclin-dependent kinase (cdk) inhibitor roscovitine and an akt inhibitor (ly294002 or api-2). |
2009-12-07 |
2023-08-12 |
Not clear |
| Joanna Jagielska, Gustavo Salguero, Bernhard Schieffer, Udo Bavendie. Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis? Atherosclerosis. vol 206. issue 2. 2009-12-07. PMID:19446813. |
additionally, digitoxin prevented tnf-alpha-induced apoptosis in ec accompanied by activation of akt. |
2009-12-07 |
2023-08-12 |
Not clear |
| Ji Cao, Danqing Xu, Duoduo Wang, Rui Wu, Lei Zhang, Hong Zhu, Qiaojun He, Bo Yan. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19482076. |
ros-driven akt dephosphorylation at ser-473 is involved in 4-hpr-mediated apoptosis in nb4 cells. |
2009-12-07 |
2023-08-12 |
Not clear |
| Ji Cao, Danqing Xu, Duoduo Wang, Rui Wu, Lei Zhang, Hong Zhu, Qiaojun He, Bo Yan. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19482076. |
herein, we provide further evidence that the akt signaling pathway is involved in 4-hpr-mediated apoptosis. |
2009-12-07 |
2023-08-12 |
Not clear |
| Ji Cao, Danqing Xu, Duoduo Wang, Rui Wu, Lei Zhang, Hong Zhu, Qiaojun He, Bo Yan. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free radical biology & medicine. vol 47. issue 5. 2009-12-07. PMID:19482076. |
all these results collectively suggest that 4-hpr-induced apoptosis is associated with a ros-mediated conformational change in akt, and this change, as a consequence, mediates dephosphorylation of akt via regulating akt-hsp90 or akt-pp2a complex formation. |
2009-12-07 |
2023-08-12 |
Not clear |
| Craig T Lefort, Young-Min Hyun, Joanne B Schultz, Foon-Yee Law, Richard E Waugh, Philip A Knauf, Minsoo Ki. Outside-in signal transmission by conformational changes in integrin Mac-1. Journal of immunology (Baltimore, Md. : 1950). vol 183. issue 10. 2009-12-07. PMID:19864611. |
mac-1 conformational activation induced by ligand occupancy or activating ab binding, but not integrin clustering, triggered similar patterns of intracellular protein tyrosine phosphorylation, including akt phosphorylation, and inhibited spontaneous neutrophil apoptosis, indicating that global conformational changes are critical for mac-1-dependent outside-in signal transduction. |
2009-12-07 |
2023-08-12 |
human |
| Y-H Paik, J K Kim, J I Lee, S H Kang, D Y Kim, S H An, S J Lee, D K Lee, K-H Han, C Y Chon, S I Lee, K S Lee, D A Brenne. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut. vol 58. issue 11. 2009-12-04. PMID:19201774. |
celecoxib induces hepatic stellate cell apoptosis through inhibition of akt activation and suppresses hepatic fibrosis in rats. |
2009-12-04 |
2023-08-12 |
rat |
| Cong Liu, Sheng Zhou, Chang-Shu Ke, Na-Ping Li, Ren-Liang W. [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927847. |
being downstream targets of the phosphatase and tensin homolog deleted on chromosome ten (pten) and epidermal growth factor receptor (egfr) pathways, serine/threonine kinase akt, nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription-3 (stat3), play important roles in cell proliferation, apoptosis and oncogenesis. |
2009-12-03 |
2023-08-12 |
Not clear |
| Vandanajay Bhatia, Ramanjaneya V Mula, Nancy L Weigel, Miriam Falzo. Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Molecular cancer research : MCR. vol 7. issue 7. 2009-12-03. PMID:19584267. |
pthrp also affects the phosphorylation state of akt substrates implicated in apoptosis suppression, including glycogen synthase kinase-3 and bad. |
2009-12-03 |
2023-08-12 |
human |
| Raushan T Kurmasheva, Lorina Dudkin, Catherine Billups, Larisa V Debelenko, Christopher L Morton, Peter J Houghto. The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. Cancer research. vol 69. issue 19. 2009-12-03. PMID:19789339. |
in ewing sarcoma (ews) cell lines, cp751,871 inhibited growth poorly (<50%), but prevented rapamycin-induced hyperphosphorylation of akt(ser473) and induced greater than additive apoptosis. |
