| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wanyeon Kim, Hee Jung Yang, HyeSook Youn, Young Ju Yun, Ki Moon Seong, BuHyun You. Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes. Journal of radiation research. vol 51. issue 3. 2010-09-28. PMID:20339252. |
myricetin inhibits akt survival signaling and induces bad-mediated apoptosis in a low dose ultraviolet (uv)-b-irradiated hacat human immortalized keratinocytes. |
2010-09-28 |
2023-08-12 |
human |
| Wanyeon Kim, Hee Jung Yang, HyeSook Youn, Young Ju Yun, Ki Moon Seong, BuHyun You. Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes. Journal of radiation research. vol 51. issue 3. 2010-09-28. PMID:20339252. |
we demonstrate here that myricetin inhibits akt activity to induce apoptosis in a low dose ('repairable dose') uvb-irradiated keratinocytes. |
2010-09-28 |
2023-08-12 |
human |
| Wanyeon Kim, Hee Jung Yang, HyeSook Youn, Young Ju Yun, Ki Moon Seong, BuHyun You. Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes. Journal of radiation research. vol 51. issue 3. 2010-09-28. PMID:20339252. |
ectopic expression of constitutively active akt granted statistically significant protection against myricetin-induced apoptosis. |
2010-09-28 |
2023-08-12 |
human |
| Sang Bae Lee, Il-Sun Kwon, Jihye Park, Kyung-Hoon Lee, Younghee Ahn, Cheolju Lee, Joon Kim, Soo Young Choi, Sung-Woo Cho, Jee-Yin Ah. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. The Journal of biological chemistry. vol 285. issue 38. 2010-09-28. PMID:20605787. |
ribosomal protein s3, a new substrate of akt, serves as a signal mediator between neuronal apoptosis and dna repair. |
2010-09-28 |
2023-08-12 |
human |
| Sang Bae Lee, Il-Sun Kwon, Jihye Park, Kyung-Hoon Lee, Younghee Ahn, Cheolju Lee, Joon Kim, Soo Young Choi, Sung-Woo Cho, Jee-Yin Ah. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. The Journal of biological chemistry. vol 285. issue 38. 2010-09-28. PMID:20605787. |
here, we show that human rps3 is a physiological target of akt kinase and a novel mediator of neuronal apoptosis. |
2010-09-28 |
2023-08-12 |
human |
| Xinchun Shen, Gang Xi, Yashwanth Radhakrishnan, David R Clemmon. PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival. The Journal of biological chemistry. vol 285. issue 38. 2010-09-28. PMID:20643654. |
these findings reveal a novel mechanism for recruitment of pdk1 to the shps-1 signaling complex, which is required for igf-i-stimulated akt thr(308) phosphorylation and inhibition of apoptosis. |
2010-09-28 |
2023-08-12 |
Not clear |
| Yasumasa Ikeda, Ken-ichi Aihara, Masashi Akaike, Takashi Sato, Kazue Ishikawa, Takayuki Ise, Shusuke Yagi, Takashi Iwase, Yuka Ueda, Sumiko Yoshida, Hiroyuki Azuma, Kenneth Walsh, Toshiaki Tamaki, Shigeaki Kato, Toshio Matsumot. Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice. Molecular endocrinology (Baltimore, Md.). vol 24. issue 7. 2010-09-23. PMID:20501642. |
thus, the androgen-ar system is thought to counteract dox-induced cardiotoxicity partly through activation of the akt pathway and up-regulation of tfam to protect cardiomyocytes from mitochondrial damage and apoptosis. |
2010-09-23 |
2023-08-12 |
mouse |
| Liang-Liang Yu, Ning Dai, Hong-Gang Yu, Lei-Min Sun, Jian-Min S. Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514451. |
the ubiquitously expressed serine-threonine kinase akt and the transcription factor nf-kappab both are involved in cell proliferation and apoptosis. |
2010-09-23 |
2023-08-12 |
human |
| Liang-Liang Yu, Ning Dai, Hong-Gang Yu, Lei-Min Sun, Jian-Min S. Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514451. |
chemotherapeutics induced apoptosis of sgc-7901 and activated akt and nf-kappab, combined use of wortmannin or mg-132 induced apoptosis further and attenuated the activation of nf-kappab. |
2010-09-23 |
2023-08-12 |
human |
| Liang-Liang Yu, Ning Dai, Hong-Gang Yu, Lei-Min Sun, Jian-Min S. Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514451. |
the chemotherapeutics induced apoptosis and induced the activation of akt and nf-kappab in sgc-7901 cell, suppression the activation of akt or nf-kappab can increase the effects of chemotherapeutics. |
2010-09-23 |
2023-08-12 |
human |
