| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Jin Lee, Ji-Hoon Jang, Hyo-Jeong Noh, Eun-Jung Park, Kyeong-Sook Choi, Taeg-Kyu Kwo. Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells. Journal of cellular biochemistry. vol 109. issue 5. 2010-06-25. PMID:20127709. |
overexpression of par-4 sensitizes trail-induced apoptosis via inactivation of nf-kappab and akt signaling pathways in renal cancer cells. |
2010-06-25 |
2023-08-12 |
Not clear |
| Oumou Goundiam, Marie-Danielle Nagel, Muriel Vayssad. Growth and survival signalling in B16F10 melanoma cells in 3D culture. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:20015052. |
for this, we analysed cell morphology, proliferation, apoptosis and the activation status of several proteins involved in cell proliferation and survival [rhoa, fak (focal adhesion kinase), akt, erk1/2 (extracellular-signal-regulated kinase 1/2)]. |
2010-06-24 |
2023-08-12 |
Not clear |
| Oumou Goundiam, Marie-Danielle Nagel, Muriel Vayssad. Growth and survival signalling in B16F10 melanoma cells in 3D culture. Cell biology international. vol 34. issue 4. 2010-06-24. PMID:20015052. |
fak and akt were transiently activated, and their inactivation was correlated with the induction of apoptosis. |
2010-06-24 |
2023-08-12 |
Not clear |
| Chuan-Bian Lim, Nung Ky, Hui-Min Ng, Mohamed Sabry Hamza, Yan Zha. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative cancer therapies. vol 9. issue 1. 2010-06-24. PMID:20150221. |
cwe-treated cells displayed reduced pten, akt, and stat3 phosphorylation and downregulation of nfkappab signaling, providing a mechanism for the g1 arrest and apoptosis observed. |
2010-06-24 |
2023-08-12 |
mouse |
| Chi Bun Chan, Keqiang Y. Multiple functions of phosphoinositide-3 kinase enhancer (PIKE). TheScientificWorldJournal. vol 10. 2010-06-24. PMID:20419274. |
interestingly, the pike gene (centg1) is also amplified in a variety of human cancers and enhances akt activity, leading to their resistance against apoptosis and invasion. |
2010-06-24 |
2023-08-12 |
mouse |
| In-Sook Park, Jeong-Rang Jo, Hua Hong, Ki-Young Nam, Jong-Bae Kim, Sang-Hee Hwang, Mi-Sun Choi, Nam-Hee Ryu, Hyun-Jung Jang, Sang-Han Lee, Chin-Soo Kim, Tae-Geon Kwon, Gy-Young Park, Jong-Wook Park, Byeong-Churl Jan. Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20116423. |
aspirin induces apoptosis in yd-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of mcl-1, and inactivation of erk-1/2 and akt. |
2010-06-22 |
2023-08-12 |
human |
| In-Sook Park, Jeong-Rang Jo, Hua Hong, Ki-Young Nam, Jong-Bae Kim, Sang-Hee Hwang, Mi-Sun Choi, Nam-Hee Ryu, Hyun-Jung Jang, Sang-Han Lee, Chin-Soo Kim, Tae-Geon Kwon, Gy-Young Park, Jong-Wook Park, Byeong-Churl Jan. Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20116423. |
these findings collectively suggest that aspirin induces apoptosis in yd-8 cells and the induction may be correlated to activation of caspases, caspase-dependent mcl-1 proteolysis, inactivation of erk-1/2 and akt, and activation of nf-kappab. |
2010-06-22 |
2023-08-12 |
human |
| Thomas B Karasic, Tom K Hei, Vladimir N Ivano. Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma. Experimental cell research. vol 316. issue 12. 2010-06-22. PMID:20417200. |
this combination substantially increased death by apoptosis for wm793 and wm9 cells, but did so only modestly for lu1205 cells with very high basal activity of akt. |
2010-06-22 |
2023-08-12 |
human |
| Shahab Uddin, Prashant Bavi, Abdul K Siraj, Maqbool Ahmed, Maha Al-Rasheed, Azhar R Hussain, Mohammed Ahmed, Tarek Amin, Ali Alzahrani, Fouad Al-Dayel, Jehad Abubaker, Rong Bu, Khawla S Al-Kuray. Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma. Endocrine-related cancer. vol 17. issue 1. 2010-06-21. PMID:20008098. |
in vitro analysis showed that leptin stimulated cell proliferation and inhibited apoptosis via activation of phosphatidylinisitol 3' kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2010-06-21 |
2023-08-12 |
human |
| Amandeep Bajwa, Sang-Kyung Jo, Hong Ye, Liping Huang, Krishna R Dondeti, Diane L Rosin, Volker H Haase, Timothy L Macdonald, Kevin R Lynch, Mark D Okus. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN. vol 21. issue 6. 2010-06-21. PMID:20338995. |
in vitro, sew2871 significantly attenuated lps- or hypoxia/reoxygenation-induced apoptosis in cultured mouse proximal tubule epithelial cells, supporting a direct protective effect of s1p1r agonists via mitogen-activated protein kinase and/or akt pathways. |
