| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong-guo Liu, Na Song, Jie-meng Li, Xiang Cui, Yan-qing Che. [Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury]. Zhonghua yi xue za zhi. vol 90. issue 7. 2010-08-17. PMID:20368077. |
investigate whether preconditioning with diazoxide (dz), a mitochondrial atp-sensitive potassium channel opener, could enhance akt protein to up-regulate bcl-2/bax protein ratio against apoptosis. |
2010-08-17 |
2023-08-12 |
rat |
| Samuel García, Myriam Liz, Juan J Gómez-Reino, Carmen Cond. Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage. Arthritis research & therapy. vol 12. issue 1. 2010-08-13. PMID:20187936. |
akt activity protects rheumatoid synovial fibroblasts from fas-induced apoptosis by inhibition of bid cleavage. |
2010-08-13 |
2023-08-12 |
Not clear |
| Zhiwei Wang, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Aamir Ahmad, Veronique Nogueira, Nissim Hay, Fazlul H Sarka. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. Journal of cellular biochemistry. vol 109. issue 4. 2010-08-12. PMID:20052673. |
down-regulation of notch-1 and jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of akt, mtor, and nf-kappab signaling pathways. |
2010-08-12 |
2023-08-12 |
Not clear |
| Zhiwei Wang, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Aamir Ahmad, Veronique Nogueira, Nissim Hay, Fazlul H Sarka. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. Journal of cellular biochemistry. vol 109. issue 4. 2010-08-12. PMID:20052673. |
using multiple cellular and molecular approaches such as mtt assay, apoptosis assay, gene transfection, real-time rt-pcr, western blotting, migration, invasion assay and elisa, we found that down-regulation of notch-1 or jagged-1 was mechanistically associated with inhibition of cell growth, migration, invasion and induction of apoptosis in prostate cancer cells, which was mediated via inactivation of akt, mtor, and nf-kappab signaling. |
2010-08-12 |
2023-08-12 |
Not clear |
| Zhiwei Wang, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Aamir Ahmad, Veronique Nogueira, Nissim Hay, Fazlul H Sarka. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. Journal of cellular biochemistry. vol 109. issue 4. 2010-08-12. PMID:20052673. |
taken together, we conclude that the down-regulation of notch-1 or jagged-1 mediated inhibition of cell growth, migration and invasion, and the induction of apoptosis was in part due to inactivation of akt, mtor, and nf-kappab signaling pathways. |
2010-08-12 |
2023-08-12 |
Not clear |
| Hui-Wen Chiu, Jing-Hua Lin, Yi-An Chen, Sheng-Yow Ho, Ying-Jan Wan. Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy. vol 6. issue 3. 2010-08-12. PMID:20200477. |
the enhanced cytotoxic effect of combined treatment occurred due to the increased induction of more autophagy and apoptosis through the inhibition of akt and the activation of erk1/2 signaling pathways in ht1080 cells. |
2010-08-12 |
2023-08-12 |
mouse |
| Jie Zheng, Alice Hudder, Kim Zukowski, Raymond F Nova. Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells. Cancer letters. vol 296. issue 1. 2010-08-10. PMID:20417028. |
the effects of inhibiting mtor, with rapamycin, and akt, with a-443654, concurrently, on cell morphology, cell proliferation, the cell cycle, and apoptosis were examined using the benign mcf10a and malignant mcf10ca1a human breast epithelial cells. |
2010-08-10 |
2023-08-12 |
human |
| Feng Fang, Yijun Tang, Zhe Gao, Qiang X. A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression. Biochemical and biophysical research communications. vol 397. issue 2. 2010-08-10. PMID:20471963. |
meanwhile, naringenin also induced t cell apoptosis by upregulation of bax, bad, parp, cleaved-caspase 3 and downregulation of phosphorylated akt, bcl-2. |
2010-08-10 |
2023-08-12 |
Not clear |
| Mina No, Eun Jung Choi, In Ah Ki. Targeting HER2 signaling pathway for radiosensitization: alternative strategy for therapeutic resistance. Cancer biology & therapy. vol 8. issue 24. 2010-08-06. PMID:19923913. |
while apoptosis was the major mode of cell death when the cells were pretreated with ly294002 or akt inhibitor viii, the cells were pretreated by rapamycin or pi103 showed mixed mode of cell death including autophagy. |
2010-08-06 |
2023-08-12 |
Not clear |
| Monica Civallero, Maria Cosenza, Giulia Grisendi, Luigi Marcheselli, Katia Todoerti, Stefano Sacch. Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines. Leukemia & lymphoma. vol 51. issue 4. 2010-08-06. PMID:20218811. |
enzastaurin induced apoptosis and inhibited phosphorylation of pkc, rsk, akt, and downstream proteins. |
2010-08-06 |
2023-08-12 |
Not clear |
