| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Calvo, Ana Russo de Boland, Claudia Gentil. PTH inactivates the AKT survival pathway in the colonic cell line Caco-2. Biochimica et biophysica acta. vol 1803. issue 3. 2010-05-21. PMID:20005908. |
we demonstrate, for the first time, that pth modulates akt phosphorylation in response to apoptosis via the serine/threonine phosphatase pp2a. |
2010-05-21 |
2023-08-12 |
human |
| Natalia Calvo, Ana Russo de Boland, Claudia Gentil. PTH inactivates the AKT survival pathway in the colonic cell line Caco-2. Biochimica et biophysica acta. vol 1803. issue 3. 2010-05-21. PMID:20005908. |
overall, our data suggest that in caco-2 cells, pp2a and the camp pathway act in concert to inactivate the akt survival pathway in pth-induced intestinal cell apoptosis. |
2010-05-21 |
2023-08-12 |
human |
| Xi Huang, Xue-Ya Zhang, Feng Qin, Xiao-Yu Wang, Ping Ren, Zhao-Qian Liu, Hong-Hao Zho. Pretreatment with a traditional Chinese formula, guanxin II, reduces cardiac apoptosis via the Akt survival pathway in rats with myocardial ischemia. The Tohoku journal of experimental medicine. vol 220. issue 2. 2010-05-21. PMID:20139667. |
pretreatment with a traditional chinese formula, guanxin ii, reduces cardiac apoptosis via the akt survival pathway in rats with myocardial ischemia. |
2010-05-21 |
2023-08-12 |
rat |
| Xi Huang, Xue-Ya Zhang, Feng Qin, Xiao-Yu Wang, Ping Ren, Zhao-Qian Liu, Hong-Hao Zho. Pretreatment with a traditional Chinese formula, guanxin II, reduces cardiac apoptosis via the Akt survival pathway in rats with myocardial ischemia. The Tohoku journal of experimental medicine. vol 220. issue 2. 2010-05-21. PMID:20139667. |
akt is necessary and sufficient for inhibition of apoptosis in cardiomyocytes. |
2010-05-21 |
2023-08-12 |
rat |
| Lirlândia P Sousa, Fernando Lopes, Douglas M Silva, Luciana P Tavares, Angélica T Vieira, Bárbara M Rezende, Aline F Carmo, Remo C Russo, Cristiana C Garcia, Cláudio A Bonjardim, Ana L Alessandri, Adriano G Rossi, Vanessa Pinho, Mauro M Teixeir. PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner. Journal of leukocyte biology. vol 87. issue 5. 2010-05-20. PMID:20103769. |
lps resulted in a time-dependent activation of akt, which was blocked by treatment with rolipram or pi3k and akt inhibitors, and pi3k and akt inhibitors also enhanced apoptosis and promoted neutrophil clearance. |
2010-05-20 |
2023-08-12 |
mouse |
| Konstantia-Maria Chavele, Luisa Martinez-Pomares, Jan Domin, Samantha Pemberton, Stuart M Haslam, Anne Dell, H Terence Cook, Charles D Pusey, Siamon Gordon, Alan D Salam. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice. The Journal of clinical investigation. vol 120. issue 5. 2010-05-20. PMID:20407205. |
mr-/- mcs demonstrated augmented apoptosis compared with wt cells, and this was associated with diminished akt phosphorylation. |
2010-05-20 |
2023-08-12 |
mouse |
| Xiaohua Gao, Dorrah Deeb, Jiang Hao, Yongbo Liu, Ali S Arbab, Scott A Dulchavsky, Subhash C Gauta. Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. Anticancer research. vol 30. issue 3. 2010-05-18. PMID:20392997. |
synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival akt, mtor and nf-{kappa}b signaling proteins in colorectal cancer cells. |
2010-05-18 |
2023-08-12 |
Not clear |
| Xiaohua Gao, Dorrah Deeb, Jiang Hao, Yongbo Liu, Ali S Arbab, Scott A Dulchavsky, Subhash C Gauta. Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells. Anticancer research. vol 30. issue 3. 2010-05-18. PMID:20392997. |
induction of apoptosis by cddo-me was associated with the inhibition of pro-survival akt, nf-kappab and mtor signaling proteins and nf-kappab-regulated anti-apoptotic bcl-2, bcl-xl, bad and survivin. |
2010-05-18 |
2023-08-12 |
Not clear |
| Johan Lennartsson, Fatima Burovic, Barbara Witek, Aleksandra Jurek, Carl-Henrik Heldi. Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis. Cellular signalling. vol 22. issue 6. 2010-05-17. PMID:20138986. |
erk 5 is necessary for sustained pdgf-induced akt phosphorylation and inhibition of apoptosis. |
2010-05-17 |
2023-08-12 |
Not clear |
| Hisatsugu Koshimizu, Shunsuke Hazama, Tomoko Hara, Akihiko Ogura, Masami Kojim. Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons. Neuroscience letters. vol 473. issue 3. 2010-05-17. PMID:20219632. |
