| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukihiro Akao, Yoshihito Nakagawa, Munekazu Iinuma, Yoshinori Nozaw. Anti-cancer effects of xanthones from pericarps of mangosteen. International journal of molecular sciences. vol 9. issue 3. 2010-06-10. PMID:19325754. |
alpha-mangostin found to induce apoptosis through the activation of intrinsic pathway following the down-regulation of signaling cascades involving map kinases and the serine/threonine kinase akt. |
2010-06-10 |
2023-08-12 |
mouse |
| Vladimir N Ivanov, Hongning Zhou, Shanaz A Ghandhi, Thomas B Karasic, Benjamin Yaghoubian, Sally A Amundson, Tom K He. Radiation-induced bystander signaling pathways in human fibroblasts: a role for interleukin-33 in the signal transmission. Cellular signalling. vol 22. issue 7. 2010-06-10. PMID:20206688. |
taken together, our results demonstrated the early activation of nf-kappab-dependent gene expression first in directly irradiated and then bystander fibroblasts, the further modulation of critical proteins, including il-33, by akt in bystander cells and late drastic changes in cell survival and in enhanced sensitivity to trail-induced apoptosis after suppression of the igf-1r-akt-il-33 signaling cascade in both directly irradiated and bystander cells. |
2010-06-10 |
2023-08-12 |
human |
| Meng Qiao, Yaqi Wang, Xiaoen Xu, Jing Lu, Yongli Dong, Wufan Tao, Janet Stein, Gary S Stein, James D Iglehart, Qian Shi, Arthur B Parde. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Molecular cell. vol 38. issue 4. 2010-06-10. PMID:20513427. |
however, akt, or other known targets of phlpps that include pkc and erk, may not fully elucidate the physiological role of the multifunctional phosphatases, especially their powerful apoptosis induction function. |
2010-06-10 |
2023-08-12 |
Not clear |
| Meng Qiao, Yaqi Wang, Xiaoen Xu, Jing Lu, Yongli Dong, Wufan Tao, Janet Stein, Gary S Stein, James D Iglehart, Qian Shi, Arthur B Parde. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Molecular cell. vol 38. issue 4. 2010-06-10. PMID:20513427. |
thus, phlpp, akt, and mst1 constitute an autoinhibitory triangle that controls the fine balance of apoptosis and proliferation that is cell type and context dependent. |
2010-06-10 |
2023-08-12 |
Not clear |
| Mousa Abkhezr, Ali Reza Keramati, Seyed Nasser Ostad, Jamshid Davoodi, Mohammad H Ghahreman. The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line. Molecular biology reports. vol 37. issue 4. 2010-06-08. PMID:19649722. |
in this study, we have studied the activity of survival pathways, i.e., akt and erk1/2 with regard to xiap (inhibitor of apoptosis) in serum starved and stimulated conditions. |
2010-06-08 |
2023-08-12 |
Not clear |
| Mousa Abkhezr, Ali Reza Keramati, Seyed Nasser Ostad, Jamshid Davoodi, Mohammad H Ghahreman. The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line. Molecular biology reports. vol 37. issue 4. 2010-06-08. PMID:19649722. |
the expression of total akt and erk1/2 has not changed significantly for 24 h. xiap expression starts at 6 h after serum stimulation, reaches to maximum level at 12 h and decreases to baseline within 24 h. furthermore, serum starvation for 24 h does not induced apoptosis and dna condensation. |
2010-06-08 |
2023-08-12 |
Not clear |
| Annalisa Natalicchio, Francesca De Stefano, Maura Roberta Orlando, Mariangela Melchiorre, Anna Leonardini, Angelo Cignarelli, Rossella Labarbuta, Piero Marchetti, Sebastio Perrini, Luigi Laviola, Francesco Giorgin. Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells. Endocrinology. vol 151. issue 5. 2010-06-08. PMID:20219981. |
when cells were pretreated with exendin-4, tnfalpha-induced jnk and irs-1/2 serine phosphorylation was markedly reduced, akt phosphorylation was increased, caspase-3 and bcl-2 protein levels were restored to normal, and tnfalpha-induced apoptosis was inhibited by 50%. |
2010-06-08 |
2023-08-12 |
human |
| Hee Jung Um, Jae Hoon Bae, Jong-Wook Park, Hongsuk Suh, Na Young Jeong, Young Hyun Yoo, Taeg Kyu Kwo. Differential effects of resveratrol and novel resveratrol derivative, HS-1793, on endoplasmic reticulum stress-mediated apoptosis and Akt inactivation. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198347. |
differential effects of resveratrol and novel resveratrol derivative, hs-1793, on endoplasmic reticulum stress-mediated apoptosis and akt inactivation. |
2010-06-04 |
2023-08-12 |
human |
| Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N Johnston, Young-Hwa Chun. Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198349. |