| Peifeng Li, Shankar Jayarama, Lakshmy Ganesh, David Mordi, Ryan Carr, Prasad Kanteti, Nissim Hay, Bellur S Prabhaka. Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4. The Journal of biological chemistry. vol 285. issue 29. 2010-08-06. PMID:20484047. |
because akt is active in most cancer cells and phosphorylated madd confers resistance to trail-induced apoptosis, co-targeting akt-madd axis is likely to increase efficacy of trail-based therapies. |
2010-08-06 |
2023-08-12 |
Not clear |
| Mee-Sun Hyun, Jung-Mu Hur, Yeun-Ja Mun, Dongho Kim, Won-Hong Wo. BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKs-linked cascade. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:19950206. |
bbr-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of map kinases (jnk and p38 mapk), ask1, akt, and p53. |
2010-08-05 |
2023-08-12 |
human |
| Jae In Jung, Han Jin Cho, Jongdai Kim, Dae Young Kwon, Jung Han Yoon Par. trans-10,cis-12 conjugated linoleic acid inhibits insulin-like growth factor-I receptor signaling in TSU-Pr1 human bladder cancer cells. Journal of medicinal food. vol 13. issue 1. 2010-08-05. PMID:20136431. |
these results indicate that the inhibition of igf-ir signaling and the activation of akt and erk-1/2 contributed to decreased cell proliferation and increased apoptosis in tsu-pr1 cells treated with t10c12. |
2010-08-05 |
2023-08-12 |
human |
| Hervé Sartelet, Shigeru Ohta, Stephane Barrette, Anne-Laure Rougemont, Marie Brevet, Marie Regairaz, Isabelle Harvey, Chantal Bernard, Monique Fabre, Louis Gaboury, Luc L Oligny, Jacques Bosq, Dominique Valteau-Couanet, Gilles Vassa. High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. Histopathology. vol 56. issue 5. 2010-08-03. PMID:20459571. |
high level of apoptosis and low akt activation in mass screening as opposed to standard neuroblastoma. |
2010-08-03 |
2023-08-12 |
Not clear |
| Jeong-Hoon Lee, Jung-Hwan Yoon, Su Jong Yu, Goh Eun Chung, Eun Uk Jung, Hwi Young Kim, Bo Hyun Kim, Dae Hee Choi, Sun Jung Myung, Yoon Jun Kim, Chung Yong Kim, Hyo-Suk Le. Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells. Cancer letters. vol 295. issue 2. 2010-07-30. PMID:20350780. |
inhibition of crabp-ii enhanced ra-induced apoptosis and sensitized ra-resistant hcc cells to ra cytotoxicity by attenuating p42/44 mapk and akt activation. |
2010-07-30 |
2023-08-12 |
Not clear |
| José Edgar Nicoletti-Carvalho, Tatiane C Araújo Nogueira, Renata Gorjão, Carla Rodrigues Bromati, Tatiana S Yamanaka, Antonio Carlos Boschero, Licio Augusto Velloso, Rui Curi, Gabriel Forato Anhê, Silvana Bordi. UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells. The Journal of endocrinology. vol 206. issue 2. 2010-07-30. PMID:20488947. |
upr-mediated trib3 expression correlates with reduced akt phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in rinm5f cells. |
2010-07-30 |
2023-08-12 |
Not clear |
| José Edgar Nicoletti-Carvalho, Tatiane C Araújo Nogueira, Renata Gorjão, Carla Rodrigues Bromati, Tatiana S Yamanaka, Antonio Carlos Boschero, Licio Augusto Velloso, Rui Curi, Gabriel Forato Anhê, Silvana Bordi. UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells. The Journal of endocrinology. vol 206. issue 2. 2010-07-30. PMID:20488947. |
the inability of il6 to activate akt in the presence of pa correlated with an inefficient protection against pa-induced apoptosis. |
2010-07-30 |
2023-08-12 |
Not clear |
| Benjamin Bonavid. What signals are generated by anti-CD20 antibody therapy? Current hematologic malignancy reports. vol 1. issue 4. 2010-07-28. PMID:20425315. |
in addition to the proposed actions mediated by rituximab (such as complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis), rituximab may signal the tumor cells and inhibit constitutively activated survival signaling pathways (raf-1-mek1/2-erk1/2, p38 mapk, nf-kappab, and akt), resulting in inhibition of cell growth and of selectively anti-apoptotic gene products such as bcl-2 and bcl-(xl). |
2010-07-28 |
2023-08-12 |
Not clear |
| Shao-Min Che, Xiao-Zhi Zhang, Lei Hou, Tian-Bao Son. Cyclooxygenase-2 inhibitor NS398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting AKT activation and inducing apoptosis. Cancer investigation. vol 28. issue 7. 2010-07-27. PMID:20486853. |
cyclooxygenase-2 inhibitor ns398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting akt activation and inducing apoptosis. |
2010-07-27 |
2023-08-12 |
Not clear |
| Shao-Min Che, Xiao-Zhi Zhang, Lei Hou, Tian-Bao Son. Cyclooxygenase-2 inhibitor NS398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting AKT activation and inducing apoptosis. Cancer investigation. vol 28. issue 7. 2010-07-27. PMID:20486853. |
our results suggest that ns398 may enhance radiosensitivity of eca109r50gy cells through blocking akt activation and inducing apoptosis. |
2010-07-27 |
2023-08-12 |
Not clear |