| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong Yeok Shin, Won Sup Lee, Jing Nan Lu, Myung Hee Kang, Chung Ho Ryu, Gi Young Kim, Ho Sung Kang, Sung Chul Shin, Yung Hyun Cho. Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. International journal of oncology. vol 35. issue 6. 2010-01-08. PMID:19885574. |
induction of apoptosis in human colon cancer hct-116 cells by anthocyanins through suppression of akt and activation of p38-mapk. |
2010-01-08 |
2023-08-12 |
human |
| Dong Yeok Shin, Won Sup Lee, Jing Nan Lu, Myung Hee Kang, Chung Ho Ryu, Gi Young Kim, Ho Sung Kang, Sung Chul Shin, Yung Hyun Cho. Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. International journal of oncology. vol 35. issue 6. 2010-01-08. PMID:19885574. |
in addition, apoptosis was associated with activation of p38-mapk and suppression of akt. |
2010-01-08 |
2023-08-12 |
human |
| Dong Yeok Shin, Won Sup Lee, Jing Nan Lu, Myung Hee Kang, Chung Ho Ryu, Gi Young Kim, Ho Sung Kang, Sung Chul Shin, Yung Hyun Cho. Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. International journal of oncology. vol 35. issue 6. 2010-01-08. PMID:19885574. |
in conclusion, this study suggests that the anthocyanins isolated from vitis coignetiae pulliat induce apoptosis might at least in part through activating p38-mapk and suppressing akt in human colon cancer hct-116 cells. |
2010-01-08 |
2023-08-12 |
human |
| V Mamidipudi, C A Cartwrigh. A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene. vol 28. issue 50. 2010-01-07. PMID:19767770. |
rack1 also induces apoptosis by blocking src activation of the akt cell survival pathway. |
2010-01-07 |
2023-08-12 |
human |
| Sakhila K Banu, JeHoon Lee, V O Speights, Anna Starzinski-Powitz, Joe A Aros. Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. Molecular endocrinology (Baltimore, Md.). vol 23. issue 8. 2010-01-06. PMID:19407222. |
selective inhibition of prostaglandin e2 receptors ep2 and ep4 induces apoptosis of human endometriotic cells through suppression of erk1/2, akt, nfkappab, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms. |
2010-01-06 |
2023-08-12 |
human |
| Jen-Chung Ko, Shih-Ci Ciou, Jhih-Yuan Jhan, Chao-Min Cheng, Ying-Jhen Su, Show-Mei Chuang, Szu-Ting Lin, Chia-Che Chang, Yun-Wei Li. Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells. Molecular cancer research : MCR. vol 7. issue 8. 2010-01-06. PMID:19671683. |
erlotinib decreased cellular levels of phosphorylated erk1/2, phosphorylated akt, rad51 protein, and mrna in erlotinib-sensitive h1650, a549, and h1869 cells, leading to cell death via apoptosis, but these results were not seen in erlotinib-resistant h520 and h1703 cells. |
2010-01-06 |
2023-08-12 |
human |
| Shu Yang, Van Chanh Ngo, Guo Bin Lew, Lih Wen Valerie Chong, Swee Shean Lee, Wei Jie Richard Ong, Wei Ling Irene Lam, Choon Hua Thng, Heng Nung Koong, Hock Soo Ong, Alexander Chung, Pierce Chow, Jonathan Lee, Khee Chee Soo, Hung Huyn. AZD6244 (ARRY-142886) enhances the therapeutic efficacy of sorafenib in mouse models of gastric cancer. Molecular cancer therapeutics. vol 8. issue 9. 2010-01-05. PMID:19723882. |
these were associated with reduction in the phosphorylation of vascular endothelial growth factor receptor-2 tyr951, c-kit tyr568/570, platelet-derived growth factor receptor-beta tyr1021, and akt ser473 and thr308, down-regulation of positive cell cycle regulators, increased apoptosis, and up-regulation of p27. |
2010-01-05 |
2023-08-12 |
mouse |
| Mallikarjuna Gu, Srirupa Roy, Komal Raina, Chapla Agarwal, Rajesh Agarwa. Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target. Cancer research. vol 69. issue 24. 2010-01-05. PMID:19920184. |
ip6 treatment of cells suppressed proliferation, induced apoptosis along with caspase-3 and poly(adp-ribose) polymerase (parp) cleavage, and inhibited constitutive activation of akt and its upstream regulators pi3k, phosphoinositide-dependent kinase-1 and integrin-linked kinase-1 (ilk1). |
2010-01-05 |
2023-08-12 |
mouse |
| Henrik Fyrst, Babak Oskouian, Padmavathi Bandhuvula, Yaqiong Gong, Hoe Sup Byun, Robert Bittman, Andrew R Lee, Julie D Sab. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer research. vol 69. issue 24. 2010-01-05. PMID:19934323. |
sphingadienes exert their influence by blocking akt translocation from the cytosol to the membrane, thereby inhibiting protein translation and promoting apoptosis and autophagy. |
2010-01-05 |
2023-08-12 |
Not clear |
| Yoshinori Sato, Hiroyo Oda, Michael S Patrick, Yukari Baba, Ahmed A Rus'd, Yoshinao Azuma, Takaya Abe, Mutsunori Shirai, Harumi Suzuk. Rac GTPases are involved in development, survival and homeostasis of T cells. Immunology letters. vol 124. issue 1. 2010-01-04. PMID:19480078. |
finally, we found increased spontaneous apoptosis of dp thymocytes and mature t cells in dnrac1-tg mice, possibly because of reduced phosphorylation of akt with or without tcr stimulation. |
