| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aydee C Estrada, Tatiana Syrovets, Kai Pitterle, Oleg Lunov, Berthold Büchele, Judith Schimana-Pfeifer, Thomas Schmidt, Samy A F Morad, Thomas Simme. Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Molecular pharmacology. vol 77. issue 3. 2010-03-19. PMID:20018812. |
tirucallic acids are novel pleckstrin homology domain-dependent akt inhibitors inducing apoptosis in prostate cancer cells. |
2010-03-19 |
2023-08-12 |
mouse |
| Elisa Giovannetti, Richard Honeywell, Axel R Hanauske, Christina Tekle, Bart Kuenen, Jennifer Sigmond, Giuseppe Giaccone, Godefridus J Peter. Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC). Current drug targets. vol 11. issue 1. 2010-03-15. PMID:19839931. |
enzastaurin-pemetrexed combination was synergistic in preclinical models, including nsclc cells, where enzastaurin reduced phosphocdc25c, resulting in g2/m-checkpoint abrogation, and akt and gsk3beta; phosphorylation, favoring apoptosis induction in pemetrexed-damaged cells. |
2010-03-15 |
2023-08-12 |
Not clear |
| Jung-Min Eom, Min-Ji Seo, Ji-Young Baek, Hyuk Chu, Seung Hyun Han, Tae Sun Min, Chong-su Cho, Cheol-Heui Yu. Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19951696. |
treatment with alpha-esa caused inhibition of phosphorylated (p)akt and elongated the sub g1 phase in the cell cycle, indicating induction of apoptosis. |
2010-03-15 |
2023-08-12 |
Not clear |
| Valeria Gabriela Antico Arciuch, Soledad Galli, María Clara Franco, Philip Y Lam, Enrique Cadenas, María Cecilia Carreras, Juan José Poderos. Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. PloS one. vol 4. issue 10. 2010-03-12. PMID:19844585. |
akt is a serine/threonine kinase involved in cell proliferation, apoptosis, and glucose metabolism. |
2010-03-12 |
2023-08-12 |
Not clear |
| Kazuhito Naka, Takayuki Hoshii, Teruyuki Muraguchi, Yuko Tadokoro, Takako Ooshio, Yukio Kondo, Shinji Nakao, Noboru Motoyama, Atsushi Hira. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature. vol 463. issue 7281. 2010-03-12. PMID:20130650. |
it is widely believed that bcr-abl activates akt signalling that suppresses the forkhead o transcription factors (foxo), supporting the proliferation or inhibiting the apoptosis of cml cells. |
2010-03-12 |
2023-08-12 |
mouse |
| E Peuhu, A Rivero-Müller, H Stykki, E Torvaldson, T Holmbom, P Eklund, M Unkila, R Sjöholm, J E Eriksso. Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis. Oncogene. vol 29. issue 6. 2010-03-10. PMID:19935713. |
inhibition of akt signaling by the lignan matairesinol sensitizes prostate cancer cells to trail-induced apoptosis. |
2010-03-10 |
2023-08-12 |
Not clear |
| Jun-Qiu Song, Xu Teng, Yan Cai, Chao-Shu Tang, Yong-Fen Q. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19757065. |
imd(1-53) (1 x 10(-7) mol/l) inhibited the h/r effect in cardiomyocytes by reducing cell death by 43% and ldh leakage by 16%; diminishing cellular apoptosis; decreasing caspase 3 activity by 50%; and increasing the phosphorylated akt and gsk-3beta by 41 and 90%, respectively. |
2010-03-09 |
2023-08-12 |
rat |
| Jung Hwa Oh, Jung Tae Lee, Eun Sun Yang, Jong-Soo Chang, Dong Sun Lee, Sang Hyun Kim, Yung Hyun Choi, Jong-Wook Park, Taeg Kyu Kwo. The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19768546. |
the coffee diterpene kahweol induces apoptosis in human leukemia u937 cells through down-regulation of akt phosphorylation and activation of jnk. |
2010-03-09 |
2023-08-12 |
human |
| Jung Hwa Oh, Jung Tae Lee, Eun Sun Yang, Jong-Soo Chang, Dong Sun Lee, Sang Hyun Kim, Yung Hyun Choi, Jong-Wook Park, Taeg Kyu Kwo. The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19768546. |
ectopic expression of bcl-2 or constitutive active akt (myr-akt) in u937 cells attenuates kahweol-induced apoptosis. |
2010-03-09 |
2023-08-12 |
human |
| Jung Hwa Oh, Jung Tae Lee, Eun Sun Yang, Jong-Soo Chang, Dong Sun Lee, Sang Hyun Kim, Yung Hyun Choi, Jong-Wook Park, Taeg Kyu Kwo. The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19768546. |
in addition, we have also shown that jnk and akt signal pathway plays a crucial role in kahweol-induced apoptosis in u937 cells. |
2010-03-09 |
2023-08-12 |
human |
| Seong-Yun Jeong, Min Ho Han, Cheng-Yun Jin, Gi-Young Kim, Byung Tae Choi, Taek-Jeong Nam, Se-Kwon Kim, Yung Hyun Cho. Apoptosis induction of human leukemia cells by Streptomyces sp. SY-103 metabolites through activation of caspase-3 and inactivation of Akt. International journal of molecular medicine. vol 25. issue 1. 2010-03-09. PMID:19956899. |