2010-06-21 |
2023-08-12 |
mouse |
| Bronislaw L Slomiany, Amalia Slomian. Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation. Mediators of inflammation. vol 2010. 2010-06-21. PMID:20369000. |
the loss in countering effect of ghrelin on the lps-induced changes in apoptosis and caspase-3 activity was attained with src kinase inhibitor, pp2, as well as akt inhibitor, sh-5, and cnos inhibitor, l-name. |
2010-06-21 |
2023-08-12 |
Not clear |
| Eva Calviño, José Luis Manjón, Pilar Sancho, M Cristina Tejedor, Angel Herráez, José C Die. Ganoderma lucidum induced apoptosis in NB4 human leukemia cells: involvement of Akt and Erk. Journal of ethnopharmacology. vol 128. issue 1. 2010-06-18. PMID:20036724. |
ganoderma lucidum induced apoptosis in nb4 human leukemia cells: involvement of akt and erk. |
2010-06-18 |
2023-08-12 |
human |
| Xiu-Lan Huang, Guo-Hui Cui, Ke-Yuan Zho. [Correlation of PI3K-Akt signal pathway to apoptosis of tumor cells]. Ai zheng = Aizheng = Chinese journal of cancer. vol 27. issue 3. 2010-06-17. PMID:18334129. |
it plays important roles in cell apoptosis and survival by affecting the activity of downstream effector molecules, and it is closely associated with the development and progression of human tumors, therefore, pi3k and akt might be potential targets for tumor therapy. |
2010-06-17 |
2023-08-12 |
human |
| Ruud Das, Holger Jahr, Gerjo J V M van Osch, Eric Farrel. The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches. Tissue engineering. Part B, Reviews. vol 16. issue 2. 2010-06-17. PMID:19698058. |
in vivo, a hypoxic environment can lead to apoptosis, but hypoxic preconditioning of mscs and overexpression of prosurvival genes like akt can reduce hypoxia-induced cell death. |
2010-06-17 |
2023-08-12 |
Not clear |
| Oskar W Rokhlin, Natalya V Guseva, Agshin F Taghiyev, Rebecca A Glover, Michael B Cohe. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer biology & therapy. vol 9. issue 3. 2010-06-17. PMID:20023417. |
the ros induction allows kn-93 to circumvent the activation of akt, which occurs in prostate cancer cells under androgen deprivation, since akt could not inhibit ros-mediated apoptosis. |
2010-06-17 |
2023-08-12 |
Not clear |
| Elisa Giovannetti, Niccola Funel, Godefridus J Peters, Marco Del Chiaro, Leyla A Erozenci, Enrico Vasile, Leticia G Leon, Luca E Pollina, Annemieke Groen, Alfredo Falcone, Romano Danesi, Daniela Campani, Henk M Verheul, Ugo Bogg. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer research. vol 70. issue 11. 2010-06-17. PMID:20460539. |
modulation of apoptosis, akt phosphorylation, and expression of genes involved in invasive behavior may contribute to the role of mir-21 in gemcitabine chemoresistance and to the rational development of new targeted combinations. |
2010-06-17 |
2023-08-12 |
Not clear |
| R W Matheny, M L Adam. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Cell death and differentiation. vol 17. issue 4. 2010-06-15. PMID:19834495. |
pi3k p110 alpha and p110 beta have differential effects on akt activation and protection against oxidative stress-induced apoptosis in myoblasts. |
2010-06-15 |
2023-08-12 |
Not clear |
| R W Matheny, M L Adam. PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts. Cell death and differentiation. vol 17. issue 4. 2010-06-15. PMID:19834495. |
we also report that igf-i protects myoblasts from h(2)o(2)-induced apoptosis through a mechanism that requires p110 alpha, but may be independent of akt or erk under conditions of akt and erk inhibition. |
2010-06-15 |
2023-08-12 |
Not clear |
| Shikha Khatri, Hasmik Yepiskoposyan, Catherine A Gallo, Preeti Tandon, David R Pla. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. The Journal of biological chemistry. vol 285. issue 21. 2010-06-14. PMID:20371605. |
akt signal transduction induces coordinated increases in glycolysis and apoptosis resistance in a broad spectrum of cancers. |
2010-06-14 |
2023-08-12 |
Not clear |
| Shikha Khatri, Hasmik Yepiskoposyan, Catherine A Gallo, Preeti Tandon, David R Pla. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. The Journal of biological chemistry. vol 285. issue 21. 2010-06-14. PMID:20371605. |
downstream of akt, the foxo transcription factors regulate apoptosis via bim, but the contributions of foxos in regulating akt-induced glycolysis are not well described. |
2010-06-14 |
2023-08-12 |
Not clear |