2009-12-03 |
2023-08-12 |
human |
| Jing-Lei Qu, Xiu-Juan Qu, Jing-Lei Qu, Xiu-Juan Qu, Ming-Fang Zhao, Yue-E Teng, Ye Zhang, Ke-Zuo Hou, You-Hong Jiang, Xiang-Hong Yang, Yun-Peng Li. The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells. Acta oncologica (Stockholm, Sweden). vol 48. issue 8. 2009-12-02. PMID:19863226. |
inhibition of proteasome led to partial restoration of akt activity and cell apoptosis. |
2009-12-02 |
2023-08-12 |
Not clear |
| Xinchun Shen, Gang Xi, Yashwanth Radhakrishnan, David R Clemmon. Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. Molecular & cellular proteomics : MCP. vol 8. issue 7. 2009-12-01. PMID:19299420. |
further studies showed that truncation of shps-1/cd significantly impaired igf-i-dependent akt signal transduction and subsequent biological functions including cell survival, protein synthesis, protein aggregation, and prevention of apoptosis. |
2009-12-01 |
2023-08-12 |
Not clear |
| Daisuke Nagata, Arihiro Kiyosue, Masao Takahashi, Hiroshi Satonaka, Kimie Tanaka, Masataka Sata, Tetsuo Nagano, Ryozo Nagai, Yasunobu Hirat. A new constitutively active mutant of AMP-activated protein kinase inhibits anoxia-induced apoptosis of vascular endothelial cell. Hypertension research : official journal of the Japanese Society of Hypertension. vol 32. issue 2. 2009-11-30. PMID:19262472. |
in conclusion, ncaampk inhibited anoxia-induced apoptosis in vascular endothelial cells through akt activation, suggesting that activation of ampk might protect against ischemic vascular injury. |
2009-11-30 |
2023-08-12 |
human |
| Rui Guo, Li Zhong, Jun Re. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clinical and experimental pharmacology & physiology. vol 36. issue 5-6. 2009-11-24. PMID:19215238. |
overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in akt and pim signalling in liver. |
2009-11-24 |
2023-08-12 |
mouse |
| Rui Guo, Li Zhong, Jun Re. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clinical and experimental pharmacology & physiology. vol 36. issue 5-6. 2009-11-24. PMID:19215238. |
pro- and anti-apoptotic proteins, including p53, omi/htra2, bcl-2, bax, x-linked inhibitor of apoptosis protein (xiap), akt, phosphorylated (p) akt, the akt downstream signalling molecule pim and ppim, were examined using immunoblot analysis. |
2009-11-24 |
2023-08-12 |
mouse |
| Rui Guo, Li Zhong, Jun Re. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clinical and experimental pharmacology & physiology. vol 36. issue 5-6. 2009-11-24. PMID:19215238. |
collectively, the results suggest that aldh2 may effectively ameliorate alcohol-induced hepatic apoptosis and changes in akt as well as pim signalling. |
2009-11-24 |
2023-08-12 |
mouse |
| Venkata Sabbisetti, Arianna Di Napoli, Apryle Seeley, Angela M Amato, Esther O'Regan, Musie Ghebremichael, Massimo Loda, Sabina Signorett. p63 promotes cell survival through fatty acid synthase. PloS one. vol 4. issue 6. 2009-11-17. PMID:19517019. |
activated akt did not cause any alteration in the fasn protein levels but induced its activity, suggesting that the rescue from apoptosis documented in the p63-silenced cells expressing myr-akt cells may be partially mediated by fasn. |
2009-11-17 |
2023-08-12 |
Not clear |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of stat3 and akt signaling pathways. |
2009-11-17 |
2023-08-12 |
mouse |
| Murugavel Ponnusamy, Maoyin Pang, Pavan Kumar Annamaraju, Zhu Zhang, Rujun Gong, Y Eugene Chin, Shougang Zhuan. Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. American journal of physiology. Renal physiology. vol 297. issue 5. 2009-11-17. PMID:19710241. |
concurrent with rptc apoptosis, phosphorylation of akt, signal transducer and activator of transcription-3 (stat3), and glucogen synthase kinase-3beta (gsk-3beta) were observed. |
2009-11-17 |
2023-08-12 |
mouse |