these results thus suggest that in cgns probdnf elicits apoptosis via activation of p75(ntr), rac-gtpase, jnk, and caspase-3, while matbdnf signals cell survival via activation of trkb, erks and akt, and deactivation of caspase-3. |
2010-05-17 |
2023-08-12 |
Not clear |
| Simona Piaggi, Chiara Raggi, Alessandro Corti, Emanuela Pitzalis, Marco C Mascherpa, Michela Saviozzi, Alfonso Pompella, Alessandro F Casin. Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity. Carcinogenesis. vol 31. issue 5. 2010-05-14. PMID:20106899. |
in conclusion, gsto1-1 overexpression appears to be associated with activation of survival pathways (akt and erk1/2) and inhibition of apoptotic pathways (jnk1), as well as protection against cisplatin-induced apoptosis. |
2010-05-14 |
2023-08-12 |
Not clear |
| A J C Pommier, G Alves, E Viennois, S Bernard, Y Communal, B Sion, G Marceau, C Damon, K Mouzat, F Caira, S Baron, J M A Lobaccar. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene. vol 29. issue 18. 2010-05-14. PMID:20190811. |
liver x receptor activation downregulates akt survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. |
2010-05-14 |
2023-08-12 |
mouse |
| A J C Pommier, G Alves, E Viennois, S Bernard, Y Communal, B Sion, G Marceau, C Damon, K Mouzat, F Caira, S Baron, J M A Lobaccar. Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene. vol 29. issue 18. 2010-05-14. PMID:20190811. |
treatment with the synthetic lxr agonist t0901317 downregulated the akt survival pathway and thus induced apoptosis of lncap pca cells in both xenografted nude mice and cell culture. |
2010-05-14 |
2023-08-12 |
mouse |
| Yuxi Zhang, Chuize Kong, Yu Zeng, Linhui Wang, Zhenhua Li, Huiqing Wang, Chuanliang Xu, Yinghao Su. Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20146252. |
ursolic acid induces pc-3 cell apoptosis via activation of jnk and inhibition of akt pathways in vitro. |
2010-05-12 |
2023-08-12 |
human |
| Yuxi Zhang, Chuize Kong, Yu Zeng, Linhui Wang, Zhenhua Li, Huiqing Wang, Chuanliang Xu, Yinghao Su. Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20146252. |
on the other hand, ua inhibited the akt pathway, subsequently upregulating the expression of fas ligand (fasl), which initiates death receptor-mediated apoptosis in pc-3 cells. |
2010-05-12 |
2023-08-12 |
human |
| Jing Wu, Min-Xiang Lei, Xiao-Yun Xie, Lan Liu, Yan-Mei She, Juan Mo, Shan Wan. Rosiglitazone inhibits high glucose-induced apoptosis in human umbilical vein endothelial cells through the PI3K/Akt/eNOS pathway. Canadian journal of physiology and pharmacology. vol 87. issue 7. 2010-05-06. PMID:19767878. |
previous studies have shown that the phosphatidylinositol 3-kinase / akt / endothelial nitric oxide synthase / no (pi3k/akt/enos/no) pathway is involved in high glucose-induced endothelial cell apoptosis and rosiglitazone has a protective effect on endothelium. |
2010-05-06 |
2023-08-12 |
human |
| Jianxin Huo, Shengli Xu, Kong-Peng La. Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20178987. |
fas apoptosis inhibitory molecule regulates t cell receptor-mediated apoptosis of thymocytes by modulating akt activation and nur77 expression. |
2010-05-06 |
2023-08-12 |
mouse |
| Rekha Rao, Pearl Lee, Warren Fiskus, Yonghua Yang, Rajeshree Joshi, Yongchao Wang, Kate Buckley, Ramesh Balusu, Jianguang Chen, Sanjay Koul, Atul Joshi, Sunil Upadhyay, Jianguo Tao, Eduardo Sotomayor, Kapil N Bhall. Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells. Cancer biology & therapy. vol 8. issue 13. 2010-05-04. PMID:19440035. |
heat shock protein (hsp) 90 inhibitors promote proteasomal degradation of pro-growth and pro-survival hsp90 client proteins, including cdk4, c-raf and akt, and induce apoptosis of human lymphoma cells. |
2010-05-04 |
2023-08-12 |
human |
| Jaleel Kizhakkayil, Faisal Thayyullathil, Shahanas Chathoth, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. Biochemical and biophysical research communications. vol 394. issue 3. 2010-05-04. PMID:20138829. |
modulation of curcumin-induced akt phosphorylation and apoptosis by pi3k inhibitor in mcf-7 cells. |
2010-05-04 |
2023-08-12 |
Not clear |
| Jaleel Kizhakkayil, Faisal Thayyullathil, Shahanas Chathoth, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. Biochemical and biophysical research communications. vol 394. issue 3. 2010-05-04. PMID:20138829. |
the active akt regulates cell survival and proliferation; and inhibits apoptosis. |
2010-05-04 |
2023-08-12 |
Not clear |