| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' N Goncharenko-Khaider, D Lane, I Matte, C Rancourt, A Pich\\xc3\\xa. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20661217.' |
thus, akt acts upstream of mitochondria and inhibits trail-induced apoptosis by decreasing bid protein levels and possibly inhibiting its cleavage. |
2010-11-01 |
2023-08-12 |
Not clear |
| B L Slomiany, A Slomian. Constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation in ghrelin protection against Porphyromonas gingivalis-induced salivary gland acinar cell apoptosis. Inflammopharmacology. vol 18. issue 3. 2010-10-29. PMID:20155328. |
the loss in countering effect of ghrelin on the lps-induced changes in apoptosis and caspase-3 activity was attained with src kinase inhibitor, pp2, as well as akt inhibitor, sh-5, and cnos inhibitor, l-name, but not the inos inhibitor, 1400w. |
2010-10-29 |
2023-08-12 |
Not clear |
| Elena Dozio, Massimiliano Ruscica, Luca Passafaro, Giada Dogliotti, Liliana Steffani, Paola Marthyn, Alessandra Pagani, Germana Demartini, Daniele Esposti, Franco Fraschini, Paolo Magn. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. European journal of pharmacology. vol 641. issue 1. 2010-10-28. PMID:20580704. |
we observed that alpha-lipoic acid is able to scavenge reactive oxygen species in mcf-7 cells and that the reduction of reactive oxygen species is followed by cell growth arrest in the g1 phase of the cell cycle, via the specific inhibition of akt pathway and the up-regulation of the cyclin-dependent kinase inhibitor p27(kip1), and by apoptosis, via changes of the ratio of the apoptotic-related protein bax/bcl-2. |
2010-10-28 |
2023-08-12 |
human |
| Patricio Godoy, Markus Schug, Alexander Bauer, Jan G Hengstle. Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities. Methods in molecular biology (Clifton, N.J.). vol 640. 2010-10-28. PMID:20645050. |
a dried stiff collagen activates akt and erk1/2 pathways that results in apoptosis resistance. |
2010-10-28 |
2023-08-12 |
mouse |
| Kyung-Jun Jang, Min-Ho Han, Byung-Hoon Lee, Byung-Woo Kim, Cheol-Hong Kim, Hyun-Min Yoon, Yung-Hyun Cho. Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. Journal of acupuncture and meridian studies. vol 3. issue 1. 2010-10-27. PMID:20633512. |
moreover the activity of akt was downregulated in egl-treated cells, and the phosphatidylinositol-3 kinase/ akt inhibitor ly294002 sensitized the cells to egl-induced apoptosis. |
2010-10-27 |
2023-08-12 |
human |
| Kyung-Jun Jang, Min-Ho Han, Byung-Hoon Lee, Byung-Woo Kim, Cheol-Hong Kim, Hyun-Min Yoon, Yung-Hyun Cho. Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. Journal of acupuncture and meridian studies. vol 3. issue 1. 2010-10-27. PMID:20633512. |
the results indicated that egl induces the apoptosis of ags cells through a signaling cascade of death receptor-mediated extrinsic, as well as mitochondria-mediated intrinsic, caspase pathways which are associated with inactivation of the akt signal pathway. |
2010-10-27 |
2023-08-12 |
human |
| Chandana Mohanty, Sanjeeb K Saho. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials. vol 31. issue 25. 2010-10-25. PMID:20553984. |
molecular basis of apoptosis studied by western blotting revealed blockade of nuclear factor kappa b (nfkappab) and its regulated gene expression through inhibition of ikappab kinase and akt activation. |
2010-10-25 |
2023-08-12 |
mouse |
| Xuan Zhou, Yu Ren, Lei Han, Mei Mei, Peng Xu, Chun-Zhi Zhang, Guang-Xiu Wang, Zhi-Fan Jia, Pei-Yu Pu, Chun-Sheng Kan. Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells. International journal of oncology. vol 36. issue 3. 2010-10-22. PMID:20126987. |
downstream factors of the akt pathway are involved in cell proliferation, apoptosis, cellular migration and angiogenesis. |
2010-10-22 |
2023-08-12 |
human |
| Youde Jiang, Jena J Steinl. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Canadian journal of physiology and pharmacology. vol 88. issue 5. 2010-10-22. PMID:20555424. |
these results suggest that diabetes activates multiple inflammatory markers in the heart, which then signal a decrease in the activities of key players in the insulin-signaling cascade, namely igf-1r, irs-2, and akt, to regulate apoptosis. |
2010-10-22 |
2023-08-12 |
rat |
| Yolanda Sánchez, Gloria P Simón, Eva Calviño, Elena de Blas, Patricio Alle. Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20605902. |