| Damir Hamamdzic, Robert S Fenning, Dhavalkumar Patel, Emile R Mohler, Ksenia A Orlova, Alexander C Wright, Raul Llano, Martin G Keane, Richard P Shannon, Morris J Birnbaum, Robert L Wilensk. Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease. American journal of physiology. Heart and circulatory physiology. vol 299. issue 3. 2010-09-22. PMID:20601459. |
aberrant akt signaling correlated with increased inflammation, cellular proliferation, apoptosis, and vv neovascularization. |
2010-09-22 |
2023-08-12 |
Not clear |
| Xiujuan Qu, Yingchun Li, Jing Liu, Ling Xu, Ye Zhang, Xuejun Hu, Kezuo Hou, Yunpeng Li. Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20177738. |
in this study, vp-16-induced rbl-2h3 cells apoptosis was accompanied by the activation of akt and erk. |
2010-09-21 |
2023-08-12 |
rat |
| Xiujuan Qu, Yingchun Li, Jing Liu, Ling Xu, Ye Zhang, Xuejun Hu, Kezuo Hou, Yunpeng Li. Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20177738. |
over expression of cbl-b significantly enhanced vp-16-induced cell apoptosis with inhibition of akt activity, while a dominant negative (dn) ring finger domain mutation completely abolished this enhancement. |
2010-09-21 |
2023-08-12 |
rat |
| Xiujuan Qu, Yingchun Li, Jing Liu, Ling Xu, Ye Zhang, Xuejun Hu, Kezuo Hou, Yunpeng Li. Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20177738. |
these observations indicate that cbl-b promotes rbl-2h3 apoptosis induced by vp-16 or ara-c, probably through inhibition of akt and activation of erk. |
2010-09-21 |
2023-08-12 |
rat |
| Annat Raiter, Chana Weiss, Zafrir Bechor, Itzik Ben-Dor, Alexander Battler, Boris Kaplan, Britta Hard. Activation of GRP78 on endothelial cell membranes by an ADAM15-derived peptide induces angiogenesis. Journal of vascular research. vol 47. issue 5. 2010-09-14. PMID:20145413. |
the mechanism of peptide-induced angiogenic activity involves inhibition of apoptosis as well as increased akt phosphorylation and erk 1/2 activation. |
2010-09-14 |
2023-08-12 |
mouse |
| Ivana Tonic, Wan-Ni Yu, Youngku Park, Chia-Chen Chen, Nissim Ha. Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci. The Journal of biological chemistry. vol 285. issue 31. 2010-09-14. PMID:20495005. |
here we show that the activation of akt is sufficient to promote these two principal processes, by inhibiting chk1 activation with concomitant inhibition of apoptosis. |
2010-09-14 |
2023-08-12 |
human |
| Miaozong Wu, Bin Wang, Jia Fei, Nalini Santanam, Eric R Bloug. Important roles of Akt/PKB signaling in the aging process. Frontiers in bioscience (Scholar edition). vol 2. 2010-09-14. PMID:20515848. |
the akt / protein kinase b (pkb) is a family of serine / threonine protein kinases, which play prominent roles in a diverse number of processes including cell survival, cell growth, gene expression, apoptosis, protein synthesis, energy metabolism and oncogenesis. |
2010-09-14 |
2023-08-12 |
Not clear |
| Kriti Rakesh, ByungSu Yoo, Il-Man Kim, Natasha Salazar, Ki-Seok Kim, Howard A Rockma. beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Science signaling. vol 3. issue 125. 2010-09-13. PMID:20530803. |
hearts from mice lacking beta-arrestin or at1rs failed to induce responses to mechanical stretch, as shown by blunted extracellular signal-regulated kinase and akt activation, impaired transactivation of the epidermal growth factor receptor, and enhanced myocyte apoptosis. |
2010-09-13 |
2023-08-12 |
mouse |
| Brian M Howard, Demirkan B Gursel, Anne-Marie Bleau, Robel T Beyene, Eric C Holland, John A Boockva. EGFR signaling is differentially activated in patient-derived glioblastoma stem cells. Journal of experimental therapeutics & oncology. vol 8. issue 3. 2010-09-09. PMID:20734923. |
inhibition of egfr signaling by ag1478 increased gsc senescence and apoptosis, likely via inhibition of akt and activation of gsk3beta. |
2010-09-09 |
2023-08-12 |
Not clear |
| Hui Jing, Xinglu Zhou, Xiaowu Dong, Ji Cao, Hong Zhu, Jianshu Lou, Yongzhou Hu, Qiaojun He, Bo Yan. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer letters. vol 294. issue 2. 2010-09-07. PMID:20167420. |
further studies reveal that ibc significantly abates akt phosphorylation at ser-473 and akt kinase activity in cells, which subsequently leads to inhibition of akt downstream substrates and evokes significant levels of apoptosis associated with mitochondria pathway. |
2010-09-07 |
2023-08-12 |
human |