2010-01-04 |
2023-08-12 |
mouse |
| Dorrah Deeb, Xiaohua Gao, Hao Jiang, Branislava Janic, Ali S Arbab, Yon Rojanasakul, Scott A Dulchavsky, Subhash C Gauta. Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism. Biochemical pharmacology. vol 79. issue 3. 2009-12-22. PMID:19782051. |
here, we show that cddo-me induces ros generation from both nonmitochondrial and mitochondrial sources, which is associated with the induction of apoptosis as characterized by increased annexin v-binding, cleavage of parp-1 and procaspases-3, -8, -9, loss of mitochondrial membrane potential and release of cytochrome c. in addition, cddo-me inhibited cell survival akt, nf-kappab and mtor signaling proteins. |
2009-12-22 |
2023-08-12 |
Not clear |
| El-Shaimaa A Arafa, Qianzheng Zhu, Bassant M Barakat, Gulzar Wani, Qun Zhao, Mohamed A El-Mahdy, Altaf A Wan. Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. Cancer research. vol 69. issue 23. 2009-12-21. PMID:19903849. |
the tangeretin-cisplatin-induced apoptosis in a2780/cp70 cells was increased by phosphoinositide-3 kinase (pi3k) inhibition and sirna-mediated akt silencing, but reduced by overexpression of constitutively activated akt and gsk-3beta inhibition. |
2009-12-21 |
2023-08-12 |
human |
| Antonella D'Anneo, Giuseppa Augello, Andrea Santulli, Michela Giuliano, Riccardo di Fiore, Concetta Messina, Giovanni Tesoriere, Renza Vent. Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt. Journal of cellular physiology. vol 222. issue 2. 2009-12-17. PMID:19918798. |
treatment with wortmannin or transfection with a dominant negative form of akt anticipated at 24 h the effects induced by ptx/lpc, suggesting a protective role against apoptosis played by akt in y79 cells. |
2009-12-17 |
2023-08-12 |
human |
| Ana Catarina R G Fonseca, Teresa Proença, Rosa Resende, Catarina R Oliveira, Cláudia M F Pereir. Neuroprotective effects of statins in an in vitro model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19363255. |
moreover, our results revealed that simvastatin, at neuroprotective concentrations against abeta-induced toxicity, is not able to activate akt or erk2, two signaling kinases with neuroprotective roles against apoptosis. |
2009-12-15 |
2023-08-12 |
Not clear |
| Hyung Sun Park, Yunha Yun, Cha Soon Kim, Kwang Hee Yang, Meeseon Jeong, Sung Kwan Ahn, Young-Woo Jin, Seon Young Na. A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression. European journal of cell biology. vol 88. issue 10. 2009-12-15. PMID:19615784. |
a critical role for akt activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression. |
2009-12-15 |
2023-08-12 |
human |
| Hyung Sun Park, Yunha Yun, Cha Soon Kim, Kwang Hee Yang, Meeseon Jeong, Sung Kwan Ahn, Young-Woo Jin, Seon Young Na. A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression. European journal of cell biology. vol 88. issue 10. 2009-12-15. PMID:19615784. |
on the other hand, suppression of endogenous akt expression by sirna resulted in the reduction of acinus expression and enhanced the radiation-induced apoptosis in both ccd-18lu and im-9 cells. |
2009-12-15 |
2023-08-12 |
human |
| Hyung Sun Park, Yunha Yun, Cha Soon Kim, Kwang Hee Yang, Meeseon Jeong, Sung Kwan Ahn, Young-Woo Jin, Seon Young Na. A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression. European journal of cell biology. vol 88. issue 10. 2009-12-15. PMID:19615784. |
our results suggest that akt activation inhibits cell death during radiation-induced apoptosis through the regulation of phosphorylation and expression of acinus. |
2009-12-15 |
2023-08-12 |
human |
| Anthony C Faber, Danan Li, Youngchul Song, Mei-Chih Liang, Beow Y Yeap, Roderick T Bronson, Eugene Lifshits, Zhao Chen, Sauveur-Michel Maira, Carlos García-Echeverría, Kwok-Kin Wong, Jeffrey A Engelma. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19850869. |
surprisingly, an akt inhibitor did not decrease mcl-1 levels, and when combined with mek inhibitors, failed to induce apoptosis. |
2009-12-15 |
2023-08-12 |
Not clear |
| Sung-Won Shin, Chi-Yeon Seo, Hoon Han, Jin-Yeong Han, Jin-Sook Jeong, Jong-Young Kwak, Joo-In Par. 15d-PGJ2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 15. issue 17. 2009-12-11. PMID:19690198. |
15d-pgj2 induces apoptosis by reactive oxygen species-mediated inactivation of akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. |
2009-12-11 |
2023-08-12 |
Not clear |
| Long Tai Zheng, Shinrye Lee, Guo Nan Yin, Kiyoshi Mori, Kyoungho Su. Down-regulation of lipocalin 2 contributes to chemoresistance in glioblastoma cells. Journal of neurochemistry. vol 111. issue 5. 2009-12-11. PMID:19860839. |
lcn2 enhanced bcnu-induced akt dephosphorylation providing a molecular basis of apoptosis sensitization. |
2009-12-11 |
2023-08-12 |
human |