the activity of akt was also inhibited in pcc-treated cells, and phosphatidylinositol 3-kinase (pi3k)/akt inhibitor, ly294002, sensitized the cells to pcc-induced apoptosis indicating that the down-regulation of the akt signaling pathway plays a key role in pcc-induced apoptosis. |
2010-03-09 |
2023-08-12 |
human |
| Rafael Ramirez, Julia Carracedo, Sonia Nogueras, Paula Buendia, Ana Merino, Sagrario Cañadillas, Mariano Rodríguez, Ciro Tetta, Alejandro Martin-Malo, Pedro Aljam. Carbamylated darbepoetin derivative prevents endothelial progenitor cell damage with no effect on angiogenesis. Journal of molecular and cellular cardiology. vol 47. issue 6. 2010-03-08. PMID:19782086. |
cell signals regulating proliferation and apoptosis (jak-2, akt, erk1/2, nfkappab and stat-5) were measured by western blotting. |
2010-03-08 |
2023-08-12 |
human |
| Hyunsoo Kim, Wei Huang, Xiuli Jiang, Brenton Pennicooke, Peter J Park, Mark D Johnso. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 5. 2010-03-05. PMID:20080666. |
we demonstrate that mir-26a alone can transform cells and it promotes glioblastoma cell growth in vitro and in the mouse brain by decreasing pten, rb1, and map3k2/mekk2 protein expression, thereby increasing akt activation, promoting proliferation, and decreasing c-jun n-terminal kinase-dependent apoptosis. |
2010-03-05 |
2023-08-12 |
mouse |
| N Aceto, P Bertino, D Barbone, G Tassi, L Manzo, C Porta, L Mutti, G Gaudin. Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma. The European respiratory journal. vol 34. issue 6. 2010-03-04. PMID:19460788. |
apoptosis induced by tn is driven by oxidative stress and cell exposure to sulfydryl donors, such as glutathione monoethylester and l-n-acetylcysteine, significantly reduced pro-apoptotic effects and akt inhibition. |
2010-03-04 |
2023-08-12 |
human |
| Takuma Kumamoto, Makoto Fujii, De-Xing Ho. Akt is a direct target for myricetin to inhibit cell transformation. Molecular and cellular biochemistry. vol 332. issue 1-2. 2010-03-04. PMID:19504174. |
akt, a serine/threonine kinase, is a critical regulator in many cellular processes including cell growth, proliferation, and apoptosis. |
2010-03-04 |
2023-08-12 |
Not clear |
| Mi-kyung Hwang, Yong Ki Min, Seong Hwan Ki. Calmodulin inhibition contributes to sensitize TRAIL-induced apoptosis in human lung cancer H1299 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 87. issue 6. 2010-03-04. PMID:19935877. |
we suggested the blockade of cam could sensitize lung cancer cells to trail-induced apoptosis in at least 2 ways: (i) it can activate death-inducing signaling complex mediated apoptosis by inhibiting trail-induced binding of flip and trail-enhanced binding of caspase-8 to fadd; (ii) it can inhibit akt phosphorylation, consequently leading to decreased expression of anti-apoptotic molecules such as flip and members of the inhibitor of apoptosis protein family. |
2010-03-04 |
2023-08-12 |
human |
| Soon Young Shin, Yeonjoong Yong, Chang Gun Kim, Young Han Lee, Yoongho Li. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer letters. vol 287. issue 2. 2010-03-02. PMID:19616373. |
together, these data suggest that dppt induces g(2)/m cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of atm, upregulation of p53 and bax, activation of caspase-3 and -7, and accumulation of pten resulting in the inhibition of the akt pathway. |
2010-03-02 |
2023-08-12 |
Not clear |
| Takashi Nishioka, Jinjin Guo, Daisuke Yamamoto, Lihua Chen, Petra Huppi, Chang Yan Che. Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation. Journal of cellular biochemistry. vol 109. issue 1. 2010-03-02. PMID:19911375. |
we demonstrated that short-term nicotine exposure moderately activated mitogenic signaling pathways (such as pkc, erk, and akt) and a mediocre protection against cisplatin-mediated apoptosis. |
2010-03-02 |
2023-08-12 |
Not clear |
| Xing Fan, Leila Khaki, Thant S Zhu, Mary E Soules, Caroline E Talsma, Naheed Gul, Cheryl Koh, Jiangyang Zhang, Yue-Ming Li, Jarek Maciaczyk, Guido Nikkhah, Francesco Dimeco, Sara Piccirillo, Angelo L Vescovi, Charles G Eberhar. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem cells (Dayton, Ohio). vol 28. issue 1. 2010-03-01. PMID:19904829. |
we found that notch pathway inhibition appears to deplete stem-like cancer cells through reduced proliferation and increased apoptosis associated with decreased akt and stat3 phosphorylation. |
2010-03-01 |
2023-08-12 |
mouse |
| Jamie M Green, Ayesha B Alvero, Fortune Kohen, Gil Mo. 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells. Cancer biology & therapy. vol 8. issue 18. 2010-02-25. PMID:19738422. |
this effect was due to the induction of apoptosis, which is characterized by caspase activation, xiap and akt degradation, and mitochondrial depolarization. |
2010-02-25 |
2023-08-12 |
Not clear |