| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Jun Peng, Juan Wang, Jun-Ying Zhou, Gen Sheng W. Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells. Biochemical and biophysical research communications. vol 394. issue 3. 2010-05-04. PMID:20214883. |
importantly, inhibition of akt or mtor sensitized resistant cells to cisplatin-induced apoptosis. |
2010-05-04 |
2023-08-12 |
human |
| Alina Nicoleta Beşliu, Gina Pistol, Carmen Maria Marica, Leontina Mirela Bănică, Cristina Chiţonu, Ruxandra Ionescu, Cristina Tănăseanu, Isabela Tamsulea, Cristiana Matache, Maria Stefănesc. PI3K/Akt signaling in peripheral T lymphocytes from systemic lupus erythematosus patients. Roumanian archives of microbiology and immunology. vol 68. issue 2. 2010-05-04. PMID:20361524. |
since p27kip1, an inhibitor of cell cycle progression, is one of the akt substrates, we analyzed its expression level in relationship with cell cycle progression and apoptosis. |
2010-05-04 |
2023-08-12 |
Not clear |
| Surekha Rani Panjala, Steven A Thomas, Jena J Steinl. Effects of insulin-like growth factor-1 (IGF-1) receptor signaling on rates of apoptosis in retina of dopamine beta hydroxylase (Dbh-/-) knockout mice. Autonomic neuroscience : basic & clinical. vol 152. issue 1-2. 2010-04-29. PMID:19748322. |
the reduction in akt phosphorylation, likely through reduced igf-1 receptor signaling, could explain the increase in cleaved caspase 3, leading to apoptosis. |
2010-04-29 |
2023-08-12 |
mouse |
| Yohei Saito, Toshiyuki Owaki, Takuya Matsunaga, Mizue Saze, Shogo Miura, Mao Maeda, Mayu Eguchi, Rika Tanaka, Junichi Taira, Hiroaki Kodama, Sumio Goto, Yoshiroh Niitsu, Hiroshi Terada, Fumio Fuka. Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4. The Journal of biological chemistry. vol 285. issue 10. 2010-04-29. PMID:20007695. |
the inactivation of erk1/2 and akt and the subsequent activation of bad were involved in the apoptosis. |
2010-04-29 |
2023-08-12 |
Not clear |
| Yongjun Fan, Kathleen G Dickman, Wei-Xing Zon. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. The Journal of biological chemistry. vol 285. issue 10. 2010-04-29. PMID:20018866. |
when cells are treated with glycolysis inhibitors, akt sensitizes cells to apoptosis, whereas c-myc does not. |
2010-04-29 |
2023-08-12 |
human |
| Noriyuki Ouchi, Yasuhide Asaumi, Koji Ohashi, Akiko Higuchi, Saki Sono-Romanelli, Yuichi Oshima, Kenneth Wals. DIP2A functions as a FSTL1 receptor. The Journal of biological chemistry. vol 285. issue 10. 2010-04-29. PMID:20054002. |
in cultured cardiac myocytes, ablation of dip2a reduced the protective actions of fstl1 on hypoxia/reoxygenation-induced apoptosis and suppressed fstl1-induced akt phosphorylation. |
2010-04-29 |
2023-08-12 |
Not clear |
| Qian Li, Geng Li, Xiaomei Lan, Ming Zheng, Kuang-Hueih Chen, Chun-Mei Cao, Rui-Ping Xia. Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20042608. |
importantly, adenoviral overexpression of rip3 not only triggers apoptosis but also causes cell cycle arrest at g(1)/g(0) phases that is associated with suppressed akt activation. |
2010-04-26 |
2023-08-12 |
rat |
| Victor May, Eve Lutz, Christopher MacKenzie, Kristin C Schutz, Kate Dozark, Karen M Braa. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20093365. |
between erk and akt pathways, pacap-stimulated akt signaling was the primary cascade that attenuated cultured neuron apoptosis after growth factor withdrawal. |
2010-04-26 |
2023-08-12 |
Not clear |
| K Tajima, R Ohashi, Y Sekido, T Hida, T Nara, M Hashimoto, S Iwakami, K Minakata, T Yae, F Takahashi, H Saya, K Takahash. Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells. Oncogene. vol 29. issue 13. 2010-04-23. PMID:20101228. |
inhibition of the akt phosphorylation increased in number of the cells underwent apoptosis induced by nvb, vp-16 and gem. |
2010-04-23 |
2023-08-12 |
Not clear |
| Yan Zhao, Manabu Okuyama, Hiroyuki Hashimoto, Yoshiaki Tagawa, Takahito Jomori, Baofeng Yan. Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 1. 2010-04-22. PMID:19683050. |
these results suggest the critical roles of pparalpha signaling in bezafibrate-induced myotoxicity and the involvement of apoptosis through akt pathway. |
2010-04-22 |
2023-08-12 |
human |
| Fan Yang, Veronica Jove, Hong Xin, Michael Hedvat, Timothy E Van Meter, Hua Y. Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. Molecular cancer research : MCR. vol 8. issue 1. 2010-04-22. PMID:20053726. |
sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting stat3 and akt signaling pathways. |
2010-04-22 |
2023-08-12 |
human |