experiments using mitogen-activated protein kinase kinase/erk inhibitors [2'-amino-3'-methoxyflavone (pd98059) and 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (u0126)] and phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (ly294002) indicate that erk activation does not mediate and even restrains apoptosis potentiation, whereas akt down-regulation facilitates apoptosis generation. |
2010-10-21 |
2023-08-12 |
human |
| Hua-Pei Song, Lei Zhang, Yong-Ming Dang, Hong Yan, Zhi-Gang Chu, Yue-Sheng Huan. The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082630. |
in burned rats, the expression of pi3-k and phosphorylated (p-) akt expression increased, as did myocardial apoptosis. |
2010-10-20 |
2023-08-12 |
rat |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
transfection with pten-specific sirna protected betatc-6 cells from cytokine or peroxynitrite-mediated cell apoptosis and partially reversed akt inhibition. |
2010-10-20 |
2023-08-12 |
Not clear |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
preventing peroxynitrite formation by administrating nac/l: -nmma, or scavenging peroxynitrite directly by ua, attenuated cytokine-induced pten upregulation, akt inhibition, and beta-cell apoptosis. |
2010-10-20 |
2023-08-12 |
Not clear |
| Gagan Deep, Subhash C Gangar, Nicholas H Oberlies, David J Kroll, Rajesh Agarwa. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Molecular carcinogenesis. vol 49. issue 10. 2010-10-20. PMID:20721970. |
isosilybin a induces apoptosis in human prostate cancer cells via targeting akt, nf-κb, and androgen receptor signaling. |
2010-10-20 |
2023-08-12 |
human |
| Sebastian W Hofbauer, Josefina D Piñón, Gabriele Brachtl, Lucia Haginger, Wei Wang, Karin Jöhrer, Ingeborg Tinhofer, Tanja Nicole Hartmann, Richard Grei. Modifying akt signaling in B-cell chronic lymphocytic leukemia cells. Cancer research. vol 70. issue 18. 2010-10-19. PMID:20823161. |
akt activation was increased by the protective presence of human bone marrow stromal cells and b-cell receptor mimicking signals but antagonized by direct akt blockade with the novel specific inhibitor aix, with preferential apoptosis induction in cll cells with an unmutated immunoglobulin status, which predicts poor clinical outcome. |
2010-10-19 |
2023-08-12 |
human |
| Azhar R Hussain, Shahab Uddin, Maqbool Ahmed, Rong Bu, Saeeda O Ahmed, Jehad Abubaker, Mehar Sultana, Dahish Ajarim, Fouad Al-Dayel, Prashant P Bavi, Khawla S Al-Kuray. Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling. The Journal of pathology. vol 222. issue 2. 2010-10-18. PMID:20632385. |
we also detected an inter-relationship between xiap expression and activated akt in dlbcl cells that may explain cellular resistance to pi3-kinase/akt inhibition-mediated apoptosis. |
2010-10-18 |
2023-08-12 |
Not clear |
| Inga Preuss, Dagmar Hildebrand, Joachim H C Orth, Klaus Aktories, Katharina F Kubatzk. Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cellular microbiology. vol 12. issue 8. 2010-10-14. PMID:20331638. |
we show that treatment of hek293 cells with pmt inhibits staurosporine-mediated apoptosis through pi3k-dependent phosphorylation of akt and constitutive expression of pim-1 kinase. |
2010-10-14 |
2023-08-12 |
human |
| Inga Preuss, Dagmar Hildebrand, Joachim H C Orth, Klaus Aktories, Katharina F Kubatzk. Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cellular microbiology. vol 12. issue 8. 2010-10-14. PMID:20331638. |
only the combined inhibition of akt and pim reverses the pmt-induced protection from staurosporine-induced apoptosis. |
2010-10-14 |
2023-08-12 |
human |
| Lifen Yang, Guilin Qiao, Haiyan Ying, Jian Zhang, Fei Yi. TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha. Biochemical and biophysical research communications. vol 400. issue 1. 2010-10-11. PMID:20691662. |
akt signaling plays a central role in t cell functions, such as proliferation, apoptosis, and regulatory t cell development. |
2010-10-11 |
2023-08-12 |
Not clear |
| E-K Park, E J Lee, S-H Lee, K H Koo, J Y Sung, E H Hwang, J H Park, C-W Kim, K-C Jeong, B-K Park, Y-N Ki. Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt. British journal of pharmacology. vol 160. issue 5. 2010-10-07. PMID:20590613. |
induction of apoptosis by the ginsenoside rh2 by internalization of lipid rafts and caveolae and inactivation of akt. |
2010-10-07 |
2023-08-12 |
Not clear |