reovirus infection induces apoptosis of trail-resistant gastric cancer cells by down-regulation of akt activation. |
2010-06-04 |
2023-08-12 |
Not clear |
| Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N Johnston, Young-Hwa Chun. Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198349. |
furthermore, co-treatment with reovirus and trail accelerated apoptosis of snu-216 cells by down-regulation of akt activation as assessed by a very low activation of akt in trail-sensitive snu-668 gastric cancer cells. |
2010-06-04 |
2023-08-12 |
Not clear |
| Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N Johnston, Young-Hwa Chun. Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198349. |
inhibition of akt signaling with wortmannin or suppression of akt expression with sh-akt lentivirus promoted reovirus-mediated apoptosis of snu-216 gastric cancer cells. |
2010-06-04 |
2023-08-12 |
Not clear |
| Il-Rae Cho, Sang Seok Koh, Hye-Jin Min, Eun-Hee Park, Ratakorn Srisuttee, Byung Hak Jhun, Chi Duk Kang, Manbok Kim, Randal N Johnston, Young-Hwa Chun. Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198349. |
accordingly, we first demonstrate that reovirus infection down-regulates akt activation, leading to apoptosis of trail-resistant gastric cancer cells. |
2010-06-04 |
2023-08-12 |
Not clear |
| O Pellerito, G Calvaruso, P Portanova, A De Blasio, A Santulli, R Vento, G Tesoriere, M Giulian. The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis. Molecular pharmacology. vol 77. issue 5. 2010-05-28. PMID:20159939. |
moreover, win induced a significant decrease in the levels of some survival factors (survivin, c-inhibitor of apoptosis protein 2, and bcl-2) and in particular in that of the active phosphorylated form of akt. |
2010-05-28 |
2023-08-12 |
human |
| Zahra Faghiri, Nicolas G Baza. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20230819. |
we found that in single-dose oxidative stress-induced apoptosis, phosphorylation of akt, mtor, and p70s6k was both time- and dose- dependent. |
2010-05-27 |
2023-08-12 |
human |
| Zahra Faghiri, Nicolas G Baza. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20230819. |
inhibition of pi3k or mtor/p70s6k by wortmannin and rapamycin, respectively, increased apoptosis and inhibited phosphorylation of akt and p70s6k induced by single-dose oxidative stress. |
2010-05-27 |
2023-08-12 |
human |
| Zahra Faghiri, Nicolas G Baza. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20230819. |
while two exposures of a low dose, non-damaging oxidation induced apoptosis and upregulation of akt, mtor, and p70s6k, longer treatment of the cells with three exposures of low dose to low-dose stress showed no changes in the levels of akt, mtor, or p70s6k, and resulted in enhanced apoptosis compared to higher doses. |
2010-05-27 |
2023-08-12 |
human |
| Zahra Faghiri, Nicolas G Baza. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20230819. |
removing the oxidative stress-inducing agents following the single-dose or short term repetitive oxidative stress at the peak of akt, mtor, and p70s6k phosphorylation (i.e., 30 min after induction) led to recovery, with no apoptosis after 16 h of incubation. |
2010-05-27 |
2023-08-12 |
human |
| Zahra Faghiri, Nicolas G Baza. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20230819. |
npd1 protected the rpe cells against both single-dose and repetitive oxidative stress-induced apoptosis and promoted higher levels of phosphorylated akt, mtor, and p70s6k. |
2010-05-27 |
2023-08-12 |
human |
| Shadan Ali, Aamir Ahmad, Sanjeev Banerjee, Subhash Padhye, Kristin Dominiak, Jacqueline M Schaffert, Zhiwei Wang, Philip A Philip, Fazlul H Sarka. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF. Cancer research. vol 70. issue 9. 2010-05-27. PMID:20388782. |
mechanistic investigations revealed a significant reduction in cell viability in cdf-treated cells compared with curcumin-treated cells, which were also associated with the induction of apoptosis, and these results were consistent with the downregulation of akt, cyclooxygenase-2, prostaglandin e(2), vascular endothelial growth factor, and nf-kappab dna binding activity. |
2010-05-27 |
2023-08-12 |
Not clear |
| Natalia Calvo, Ana Russo de Boland, Claudia Gentil. PTH inactivates the AKT survival pathway in the colonic cell line Caco-2. Biochimica et biophysica acta. vol 1803. issue 3. 2010-05-21. PMID:20005908. |
this study was conducted to investigate the modulation of different players implicated in the akt survival pathway in pth-induced intestinal cell apoptosis. |
2010-05-21 |
2023-08-12 |
human |