| Damien Calay, Dina Vind-Kezunovic, Aurelie Frankart, Sylviane Lambert, Yves Poumay, Robert Gniadeck. Inhibition of Akt signaling by exclusion from lipid rafts in normal and transformed epidermal keratinocytes. The Journal of investigative dermatology. vol 130. issue 4. 2010-04-16. PMID:20054340. |
diminished akt activity resulted in deactivation of mammalian target of rapamycin, activation of foxo3a, and increased sensitivity to apoptosis stimuli. |
2010-04-16 |
2023-08-12 |
human |
| Donghwa Kim, Mei Sun, Lili He, Qing-Hua Zhou, Jun Chen, Xia-Meng Sun, Gerold Bepler, Said M Sebti, Jin Q Chen. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. The Journal of biological chemistry. vol 285. issue 11. 2010-04-15. PMID:20068047. |
the inhibition of akt by api-1 resulted in induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated akt. |
2010-04-15 |
2023-08-12 |
mouse |
| Reika Takamatsu, Eriko Takeshima, Chie Ishikawa, Kei Yamamoto, Hiromitsu Teruya, Klaus Heuner, Futoshi Higa, Jiro Fujita, Naoki Mor. Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis. The Biochemical journal. vol 427. issue 1. 2010-04-15. PMID:20102336. |
it also caused the activation of the pro-apoptotic protein bax and inhibited the expression of the anti-apoptotic protein xiap (x-linked inhibitor of apoptosis) via inhibition of the akt pathway. |
2010-04-15 |
2023-08-12 |
human |
| Lan Shen, Xuewu Liu, Wugang Hou, Guodong Yang, Yousheng Wu, Rui Zhang, Xia Li, Honglei Che, Zifan Lu, Yuanqiang Zhang, Xinping Liu, Libo Ya. NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity. Cellular and molecular life sciences : CMLS. vol 67. issue 8. 2010-04-13. PMID:20127388. |
overexpression of constitutively active akt enhanced ndrg2 phosphorylation and abolished the apoptosis induced by ffa in beta-tc3 cells, whereas ndrg2 knock-down attenuated akt-mediated protection of beta cells against fatty acid-triggered apoptosis. |
2010-04-13 |
2023-08-12 |
Not clear |
| Anguraj Sadanandam, Erin G Rosenbaugh, Seema Singh, Michelle Varney, Rakesh K Sing. Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvascular research. vol 79. issue 1. 2010-04-12. PMID:19850054. |
in addition, our data suggest that sema5a decreases apoptosis through activation of akt, increases migration through activating met tyrosine kinases and extracellular matrix degradation through matrix metalloproteinase 9. |
2010-04-12 |
2023-08-12 |
mouse |
| Mihoko Kondo-Nakamura, Kaori Shintani-Ishida, Koichi Uemura, Ken-ichi Yoshid. Brief exposure to carbon monoxide preconditions cardiomyogenic cells against apoptosis in ischemia-reperfusion. Biochemical and biophysical research communications. vol 393. issue 3. 2010-04-12. PMID:20152804. |
these results suggest that co pretreatment induces mitochondrial generation of o2(-), which is then converted by sod to h2o2, and subsequent akt activation by h2o2 attenuates apoptosis in ischemia-reperfusion. |
2010-04-12 |
2023-08-12 |
Not clear |
| Feijun Luo, Hongtao Ye, Rifat Hamoudi, Gehong Dong, Wenyan Zhang, Charles E Patek, George Poulogiannis, Mark J Arend. K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation. The Journal of pathology. vol 220. issue 5. 2010-04-09. PMID:20087880. |
immunohistochemical studies showed that adenomas of k-ras(tmdelta4a/tmdelta4a) mice had significantly increased cell proliferation and significantly decreased apoptosis with evidence of activation of mapkinase and akt pathways, with increased phospho-erk1/2 and both phospho-akt-thr308 and phospho-akt-ser473 immunostaining, compared with adenomas from k-ras(tmdelta4a/+) and wild-type mice. |
2010-04-09 |
2023-08-12 |
mouse |
| Feijun Luo, Hongtao Ye, Rifat Hamoudi, Gehong Dong, Wenyan Zhang, Charles E Patek, George Poulogiannis, Mark J Arend. K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation. The Journal of pathology. vol 220. issue 5. 2010-04-09. PMID:20087880. |
in conclusion, following dmh treatment, k-ras exon 4a deletion promoted increased number and size of colonic adenomas showing increased k-ras 4b expression, increased proliferation, decreased apoptosis, and activation of mapkinase and akt pathways, in the absence of k-ras mutations. |
2010-04-09 |
2023-08-12 |
mouse |
| Nicolas Pallet, Nicolas Bouvier, Christophe Legendre, Philippe Beaune, Eric Thervet, Gabriel Choukroun, Frank Martine. Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity. Pharmacological research. vol 61. issue 1. 2010-04-08. PMID:19766721. |
our data suggest that this nephroprotective effect is mediated by akt activation and inhibition of tubular apoptosis. |
2010-04-08 |
2023-08-12 |
human |